Gene: CNTNAP4

85445
CASPR4
contactin associated protein like 4
protein-coding
16q23.1
Ensembl:ENSG00000152910 MIM:610518 Vega:OTTHUMG00000137617 UniprotKB:Q9C0A0
NC_000016.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.177e-1 (AD)  5.224e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs929853chr16:76300776 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NIPAL30.873
KIAA1324L0.849
NIPA10.843
SPOCK30.84
PLCL10.837
SLC22A150.831
DLG10.831
NKAIN20.831
SECISBP2L0.83
KLHL40.827

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.405
PPP1R3G-0.392
EYA2-0.376
STK17B-0.373
GPR143-0.371
SYPL2-0.37
TLCD1-0.37
RFX2-0.364
WNT7B-0.354
OR4F5-0.349

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5850042-monochloropropanediol2-monochloropropanediol results in increased expression of CNTNAP4 mRNA28522335
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of CNTNAP4 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of CNTNAP4 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CNTNAP4 mRNA22100608
C487081belinostatbelinostat results in decreased expression of CNTNAP4 mRNA27188386
C006780bisphenol Abisphenol A results in decreased expression of CNTNAP4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CNTNAP4 gene28505145
D003300CopperCopper deficiency results in increased expression of CNTNAP4 mRNA26033743
D016572CyclosporineCyclosporine results in decreased expression of CNTNAP4 mRNA20106945
D019422Dietary SucroseDietary Sucrose results in increased expression of CNTNAP4 mRNA26033743
D002117CalcitriolCalcitriol results in increased expression of CNTNAP4 mRNA16002434
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of CNTNAP4 mRNA"23811387
C540355fenamidonefenamidone results in decreased expression of CNTNAP4 mRNA27029645
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CNTNAP4 mRNA"20188158
C028577monobutyl phthalatemonobutyl phthalate results in increased expression of CNTNAP4 mRNA29162477
D009285NaphthoquinonesNaphthoquinones results in increased expression of CNTNAP4 mRNA23811387
D011441PropylthiouracilPropylthiouracil results in increased expression of CNTNAP4 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of CNTNAP4 mRNA27029645
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CNTNAP4 mRNA26290441
D014212TretinoinTretinoin results in decreased expression of CNTNAP4 mRNA23724009
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CNTNAP4 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO:0032225regulation of synaptic transmission, dopaminergic-ISS-  
GO:0032228regulation of synaptic transmission, GABAergic-ISS-  
GO:2000821regulation of grooming behavior-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0030425dendrite-IEA-  
GO:0042734presynaptic membrane-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal