Gene info: ID 8553

Gene: BHLHE40

GENE ID: 8553

Description: basic helix-loop-helix family member e40

Gene type: protein-coding

Location: 3p26.1

dbXrefs: Ensembl:ENSG00000134107 MIM:604256 Vega:OTTHUMG00000119035 UniprotKB:O14503

RefSeq: NC_000003.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.410e-1 (AD) 1.126e-2 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg16320419	chr3:5025570	BHLHE40		4.400e-9	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CTNND1	0.786
ETS2	0.784
SLC2A3	0.767
OXSR1	0.75
ILF3	0.742
KBTBD2	0.739
SUN1	0.738
TNFAIP1	0.738
SNRNP200	0.736
ATP1B3	0.734

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.644
OR4F5	-0.635
ANXA13	-0.22
C9orf92	-0.212
OR51A2	-0.194
LRRC63	-0.192
MIA	-0.19
IRX2	-0.189
C20orf85	-0.187
UNCX	-0.186

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of BHLHE40 mRNA"	26377693
C576882	1-(2-trifluoromethoxyphenyl)-2-nitroethanone	1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of BHLHE40 mRNA	25596134
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of BHLHE40 mRNA"	28903501
C046760	15-acetyldeoxynivalenol	15-acetyldeoxynivalenol results in increased expression of BHLHE40 mRNA	23792671
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of BHLHE40 mRNA"	20453058
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of BHLHE40 mRNA	19933214
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of BHLHE40 mRNA"	19095052
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the expression of BHLHE40 mRNA"	19414516
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of BHLHE40 mRNA"	19167446
C063002	2,3-dimethoxy-1,4-naphthoquinone	"2,3-dimethoxy-1,4-naphthoquinone results in increased expression of BHLHE40 mRNA"	17547211
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of BHLHE40 mRNA"	20638727
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of BHLHE40 mRNA"	21346803
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of BHLHE40 mRNA"	23196670
C017906	3-dinitrobenzene	3-dinitrobenzene results in increased expression of BHLHE40 mRNA	21983209
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BHLHE40 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BHLHE40 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BHLHE40 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BHLHE40 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BHLHE40 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BHLHE40 mRNA"	27188386
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of BHLHE40 mRNA	19191707
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BHLHE40 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BHLHE40 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BHLHE40 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BHLHE40 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BHLHE40 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BHLHE40 mRNA"	27188386
D000079	Acetaldehyde	Acetaldehyde results in increased expression of BHLHE40 mRNA	23416264
D000082	Acetaminophen	Acetaminophen results in increased expression of BHLHE40 mRNA	29067470
D020106	Acrylamide	Acrylamide results in decreased expression of BHLHE40 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of BHLHE40 gene	27153756
D000638	Amiodarone	Amiodarone results in increased expression of BHLHE40 mRNA	19774075
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of BHLHE40 mRNA	16483693
D001151	Arsenic	BHLHE40 mRNA results in decreased susceptibility to Arsenic	17976673
C006632	arsenic trioxide	arsenic trioxide results in increased expression of BHLHE40 mRNA	15761015
C006632	arsenic trioxide	[Tretinoin co-treated with arsenic trioxide] results in increased expression of BHLHE40 mRNA	15894607
C015001	arsenite	arsenite results in decreased methylation of BHLHE40 promoter	23974009
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of BHLHE40 mRNA"	18687144\|2535159
D001280	Atrazine	Atrazine results in increased expression of BHLHE40 mRNA	22378314
C406592	azaspiracid	azaspiracid results in increased expression of BHLHE40 mRNA	28939011
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of BHLHE40 mRNA	27858113
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of BHLHE40 mRNA	27858113
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of BHLHE40 mRNA	26377693
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of BHLHE40 mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of BHLHE40 mRNA	19770486
D004958	Estradiol	EGF protein inhibits the reaction [Estradiol results in decreased expression of BHLHE40 mRNA]	24758408
D004958	Estradiol	Estradiol results in decreased expression of BHLHE40 mRNA	16474171\|1916744
