Gene: LGR5

8549
FEX|GPR49|GPR67|GRP49|HG38
leucine rich repeat containing G protein-coupled receptor 5
protein-coding
12q21.1
Ensembl:ENSG00000139292 MIM:606667 Vega:OTTHUMG00000169543 UniprotKB:O75473
NC_000012.12
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.313e-1 (AD)  9.172e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRP20.902
ST180.9
TRIM590.895
DNAH170.887
PIEZO20.886
HHIP0.884
SH3TC20.883
C21orf910.882
NIPAL40.881
LRRC630.88

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WTIP-0.368
SLC29A4-0.367
PAX2-0.342
PRTN3-0.341
CCDC85C-0.338
LTK-0.335
CALB2-0.327
POU3F1-0.325
NEUROD1-0.32
GOLGA6L1-0.319

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0317631,3-butadiene"1,3-butadiene results in decreased expression of LGR5 mRNA"21147608
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of LGR5 mRNA"28903501
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LGR5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LGR5 mRNA"27188386
C5550214-acetylantroquinonol B4-acetylantroquinonol B results in decreased expression of LGR5 mRNA26235807
C5550214-acetylantroquinonol B4-acetylantroquinonol B results in decreased expression of LGR5 protein26235807
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LGR5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LGR5 mRNA"27188386
C4833216-bromoindirubin-3'-oxime6-bromoindirubin-3'-oxime results in increased expression of LGR5 mRNA26259606
D000082AcetaminophenAcetaminophen affects the expression of LGR5 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of LGR5 mRNA19420014
D020106AcrylamideAcrylamide results in decreased expression of LGR5 mRNA28959563
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of LGR5 mRNA24449571
D001151ArsenicArsenic affects the expression of LGR5 mRNA28615018
C006632arsenic trioxidearsenic trioxide results in decreased expression of LGR5 mRNA26705709
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of LGR5 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LGR5 mRNA20106945|2163298
D004958EstradiolEstradiol results in increased expression of LGR5 mRNA25878060
D004958EstradiolEstradiol results in decreased expression of LGR5 mRNA26945725
C006780bisphenol Abisphenol A results in decreased expression of LGR5 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide affects the expression of LGR5 mRNA23410634
C473711Chir 99021Chir 99021 results in increased expression of LGR5 mRNA26259606
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LGR5 gene20938992
D002922CiguatoxinsCiguatoxins affects the expression of LGR5 mRNA18353800
D002994ClofibrateClofibrate results in increased expression of LGR5 mRNA17585979
D003042CocaineCocaine results in decreased expression of LGR5 mRNA27899881
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of LGR5 mRNA20971185
D016572CyclosporineCyclosporine results in decreased expression of LGR5 mRNA25562108
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of LGR5 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of LGR5 mRNA24535843
C118739entinostatentinostat results in decreased expression of LGR5 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LGR5 mRNA"27188386
D005485FlutamideFlutamide results in increased expression of LGR5 mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LGR5 gene20938992
D004397FonofosFonofos results in increased methylation of LGR5 promoter22847954
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of LGR5 mRNA23410634
C008261lead acetatelead acetate results in decreased expression of LGR5 mRNA22613225
C045463leflunomideleflunomide results in increased expression of LGR5 mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LGR5 gene20938992
D008727MethotrexateMethotrexate results in decreased expression of LGR5 mRNA17400583
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of LGR5 mRNA28001369
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate affects the expression of LGR5 mRNA21195148
C028577monobutyl phthalatemonobutyl phthalate affects the expression of LGR5 mRNA21195148
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of LGR5 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of LGR5 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of LGR5 mRNA"25620056
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of LGR5 mRNA19812364
D009532NickelNickel results in decreased expression of LGR5 mRNA24768652|2558310
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of LGR5 mRNA20971185
D010100OxygenOxygen deficiency results in decreased expression of LGR5 mRNA24236059
D010278ParathionParathion results in increased methylation of LGR5 promoter22847954
D010416PentachlorophenolPentachlorophenol results in increased expression of LGR5 mRNA23892564
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of LGR5 mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of LGR5 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of LGR5 mRNA19270015|2309116
D010634PhenobarbitalPhenobarbital results in increased expression of LGR5 mRNA19482888
C006253pirinixic acidpirinixic acid results in decreased expression of LGR5 mRNA23811191
D011374ProgesteroneProgesterone results in decreased expression of LGR5 mRNA22238285
D011441PropylthiouracilPropylthiouracil results in increased expression of LGR5 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of LGR5 mRNA21632981
C059514resveratrolresveratrol results in decreased expression of LGR5 mRNA21291235
C059514resveratrolresveratrol results in decreased expression of LGR5 protein25280562
C417521SB 216763SB 216763 results in increased expression of LGR5 mRNA19448134
D012822Silicon DioxideSilicon Dioxide results in decreased expression of LGR5 mRNA23221170
D012906SmokeSmoke affects the expression of LGR5 mRNA23693141
D013629TamoxifenESR1 protein affects the reaction [Tamoxifen results in decreased expression of LGR5 mRNA]14699072
D013629TamoxifenTamoxifen affects the expression of LGR5 mRNA14699072
C012568terbufosterbufos results in increased methylation of LGR5 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LGR5 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LGR5 mRNA25975270|2629044
D013849ThimerosalThimerosal results in increased expression of LGR5 mRNA24675092
D014241TrichloroethyleneTrichloroethylene results in decreased expression of LGR5 mRNA25549359
C012589trichostatin Atrichostatin A results in decreased expression of LGR5 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of LGR5 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of LGR5 mRNA19042947
D014520UrethaneUrethane results in decreased expression of LGR5 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LGR5 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of LGR5 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of LGR5 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of LGR5 mRNA24383497|2800136
D014635Valproic AcidValproic Acid affects the expression of LGR5 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions affects the methylation of LGR5 gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of LGR5 mRNA23410634
C111237vorinostatvorinostat results in increased expression of LGR5 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-IDA21693646  22815884  
GO:0004930G-protein coupled receptor activityNOTIDA21693646  22815884  
GO:0005515protein binding-IPI21693646  21727895  22815884  
GO:0008528G-protein coupled peptide receptor activity-IBA21873635  
GO:0016500protein-hormone receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001942hair follicle development-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-IEA-  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007190activation of adenylate cyclase activity-IBA21873635  
GO:0009755hormone-mediated signaling pathway-IBA21873635  
GO:0009994oocyte differentiation-IEA-  
GO:0042127regulation of cell proliferation-IEA-  
GO:0048839inner ear development-IEA-  
GO:0090263positive regulation of canonical Wnt signaling pathway-IDA21693646  22815884  
GO:2001013epithelial cell proliferation involved in renal tubule morphogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA21693646  22815884  23439653  
GO:0032588trans-Golgi network membrane-IDA23439653  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-4641263Regulation of FZD by ubiquitinationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24890784Exon microarray analysis of human dorsolateral prefrontal cortex in alcoholism. (2014 Jun)Manzardo AMAlcohol Clin Exp Res