Gene: RHPN2

85415
P76RBE|RHOBP
rhophilin Rho GTPase binding protein 2
protein-coding
19q13.11
Ensembl:ENSG00000131941 MIM:617932 Vega:OTTHUMG00000180340 UniprotKB:Q8IUC4
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.128e-1 (AD)  7.496e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
F30.88
RFX40.878
LRIG10.873
SDC20.867
ARHGEF260.862
ADORA2B0.861
TGFB20.857
NEK60.856
FGF20.855
SOX90.852

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CACNA1F-0.515
CALHM1-0.472
CNTN6-0.469
SLC7A4-0.468
ADTRP-0.465
MYOZ3-0.463
SLIT3-0.457
AGMAT-0.456
KCNK2-0.451
SAMD5-0.449

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of RHPN2 mRNA28329830
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of RHPN2 mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of RHPN2 mRNA"23829299
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of RHPN2 mRNA"19114083
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl affects the expression of RHPN2 mRNA"23829299
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of RHPN2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RHPN2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RHPN2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of RHPN2 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of RHPN2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RHPN2 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of RHPN2 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RHPN2 mRNA19770486|2171566
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RHPN2 mRNA"19150397|2038263
C006780bisphenol Abisphenol A affects the expression of RHPN2 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of RHPN2 mRNA14729362
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of RHPN2 mRNA27339419
D002509CephaloridineCephaloridine results in increased expression of RHPN2 mRNA18500788
D016572CyclosporineCyclosporine results in decreased expression of RHPN2 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of RHPN2 mRNA25562108
D003561CytarabineCytarabine results in decreased expression of RHPN2 mRNA21198554
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of RHPN2 mRNA28962523
D002945CisplatinCisplatin results in increased phosphorylation of RHPN2 protein22006019
D002117CalcitriolCalcitriol results in increased expression of RHPN2 mRNA16002434|2648566
D004221DisulfiramDisulfiram results in decreased expression of RHPN2 mRNA20530235
C118739entinostatentinostat results in increased expression of RHPN2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RHPN2 mRNA"27188386
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of RHPN2 mRNA28329830
C069837fullerene C60fullerene C60 results in decreased expression of RHPN2 mRNA19167457
D017313FenretinideFenretinide results in decreased expression of RHPN2 mRNA28973697
D017313FenretinideFenretinide results in increased expression of RHPN2 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of RHPN2 mRNA26846883
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RHPN2 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of RHPN2 mRNA24796395
C410337K 7174K 7174 results in increased expression of RHPN2 mRNA24086573
D007854LeadLead affects the expression of RHPN2 mRNA28903495
C045463leflunomideleflunomide results in increased expression of RHPN2 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of RHPN2 mRNA"24972896
D008727MethotrexateMethotrexate affects the expression of RHPN2 mRNA18502557
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of RHPN2 mRNA23179753
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of RHPN2 mRNA24810058
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of RHPN2 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RHPN2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RHPN2 mRNA"25554681|2562005
D009532NickelNickel results in decreased expression of RHPN2 mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in decreased expression of RHPN2 mRNA16780908
C410127PCB 180PCB 180 results in increased expression of RHPN2 mRNA23829299
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of RHPN2 mRNA18593933
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of RHPN2 mRNA26705709
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of RHPN2 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of RHPN2 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of RHPN2 mRNA19482888
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of RHPN2 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of RHPN2 mRNA18301758
D011374ProgesteroneProgesterone results in decreased expression of RHPN2 mRNA23018184
D011374ProgesteroneNCOA2 protein affects the reaction [Progesterone results in decreased expression of RHPN2 mRNA]17556502
D011374ProgesteroneProgesterone results in decreased expression of RHPN2 mRNA17556502
C045950propiconazolepropiconazole results in decreased expression of RHPN2 mRNA21278054
C017947sodium arsenitesodium arsenite results in decreased expression of RHPN2 mRNA25879800
D013629TamoxifenTamoxifen affects the expression of RHPN2 mRNA20937368
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of RHPN2 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RHPN2 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RHPN2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RHPN2 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RHPN2 mRNA25613284
D013893ThiramThiram results in decreased expression of RHPN2 mRNA20530235
C009495titanium dioxidetitanium dioxide results in decreased expression of RHPN2 mRNA23557971
D014520UrethaneUrethane results in increased expression of RHPN2 mRNA28818685
C406224valdecoxibvaldecoxib results in increased expression of RHPN2 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of RHPN2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of RHPN2 mRNA23179753|2519280
D014635Valproic AcidValproic Acid results in increased methylation of RHPN2 gene29154799
D014635Valproic AcidValproic Acid affects the expression of RHPN2 mRNA17292431|1796380
C025643vinclozolinvinclozolin results in decreased expression of RHPN2 mRNA23034163
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of RHPN2 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194315Signaling by Rho GTPasesIEA
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-195258RHO GTPase EffectorsIEA
R-HSA-5666185RHO GTPases Activate Rhotekin and RhophilinsTAS
R-HSA-5666185RHO GTPases Activate Rhotekin and RhophilinsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22367214Characterization of gene-environment interactions for colorectal cancer susceptibility loci. (2012 Apr 15)Hutter CMCancer Res