Gene: MADD

8567
DENN|IG20|RAB3GEP
MAP kinase activating death domain
protein-coding
11p11.2
Ensembl:ENSG00000110514 MIM:603584 Vega:OTTHUMG00000150350 UniprotKB:Q8WXG6
NG_029462.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.711e-1 (AD)  5.885e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PI4KA0.979
DOCK30.978
MYH100.978
NUDCD30.977
ENO20.977
TRIM30.977
STXBP10.976
SV2A0.975
SYNGR10.973
UBE2O0.973

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.534
REST-0.506
YES1-0.505
RAI14-0.498
TFPI2-0.498
HEY2-0.497
WWTR1-0.497
OR4F29-0.496
RNF135-0.479
MYL3-0.474

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C47167410'(Z),13'(E),15'(E)-heptadecatrienylhydroquinone"10'(Z),13'(E),15'(E)-heptadecatrienylhydroquinone results in increased expression of MADD mRNA"23088786
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MADD mRNA"21346803
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of MADD gene27153756
D0150812-Naphthylamine2-Naphthylamine results in increased expression of MADD mRNA18247414
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MADD mRNA16483693
D001241AspirinAspirin results in decreased expression of MADD mRNA15928584
D001280AtrazineAtrazine results in decreased expression of MADD mRNA25929836
D001280AtrazineAtrazine results in decreased expression of MADD mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MADD mRNA18247414
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MADD mRNA22228805
D004958EstradiolEstradiol results in decreased expression of MADD mRNA23373633
D004958EstradiolEstradiol results in increased expression of MADD mRNA16705744
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid results in decreased expression of MADD mRNA18192240
C006780bisphenol Abisphenol A affects the expression of MADD mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MADD mRNA28628672
C038590cardanolcardanol results in decreased expression of MADD mRNA26694491
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MADD mRNA20938992
D002922CiguatoxinsCiguatoxins affects the expression of MADD mRNA18353800
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MADD mRNA28628672
D003976DiazinonDiazinon affects the expression of MADD mRNA22546817
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of MADD mRNA20360939
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of MADD mRNA"22485181
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of MADD mRNA27776689
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MADD mRNA20938992
D019833GenisteinGenistein results in decreased expression of MADD mRNA16705744
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MADD mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MADD mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MADD mRNA28628672
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of MADD protein17337753
C008261lead acetatelead acetate affects the expression of MADD mRNA21147602
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of MADD mRNA25613284
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MADD mRNA20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of MADD mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MADD mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MADD mRNA"25554681
C022838nickel chloridenickel chloride affects the expression of MADD mRNA22546817
C028007nickel monoxidenickel monoxide results in increased expression of MADD mRNA19167457
D009538NicotineNicotine results in decreased expression of MADD mRNA18247414
D017239PaclitaxelPaclitaxel results in decreased expression of MADD mRNA15000894
C016030pantogabpantogab results in decreased expression of MADD mRNA17379144
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of MADD mRNA28903501
C045950propiconazolepropiconazole results in decreased expression of MADD mRNA21278054
C059514resveratrolresveratrol results in decreased expression of MADD mRNA12002526
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in increased expression of MADD mRNA12818353
D012834SilverSilver results in increased expression of MADD mRNA27131904
D012999SomanSoman results in decreased expression of MADD mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MADD mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MADD mRNA18796159
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MADD mRNA25613284
D014212TretinoinTretinoin results in increased expression of MADD mRNA15894607
C012589trichostatin Atrichostatin A results in increased expression of MADD mRNA23558232
C022884undecaneundecane results in decreased expression of MADD protein17337753
D014520UrethaneUrethane results in increased expression of MADD mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of MADD gene29154799
C025643vinclozolinvinclozolin results in decreased expression of MADD mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005123death receptor binding-TAS9115275  
GO:0005515protein binding-IPI9115275  16273344  21044950  
GO:0017112Rab guanyl-nucleotide exchange factor activity-IBA21873635  
GO:0017112Rab guanyl-nucleotide exchange factor activity-IDA20937701  
GO:0017112Rab guanyl-nucleotide exchange factor activity-IMP9115275  
GO:0017112Rab guanyl-nucleotide exchange factor activity-TAS-  
GO:0030295protein kinase activator activity-TAS9115275  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-IMP9115275  
GO:0007166cell surface receptor signaling pathway-TAS9115275  
GO:0010803regulation of tumor necrosis factor-mediated signaling pathway-TAS-  
GO:0032483regulation of Rab protein signal transduction-IBA21873635  
GO:0032483regulation of Rab protein signal transduction-IDA20937701  
GO:0042981regulation of apoptotic process-IMP11577081  
GO:0051726regulation of cell cycle-IMP14735464  
GO:0097194execution phase of apoptosis-IMP14735464  
GO:1902041regulation of extrinsic apoptotic signaling pathway via death domain receptors-IBA21873635  
GO:1902041regulation of extrinsic apoptotic signaling pathway via death domain receptors-IMP9115275  
GO:2001236regulation of extrinsic apoptotic signaling pathway-IDA11577081  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-TAS8988362  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0016021integral component of membrane-IDA8988362  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-5357905Regulation of TNFR1 signalingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-73887Death Receptor SignallingTAS
R-HSA-75893TNF signalingTAS
R-HSA-8876198RAB GEFs exchange GTP for GDP on RABsTAS
R-HSA-9007101Rab regulation of traffickingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27070640MADD-FOLH1 Polymorphisms and Their Haplotypes with Serum Lipid Levels and the Risk of Coronary Heart Disease and Ischemic Stroke in a Chinese Han Population. (2016 Apr 8)Wu DFNutrients
28456887Heterogeneous Phenotypes in Lipid Storage Myopathy Due to ETFDH Gene Mutations. (2018)Angelini CJIMD Rep