Gene: LMO4

8543
-
LIM domain only 4
protein-coding
1p22.3
Ensembl:ENSG00000143013 MIM:603129 Vega:OTTHUMG00000010248 UniprotKB:P61968
NC_000001.11
PubMed
0   ANCO-SNPs
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.616e-1 (AD)  4.748e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YWHAH0.971
VSNL10.969
SNAP250.967
RTN30.964
SERPINI10.964
BASP10.963
ATP6V1G20.963
ATP6V1B20.962
PFN20.962
YWHAG0.962

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.639
OR4F29-0.601
REST-0.429
RAI14-0.418
WWTR1-0.414
TFPI2-0.411
HEY2-0.409
ARHGEF5-0.408
CCR2-0.407
CNN2-0.405

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of LMO4 mRNA28329830
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of LMO4 mRNA"15215175
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of LMO4 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LMO4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LMO4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LMO4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LMO4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LMO4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LMO4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LMO4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LMO4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of LMO4 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of LMO4 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of LMO4 gene27153756
C015001arsenitearsenite results in increased methylation of LMO4 promoter23974009
D001280AtrazineAtrazine results in decreased expression of LMO4 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of LMO4 mRNA22342234
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of LMO4 mRNA"20382639
C038328BEP protocolBEP protocol results in increased expression of LMO4 mRNA18987330
C006780bisphenol Abisphenol A results in decreased expression of LMO4 mRNA29275510
C006780bisphenol Abisphenol A affects the methylation of LMO4 promoter27334623
C006780bisphenol Abisphenol A affects the expression of LMO4 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of LMO4 mRNA25979313
C100187chloropicrinchloropicrin affects the expression of LMO4 mRNA26352163
D002922CiguatoxinsCiguatoxins affects the expression of LMO4 mRNA18353800
D019327Copper SulfateCopper Sulfate results in increased expression of LMO4 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of LMO4 mRNA20106945|2214713
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of LMO4 mRNA21266533
D004041Dietary FatsDietary Fats results in increased expression of LMO4 mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of LMO4 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of LMO4 mRNA]19850644
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of LMO4 mRNA15171707
D004147DioxinsDioxins affects the expression of LMO4 mRNA20463971
D004237DiuronDiuron results in increased expression of LMO4 mRNA21551480
D004317DoxorubicinDoxorubicin results in decreased expression of LMO4 mRNA16243910
C118739entinostatentinostat results in decreased expression of LMO4 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LMO4 mRNA"27188386
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LMO4 mRNA17942748
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of LMO4 mRNA28329830
D005839GentamicinsGentamicins results in increased expression of LMO4 mRNA22061828
C492448ICG 001ICG 001 results in increased expression of LMO4 mRNA26191083
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of LMO427256375
C410337K 7174K 7174 results in increased expression of LMO4 mRNA24086573
C045463leflunomideleflunomide results in increased expression of LMO4 mRNA28988120
D008727MethotrexateMethotrexate results in increased expression of LMO4 mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of LMO4 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of LMO4 mRNA28001369
D008777MethyltestosteroneMethyltestosterone results in decreased expression of LMO4 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of LMO4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LMO4 mRNA"25620056
D009532NickelNickel results in decreased expression of LMO4 mRNA24768652
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of LMO4 mRNA25729387
D000073878Palm OilPalm Oil results in increased expression of LMO4 mRNA18042831
C016030pantogabpantogab results in increased expression of LMO4 mRNA17379144
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of LMO4 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of LMO4 mRNA19363144|1948288
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LMO4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of LMO4 mRNA26272509
C018637phoronephorone affects the expression of LMO4 mRNA18198479
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of LMO4 mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of LMO4 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of LMO4 mRNA18445702
D011192Potassium DichromatePotassium Dichromate results in increased expression of LMO4 mRNA11678601
D011374ProgesteroneProgesterone results in increased expression of LMO4 mRNA18037150
D011372ProgestinsProgestins results in increased expression of LMO4 mRNA19609016
D011441PropylthiouracilPropylthiouracil results in increased expression of LMO4 mRNA24780913
D012715Sesame OilSesame Oil results in increased expression of LMO4 mRNA29191790
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LMO4 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LMO4 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LMO4 mRNA17942748
D019284ThapsigarginThapsigargin results in increased expression of LMO4 mRNA22378314
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of LMO4 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of LMO4 mRNA23724009
C032910triadimefontriadimefon results in increased expression of LMO4 mRNA26705709
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LMO4 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of LMO4 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of LMO4 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of LMO4 mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of LMO4 mRNA22378314
D014520UrethaneUrethane results in increased expression of LMO4 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LMO4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of LMO4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of LMO4 mRNA28001369
D014635Valproic AcidValproic Acid results in decreased methylation of LMO4 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of LMO4 mRNA26272509
D014635Valproic AcidValproic Acid affects the expression of LMO4 mRNA17292431|1796380
D014635Valproic AcidValproic Acid results in decreased expression of LMO4 mRNA19136453
D001335Vehicle EmissionsVehicle Emissions affects the methylation of LMO4 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of LMO4 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001158enhancer sequence-specific DNA binding-IEA-  
GO:0003700DNA-binding transcription factor activity-TAS10209267  
GO:0005515protein binding-IPI15231748  18330356  25416956  
GO:0008134transcription factor binding-ISS-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001843neural tube closure-ISS-  
GO:0003281ventricular septum development-IEA-  
GO:0006366transcription by RNA polymerase II-ISS-  
GO:0021514ventral spinal cord interneuron differentiation-IEA-  
GO:0021522spinal cord motor neuron differentiation-IEA-  
GO:0021527spinal cord association neuron differentiation-IEA-  
GO:0030334regulation of cell migration-ISS-  
GO:0031333negative regulation of protein complex assembly-IEA-  
GO:0033674positive regulation of kinase activity-ISS-  
GO:0042659regulation of cell fate specification-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0048538thymus development-IEA-  
GO:0050865regulation of cell activation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005667transcription factor complex-ISS-  
GO:0031252cell leading edge-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20618444Lmo4 in the nucleus accumbens regulates cocaine sensitivity. (2010 Oct)Lasek AWGenes Brain Behav