Gene: KMO

8564
dJ317G22.1
kynurenine 3-monooxygenase
protein-coding
1q43
Ensembl:ENSG00000117009 MIM:603538 Vega:OTTHUMG00000039635 UniprotKB:O15229
NC_000001.11
PubMed
0   ANCO-SNPs
CD|ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.837e-1 (AD)  3.076e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VIP0.698
OSBPL30.687
IGF10.677
PNOC0.674
ARL4C0.673
PTHLH0.673
SLC10A40.672
DUSP60.668
GJD20.664
SERTM10.662

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ROM1-0.482
AZGP1-0.46
AQP1-0.453
TGFB3-0.431
SNHG18-0.424
OTOS-0.422
KIF19-0.417
MYOT-0.411
UHRF1-0.409
FAM107B-0.406

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of KMO mRNA"20453058
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of KMO mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of KMO mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of KMO mRNA"20959002
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of KMO mRNA"25380136
D000082AcetaminophenAcetaminophen results in decreased expression of KMO mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of KMO mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of KMO mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of KMO gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of KMO mRNA19770486
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of KMO mRNA"23195993
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KMO mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of KMO mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of KMO mRNA"25351596
C547126AZM551248AZM551248 results in increased expression of KMO mRNA22323515
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with sodium bichromate] results in increased expression of KMO mRNA21632023
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of KMO mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of KMO mRNA25181051
C006780bisphenol Abisphenol A results in decreased activity of KMO protein15678936
D002104CadmiumCadmium results in decreased expression of KMO mRNA24084258
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of KMO mRNA23741332
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of KMO mRNA27339419
D003300CopperCopper results in decreased expression of KMO mRNA22465980
D016572CyclosporineCyclosporine results in decreased expression of KMO mRNA27989131
D016572CyclosporineCyclosporine results in decreased expression of KMO mRNA19770486
D003561CytarabineKMO results in increased susceptibility to Cytarabine21755009
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of KMO mRNA24317228
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of KMO mRNA28628672
D004041Dietary FatsDietary Fats results in decreased expression of KMO mRNA21852083
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in decreased expression of KMO mRNA]21852083
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of KMO mRNA19638242
D002117CalcitriolCalcitriol results in decreased expression of KMO mRNA16002434
D004117DimethoateDimethoate results in decreased activity of KMO protein2119399
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of KMO mRNA25380136
C082360fipronilfipronil results in increased expression of KMO mRNA23962444
D005485FlutamideFlutamide results in decreased expression of KMO mRNA24793618
C412815GW 4064GW 4064 results in increased expression of KMO mRNA26655953
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of KMO mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of KMO mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of KMO mRNA28628672
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of KMO mRNA22401849
C500085muraglitazarmuraglitazar results in decreased expression of KMO mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of KMO mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of KMO mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of KMO mRNA25380136
D009532NickelNickel results in decreased expression of KMO mRNA23195993
D009532NickelNickel results in increased expression of KMO mRNA25583101
D009532NickelNickel results in decreased expression of KMO mRNA24084258
C012655nimesulidenimesulide results in decreased expression of KMO mRNA24136188
D009966OrphenadrineOrphenadrine affects the expression of KMO mRNA23665939
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of KMO mRNA19162173
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of KMO mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of KMO mRNA19482888
C006253pirinixic acidpirinixic acid results in decreased expression of KMO mRNA18445702
C006253pirinixic acidpirinixic acid results in decreased expression of KMO mRNA19162173
C045950propiconazolepropiconazole results in decreased expression of KMO mRNA19363144
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in decreased expression of KMO mRNA]21852083
C110196Ro 61-8048Ro 61-8048 results in decreased activity of KMO protein15954116|1786893
C089730rosiglitazonerosiglitazone results in decreased expression of KMO mRNA25572481
D012822Silicon DioxideSilicon Dioxide results in increased expression of KMO mRNA25351596
C016104sodium bichromatesodium bichromate results in decreased expression of KMO mRNA24612858
C016104sodium bichromate[Benzo(a)pyrene co-treated with sodium bichromate] results in increased expression of KMO mRNA21632023
C016104sodium bichromatesodium bichromate results in decreased expression of KMO mRNA25993096
C501413tesaglitazartesaglitazar results in decreased expression of KMO mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KMO mRNA19692669
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KMO mRNA16054898|1879615
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of KMO mRNA25613284
D014635Valproic AcidValproic Acid results in decreased expression of KMO mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of KMO gene29154799
D014640VancomycinVancomycin results in increased expression of KMO mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of KMO gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of KMO mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004502kynurenine 3-monooxygenase activity-IBA21873635  
GO:0004502kynurenine 3-monooxygenase activity-IDA9237672  10672018  23575632  26752518  29208702  29429898  
GO:0004502kynurenine 3-monooxygenase activity-TAS-  
GO:0016174NAD(P)H oxidase activity-IBA21873635  
GO:0016174NAD(P)H oxidase activity-IDA10672018  23575632  29429898  
GO:0050660flavin adenine dinucleotide binding-IBA21873635  
GO:0050660flavin adenine dinucleotide binding-IDA10672018  
GO:0071949FAD binding-IDA29429898  
GO ID GO Term Qualifier Evidence PubMed
GO:0006569tryptophan catabolic process-TAS-  
GO:0009435NAD biosynthetic process-IEA-  
GO:0009651response to salt stress-IDA10672018  
GO:0019674NAD metabolic process-IBA21873635  
GO:0019674NAD metabolic process-IDA23575632  29429898  
GO:0019805quinolinate biosynthetic process-IEA-  
GO:0032496response to lipopolysaccharide-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO:0070189kynurenine metabolic process-IBA21873635  
GO:0070189kynurenine metabolic process-IDA10672018  26752518  29208702  29429898  
GO:0071347cellular response to interleukin-1-IEA-  
GO:0097052L-kynurenine metabolic process-IEA-  
GO:1901216positive regulation of neuron death-IEA-  
GO:1903296positive regulation of glutamate secretion, neurotransmission-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005741mitochondrial outer membrane-IBA21873635  
GO:0005741mitochondrial outer membrane-ISS10672018  
GO:0005829cytosol-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00380Tryptophan metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-6788656Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismTAS
R-HSA-71240Tryptophan catabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28241062Increased breakdown of kynurenine towards its neurotoxic branch in bipolar disorder. (2017)Birner APLoS One