Gene: AGPS

8540
ADAP-S|ADAS|ADHAPS|ADPS|ALDHPSY|RCDP3
alkylglycerone phosphate synthase
protein-coding
2q31.2
Ensembl:ENSG00000018510 MIM:603051 Vega:OTTHUMG00000132530 UniprotKB:O00116
NG_008968.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.021e-1 (AD)  5.912e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ITCH0.921
CREB10.905
MTDH0.901
SPAST0.899
ABCE10.894
STX70.894
USO10.892
ZFP900.891
USP80.891
PBRM10.889

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.58
OR4F29-0.567
MTRNR2L10-0.215
CSAG1-0.203
PPP1R3G-0.203
MTRNR2L6-0.202
RSPO1-0.2
MMP23B-0.195
MUC6-0.194
MTRNR2L9-0.19

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of AGPS mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of AGPS mRNA21420995|2570463
D000082AcetaminophenAcetaminophen affects the expression of AGPS mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of AGPS mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of AGPS gene27153756
D013196DihydrotestosteroneDihydrotestosterone results in decreased expression of AGPS mRNA16631469
D001280AtrazineAtrazine results in increased expression of AGPS mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AGPS mRNA20064835
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of AGPS mRNA"19150397|2001819
C044887beta-methylcholinebeta-methylcholine affects the expression of AGPS mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of AGPS mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of AGPS mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of AGPS mRNA28628672
C018021cobaltous chloridecobaltous chloride results in decreased expression of AGPS mRNA19320972
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of AGPS mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of AGPS mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of AGPS mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of AGPS mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of AGPS mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of AGPS mRNA20106945
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of AGPS mRNA28628672
C000944dicrotophosdicrotophos results in decreased expression of AGPS mRNA28302478
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AGPS mRNA22079256
D000431EthanolEthanol results in decreased expression of AGPS mRNA28069986
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of AGPS mRNA29097150
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of AGPS mRNA23649840
D005419FlavonoidsFlavonoids results in increased expression of AGPS mRNA18035473
D005557FormaldehydeFormaldehyde results in decreased expression of AGPS mRNA23649840
C039281furanfuran results in increased expression of AGPS mRNA25539665
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of AGPS mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of AGPS mRNA28628672
C544151jinfukangjinfukang results in decreased expression of AGPS mRNA27392435
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of AGPS mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of AGPS mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of AGPS mRNA23649840
D009532NickelNickel results in increased expression of AGPS mRNA24768652
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of AGPS mRNA17616710
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of AGPS mRNA20971185
C558013NSC 689534NSC 689534 results in decreased expression of AGPS mRNA20971185
D010634PhenobarbitalPhenobarbital affects the expression of AGPS mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of AGPS mRNA19710929
D010936Plant ExtractsPlant Extracts results in increased expression of AGPS mRNA23557933
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of AGPS mRNA21334430
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AGPS mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of AGPS mRNA22079256
C059514resveratrolresveratrol results in increased expression of AGPS protein25505154
C089730rosiglitazonerosiglitazone results in increased expression of AGPS protein18543250
C010327salinomycinsalinomycin results in decreased expression of AGPS mRNA19682730
C009277sodium arsenatesodium arsenate results in decreased expression of AGPS mRNA23922661
C061133tamibarotenetamibarotene affects the expression of AGPS mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AGPS mRNA17101203
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AGPS mRNA21570461
D013853ThioacetamideThioacetamide results in increased expression of AGPS mRNA23411599
D014212TretinoinTretinoin results in decreased expression of AGPS mRNA15498508
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of AGPS mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of AGPS mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of AGPS mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of AGPS mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of AGPS mRNA23179753
C029297vinylidene chloridevinylidene chloride results in decreased expression of AGPS mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO:0008609alkylglycerone-phosphate synthase activity-IDA9553082  10415121  
GO:0016614oxidoreductase activity, acting on CH-OH group of donors-IEA-  
GO:0071949FAD binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006625protein targeting to peroxisome-TAS-  
GO:0008610lipid biosynthetic process-IDA9553082  
GO:0008611ether lipid biosynthetic process-IEA-  
GO:0008611ether lipid biosynthetic process-ISS-  
GO:0008611ether lipid biosynthetic process-TAS-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005730nucleolus-IDA-  
GO:0005739mitochondrion-HDA20833797  
GO:0005777peroxisome-IDA9553082  10415121  
GO:0005778peroxisomal membrane-HDA21525035  
GO:0005782peroxisomal matrix-TAS-  
GO:0005829cytosol-TAS-  
GO:0016020membrane-HDA19946888  
KEGG ID KEGG Term
hsa00565Ether lipid metabolism
hsa01100Metabolic pathways
hsa04146Peroxisome
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-75896Plasmalogen biosynthesisTAS
R-HSA-9033241Peroxisomal protein importIEA
R-HSA-9033241Peroxisomal protein importTAS
R-HSA-9033500TYSND1 cleaves peroxisomal proteinsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24818754Interleukin-1 receptor gene variants are associated with aggressive periodontitis in the Japanese. (2014 Jul)Kamei HArch Oral Biol