Gene: DGKZ

8525
DAGK5|DAGK6|DGK-ZETA|hDGKzeta
diacylglycerol kinase zeta
protein-coding
11p11.2
Ensembl:ENSG00000149091 MIM:601441 Vega:OTTHUMG00000166437 UniprotKB:Q13574
NG_047092.1
PubMed
0   ANCO-SNPs
OD|CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.689e-2 (AD)  3.089e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18908017chr11:46353622DGKZPromoter3.262e-4Alcohol use disorders26763658
cg18765542chr11:46354101DGKZ2.280e-9Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEPT50.961
KCNH30.96
NRGN0.958
RUNDC3A0.958
KCNAB20.957
BRSK10.954
PPFIA30.951
AGAP30.951
RAB11FIP30.951
JPH30.95

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.674
OR4F29-0.632
C1orf87-0.474
TFPI2-0.47
C9orf135-0.452
IGF2BP2-0.439
REST-0.438
WWTR1-0.437
CLEC2B-0.435
AGTR1-0.433

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of DGKZ mRNA"21394737
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of DGKZ mRNA"21346803
D000082AcetaminophenAcetaminophen results in increased expression of DGKZ mRNA22230336|2906747
D000082AcetaminophenAcetaminophen affects the expression of DGKZ mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of DGKZ mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DGKZ mRNA16483693
C015001arsenitearsenite results in increased methylation of DGKZ promoter23974009
D001280AtrazineAtrazine results in decreased expression of DGKZ mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DGKZ mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DGKZ mRNA22228805
D004958EstradiolEstradiol results in increased expression of DGKZ mRNA23019147
C006780bisphenol Abisphenol A affects the expression of DGKZ mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of DGKZ gene28505145
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of DGKZ mRNA17553608
D002166CamptothecinDGKZ mRNA results in decreased susceptibility to Camptothecin25269479
D002737ChloropreneChloroprene results in decreased expression of DGKZ mRNA23125180
D003471CuprizoneCuprizone results in decreased expression of DGKZ mRNA26577399
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of DGKZ mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of DGKZ mRNA21266533
D004075DiglyceridesDGKZ protein inhibits the reaction [Phenylephrine results in increased abundance of Diglycerides]16380548
D000431EthanolEthanol results in decreased expression of DGKZ mRNA29018328
D005485FlutamideFlutamide results in decreased expression of DGKZ mRNA24793618
D005839GentamicinsGentamicins results in increased expression of DGKZ mRNA22061828
D017313FenretinideFenretinide results in increased expression of DGKZ mRNA28973697
D007657Ketone BodiesKetone Bodies results in increased expression of DGKZ mRNA16807920
D008694MethamphetamineMethamphetamine results in increased expression of DGKZ mRNA26307267
D008731MethoxychlorMethoxychlor results in increased methylation of DGKZ gene23303685
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of DGKZ mRNA"20188158
D008777MethyltestosteroneMethyltestosterone results in increased expression of DGKZ mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DGKZ mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of DGKZ mRNA24136188
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of DGKZ mRNA"12756304
D052638Particulate MatterParticulate Matter results in increased expression of DGKZ mRNA28412507
D010656PhenylephrineDGKZ protein inhibits the reaction [Phenylephrine results in increased abundance of Diglycerides]16380548
D010656PhenylephrineDGKZ protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]16380548
D010936Plant ExtractsPlant Extracts results in decreased expression of DGKZ mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of DGKZ mRNA19162173
C045950propiconazolepropiconazole results in decreased expression of DGKZ mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of DGKZ mRNA24780913
D018038Sodium SeleniteSodium Selenite results in increased expression of DGKZ mRNA18175754
D012999SomanSoman results in decreased expression of DGKZ mRNA19281266
D013654TaurineTaurine results in increased expression of DGKZ mRNA16579726
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DGKZ mRNA21570461
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of DGKZ mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DGKZ mRNA16054898|2121527
D014212TretinoinTretinoin results in increased expression of DGKZ mRNA17218384
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate results in increased expression of DGKZ mRNA25855008
D014635Valproic AcidValproic Acid affects the expression of DGKZ mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of DGKZ mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of DGKZ gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003951NAD+ kinase activity-IEA-  
GO:0004143diacylglycerol kinase activity-IDA18004883  22627129  
GO:0004143diacylglycerol kinase activity-TAS-  
GO:0005515protein binding-IPI17664281  
GO:0005524ATP binding-IEA-  
GO:0016301kinase activity-IDA18004883  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway-IEA-  
GO:0016477cell migration-NAS15157668  
GO:0030168platelet activation-TAS-  
GO:0035556intracellular signal transduction-IEA-  
GO:0046339diacylglycerol metabolic process-IDA22627129  
GO:0046486glycerolipid metabolic process-IDA22627129  
GO:0046834lipid phosphorylation-IDA18004883  22627129  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA15157668  17664281  
GO:0005737cytoplasm-TAS11309392  
GO:0005886plasma membrane-TAS-  
GO:0016607nuclear speck-IDA-  
GO:0030027lamellipodium-IDA15157668  
KEGG ID KEGG Term
hsa00561Glycerolipid metabolism
hsa00564Glycerophospholipid metabolism
hsa01100Metabolic pathways
hsa04070Phosphatidylinositol signaling system
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114508Effects of PIP2 hydrolysisTAS
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27269905African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction. (2016 Jun)Levran OPharmacogenomics