D004958	Estradiol	Estradiol results in increased expression of BHLHE40 mRNA	19153601
D004958	Estradiol	Estradiol results in increased expression of BHLHE40 mRNA	15289156\|2521013
D004958	Estradiol	Estradiol results in decreased expression of BHLHE40 mRNA	20068009
D001622	Betaine	Betaine results in increased expression of BHLHE40 mRNA	26391144
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of BHLHE40 mRNA	28628672
C002791	bismuth tripotassium dicitrate	bismuth tripotassium dicitrate results in increased expression of BHLHE40 mRNA	15912405
C006780	bisphenol A	bisphenol A results in decreased expression of BHLHE40 mRNA	16474171
C006780	bisphenol A	bisphenol A results in increased expression of BHLHE40 mRNA	29275510
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of BHLHE40 mRNA	28628672
C006780	bisphenol A	bisphenol A affects the methylation of BHLHE40 promoter	27334623
C006780	bisphenol A	bisphenol A results in increased expression of BHLHE40 mRNA	25270620
C006780	bisphenol A	bisphenol A results in increased expression of BHLHE40 mRNA	25181051
D002065	Buspirone	Buspirone results in decreased expression of BHLHE40 mRNA	24136188
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of BHLHE40 mRNA	25596134
C037123	cadmium sulfate	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of BHLHE40 mRNA	18654764
C037123	cadmium sulfate	cadmium sulfate results in decreased expression of BHLHE40 mRNA	21783983
D002220	Carbamazepine	Carbamazepine affects the expression of BHLHE40 mRNA	25979313
C004656	chloroacetaldehyde	chloroacetaldehyde results in decreased expression of BHLHE40 mRNA	25596134
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of BHLHE40 mRNA	16934159
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of BHLHE40 mRNA	25270620
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BHLHE40 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of BHLHE40 mRNA	26272509
C100187	chloropicrin	chloropicrin affects the expression of BHLHE40 mRNA	26352163
D002737	Chloroprene	Chloroprene results in increased expression of BHLHE40 mRNA	23125180
D002746	Chlorpromazine	Chlorpromazine analog results in increased expression of BHLHE40 mRNA	15924885
D002857	Chromium	Chromium results in increased expression of BHLHE40 mRNA	17547211
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of BHLHE40 mRNA	27858113
D002994	Clofibrate	Clofibrate results in increased expression of BHLHE40 mRNA	25270620
C018021	cobaltous chloride	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of BHLHE40 mRNA	18654764
C018021	cobaltous chloride	cobaltous chloride results in increased expression of BHLHE40 mRNA	22202117
C018021	cobaltous chloride	zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of BHLHE40 mRNA]	22202117
C018021	cobaltous chloride	cobaltous chloride results in increased expression of BHLHE40 mRNA	24386269
C060728	cobalt oxide	cobalt oxide analog results in increased expression of BHLHE40 mRNA	24821434
D003042	Cocaine	Cocaine affects the expression of BHLHE40 mRNA	20187946
D003300	Copper	Copper results in decreased expression of BHLHE40 mRNA	26293553
D003314	Corn Oil	Corn Oil affects the expression of BHLHE40 mRNA	16360708
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of BHLHE40 mRNA"	19167446
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in decreased expression of BHLHE40 mRNA	19167446
D003375	Coumestrol	Coumestrol results in decreased expression of BHLHE40 mRNA	19167446
D016572	Cyclosporine	Cyclosporine results in increased expression of BHLHE40 mRNA	20106945\|2556210
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of BHLHE40 mRNA	24317228
C014347	decitabine	decitabine affects the expression of BHLHE40 mRNA	23300844
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of BHLHE40 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of BHLHE40 mRNA	28628672
D003907	Dexamethasone	Dexamethasone results in decreased expression of BHLHE40 mRNA	22733784
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of BHLHE40 mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of BHLHE40 mRNA	21266533
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in decreased expression of BHLHE40 mRNA	28962523
D002945	Cisplatin	Cisplatin affects the expression of BHLHE40 mRNA	23300844
D002945	Cisplatin	Cisplatin results in decreased expression of BHLHE40 mRNA	21151649
D004041	Dietary Fats	Dietary Fats results in increased expression of BHLHE40 mRNA	18042831
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of BHLHE40 mRNA	27614199
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of BHLHE40 mRNA	15289156
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of BHLHE40 mRNA	17606305
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of BHLHE40 mRNA	15576828\|1583489
