Gene: MAPKAPK5

8550
MAPKAP-K5|MK-5|MK5|PRAK
mitogen-activated protein kinase-activated protein kinase 5
protein-coding
12q24.12-q24.13
Ensembl:ENSG00000089022 MIM:606723 Vega:OTTHUMG00000169605 UniprotKB:Q8IW41
NC_000012.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.338e-1 (AD)  4.875e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11066053chr12:111866549 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STX120.888
CDV30.887
ETF10.886
CHMP2B0.877
HNRNPR0.876
DAP30.873
ARPC20.868
C11orf580.867
DDX500.864
PTP4A10.863

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.681
OR4F5-0.679
MTRNR2L6-0.239
IFNK-0.232
PRDM14-0.225
MTRNR2L10-0.222
MTRNR2L9-0.222
CYP11B2-0.211
PRAMEF17-0.21
CCL11-0.207

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of MAPKAPK5 mRNA"18343893
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of MAPKAPK5 mRNA"23994337
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of MAPKAPK5 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of MAPKAPK5 mRNA17562736
D017638Asbestos, Crocidolite"Asbestos, Crocidolite inhibits the reaction [SPARC gene mutant form results in increased expression of MAPKAPK5 mRNA]"19446018
C547126AZM551248AZM551248 results in decreased expression of MAPKAPK5 mRNA22323515
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of MAPKAPK5 mRNA23994337
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MAPKAPK5 mRNA"19150397
C006780bisphenol Abisphenol A affects the expression of MAPKAPK5 mRNA21786754
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of MAPKAPK5 mRNA19524605
D016572CyclosporineCyclosporine results in increased expression of MAPKAPK5 mRNA20106945
C017160cypermethrinMinocycline inhibits the reaction [cypermethrin results in increased expression of MAPKAPK5 protein]21561882
D004785Environmental PollutantsEnvironmental Pollutants affects the expression of MAPKAPK5 mRNA19118595
C045651epigallocatechin gallateepigallocatechin gallate results in decreased activity of MAPKAPK5 protein12534346
D019833GenisteinGenistein results in decreased expression of MAPKAPK5 mRNA22228119
D005897GlafenineGlafenine results in increased expression of MAPKAPK5 mRNA24136188
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MAPKAPK5 mRNA25613284
C410337K 7174K 7174 results in increased expression of MAPKAPK5 mRNA24086573
C063302KN 62KN 62 results in decreased activity of MAPKAPK5 protein10998351
C073601KT 5823KT 5823 results in decreased activity of MAPKAPK5 protein12534346
D008911MinocyclineMinocycline inhibits the reaction [cypermethrin results in increased expression of MAPKAPK5 protein]21561882
D017239PaclitaxelMAPKAPK5 protein affects the susceptibility to Paclitaxel16217747
C006253pirinixic acidpirinixic acid results in increased expression of MAPKAPK5 mRNA23811191
D011374ProgesteroneProgesterone results in increased expression of MAPKAPK5 mRNA23012394
C085746rottlerinrottlerin results in decreased activity of MAPKAPK5 protein10998351
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of MAPKAPK5 mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MAPKAPK5 mRNA18343893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MAPKAPK5 mRNA15328365|2399433
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MAPKAPK5 mRNA25613284
D014118Toxins, Biological"Toxins, Biological affects the expression of MAPKAPK5 mRNA"19682533
D014415TunicamycinTunicamycin results in decreased expression of MAPKAPK5 mRNA17127020
C113580U 0126U 0126 results in decreased activity of MAPKAPK5 protein10998351
D014635Valproic AcidValproic Acid affects the expression of MAPKAPK5 mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of MAPKAPK5 mRNA17292431
D014747VinblastineMAPKAPK5 protein affects the susceptibility to Vinblastine16217747

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002039p53 binding-IDA17254968  
GO:0004674protein serine/threonine kinase activity-EXP17254968  
GO:0004674protein serine/threonine kinase activity-IDA17254968  21329882  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0004683calmodulin-dependent protein kinase activity-IBA21873635  
GO:0004708MAP kinase kinase activity-TAS9628874  
GO:0005515protein binding-IPI17254968  20936779  21329882  21575178  21900206  23602568  
25416956  26972000  
GO:0005516calmodulin binding-IBA21873635  
GO:0005524ATP binding-IEA-  
GO:0009931calcium-dependent protein serine/threonine kinase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-IBA21873635  
GO:0000165MAPK cascade-IEA-  
GO:0000187activation of MAPK activity-IEA-  
GO:0006417regulation of translation-IDA21329882  
GO:0007165signal transduction-TAS9628874  
GO:0007166cell surface receptor signaling pathway-IBA21873635  
GO:0007265Ras protein signal transduction-IBA21873635  
GO:0007265Ras protein signal transduction-IDA17254968  
GO:0018105peptidyl-serine phosphorylation-IBA21873635  
GO:0032007negative regulation of TOR signaling-ISS-  
GO:0032212positive regulation of telomere maintenance via telomerase-IMP21531765  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0046777protein autophosphorylation-IBA21873635  
GO:0046777protein autophosphorylation-IDA21329882  
GO:0051973positive regulation of telomerase activity-IMP21531765  
GO:0090400stress-induced premature senescence-IDA17254968  
GO:1901796regulation of signal transduction by p53 class mediator-TAS-  
GO:1904355positive regulation of telomere capping-IMP21531765  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559580Oxidative Stress Induced SenescenceTAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5687128MAPK6/MAPK4 signalingTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal