Gene: CBX4

8535
NBP16|PC2
chromobox 4
protein-coding
17q25.3
Ensembl:ENSG00000141582 MIM:603079 Vega:OTTHUMG00000150415 UniprotKB:O00257
NC_000017.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.332e-1 (AD)  1.480e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg06269419chr17:77807201CBX42.200e-9Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMUB20.901
DHX300.9
CCAR20.899
PSMD30.899
DNAJA30.894
AP3D10.893
WDR50.893
ASB60.891
NFYC0.891
USP200.89

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.641
OR4F29-0.583
MTRNR2L6-0.362
MTRNR2L9-0.362
MTRNR2L10-0.354
KLRB1-0.35
PPBP-0.349
FMO3-0.348
P2RY14-0.341
GZMK-0.317

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in increased expression of CBX4 mRNA"19936915
D000082AcetaminophenAcetaminophen results in increased expression of CBX4 mRNA21420995|2906747
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CBX4 mRNA19770486
D001151ArsenicArsenic affects the methylation of CBX4 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased sumoylation of CBX4 protein28318385
C015001arsenitearsenite results in increased methylation of CBX4 promoter23974009
D001280AtrazineAtrazine results in decreased expression of CBX4 mRNA25929836
D001280AtrazineAtrazine results in increased expression of CBX4 mRNA22378314
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CBX4 mRNA"20018196
C006780bisphenol Abisphenol A affects the expression of CBX4 mRNA21786754
C006780bisphenol Abisphenol A results in increased methylation of CBX4 promoter27312807
C584509C646 compoundC646 compound results in decreased expression of CBX4 mRNA26191083
C100187chloropicrinchloropicrin results in increased expression of CBX4 mRNA26352163
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in decreased expression of CBX4 mRNA21356183
C018021cobaltous chloridecobaltous chloride results in increased expression of CBX4 mRNA19376846
D003300Copper[Copper co-treated with Chlorpyrifos] results in decreased expression of CBX4 mRNA21356183
D003300CopperCopper results in decreased expression of CBX4 mRNA21356183
D019327Copper SulfateCopper Sulfate results in increased expression of CBX4 mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of CBX4 mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of CBX4 mRNA20106945|2556210
D047630DepsipeptidesDepsipeptides results in increased expression of CBX4 mRNA17064661
D002945CisplatinCisplatin results in increased expression of CBX4 mRNA27594783
D004041Dietary FatsDietary Fats results in decreased expression of CBX4 mRNA18042831
D004147DioxinsDioxins affects the expression of CBX4 mRNA20463971
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CBX4 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of CBX4 mRNA22079256
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of CBX4 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of CBX4 mRNA20655997|2364984
D017313FenretinideFenretinide results in decreased expression of CBX4 mRNA28973697
C492448ICG 001ICG 001 results in increased expression of CBX4 mRNA26191083
C045463leflunomideleflunomide results in increased expression of CBX4 mRNA28988120
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CBX4 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CBX4 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CBX4 mRNA"26251327
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of CBX4 mRNA24810058
C523799MRK 003CBX4 results in decreased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CBX4 mRNA"25554681
D009534NiclosamideNiclosamide results in increased expression of CBX4 mRNA26452273
D009966OrphenadrineOrphenadrine affects the expression of CBX4 mRNA23665939
D000073878Palm OilPalm Oil results in decreased expression of CBX4 mRNA18042831
C016030pantogabpantogab results in decreased expression of CBX4 mRNA17379144
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of CBX4 mRNA18593933
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of CBX4 mRNA25510869
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of CBX4 protein25510869
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CBX4 mRNA19710929
D010938Plant OilsPlant Oils results in increased expression of CBX4 mRNA23370395
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of CBX4 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of CBX4 mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of CBX4 mRNA28903501
D012822Silicon DioxideSilicon Dioxide results in decreased expression of CBX4 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in decreased expression of CBX4 mRNA19073995
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CBX4 mRNA19770486|2629044
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CBX4 mRNA28065790
D014212TretinoinTretinoin results in increased expression of CBX4 mRNA16604517
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CBX4 mRNA"26179874
C057693troglitazone[troglitazone co-treated with TNF protein] results in decreased expression of CBX4 mRNA12732648
D014415TunicamycinTunicamycin results in increased expression of CBX4 mRNA22378314
D014520UrethaneUrethane results in increased expression of CBX4 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of CBX4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CBX4 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased methylation of CBX4 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CBX4 mRNA19136453
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CBX4 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of CBX4 mRNA23034163
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of CBX4 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-IEA-  
GO:0003714transcription corepressor activity-TAS9315667  
GO:0003727single-stranded RNA binding-IEA-  
GO:0005515protein binding-IPI15710417  16169070  17332741  18567530  19636380  20601937  
22078878  24434214  26496610  27705803  
GO:0019789SUMO transferase activity-EXP12679040  20098713  20176810  
GO:0019899enzyme binding-IPI17087506  
GO:0032183SUMO binding-IDA20176810  
GO:0035064methylated histone binding-IEA-  
GO:0044212transcription regulatory region DNA binding-IEA-  
GO:0051219phosphoprotein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IMP21282530  
GO:0006325chromatin organization-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0016925protein sumoylation-IEA-  
GO:0043066negative regulation of apoptotic process-TAS9315667  
GO:0045892negative regulation of transcription, DNA-templated-IDA18567530  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA9367786  21282530  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0016604nuclear body-IDA-  
GO:0016607nuclear speck-IEA-  
GO:0031519PcG protein complex-IDA21282530  
GO:0035102PRC1 complex-IDA12167701  19636380  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1257604PIP3 activates AKT signalingIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559580Oxidative Stress Induced SenescenceTAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2990846SUMOylationTAS
R-HSA-3108214SUMOylation of DNA damage response and repair proteinsTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4551638SUMOylation of chromatin organization proteinsTAS
R-HSA-4570464SUMOylation of RNA binding proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6807070PTEN RegulationTAS
R-HSA-6807070PTEN RegulationIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8939243RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownTAS
R-HSA-8943724Regulation of PTEN gene transcriptionTAS
R-HSA-8943724Regulation of PTEN gene transcriptionIEA
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006925Intracellular signaling by second messengersIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25839328Genomic analyses reveal mutational signatures and frequently altered genes in esophageal squamous cell carcinoma. (2015 Apr 2)Zhang LAm J Hum Genet