D011345	Fenofibrate	Fenofibrate results in decreased expression of BHLHE40 mRNA	25596134
D011345	Fenofibrate	Fenofibrate results in decreased expression of BHLHE40 mRNA	25596134
C000499	ferric oxide	ferric oxide analog results in increased expression of BHLHE40 mRNA	25086211
D005485	Flutamide	Flutamide results in decreased expression of BHLHE40 mRNA	24793618
C065180	fluvastatin	[zoledronic acid co-treated with fluvastatin] results in increased expression of BHLHE40 mRNA	16996129
D005492	Folic Acid	[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of BHLHE40 mRNA	24657277
D005557	Formaldehyde	Formaldehyde results in increased expression of BHLHE40 mRNA	17938736\|2364984
C039281	furan	furan results in decreased expression of BHLHE40 mRNA	25539665\|2619464
D019833	Genistein	Genistein results in decreased expression of BHLHE40 mRNA	16474171
D019833	Genistein	Genistein results in increased expression of BHLHE40 mRNA	15289156
D005897	Glafenine	Glafenine results in increased expression of BHLHE40 mRNA	24136188
C010176	halofuginone	halofuginone results in decreased expression of BHLHE40 mRNA	17180598
D006534	Heptachlor Epoxide	Heptachlor Epoxide results in increased expression of BHLHE40 mRNA	25270620
D017313	Fenretinide	Fenretinide results in increased expression of BHLHE40 mRNA	15958647
D017313	Fenretinide	Fenretinide results in increased expression of BHLHE40 mRNA	28973697
C475919	hydroxytamoxifen	GPER1 protein affects the reaction [hydroxytamoxifen results in increased expression of BHLHE40 mRNA]	19153601
C475919	hydroxytamoxifen	hydroxytamoxifen results in increased expression of BHLHE40 mRNA	16849584\|1915360
D006997	Hypochlorous Acid	Hypochlorous Acid results in decreased expression of BHLHE40 mRNA	19376150
D007069	Ifosfamide	Ifosfamide results in increased expression of BHLHE40 mRNA	25596134
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of BHLHE40 mRNA	21396975
D007213	Indomethacin	Indomethacin results in increased expression of BHLHE40 mRNA	16984733
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of BHLHE40 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of BHLHE40 mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BHLHE40 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of BHLHE40 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of BHLHE40 mRNA	28628672
C098607	JP8 aviation fuel	JP8 aviation fuel results in increased expression of BHLHE40 protein	17337753
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of BHLHE40 mRNA	23086925
D007649	Ketamine	Ketamine results in increased expression of BHLHE40 mRNA	20080153
D007854	Lead	Lead affects the expression of BHLHE40 mRNA	28903495
C029891	lead chloride	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of BHLHE40 mRNA	18654764
C045463	leflunomide	leflunomide results in increased expression of BHLHE40 mRNA	28988120
C533894	LG 100815	LG 100815 results in increased expression of BHLHE40 mRNA	16951191
D001556	Lindane	Lindane results in decreased expression of BHLHE40 mRNA	17785943
C482199	lipopolysaccharide, E coli O55-B5	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of BHLHE40 mRNA"	18930950
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of BHLHE40 mRNA	16415329
D008070	Lipopolysaccharides	Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of BHLHE40 mRNA]	16415329
C042720	mercuric bromide	mercuric bromide results in increased expression of BHLHE40 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BHLHE40 mRNA"	27188386
D008628	Mercury	Mercury results in increased expression of BHLHE40 mRNA	17547211\|1993728
D008687	Metformin	Metformin affects the expression of BHLHE40 mRNA	25596134
D008727	Methotrexate	[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of BHLHE40 mRNA	24657277
D008727	Methotrexate	Methotrexate results in increased expression of BHLHE40 mRNA	24657277
D008730	Methoxsalen	BHLHE40 protein inhibits the reaction [Methoxsalen results in decreased expression of BIRC5 protein]	22796345
D008730	Methoxsalen	BHLHE40 protein inhibits the reaction [Methoxsalen results in increased activity of and results in decreased expression of CASP3 protein]	22796345
D008730	Methoxsalen	BHLHE40 protein results in decreased susceptibility to Methoxsalen	22796345
D008730	Methoxsalen	Methoxsalen results in decreased expression of BHLHE40 mRNA	22796345
D008730	Methoxsalen	Methoxsalen results in decreased expression of BHLHE40 protein	22796345
D008752	Methylene Chloride	Methylene Chloride results in increased expression of BHLHE40 mRNA	28392392
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of BHLHE40 mRNA	23179753
