Gene: STON2

85439
STN2|STNB|STNB2
stonin 2
protein-coding
14q31.1
Ensembl:ENSG00000140022 MIM:608467 Vega:OTTHUMG00000171416 UniprotKB:Q8WXE9
NC_000014.9
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.408e-2 (AD)  8.204e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg10334928chr14:81865007STON23.200e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MRVI10.895
NPAS30.891
RHOBTB30.889
RFX40.874
NHSL10.868
BMPR1B0.867
ALDH1L10.866
NFIA0.865
STK330.864
ARHGEF260.862

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AGMAT-0.646
GABRG3-0.622
CALHM1-0.616
TYRP1-0.613
MCHR1-0.612
OSBPL10-0.604
ZNF860-0.602
ANKRD34C-0.601
KCNH1-0.6
EPHA5-0.599

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of STON2 mRNA"19167446
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of STON2 mRNA"20816883
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STON2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STON2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STON2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STON2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of STON2 mRNA29067470
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of STON2 mRNA21298039
D004958EstradiolEstradiol results in decreased expression of STON2 mRNA19167446|2118537
C006780bisphenol Abisphenol A affects the expression of STON2 mRNA20170705
C006780bisphenol Abisphenol A results in increased expression of STON2 mRNA27685785
C006780bisphenol Abisphenol A affects the expression of STON2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of STON2 gene28505145
C018475butyraldehydebutyraldehyde results in increased expression of STON2 mRNA26079696
D002737ChloropreneChloroprene results in increased expression of STON2 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of STON2 mRNA20938992
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of STON2 mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of STON2 mRNA19167446
D002945CisplatinCisplatin results in increased expression of STON2 mRNA27392435
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of STON2 mRNA20170705
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of STON2 mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of STON2 mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of STON2 mRNA23649840
D017313FenretinideFenretinide results in increased expression of STON2 mRNA28973697
D007854LeadLead results in decreased expression of STON2 mRNA19921347
C045463leflunomideleflunomide results in increased expression of STON2 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of STON2 mRNA"24972896
D008344Maneb[Paraquat co-treated with Maneb] affects the expression of STON2 mRNA22563483
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of STON2 mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of STON2 mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of STON2 mRNA26272509
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of STON2 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of STON2 mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in decreased expression of STON2 mRNA29191790
C523799MRK 003STON2 results in increased susceptibility to MRK 00319903844
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of STON2 mRNA25729387
D010269Paraquat[Paraquat co-treated with Maneb] affects the expression of STON2 mRNA22563483
D010269ParaquatParaquat results in increased expression of STON2 mRNA22563483
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STON2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of STON2 mRNA26272509
D011192Potassium DichromatePotassium Dichromate results in increased expression of STON2 protein23718831
D011441PropylthiouracilPropylthiouracil results in increased expression of STON2 mRNA24780913
C428725pyridabenpyridaben results in increased expression of STON2 mRNA22563483
D012715Sesame OilSesame Oil results in increased expression of STON2 mRNA29191790
D012906SmokeSmoke results in decreased expression of STON2 mRNA21095227
D012999SomanSoman results in decreased expression of STON2 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of STON2 mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STON2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of STON2 mRNA20159946
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STON2 mRNA22298810
D013849ThimerosalThimerosal results in decreased expression of STON2 mRNA27188386
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of STON2 mRNA25729387
C483909torcetrapibtorcetrapib results in increased expression of STON2 mRNA23228038
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STON2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of STON2 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of STON2 mRNA"26179874
D014520UrethaneUrethane results in increased expression of STON2 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of STON2 mRNA23179753|2718838

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11454741  18200045  19380743  21102408  
GO ID GO Term Qualifier Evidence PubMed
GO:0002244hematopoietic progenitor cell differentiation-IEA-  
GO:0030100regulation of endocytosis-IBA21873635  
GO:0030100regulation of endocytosis-ISS14726597  
GO:0048488synaptic vesicle endocytosis-IGI21102408  
GO:0061024membrane organization-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005730nucleolus-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0008021synaptic vesicle-IEA-  
GO:0016020membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0030136clathrin-coated vesicle-IEA-  
GO:0043005neuron projection-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21547531Polymorphisms in ABLIM1 are associated with personality traits and alcohol dependence. (2012 Feb)Wang KSJ Mol Neurosci