Gene: FBF1

85302
Alb|FBF-1
Fas binding factor 1
protein-coding
17q25.1
Ensembl:ENSG00000188878 MIM:616807 Vega:OTTHUMG00000179919 UniprotKB:Q8TES7
NC_000017.11
PubMed
0   ANCO-SNPs
ND|AD
0   
8.535e-1 (AD)  4.727e-1 (ND)   (Frontal_Cortex)
9.676e-1 (AD)  6.608e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPPL2B0.864
RECQL50.859
SCNN1D0.846
NUMA10.841
ZNF760.837
ZNF2760.836
AKT20.836
CAD0.835
ADAMTS130.834
TUBGCP60.833

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.513
OR4F29-0.503
MTRNR2L6-0.369
MTRNR2L9-0.363
MTRNR2L10-0.356
UNC45B-0.322
SPRR4-0.317
C17orf112-0.316
FER1L6-0.314
TTLL10-AS1-0.314

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of FBF1 mRNA"28903501
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of FBF1 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FBF1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FBF1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of FBF1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FBF1 mRNA19770486
D001151ArsenicArsenic affects the methylation of FBF1 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of FBF1 mRNA20458559
C547126AZM551248AZM551248 results in decreased expression of FBF1 mRNA22323515
C006780bisphenol Abisphenol A affects the expression of FBF1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of FBF1 mRNA29097150
C018475butyraldehydebutyraldehyde results in decreased expression of FBF1 mRNA26079696
D002104CadmiumCadmium results in decreased expression of FBF1 mRNA26187450
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FBF1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of FBF1 mRNA26272509
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of FBF1 mRNA28472532
D002994ClofibrateClofibrate results in increased expression of FBF1 mRNA23811191
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of FBF1 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of FBF1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of FBF1 mRNA27594783
C039281furanfuran results in increased expression of FBF1 mRNA24183702
D017313FenretinideFenretinide results in increased expression of FBF1 mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of FBF1 mRNA27392435
C544151jinfukangjinfukang results in increased expression of FBF1 mRNA27392435
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of FBF1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FBF1 mRNA"25620056
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in decreased expression of FBF1 mRNA28973697
C006253pirinixic acidpirinixic acid results in increased expression of FBF1 mRNA18301758|1844570
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of FBF1 mRNA28903501
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FBF1 mRNA22298810
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of FBF1 mRNA28973375
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of FBF1 mRNA28973375
D014241TrichloroethyleneTrichloroethylene results in increased expression of FBF1 mRNA25549359|2897337
C025643vinclozolinvinclozolin results in decreased expression of FBF1 mRNA22570695

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI18838552  
GO ID GO Term Qualifier Evidence PubMed
GO:0043297apical junction assembly-IMP18838552  
GO:0060271cilium assembly-IMP23348840  
GO:0090162establishment of epithelial cell polarity-IMP18838552  
GO:0097711ciliary basal body-plasma membrane docking-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000922spindle pole-IDA21399614  
GO:0005813centrosome-IDA-  
GO:0005814centriole-IDA23348840  
GO:0005829cytosol-TAS-  
GO:0043296apical junction complexcolocalizes_withIDA18838552  
GO:0045095keratin filamentcolocalizes_withIDA18838552  
GO:0097539ciliary transition fiber-IDA23348840  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-5617833Cilium AssemblyTAS
R-HSA-5620912Anchoring of the basal body to the plasma membraneTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal