Gene: GCM1

8521
GCMA|hGCMa
glial cells missing homolog 1
protein-coding
6p12.1
Ensembl:ENSG00000137270 MIM:603715 Vega:OTTHUMG00000014871 UniprotKB:Q9NP62
NC_000006.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.142e-2 (AD)  9.650e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM950.797
CA60.748
TMPRSS130.732
SPO110.711
PLA2G2E0.705
GDNF0.691
IGFL30.687
OTOR0.684
GJA80.683
C11orf520.681

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPR17-0.388
PDGFRA-0.332
NXPH1-0.317
ERBB4-0.313
CHAD-0.305
OMG-0.303
KCNMB2-0.302
KBTBD7-0.294
SLITRK4-0.293
GPR85-0.292

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of GCM1 mRNA"27291303
C5850042-monochloropropanediol2-monochloropropanediol results in increased expression of GCM1 mRNA28522335
D000079AcetaldehydeAcetaldehyde affects the expression of GCM1 mRNA22634333
D019342Acetic AcidAcetic Acid results in increased expression of GCM1 protein21296659
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GCM1 mRNA16483693
C547126AZM551248AZM551248 results in decreased expression of GCM1 mRNA22323515
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of GCM1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of GCM1 mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of GCM1 mRNA27858113
C006780bisphenol Abisphenol A affects the methylation of GCM1 promoter27334623
C006780bisphenol Abisphenol A results in increased methylation of GCM1 gene28505145
C099813bromochloroacetic acidbromochloroacetic acid results in increased expression of GCM1 protein21296659
D002330CarmustineCarmustine results in increased expression of GCM1 mRNA15980968
D004390ChlorpyrifosChlorpyrifos results in increased expression of GCM1 mRNA22285354
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of GCM1 mRNA27858113
D003033Coal TarCoal Tar results in decreased expression of GCM1 mRNA27858113
D005576ColforsinColforsin promotes the reaction [GCM1 protein binds to CREBBP protein]16166624
D005576ColforsinColforsin results in increased acetylation of and results in increased activity of GCM1 protein16166624
D005576ColforsinCREBBP protein affects the reaction [Colforsin results in increased activity of GCM1 protein]16166624
D005576ColforsinN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased activity of GCM1 protein]16166624
D005576Colforsintrichostatin A promotes the reaction [Colforsin results in increased acetylation of and results in increased activity of GCM1 protein]16166624
D013759DronabinolDronabinol results in decreased expression of GCM1 mRNA26070387
D013759Dronabinoliodopravadoline inhibits the reaction [Dronabinol results in decreased expression of GCM1 mRNA]26070387
D005419FlavonoidsFlavonoids results in increased expression of GCM1 mRNA18035473
C061365flusilazoleflusilazole affects the expression of GCM1 mRNA22634333
C094023iodopravadolineiodopravadoline inhibits the reaction [Dronabinol results in decreased expression of GCM1 mRNA]26070387
C045463leflunomideleflunomide results in increased expression of GCM1 mRNA28988120
D015122MercaptopurineMercaptopurine results in decreased expression of GCM1 mRNA23358152
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GCM1 mRNA23903816|2800136
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of GCM1 mRNA23876855
D009151Mustard GasMustard Gas results in increased expression of GCM1 mRNA15674843
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased activity of GCM1 protein]16166624
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GCM1 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GCM1 mRNA"25554681|2562005
D009538NicotineNicotine results in decreased expression of GCM1 mRNA24368670
D009538NicotineNicotine results in decreased expression of GCM1 protein24368670
D059808PolyphenolsPolyphenols results in decreased expression of GCM1 mRNA16293270
C089730rosiglitazonerosiglitazone results in increased expression of GCM1 mRNA27879033
D053260SootSoot results in decreased expression of GCM1 mRNA26551751
C458508T 0070907T 0070907 results in decreased expression of GCM1 mRNA27879033
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GCM1 mRNA24058054
C012589trichostatin Atrichostatin A promotes the reaction [Colforsin results in increased acetylation of and results in increased activity of GCM1 protein]16166624
D014520UrethaneUrethane results in increased expression of GCM1 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of GCM1 mRNA27188386
D014635Valproic AcidValproic Acid results in increased methylation of GCM1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA15385555  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IDA23867755  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA15385555  
GO:0003677DNA binding-TAS8962155  
GO:0003700DNA-binding transcription factor activity-IDA15385555  
GO:0005515protein binding-IPI23867755  
GO:0008134transcription factor binding-IPI15385555  
GO:0008270zinc ion binding-IEA-  
GO:0042826histone deacetylase binding-IPI23867755  
GO ID GO Term Qualifier Evidence PubMed
GO:0006355regulation of transcription, DNA-templated-IDA15385555  
GO:0006366transcription by RNA polymerase II-IDA23867755  
GO:0009653anatomical structure morphogenesis-TAS8962155  
GO:0042063gliogenesis-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA15385555  
GO:0060018astrocyte fate commitment-IEA-  
GO:0060143positive regulation of syncytium formation by plasma membrane fusion-IEA-  
GO:0060670branching involved in labyrinthine layer morphogenesis-IEA-  
GO:0060706cell differentiation involved in embryonic placenta development-IBA21873635  
GO:0060706cell differentiation involved in embryonic placenta development-IEA-  
GO:0060800regulation of cell differentiation involved in embryonic placenta development-IMP19219068  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA23867755  
GO:0005667transcription factor complex-IDA15385555  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24368670Characterization of the adverse effects of nicotine on placental development: in vivo and in vitro studies. (2014 Feb 15)Holloway ACAm J Physiol Endocrinol Metab