Gene: CDK10

8558
ALSAS|PISSLRE
cyclin dependent kinase 10
protein-coding
16q24.3
Ensembl:ENSG00000185324 MIM:603464 Vega:OTTHUMG00000138049 UniprotKB:Q15131
NC_000016.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.091e-1 (AD)  1.236e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg27543607chr16:89762101CDK10Gene body3.890e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACD0.931
TRMT10.923
ABCB60.916
CENPT0.914
ATG4B0.913
NPDC10.906
DMAP10.905
DGAT10.904
ANKRD13B0.903
DTX30.902

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.646
OR4F29-0.609
TFPI2-0.357
KCNJ15-0.356
KLRB1-0.349
C9orf153-0.344
PABPC4L-0.337
CEACAM3-0.327
DNASE1L3-0.322
MTRNR2L9-0.317

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of CDK10 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of CDK10 mRNA17562736
D000447AldehydesAldehydes results in decreased expression of CDK10 mRNA25014914
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased methylation of CDK10 promoter28329817
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CDK10 mRNA22228805
D004958EstradiolEstradiol affects the expression of CDK10 mRNA21826169
C006780bisphenol Abisphenol A affects the expression of CDK10 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of CDK10 mRNA21826169
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of CDK10 mRNA12419474
C018475butyraldehydebutyraldehyde results in decreased expression of CDK10 mRNA26079696
C018021cobaltous chloridecobaltous chloride results in decreased expression of CDK10 mRNA24386269
D004026DieldrinDieldrin results in decreased expression of CDK10 mRNA20584760
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CDK10 mRNA15766595
C024629dimethyl phthalatedimethyl phthalate affects the expression of CDK10 mRNA26924002
D004317DoxorubicinDoxorubicin results in increased expression of CDK10 mRNA16404146
D005485FlutamideFlutamide results in decreased expression of CDK10 mRNA24793618
D004397FonofosFonofos results in increased methylation of CDK10 promoter22847954
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of CDK10 mRNA12419474
C544151jinfukangjinfukang results in increased expression of CDK10 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CDK10 mRNA23430699
C011890kojic acidkojic acid results in decreased expression of CDK10 mRNA16595896
D008694MethamphetamineMethamphetamine results in decreased expression of CDK10 mRNA19564919
C008493methylselenic acidmethylselenic acid results in decreased expression of CDK10 mRNA11830524
C517284monomethyl phthalatemonomethyl phthalate affects the expression of CDK10 mRNA26924002
C029938nickel sulfatenickel sulfate results in increased expression of CDK10 mRNA22714537
D010278ParathionParathion results in increased methylation of CDK10 promoter22847954
C046012pentanalpentanal results in decreased expression of CDK10 mRNA26079696
D010936Plant ExtractsPlant Extracts results in increased expression of CDK10 mRNA23557933
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of CDK10 mRNA22714537
C045950propiconazolepropiconazole results in decreased expression of CDK10 mRNA21278054
C005556propionaldehydepropionaldehyde results in decreased expression of CDK10 mRNA26079696
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of CDK10 mRNA19244175
D012643SeleniumSelenium results in increased expression of CDK10 mRNA19244175
C061133tamibarotenetamibarotene affects the expression of CDK10 mRNA15498508
C012568terbufosterbufos results in increased methylation of CDK10 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CDK10 mRNA21570461
D014212TretinoinTretinoin affects the expression of CDK10 mRNA15498508
C012589trichostatin Atrichostatin A affects the expression of CDK10 mRNA28542535
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of CDK10 mRNA29024780
D014520UrethaneUrethane results in decreased expression of CDK10 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of CDK10 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CDK10 gene25560391
D014750VincristineVincristine results in decreased expression of CDK10 mRNA23649840
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of CDK10 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IDA27104747  
GO:0004693cyclin-dependent protein serine/threonine kinase activity-IBA21873635  
GO:0005515protein binding-IPI18242510  22158035  22939624  27104747  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IBA21873635  
GO:0007089traversing start control point of mitotic cell cycle-TAS8208557  
GO:0008285negative regulation of cell proliferation-TAS8208557  
GO:0018107peptidyl-threonine phosphorylation-IDA27104747  
GO:0030030cell projection organization-IEA-  
GO:0032956regulation of actin cytoskeleton organization-IMP27104747  
GO:0043410positive regulation of MAPK cascade-IEA-  
GO:1902018negative regulation of cilium assembly-IMP27104747  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IEA-  
GO:0036064ciliary basal body-IDA27104747  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26683928Genomic Copy Number Variations Characterize the Prognosis of Both P16-Positive and P16-Negative Oropharyngeal Squamous Cell Carcinoma After Curative Resection. (2015 Dec)Rhie AMedicine (Baltimore)