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of BHLHE40 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of BHLHE40 mRNA	26011545
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of BHLHE40 mRNA	17475336
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of BHLHE40 mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of BHLHE40 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of BHLHE40 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of BHLHE40 mRNA"	25554681
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of BHLHE40 mRNA	19812364
C028007	nickel monoxide	nickel monoxide results in increased expression of BHLHE40 mRNA	19167457
C029938	nickel sulfate	nickel sulfate results in increased expression of BHLHE40 mRNA	18651567\|2271453
C012655	nimesulide	nimesulide results in decreased expression of BHLHE40 mRNA	24136188
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in decreased expression of BHLHE40 mRNA	17616710
C570896	NSC305787	NSC305787 results in increased expression of BHLHE40 mRNA	27137931
C062198	octa-2,4,6-trienoic acid	"octa-2,4,6-trienoic acid results in increased expression of BHLHE40 mRNA"	16951191
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of BHLHE40 mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in increased expression of BHLHE40 mRNA	20042640\|2423605
D010100	Oxygen	Oxygen deficiency affects the expression of BHLHE40 mRNA	17193925
D010100	Oxygen	Oxygen deficiency results in increased expression of BHLHE40 mRNA	20880076
D010126	Ozone	Ozone results in increased expression of BHLHE40 mRNA	28623178
D000073878	Palm Oil	Palm Oil results in increased expression of BHLHE40 mRNA	18042831
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BHLHE40 mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of BHLHE40 mRNA	26272509
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether analog results in increased expression of BHLHE40 mRNA	19095052
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of BHLHE40 mRNA	27614199
D010634	Phenobarbital	Phenobarbital results in increased expression of BHLHE40 mRNA	19270015
D019800	Phenol	Phenol results in increased expression of BHLHE40 mRNA	17547211
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BHLHE40 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of BHLHE40 mRNA	26272509
D010705	Phosgene	Phosgene affects the expression of BHLHE40 mRNA	16300373
C006253	pirinixic acid	pirinixic acid results in decreased expression of BHLHE40 mRNA	23811191
C006253	pirinixic acid	pirinixic acid results in increased expression of BHLHE40 mRNA	18445702
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls analog results in decreased expression of BHLHE40 mRNA	16474171
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of BHLHE40 mRNA	22714537
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of BHLHE40 mRNA	17547211
D011374	Progesterone	Progesterone results in increased expression of BHLHE40 mRNA	18037150
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of BHLHE40 mRNA	24780913
D011794	Quercetin	Quercetin results in increased expression of BHLHE40 mRNA	21632981
D011794	Quercetin	Quercetin results in decreased expression of BHLHE40 mRNA	18095365
D015125	Oxyquinoline	Oxyquinoline results in decreased expression of BHLHE40 mRNA	21632981
D011899	Ranitidine	Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of BHLHE40 mRNA]	16415329
C031389	resorcinol	resorcinol results in increased expression of BHLHE40 mRNA	22623647
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in decreased expression of BHLHE40 mRNA	19167446
D015474	Isotretinoin	Isotretinoin results in increased expression of BHLHE40 mRNA	18769122
D012293	Rifampin	[Rifampin co-treated with NR1I2 protein] results in increased expression of BHLHE40 mRNA	21127053
D012402	Rotenone	Rotenone results in increased expression of BHLHE40 mRNA	27900601
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of BHLHE40 mRNA	25351596
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of BHLHE40 mRNA	19073995
D012834	Silver	Silver results in increased expression of BHLHE40 mRNA	26014281
D012834	Silver	Silver results in decreased expression of BHLHE40 mRNA	27131904
C017947	sodium arsenite	sodium arsenite results in decreased expression of BHLHE40 mRNA	25270620
D053260	Soot	Soot results in increased expression of BHLHE40 mRNA	26551751
C041711	St. Thomas' Hospital cardioplegic solution	St. Thomas' Hospital cardioplegic solution results in increased expression of BHLHE40 mRNA	16214533
D020058	Styrene	Styrene results in increased expression of BHLHE40 mRNA	28951217
C016766	sulforafan	sulforafan results in increased expression of BHLHE40 mRNA	26833863
