Gene: TANC1

85461
ROLSB|TANC
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
protein-coding
2q24.2
Ensembl:ENSG00000115183 MIM:611397 Vega:OTTHUMG00000153945 UniprotKB:Q9C0D5
NC_000002.12
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.558e-1 (AD)  4.180e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs890622chr2:159108877 (GRCh38.p7)G>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg08384239chr2:160041968TANC18.700e-13Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLIC40.891
CREB3L20.89
ITGB10.87
BAZ1A0.869
ELF10.855
SPATA130.852
ATL30.849
IQGAP10.844
BACH10.843
LBR0.839

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDH22-0.502
BHLHA9-0.477
SPEF1-0.476
YBX2-0.475
KCNB2-0.475
ABCC12-0.474
RTN4R-0.473
LRTM2-0.473
DLK2-0.47
MYADML2-0.469

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TANC1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TANC1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TANC1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TANC1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TANC1 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TANC1 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TANC1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TANC1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TANC1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TANC1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TANC1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TANC1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TANC1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TANC1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of TANC1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of TANC1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TANC1 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TANC1 mRNA24449571
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of TANC1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TANC1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TANC1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TANC1 mRNA21839799
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TANC1 mRNA"19150397
C006780bisphenol Abisphenol A results in increased expression of TANC1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of TANC1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TANC1 gene28505145
C013418bromfenacoumbromfenacoum results in decreased expression of TANC1 protein28903499
D002220CarbamazepineCarbamazepine affects the expression of TANC1 mRNA25979313
D003300Copper[Disulfiram binds to Copper] which results in increased expression of TANC1 mRNA24690739
D003471CuprizoneCuprizone results in decreased expression of TANC1 mRNA27523638
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TANC1 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of TANC1 mRNA19561079
D004041Dietary FatsDietary Fats results in increased expression of TANC1 mRNA18042831
D002117CalcitriolCalcitriol results in decreased expression of TANC1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of TANC1 mRNA21592394
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of TANC1 mRNA24690739
D004317DoxorubicinDoxorubicin affects the methylation of TANC1 gene28962528
C118739entinostatentinostat results in increased expression of TANC1 mRNA27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TANC1 mRNA22079256
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of TANC1 mRNA23649840
C082360fipronilfipronil results in increased expression of TANC1 mRNA23962444
D005557FormaldehydeFormaldehyde results in decreased expression of TANC1 mRNA20655997
D005557FormaldehydeFormaldehyde results in increased expression of TANC1 mRNA23649840
C042720mercuric bromidemercuric bromide results in increased expression of TANC1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TANC1 mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TANC1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TANC1 mRNA"25554681
D009532NickelNickel results in decreased expression of TANC1 mRNA24768652|2558310
D010100OxygenOxygen deficiency affects the methylation of TANC1 promoter24205000
D010100OxygenOxygen deficiency results in increased expression of TANC1 mRNA24205000
D000073878Palm OilPalm Oil results in increased expression of TANC1 mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TANC1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of TANC1 mRNA26272509
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TANC1 mRNA"25510870
D010634PhenobarbitalPhenobarbital results in increased expression of TANC1 mRNA19270015
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TANC1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of TANC1 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TANC1 mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TANC1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TANC1 mRNA22079256
C513428pyrachlostrobinpyrachlostrobin results in increased expression of TANC1 mRNA27029645
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of TANC1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of TANC1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TANC1 mRNA20106945|2163298
D014212TretinoinTretinoin results in increased expression of TANC1 mRNA21934132|2372400
D014241TrichloroethyleneTrichloroethylene results in increased methylation of TANC1 gene27618143
C012589trichostatin Atrichostatin A results in increased expression of TANC1 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of TANC1 mRNA19042947
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of TANC1 mRNA29024780
C057693troglitazonetroglitazone results in decreased expression of TANC1 mRNA28973697
D014520UrethaneUrethane results in increased expression of TANC1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TANC1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TANC1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TANC1 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions affects the methylation of TANC1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007520myoblast fusion-IEA-  
GO:0008542visual learning-IEA-  
GO:0097062dendritic spine maintenance-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0014069postsynaptic density-IEA-  
GO:0030054cell junction-IEA-  
GO:0030425dendrite-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0043679axon terminus-IEA-  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal