Gene: MBD3L1

85509
MBD3L
methyl-CpG binding domain protein 3 like 1
protein-coding
19p13.2
Ensembl:ENSG00000170948 MIM:607963 Vega:OTTHUMG00000182198 UniprotKB:Q8WWY6
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.043e-1 (AD)  5.828e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDHA20.439
MMP30.426
MBD3L20.406
SLC36A20.389
WFDC110.385
KRT33A0.38
RBM460.368
CTAGE60.355
FAM3D0.355
CDKN2A0.354

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPR17-0.237
MUSTN1-0.235
ITIH5-0.215
PTGDR2-0.215
RERGL-0.205
COL9A1-0.188
SLC38A5-0.185
CA4-0.18
CYP2A13-0.179
PGA5-0.174

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001151ArsenicArsenic affects the methylation of MBD3L1 gene25304211
D001280AtrazineAtrazine results in increased expression of MBD3L1 mRNA22378314
C006780bisphenol Abisphenol A results in decreased expression of MBD3L1 mRNA25181051

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI26275350  
GO:0008327methyl-CpG binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006346methylation-dependent chromatin silencing-IBA21873635  
GO:0006351transcription, DNA-templated-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28889375A Versatile Assay for Detection of Aberrant DNA Methylation in Bladder Cancer. (2018)Tommasi SMethods Mol Biol