Gene info: ID 8544

Gene: PIR

GENE ID: 8544

Synonyms: -

Description: pirin

Gene type: protein-coding

Location: Xp22.2

dbXrefs: Ensembl:ENSG00000087842 MIM:300931 Vega:OTTHUMG00000021176 UniprotKB:O00625

RefSeq: NG_012549.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|ND|AD

# Publications: 5

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ATP6V0E1	0.827
CPQ	0.818
PLCD1	0.804
MGST1	0.794
TMEM176A	0.788
COMT	0.786
ECI2	0.783
FBXO8	0.783
TRIP6	0.782
AKR1C3	0.782

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GABRG3	-0.522
IL12RB2	-0.511
CALHM1	-0.504
CDH7	-0.503
PRSS12	-0.503
ABCC12	-0.501
OTOGL	-0.501
ZNF860	-0.495
ARHGAP20	-0.494
ADRA1D	-0.494

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of PIR mRNA"	27071940
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of PIR mRNA]"	27071940
C576882	1-(2-trifluoromethoxyphenyl)-2-nitroethanone	1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of PIR mRNA	25596134
C032668	1-nitropyrene	1-nitropyrene results in decreased expression of PIR mRNA	19041380
C029141	2,2,5,7,8-pentamethyl-1-hydroxychroman	"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of PIR mRNA"	21920950
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of PIR mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of PIR mRNA"	21346803
C035208	2-amino-4,6-dinitrotoluene	"2-amino-4,6-dinitrotoluene affects the expression of PIR mRNA"	21346803
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of PIR mRNA	16788091
C017906	3-dinitrobenzene	3-dinitrobenzene results in increased expression of PIR mRNA	21983209
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PIR mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Mercuric Chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PIR mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PIR mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PIR mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PIR mRNA"	27188386
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of PIR mRNA"	21346803
C002202	4-oxoretinoic acid	4-oxoretinoic acid results in increased expression of PIR mRNA	15982314
C029728	4-phenylenediamine	4-phenylenediamine results in increased expression of PIR mRNA	16314067
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PIR mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Mercuric Chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PIR mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PIR mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PIR mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PIR mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of PIR mRNA	25064622
D000082	Acetaminophen	Acetaminophen affects the expression of PIR mRNA	17562736
C106812	adefovir dipivoxil	adefovir dipivoxil results in increased expression of PIR mRNA	25596134
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of PIR protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of PIR mRNA	21632981\|2715375
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of PIR mRNA	19770486
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of PIR mRNA	23630614
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of PIR mRNA	21757418
C103303	alitretinoin	alitretinoin results in increased expression of PIR mRNA	15982314
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of PIR mRNA	28522335
D000638	Amiodarone	Amiodarone affects the expression of PIR mRNA	25064622
D000667	Ampicillin	Ampicillin results in increased expression of PIR mRNA	22609641
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of PIR mRNA	24449571
C006632	arsenic trioxide	arsenic trioxide results in increased expression of PIR mRNA	15761015\|1941714
C015001	arsenite	arsenite results in increased expression of PIR mRNA	18929588
C015001	arsenite	TRP53 protein affects the reaction [arsenite results in increased expression of PIR mRNA]	18929588
C030935	benz(a)anthracene	benz(a)anthracene results in increased expression of PIR mRNA	23656968
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PIR mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PIR mRNA	19770486\|2156981
C044887	beta-methylcholine	beta-methylcholine affects the expression of PIR mRNA	21179406
C006780	bisphenol A	bisphenol A affects the expression of PIR mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of PIR mRNA	22576693
C006780	bisphenol A	bisphenol A results in increased expression of PIR mRNA	29275510
C006780	bisphenol A	bisphenol A results in increased methylation of PIR gene	22576693
C006780	bisphenol A	bisphenol A results in increased methylation of PIR promoter	27312807
C006780	bisphenol A	bisphenol A results in increased expression of PIR mRNA	25181051
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PIR mRNA	28628672
D000069286	Bortezomib	Bortezomib results in increased expression of PIR mRNA	20977926
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of PIR mRNA	25596134
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of PIR protein	24527689
C037123	cadmium sulfate	cadmium sulfate results in increased expression of PIR mRNA	16221973
D002220	Carbamazepine	Carbamazepine affects the expression of PIR mRNA	25979313
D002509	Cephaloridine	Cephaloridine results in increased expression of PIR mRNA	18500788
C004656	chloroacetaldehyde	chloroacetaldehyde affects the expression of PIR mRNA	25596134
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PIR mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of PIR mRNA	26272509
D002737	Chloroprene	Chloroprene results in increased expression of PIR mRNA	23125180
D002737	Chloroprene	Chloroprene results in increased expression of PIR mRNA	23125180
D002746	Chlorpromazine	Chlorpromazine affects the expression of PIR mRNA	25064622
D002746	Chlorpromazine	Chlorpromazine results in decreased expression of PIR mRNA	25596134
C059262	cidofovir	cidofovir results in increased expression of PIR mRNA	25596134
C012843	cinnamic aldehyde	cinnamic aldehyde results in increased expression of PIR mRNA	19524605
D004002	Clodronic Acid	Clodronic Acid results in increased expression of PIR mRNA	25596134
D003035	Cobalt	[tungsten carbide co-treated with Cobalt] results in increased expression of PIR mRNA	23052192
C018021	cobaltous chloride	cobaltous chloride results in increased expression of PIR mRNA	24612858
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of PIR mRNA	19376846
C018021	cobaltous chloride	cobaltous chloride results in increased expression of PIR mRNA	24386269
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of PIR mRNA	20971185
D003474	Curcumin	Curcumin results in increased expression of PIR mRNA	18299980
D016572	Cyclosporine	Cyclosporine affects the expression of PIR mRNA	25064622
D016572	Cyclosporine	Cyclosporine results in increased expression of PIR mRNA	25562108\|2559613
C515055	darinaparsin	darinaparsin results in increased expression of PIR mRNA	19417148
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PIR mRNA	28628672
C016366	dibenzothiophene	dibenzothiophene results in decreased expression of PIR mRNA	23656968
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of PIR mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of PIR mRNA	27392435
D004041	Dietary Fats	Dietary Fats affects the expression of PIR mRNA	19680557
D004041	Dietary Fats	Dietary Fats results in decreased expression of PIR mRNA	18042831
C014476	diethyl maleate	diethyl maleate results in increased expression of PIR mRNA	25270620
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of PIR mRNA	19638242
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of PIR mRNA	21658437
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of PIR mRNA"	22485181
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of PIR mRNA	16314067
D004317	Doxorubicin	PIR protein affects the susceptibility to Doxorubicin	16217747
