Gene info: ID 8557

Gene: TCAP

GENE ID: 8557

Description: titin-cap

Gene type: protein-coding

Location: 17q12

dbXrefs: Ensembl:ENSG00000173991 MIM:604488 Vega:OTTHUMG00000133215 UniprotKB:O15273

RefSeq: NG_008892.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|AD

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.719e-1 (AD) 6.990e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TLR9	0.692
CNTD2	0.69
LMAN2L	0.672
CLDN9	0.658
MKNK2	0.658
AOC2	0.656
CCNA2	0.651
DNASE1L2	0.651
SLFNL1	0.651
KLK14	0.65

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.37
OR4F29	-0.336
MYLK2	-0.302
HSF2BP	-0.302
SLC35G1	-0.3
STARD6	-0.296
HAPLN1	-0.29
CYSLTR1	-0.273
OSTN	-0.267
ZNF683	-0.263

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of TCAP mRNA"	26377693
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TCAP mRNA"	25614096
C063002	2,3-dimethoxy-1,4-naphthoquinone	"2,3-dimethoxy-1,4-naphthoquinone results in increased expression of TCAP mRNA"	20856801
C107946	2,7-dihydroxynaphthalene	"2,7-dihydroxynaphthalene results in decreased expression of TCAP mRNA"	28940058
C006551	2-amino-2-methyl-1-propanol	2-amino-2-methyl-1-propanol results in decreased expression of TCAP mRNA	25088246
D000082	Acetaminophen	Acetaminophen results in decreased expression of TCAP mRNA	25064622
D000638	Amiodarone	Amiodarone results in decreased expression of TCAP mRNA	25064622
D001507	Beclomethasone	Beclomethasone results in increased expression of TCAP mRNA	23656298
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in increased expression of TCAP mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [AHR protein binds to TCAP promoter]	19654925
C006780	bisphenol A	bisphenol A results in decreased expression of TCAP mRNA	25181051
D002746	Chlorpromazine	Chlorpromazine results in decreased expression of TCAP mRNA	25064622
D019327	Copper Sulfate	Copper Sulfate results in increased expression of TCAP mRNA	19549813
C000541	cyclopamine	cyclopamine results in decreased expression of TCAP mRNA	22265815
D016572	Cyclosporine	Cyclosporine results in increased expression of TCAP mRNA	25064622
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of TCAP mRNA	24317228
C016366	dibenzothiophene	dibenzothiophene results in increased expression of TCAP mRNA	23656968
D002945	Cisplatin	Cisplatin results in decreased expression of TCAP mRNA	27392435
D004317	Doxorubicin	Doxorubicin results in decreased expression of TCAP mRNA	28940058
D004317	Doxorubicin	Doxorubicin results in increased expression of TCAP mRNA	20856801
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of TCAP mRNA	25064622
D006108	Graphite	Graphite results in increased expression of TCAP mRNA	27440207
D007052	Ibuprofen	Ibuprofen results in decreased expression of TCAP mRNA	28201806
C544151	jinfukang	jinfukang results in decreased expression of TCAP mRNA	27392435
C568376	MT19c compound	MT19c compound results in decreased expression of TCAP mRNA	21781307
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of TCAP mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of TCAP mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of TCAP mRNA"	25620056
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of TCAP mRNA	27935865
C060836	pioglitazone	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of TCAP mRNA	27935865
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TCAP mRNA	19710929
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of TCAP mRNA	24780913
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in decreased expression of TCAP mRNA"	21514415
D017632	Asbestos, Serpentine	"SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of TCAP mRNA]"	21514415
D053260	Soot	Soot results in decreased expression of TCAP mRNA	26551751
D013629	Tamoxifen	Tamoxifen results in decreased expression of TCAP mRNA	17555576
C004648	testosterone enanthate	testosterone enanthate affects the expression of TCAP mRNA	17440010
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of TCAP protein	27239688
D013853	Thioacetamide	Thioacetamide results in decreased expression of TCAP mRNA	25064622
C009495	titanium dioxide	titanium dioxide results in decreased expression of TCAP mRNA	23409001\|2355797
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of TCAP mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of TCAP mRNA	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of TCAP mRNA	28111298
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of TCAP mRNA	26745549
D014260	Triclosan	Triclosan results in decreased expression of TCAP mRNA	28940058
C005445	triphenyl phosphate	triphenyl phosphate results in increased expression of TCAP mRNA	29529285
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TCAP mRNA"	26743178
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of TCAP mRNA	29024780
D014520	Urethane	Urethane results in decreased expression of TCAP mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in decreased expression of TCAP mRNA	25064622
D014635	Valproic Acid	Valproic Acid results in increased methylation of TCAP gene	29154799

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	10984498 11842093 11846417 15582318 16407954 16962094 17921333 19622741 23414517 24860983
GO:0008307	structural constituent of muscle	-	IMP	9817758
GO:0030674	protein binding, bridging	-	IDA	15582318
GO:0031432	titin binding	-	IPI	9817758 11846417 15582318
GO:0036122	BMP binding	-	IPI	17921333
GO:0044325	ion channel binding	-	IPI	11697903
GO:0051373	FATZ binding	-	IPI	15582318
GO:0070080	titin Z domain binding	-	IPI	11846417

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001756	somitogenesis	-	IEA	-
GO:0003009	skeletal muscle contraction	-	IEP	9817758
GO:0003300	cardiac muscle hypertrophy	-	IMP	15582318
GO:0007512	adult heart development	-	IMP	9817758
GO:0014898	cardiac muscle hypertrophy in response to stress	-	IMP	12507422
GO:0030049	muscle filament sliding	-	TAS	-
GO:0030240	skeletal muscle thin filament assembly	-	IMP	9817758
GO:0030241	skeletal muscle myosin thick filament assembly	-	IMP	9817758
GO:0030916	otic vesicle formation	-	IEA	-
GO:0035994	response to muscle stretch	-	TAS	17921333
GO:0035995	detection of muscle stretch	-	IMP	12507422
GO:0045214	sarcomere organization	-	IMP	9817758
GO:0045214	sarcomere organization	-	TAS	17921333
GO:0048739	cardiac muscle fiber development	-	IMP	9817758
GO:0048769	sarcomerogenesis	-	IMP	9817758
GO:0050982	detection of mechanical stimulus	-	TAS	17921333
GO:0055003	cardiac myofibril assembly	-	IMP	9817758
GO:0055008	cardiac muscle tissue morphogenesis	-	IMP	9817758
GO:0060048	cardiac muscle contraction	-	IMP	12507422 15582318
GO:0065003	protein-containing complex assembly	-	TAS	9817758

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005829	cytosol	-	TAS	-
GO:0030018	Z disc	-	IDA	9817758 17921333
GO:0031674	I band	-	ISS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-390522	Striated Muscle Contraction	TAS
R-HSA-397014	Muscle contraction	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
20883474	Teneurin C-terminal associated peptide-1 blocks the effects of corticotropin-releasing factor on reinstatement of cocaine seeking and on cocaine-induced behavioural sensitization. (2011 Feb)	Kupferschmidt DA	Br J Pharmacol
24037902	The genetics of dilated cardiomyopathy: a prioritized candidate gene study of LMNA, TNNT2, TCAP, and PLN. (2013 Oct)	Hirtle-Lewis M	Clin Cardiol