D000952	Antigens, Polyomavirus Transforming	"Antigens, Polyomavirus Transforming results in increased expression of BHLHE40 mRNA"	26680231
C061133	tamibarotene	tamibarotene affects the expression of BHLHE40 mRNA	15498508
D013629	Tamoxifen	Tamoxifen affects the expression of BHLHE40 mRNA	14699072
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in decreased expression of BHLHE40 mRNA	20189893
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of BHLHE40 mRNA	17884332
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of BHLHE40 mRNA	20106945
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of BHLHE40 mRNA	21570461\|2468072
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of BHLHE40 mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of BHLHE40 mRNA	19770486\|1993321
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of BHLHE40 mRNA	16960034\|1703548
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of BHLHE40 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of BHLHE40 mRNA	20959002\|2121527
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of BHLHE40 mRNA	16960034
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BHLHE40 mRNA	25613284
D019284	Thapsigargin	Thapsigargin results in decreased expression of BHLHE40 mRNA	22378314
D013849	Thimerosal	Thimerosal results in decreased expression of BHLHE40 mRNA	27188386
D013893	Thiram	Thiram results in increased expression of BHLHE40 mRNA	20530235
C009495	titanium dioxide	titanium dioxide results in increased expression of BHLHE40 mRNA	23409001\|2776080
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of BHLHE40 mRNA	20133372
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of BHLHE40 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of BHLHE40 mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of BHLHE40 mRNA	20530235
D014212	Tretinoin	Tretinoin results in increased expression of BHLHE40 mRNA	18230668
D014212	Tretinoin	Tretinoin affects the expression of BHLHE40 mRNA	15498508
D014212	Tretinoin	[Tretinoin co-treated with arsenic trioxide] results in increased expression of BHLHE40 mRNA	15894607
D014212	Tretinoin	Tretinoin results in increased expression of BHLHE40 mRNA	15894607
D014212	Tretinoin	Tretinoin results in increased expression of BHLHE40 mRNA	16604517
C011559	tributyltin	tributyltin results in decreased expression of BHLHE40 mRNA	27614199
C012589	trichostatin A	trichostatin A results in decreased expression of BHLHE40 mRNA	15901671
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BHLHE40 mRNA"	27188386
C012589	trichostatin A	trichostatin A affects the expression of BHLHE40 mRNA	28542535
C012589	trichostatin A	trichostatin A results in increased expression of BHLHE40 mRNA	24935251\|2627250
C012589	trichostatin A	trichostatin A results in increased expression of BHLHE40 mRNA	15901671
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of BHLHE40 mRNA"	26743178
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BHLHE40 mRNA"	26179874
C057693	troglitazone	troglitazone results in decreased expression of BHLHE40 mRNA	25572481
C080163	trovafloxacin	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of BHLHE40 mRNA"	18930950
D014415	Tunicamycin	Tunicamycin results in decreased expression of BHLHE40 mRNA	22378314
C022884	undecane	undecane results in increased expression of BHLHE40 protein	17337753
D017974	Uranium Compounds	Uranium Compounds results in decreased expression of BHLHE40 mRNA	19654044
D014520	Urethane	Urethane results in decreased expression of BHLHE40 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in decreased expression of BHLHE40 mRNA	15901671
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BHLHE40 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of BHLHE40 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of BHLHE40 mRNA	19949822
D014635	Valproic Acid	Valproic Acid results in decreased methylation of BHLHE40 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of BHLHE40 mRNA	23179753\|2352703
D014635	Valproic Acid	Valproic Acid affects the expression of BHLHE40 mRNA	17963808
D014635	Valproic Acid	Valproic Acid results in increased expression of BHLHE40 mRNA	15901671
C025643	vinclozolin	vinclozolin affects the expression of BHLHE40 mRNA	19015723
C025643	vinclozolin	vinclozolin results in increased expression of BHLHE40 mRNA	23034163
C111237	vorinostat	vorinostat results in decreased expression of BHLHE40 mRNA	27188386
C111237	vorinostat	vorinostat results in increased expression of BHLHE40 mRNA	26272509
C016837	zinc chloride	zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of BHLHE40 mRNA]	22202117
C088658	zoledronic acid	[zoledronic acid co-treated with fluvastatin] results in increased expression of BHLHE40 mRNA	16996129