C118739	entinostat	entinostat results in increased expression of PIR mRNA	27188386
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of PIR mRNA	25064622
D011345	Fenofibrate	Fenofibrate results in decreased expression of PIR mRNA	25596134
D018120	Finasteride	Finasteride results in increased expression of PIR mRNA	24136188
C082360	fipronil	fipronil results in increased expression of PIR mRNA	23962444
D005472	Fluorouracil	Fluorouracil results in decreased expression of PIR protein	15352031
D005472	Fluorouracil	PIR protein affects the susceptibility to Fluorouracil	15352031
D005485	Flutamide	Flutamide results in increased expression of PIR mRNA	24136188
D005557	Formaldehyde	Formaldehyde results in decreased expression of PIR mRNA	23649840
D017313	Fenretinide	Fenretinide results in increased expression of PIR mRNA	16671099
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of PIR mRNA	26846883
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of PIR mRNA	20044591
C492448	ICG 001	ICG 001 results in increased expression of PIR mRNA	26191083
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of PIR mRNA	21396975
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PIR mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PIR mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PIR mRNA	28628672
D007529	Isoflavones	Isoflavones results in increased expression of PIR mRNA	17374662
D007545	Isoproterenol	Isoproterenol results in increased expression of PIR mRNA	20003209
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of PIR mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of PIR mRNA	27392435
C008261	lead acetate	lead acetate results in increased expression of PIR mRNA	22839698\|2756223
C045463	leflunomide	leflunomide results in increased expression of PIR mRNA	24136188
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PIR mRNA	26378955
C042720	mercuric bromide	mercuric bromide results in increased expression of PIR mRNA	26272509\|2718838
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PIR mRNA"	27188386
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of PIR mRNA	27188386
D008627	Mercuric Chloride	"[NOG protein co-treated with Mercuric Chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PIR mRNA"	27188386
D008687	Metformin	Metformin results in decreased expression of PIR mRNA	25596134
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of PIR mRNA	23179753\|2627250
C004925	methylmercuric chloride	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PIR mRNA"	27188386
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of PIR mRNA	24810058
D016685	Mitomycin	PIR protein affects the susceptibility to Mitomycin	16217747
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of PIR mRNA"	29244179
C001478	N(6)-(delta(2)-isopentenyl)adenine	N(6)-(delta(2)-isopentenyl)adenine results in increased expression of PIR mRNA	16129123
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of PIR mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of PIR mRNA"	25554681\|2562005
C051752	nefazodone	nefazodone results in increased expression of PIR mRNA	24136188
D019829	Nevirapine	Nevirapine metabolite results in increased expression of PIR mRNA	23947594
C022838	nickel chloride	nickel chloride results in increased expression of PIR mRNA	24612858
C029938	nickel sulfate	nickel sulfate results in increased expression of PIR mRNA	16314067\|2271453
C012655	nimesulide	nimesulide results in increased expression of PIR mRNA	24136188
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of PIR mRNA	20971185
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of PIR mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in decreased expression of PIR mRNA	25596134
D000073878	Palm Oil	Palm Oil affects the expression of PIR mRNA	19680557
D000073878	Palm Oil	Palm Oil results in decreased expression of PIR mRNA	18042831
D010269	Paraquat	Paraquat affects the expression of PIR mRNA	25064622
D052638	Particulate Matter	Particulate Matter results in increased expression of PIR mRNA	23085030
D010400	Penicillin G	Penicillin G results in increased expression of PIR mRNA	22609641
D010404	Penicillin V	Penicillin V results in increased expression of PIR mRNA	22609641
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of PIR mRNA	23892564
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of PIR mRNA]	19482888
D010634	Phenobarbital	Phenobarbital affects the expression of PIR mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in increased expression of PIR mRNA	19482888
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PIR mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of PIR mRNA	26272509
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PIR mRNA	19710929
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PIR mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of PIR mRNA	23811191
D011794	Quercetin	Quercetin results in decreased expression of PIR mRNA	21632981
D015474	Isotretinoin	Isotretinoin results in decreased expression of PIR mRNA	20436886
D015474	Isotretinoin	Isotretinoin results in increased expression of PIR mRNA	15982314
D012402	Rotenone	Rotenone results in decreased expression of PIR mRNA	19013527
D012906	Smoke	Smoke results in increased expression of PIR mRNA	21095227
C017947	sodium arsenite	sodium arsenite results in increased expression of PIR mRNA	23876855\|2451658
C017947	sodium arsenite	sodium arsenite results in increased expression of PIR mRNA alternative form	21281968
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PIR mRNA	26378955
D013420	Sulfamethoxazole	Sulfamethoxazole results in increased expression of PIR mRNA	22609641
C013698	tallow	tallow affects the expression of PIR mRNA	19680557
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of PIR mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PIR mRNA	20558275
D013752	Tetracycline	Tetracycline affects the expression of PIR mRNA	25064622
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PIR mRNA	25613284
D013849	Thimerosal	Thimerosal results in increased expression of PIR mRNA	27188386
D013853	Thioacetamide	Thioacetamide affects the expression of PIR mRNA	25064622
D013853	Thioacetamide	Thioacetamide results in increased expression of PIR mRNA	23411599
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of PIR mRNA	22363418\|2806579
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of PIR mRNA	25729387
D014212	Tretinoin	Tretinoin metabolite results in increased expression of PIR mRNA	15982314
D014212	Tretinoin	Tretinoin results in increased expression of PIR mRNA	15982314
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of PIR mRNA	19524605\|2260964
D014303	Trinitrotoluene	Trinitrotoluene affects the expression of PIR mRNA	21346803
C002802	tungsten carbide	[tungsten carbide co-treated with Cobalt] results in increased expression of PIR mRNA	23052192
D014520	Urethane	Urethane results in decreased expression of PIR mRNA	28818685
C406224	valdecoxib	valdecoxib results in increased expression of PIR mRNA	24136188
D014635	Valproic Acid	Valproic Acid affects the expression of PIR mRNA	25064622
D014635	Valproic Acid	Valproic Acid affects the expression of PIR mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of PIR mRNA	23179753\|2718838
D014635	Valproic Acid	Valproic Acid affects the expression of PIR mRNA	17963808
D014747	Vinblastine	PIR protein affects the susceptibility to Vinblastine	16217747
C025643	vinclozolin	vinclozolin results in decreased expression of PIR mRNA	20566332
C025643	vinclozolin	vinclozolin results in increased expression of PIR mRNA	23034163
C029297	vinylidene chloride	vinylidene chloride results in increased expression of PIR mRNA	26682919
C088658	zoledronic acid	zoledronic acid results in increased expression of PIR mRNA	25596134

