Gene: PARG

8505
PARG99
poly(ADP-ribose) glycohydrolase
protein-coding
10q11.23
Ensembl:ENSG00000227345 MIM:603501 Vega:OTTHUMG00000018201 UniprotKB:Q86W56
NC_000010.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.445e-1 (AD)  3.791e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUL20.951
C10orf880.951
RASA10.943
USP140.943
NAPG0.941
VPS350.941
G3BP20.941
COL4A3BP0.94
PIK3CB0.94
CAND10.939

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.463
CSAG1-0.434
MTRNR2L10-0.429
OR4F29-0.425
MTRNR2L6-0.411
MTRNR2L9-0.41
HEY2-0.408
ASB4-0.408
MAGEA12-0.399
FZD10-0.397

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PARG mRNA"19114083
D020106AcrylamideAcrylamide results in increased expression of PARG mRNA28959563
D000246Adenosine Diphosphate RibosePARG protein results in increased degradation of Adenosine Diphosphate Ribose17640816
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PARG gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of PARG mRNA"23195993
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PARG mRNA16483693
D001104ArbutinArbutin results in increased expression of PARG mRNA17103032
C037689benzamidebenzamide inhibits the reaction [PARG affects the susceptibility to Methylnitronitrosoguanidine]15591342
C037689benzamidebenzamide inhibits the reaction [PARG affects the susceptibility to Vitamin K 3]15591342
D001564Benzo(a)pyrenePARG affects the reaction [Benzo(a)pyrene results in increased expression of ALDH1A3 protein]25628927
D001564Benzo(a)pyrenePARG affects the reaction [Benzo(a)pyrene results in increased expression of ATM mRNA]22266578
D001564Benzo(a)pyrenePARG affects the reaction [Benzo(a)pyrene results in increased expression of ATM protein]22266578
D001564Benzo(a)pyrenePARG affects the reaction [Benzo(a)pyrene results in increased expression of CACYBP protein]25628927
D001564Benzo(a)pyrenePARG affects the reaction [Benzo(a)pyrene results in increased expression of CFL1 protein]25628927
D001564Benzo(a)pyrenePARG affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]22266578
D001564Benzo(a)pyrenePARG affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]22266578
D001564Benzo(a)pyrenePARG affects the reaction [Benzo(a)pyrene results in increased expression of EEF2 protein]25628927
D001564Benzo(a)pyrenePARG affects the reaction [Benzo(a)pyrene results in increased expression of HNRNPA1 protein]25628927
D001564Benzo(a)pyrenePARG affects the reaction [Benzo(a)pyrene results in increased expression of HSPA8 protein]25628927
D001564Benzo(a)pyrenePARG affects the reaction [Benzo(a)pyrene results in increased expression of PFN1 protein]25628927
D001564Benzo(a)pyrenePARG affects the reaction [Benzo(a)pyrene results in increased expression of PLS3 protein]25628927
D001564Benzo(a)pyrenePARG affects the reaction [Benzo(a)pyrene results in increased expression of STOML2 protein]25628927
D001564Benzo(a)pyrenePARG affects the reaction [Benzo(a)pyrene results in increased expression of TP53 mRNA]22266578
D001564Benzo(a)pyrenePARG affects the reaction [Benzo(a)pyrene results in increased expression of TP53 protein]22266578
D001564Benzo(a)pyrenePARG affects the reaction [Benzo(a)pyrene results in increased expression of TPT1 protein]25628927
D001564Benzo(a)pyrenePARG affects the reaction [Benzo(a)pyrene results in increased expression of TRAP1 protein]25628927
D001564Benzo(a)pyrenePARG results in increased susceptibility to Benzo(a)pyrene22266578|2562892
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PARG mRNA"19150397
C038328BEP protocolBEP protocol results in decreased expression of PARG mRNA18987330
C006780bisphenol Abisphenol A results in increased expression of PARG mRNA25181051
D002118CalciumPARG protein promotes the reaction [Hydrogen Peroxide results in increased uptake of Calcium]20878536
D019327Copper SulfateCopper Sulfate results in decreased expression of PARG mRNA19549813
D036563Cyclic ADP-Ribose[PARG protein results in increased degradation of Poly Adenosine Diphosphate Ribose] which results in increased abundance of Cyclic ADP-Ribose28525621
D016572CyclosporineCyclosporine results in increased expression of PARG mRNA27989131
D002945CisplatinCisplatin results in decreased phosphorylation of PARG protein22006019
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of PARG mRNA26924002
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of PARG mRNA"27840820
C024629dimethyl phthalatedimethyl phthalate affects the expression of PARG mRNA26924002
D004610Ellagic AcidEllagic Acid results in decreased activity of PARG protein19840838
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PARG protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PARG mRNA22079256
D005839GentamicinsGentamicins results in increased expression of PARG mRNA22061828
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of PARG mRNA18951874
D006861Hydrogen Peroxide[Hydrolyzable Tannins results in decreased activity of PARG protein] which results in decreased susceptibility to Hydrogen Peroxide11593040
D006861Hydrogen Peroxide[nobotanin B results in decreased activity of PARG protein] which results in decreased susceptibility to Hydrogen Peroxide11593040
D006861Hydrogen PeroxidePARG protein promotes the reaction [Hydrogen Peroxide results in increased uptake of Calcium]20878536
D006861Hydrogen PeroxidePARG protein results in increased susceptibility to Hydrogen Peroxide20878536
D047348Hydrolyzable TanninsHydrolyzable Tannins results in decreased activity of PARG protein11593040
D047348Hydrolyzable Tannins[Hydrolyzable Tannins results in decreased activity of PARG protein] which results in decreased susceptibility to Hydrogen Peroxide11593040
D047348Hydrolyzable Tannins[Hydrolyzable Tannins results in decreased activity of PARG protein] which results in decreased susceptibility to Methylnitronitrosoguanidine11593040
D047348Hydrolyzable TanninsHydrolyzable Tannins results in decreased activity of PARG18693296
C011890kojic acidkojic acid results in increased expression of PARG mRNA16595896
D008070LipopolysaccharidesPARG gene mutant form results in increased susceptibility to Lipopolysaccharides15282315
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of PARG mRNA24118919
C004925methylmercuric chloridePARG protein results in decreased susceptibility to methylmercuric chloride24118919
D008769Methylnitronitrosoguanidinebenzamide inhibits the reaction [PARG affects the susceptibility to Methylnitronitrosoguanidine]15591342
D008769Methylnitronitrosoguanidine[Hydrolyzable Tannins results in decreased activity of PARG protein] which results in decreased susceptibility to Methylnitronitrosoguanidine11593040
D008769Methylnitronitrosoguanidine[nobotanin B results in decreased activity of PARG protein] which results in decreased susceptibility to Methylnitronitrosoguanidine11593040
D008769MethylnitronitrosoguanidinePARG affects the susceptibility to Methylnitronitrosoguanidine15591342
D008770MethylnitrosoureaPARG gene mutant form results in increased susceptibility to Methylnitrosourea15282315
C517284monomethyl phthalatemonomethyl phthalate affects the expression of PARG mRNA26924002
C040015myricetinmyricetin results in decreased activity of PARG protein19840838
D009532NickelNickel results in decreased expression of PARG mRNA23195993
C075603nobotanin Bnobotanin B results in decreased activity of PARG protein11593040
C075603nobotanin B[nobotanin B results in decreased activity of PARG protein] which results in decreased susceptibility to Hydrogen Peroxide11593040
C075603nobotanin B[nobotanin B results in decreased activity of PARG protein] which results in decreased susceptibility to Methylnitronitrosoguanidine11593040
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PARG mRNA25729387
D010672PhenytoinPhenytoin results in increased expression of PARG mRNA20345932
D011064Poly Adenosine Diphosphate RibosePARG affects the abundance of Poly Adenosine Diphosphate Ribose15591342
D011064Poly Adenosine Diphosphate Ribose[PARG protein results in increased degradation of Poly Adenosine Diphosphate Ribose] which results in increased abundance of Cyclic ADP-Ribose28525621
D011064Poly Adenosine Diphosphate RibosePARG protein results in increased metabolism of Poly Adenosine Diphosphate Ribose20878536
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PARG mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PARG mRNA22079256
C041376rosmarinic acidrosmarinic acid results in decreased activity of PARG protein19840838
D012834SilverSilver results in decreased expression of PARG mRNA27131904
D018038Sodium SeleniteSodium Selenite results in increased expression of PARG mRNA18175754
D013311StreptozocinPARG gene mutant form results in increased susceptibility to Streptozocin15282315
D013629TamoxifenTamoxifen results in increased expression of PARG mRNA15590111
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PARG mRNA24680724
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PARG mRNA25729387
D024483Vitamin K 3benzamide inhibits the reaction [PARG affects the susceptibility to Vitamin K 3]15591342
D024483Vitamin K 3PARG affects the susceptibility to Vitamin K 315591342