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	-	IBA	21873635
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	IDA	12397359
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IBA	21873635
GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IDA	12624110 15193144 18411297
GO:0001102	RNA polymerase II activating transcription factor binding	-	ISS	-
GO:0001191	transcriptional repressor activity, RNA polymerase II transcription factor binding	-	IDA	12397359 18411297
GO:0003700	DNA-binding transcription factor activity	-	NAS	9240428
GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	-	ISS	-
GO:0003714	transcription corepressor activity	-	IBA	21873635
GO:0003714	transcription corepressor activity	-	IDA	19786558
GO:0005515	protein binding	-	IPI	11278694 12397359 17347673 19786558 22458338 22723347 25416956 25910212 29234281
GO:0008134	transcription factor binding	-	IBA	21873635
GO:0019904	protein domain specific binding	-	IPI	15560782
GO:0042803	protein homodimerization activity	-	IDA	15560782
GO:0043425	bHLH transcription factor binding	-	IPI	12397359 15193144
GO:0043426	MRF binding	-	ISS	-
GO:0043565	sequence-specific DNA binding	-	IBA	21873635
GO:0046982	protein heterodimerization activity	-	IPI	12397359 15193144 15560782
GO:0070888	E-box binding	-	IDA	12397359 12624110 14672706 15193144 15560782 18411297
GO:1990837	sequence-specific double-stranded DNA binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IDA	12397359 12624110 14672706 15193144
GO:0001756	somitogenesis	-	IBA	21873635
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006355	regulation of transcription, DNA-templated	-	NAS	9240428
GO:0007219	Notch signaling pathway	-	IBA	21873635
GO:0030154	cell differentiation	-	IBA	21873635
GO:0032922	circadian regulation of gene expression	-	IDA	18411297
GO:0043153	entrainment of circadian clock by photoperiod	-	ISS	18411297
GO:0043433	negative regulation of DNA-binding transcription factor activity	-	IDA	18411297
GO:0045892	negative regulation of transcription, DNA-templated	-	IDA	12397359
GO:0050767	regulation of neurogenesis	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	12624110
GO:0005634	nucleus	-	NAS	9240428
GO:0005737	cytoplasm	-	IEA	-
GO:0016604	nuclear body	-	IDA	-

KEGG ID	KEGG Term
hsa04710	Circadian rhythm

Reactome ID	Reactome Term	Evidence
R-HSA-1368108	BMAL1:CLOCK,NPAS2 activates circadian gene expression	IEA
R-HSA-400253	Circadian Clock	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28296937	Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis. (2017)	Lin E	PLoS One