Gene: TSPYL5

85453
-
TSPY like 5
protein-coding
8q22.1
Ensembl:ENSG00000180543 MIM:614721 Vega:OTTHUMG00000164857 UniprotKB:Q86VY4
NC_000008.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.811e-2 (AD)  2.885e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPRASP20.95
NECAP10.949
ITFG10.946
GPRASP10.946
TMX40.945
EID20.945
PNMA20.945
SLC35B40.944
RUNDC10.943
INPP5F0.942

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.489
OR4F5-0.488
HEY2-0.46
OR4F29-0.441
RAI14-0.435
CNN2-0.428
MYL3-0.421
KCNE4-0.412
MAGEA12-0.411
MTRNR2L6-0.406

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in increased expression of TSPYL5 mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TSPYL5 mRNA22100608
D001151ArsenicTSPYL5 mRNA results in decreased susceptibility to Arsenic17976673
D001280AtrazineAtrazine results in decreased expression of TSPYL5 mRNA22378314
C006780bisphenol Abisphenol A results in decreased expression of TSPYL5 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of TSPYL5 mRNA29097150
C018475butyraldehydebutyraldehyde results in increased expression of TSPYL5 mRNA26079696
D004041Dietary FatsDietary Fats results in increased expression of TSPYL5 mRNA25016146
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in increased expression of TSPYL5 mRNA]21233418
D004967EstrogensEstrogens results in increased expression of TSPYL5 mRNA21233418
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TSPYL5 mRNA29097150
D019833GenisteinGenistein promotes the reaction [TSPYL5 protein binds to ESR1 protein]27156127
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TSPYL5 mRNA28001369
D012969Sodium FluorideSodium Fluoride results in increased expression of TSPYL5 mRNA27862939
D014212TretinoinTretinoin results in increased expression of TSPYL5 mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of TSPYL5 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of TSPYL5 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TSPYL5 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased methylation of TSPYL5 gene29154799
C029297vinylidene chloridevinylidene chloride results in decreased expression of TSPYL5 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21170034  
GO ID GO Term Qualifier Evidence PubMed
GO:0006334nucleosome assembly-IEA-  
GO:0008284positive regulation of cell proliferation-IDA21170034  
GO:0008284positive regulation of cell proliferation-IMP20079711  
GO:0031398positive regulation of protein ubiquitination-IDA21170034  
GO:0040008regulation of growth-IEA-  
GO:0051897positive regulation of protein kinase B signaling-IMP20079711  
GO:0071480cellular response to gamma radiation-IMP20079711  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19472401The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history: a target for risk diagnosis and prevention of esophageal cancers. (2009 Aug 1)Oka DCancer