Gene: DEGS1

8560
DEGS|DEGS-1|DES1|Des-1|FADS7|MIG15|MLD
delta 4-desaturase, sphingolipid 1
protein-coding
1q42.11
Ensembl:ENSG00000143753 MIM:615843 Vega:OTTHUMG00000037496 UniprotKB:O15121
NC_000001.11
PubMed
0   ANCO-SNPs
ND
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.286e-1 (AD)  7.889e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BUB30.927
RNF1390.926
UBA30.926
PSMD60.925
XRCC50.924
ILF20.923
SGPP10.921
VAPA0.92
RAB180.919
PSMC20.918

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.745
OR4F29-0.693
MTRNR2L6-0.247
MTRNR2L9-0.24
HMHB1-0.214
MTRNR2L10-0.202
OR6C74-0.186
CSAG2-0.181
IFNG-0.173
TCL1A-0.171

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of DEGS1 mRNA"21346803
D000082AcetaminophenAcetaminophen results in increased expression of DEGS1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of DEGS1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of DEGS1 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DEGS1 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of DEGS1 mRNA22378314
C547126AZM551248AZM551248 results in increased expression of DEGS1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DEGS1 mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DEGS1 mRNA22228805
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of DEGS1 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of DEGS1 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of DEGS1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of DEGS1 mRNA23741332
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DEGS1 mRNA20360939
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of DEGS1 mRNA23650126
D002994ClofibrateClofibrate results in increased expression of DEGS1 mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of DEGS1 mRNA19376846
D003513CycloheximideCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of DEGS1 mRNA]11007951
D003907DexamethasoneDexamethasone results in decreased expression of DEGS1 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of DEGS1 mRNA]20032058
D004026DieldrinDieldrin results in increased expression of DEGS1 mRNA28385952
D004026DieldrinDieldrin results in decreased expression of DEGS1 mRNA23041725
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DEGS1 mRNA20360939
D004147DioxinsDioxins affects the expression of DEGS1 mRNA20463971
C118739entinostatentinostat results in increased expression of DEGS1 mRNA26272509|2718838
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of DEGS1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DEGS1 mRNA17942748
D018120FinasterideFinasteride results in increased expression of DEGS1 mRNA24136188
D005485FlutamideFlutamide results in decreased expression of DEGS1 mRNA21126777
D005485FlutamideFlutamide results in increased expression of DEGS1 mRNA24136188
C056933fumonisin B1fumonisin B1 results in increased expression of DEGS1 mRNA16221962
D005839GentamicinsGentamicins results in increased expression of DEGS1 mRNA22061828
D017313FenretinideFenretinide results in decreased expression of DEGS1 mRNA28973697
C410337K 7174K 7174 results in increased expression of DEGS1 mRNA24086573
D008095Lithocholic AcidLithocholic Acid results in increased expression of DEGS1 mRNA21480330
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to DEGS1 promoter]20348232
C523799MRK 003DEGS1 results in increased susceptibility to MRK 00319903844
C051752nefazodonenefazodone results in increased expression of DEGS1 mRNA24136188
C022838nickel chloridenickel chloride results in decreased expression of DEGS1 mRNA17312168
D010416PentachlorophenolPentachlorophenol results in increased expression of DEGS1 mRNA23892564
D010894PiroxicamPiroxicam results in increased expression of DEGS1 mRNA21858171
D010936Plant ExtractsPlant Extracts results in increased expression of DEGS1 mRNA23557933
D059808PolyphenolsPolyphenols results in decreased expression of DEGS1 mRNA16293270
D011441PropylthiouracilPropylthiouracil results in decreased expression of DEGS1 mRNA24780913
C031389resorcinolresorcinol results in increased expression of DEGS1 mRNA22623647
D012643SeleniumSelenium results in decreased expression of DEGS1 mRNA19244175
D013467SulindacSulindac results in increased expression of DEGS1 mRNA24136188
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of DEGS1 mRNA]20032058
D013749TetrachlorodibenzodioxinCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of DEGS1 mRNA]11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DEGS1 mRNA11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DEGS1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DEGS1 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of DEGS1 mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DEGS1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DEGS1 mRNA18796159|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DEGS1 mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DEGS1 mRNA21215274
D014212TretinoinTretinoin results in decreased expression of DEGS1 mRNA16249480
D014212TretinoinTretinoin results in decreased expression of DEGS1 mRNA16604517
D014520UrethaneUrethane results in increased expression of DEGS1 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of DEGS1 mRNA23179753|2718838

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0009055electron transfer activity-TAS9188692  
GO:0042284sphingolipid delta-4 desaturase activity-IBA21873635  
GO:0042284sphingolipid delta-4 desaturase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006636unsaturated fatty acid biosynthetic process-TAS9188692  
GO:0022900electron transport chain-IEA-  
GO:0030148sphingolipid biosynthetic process-TAS-  
GO:0043312neutrophil degranulation-TAS-  
GO:0046513ceramide biosynthetic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA-  
GO:0005783endoplasmic reticulum-TAS9188692  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS9188692  
GO:0016020membrane-TAS9188692  
GO:0035579specific granule membrane-TAS-  
KEGG ID KEGG Term
hsa00600Sphingolipid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1660661Sphingolipid de novo biosynthesisTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-428157Sphingolipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26205716Modifiable cardiovascular risk factors in adults aged 40-79 years in Germany with and without prior coronary heart disease or stroke. (2015 Jul 24)Truthmann JBMC Public Health
24773140Residential traffic and incidence of Type 2 diabetes: the German Health Interview and Examination Surveys. (2014 Oct)Heidemann CDiabet Med
28919495Physical exercise and cognitive function across the life span: Results of a nationwide population-based study. (2018 May)Gaertner BJ Sci Med Sport
23703501[Prevalence of smoking in the adult population of Germany: results of the German Health Interview and Examination Survey for Adults (DEGS1)]. (2013 May)Lampert TBundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
25824135[Health status of people with a migrant background and impact of socio-economic factors: First results of the German Health Interview and Examination Survey for Adults (DEGS1)]. (2015 Jun)Rommel ABundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
29145538Association Between Socioeconomic Determinants and the Metabolic Syndrome in the German Health Interview and Examination Survey for Adults (DEGS1) - A Mediation Analysis. (2017 Summer-Fall)Montano DRev Diabet Stud
26629347Changes in diabetes care indicators: findings from German National Health Interview and Examination Surveys 1997-1999 and 2008-2011. (2015)Du YBMJ Open Diabetes Res Care
27908276Changes in physical functioning among men and women aged 50-79 years in Germany: an analysis of National Health Interview and Examination Surveys, 1997-1999 and 2008-2011. (2016 Dec 1)Buttery AKBMC Geriatr