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004649poly(ADP-ribose) glycohydrolase activity-IBA21873635  
GO:0004649poly(ADP-ribose) glycohydrolase activity-IDA9074616  15450800  
GO:0004649poly(ADP-ribose) glycohydrolase activity-TAS-  
GO:0005515protein binding-IPI27257257  
GO ID GO Term Qualifier Evidence PubMed
GO:0005975carbohydrate metabolic process-IEA-  
GO:0006282regulation of DNA repair-IBA21873635  
GO:0009225nucleotide-sugar metabolic process-IBA21873635  
GO:0031056regulation of histone modification-IBA21873635  
GO:1990966ATP generation from poly-ADP-D-ribose-IBA21873635  
GO:1990966ATP generation from poly-ADP-D-ribose-IDA27257257  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA9074616  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-TAS9925755  
GO:0005759mitochondrial matrix-IEA-  
GO:0005829cytosol-IDA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-110362POLB-Dependent Long Patch Base Excision RepairTAS
R-HSA-110373Resolution of AP sites via the multiple-nucleotide patch replacement pathwayTAS
R-HSA-73884Base Excision RepairTAS
R-HSA-73894DNA RepairTAS
R-HSA-73933Resolution of Abasic Sites (AP sites)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22964577Poly(ADP-ribosyl)ation is a survival mechanism in cigarette smoke-induced and hydrogen peroxide-mediated cell death. (2012 Nov 1)Kovacs KFree Radic Biol Med