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003712	transcription coregulator activity	-	IMP	23716661
GO:0005515	protein binding	-	IPI	10362352
GO:0008127	quercetin 2,3-dioxygenase activity	-	IBA	21873635
GO:0008127	quercetin 2,3-dioxygenase activity	-	IDA	15951572
GO:0008127	quercetin 2,3-dioxygenase activity	-	TAS	-
GO:0046872	metal ion binding	-	IDA	20711196
GO:0051213	dioxygenase activity	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006355	regulation of transcription, DNA-templated	-	IEA	-
GO:0006366	transcription by RNA polymerase II	-	TAS	9079676
GO:0007586	digestion	-	TAS	-
GO:0030224	monocyte differentiation	-	IBA	21873635
GO:0030224	monocyte differentiation	-	IMP	20010624
GO:0055114	oxidation-reduction process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	9079676
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IDA	20089166
GO:0005829	cytosol	-	IDA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-8935690	Digestion	TAS
R-HSA-8963743	Digestion and absorption	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
19593404	Coordinate control of expression of Nrf2-modulated genes in the human small airway epithelium is highly responsive to cigarette smoking. (2009 Jul-Aug)	Hubner RH	Mol Med
11425502	Extinction of cocaine self-administration produces a differential time-related regulation of proenkephalin gene expression in rat brain. (2001 Aug)	Crespo JA	Neuropsychopharmacology
24953790	Iron deficiency is associated with food insecurity in pregnant females in the United States: National Health and Nutrition Examination Survey 1999-2010. (2014 Dec)	Park CY	J Acad Nutr Diet
9480464	[The evaluation of bone mineral density and selected markers of bone turnover in patients with insulin dependent diabetes mellitus]. (1997)	Miazgowski T	Przegl Lek
24492686	Insulin resistance correlates with the arterial stiffness before glucose intolerance. (2014)	Fang FS	Intern Med