Gene: KHSRP

8570
FBP2|FUBP2|KSRP
KH-type splicing regulatory protein
protein-coding
19p13.3
Ensembl:ENSG00000088247 MIM:603445 Vega:OTTHUMG00000180850 UniprotKB:Q92945
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.354e-1 (AD)  8.383e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
U2AF20.948
RNF400.942
SURF40.937
HGS0.935
PI4KB0.934
TRIM280.932
RAF10.93
ZC3H180.93
P4HB0.929
SF10.928

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.823
OR4F29-0.783
OR6C74-0.221
MTRNR2L6-0.212
MTRNR2L9-0.212
CPA3-0.209
MTRNR2L10-0.205
HMHB1-0.204
OR4F16-0.198
CETP-0.188

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02709ResveratrolSmall Molecule501-36-0Approved|Experimental|InvestigationalTarget
DB11638ArtenimolSmall Molecule71939-50-9Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of KHSRP mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KHSRP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KHSRP mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of KHSRP mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KHSRP mRNA16483693
D001151ArsenicArsenic results in increased methylation of KHSRP gene24525453
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of KHSRP mRNA"19150397
D001622BetaineBetaine inhibits the reaction [Copper deficiency affects the expression of KHSRP protein]25150618
C006780bisphenol Abisphenol A affects the expression of KHSRP mRNA21786754
C006780bisphenol Abisphenol A affects the expression of KHSRP mRNA21786754
C006780bisphenol Abisphenol A affects the expression of KHSRP mRNA25181051
D001761BleomycinBleomycin results in increased expression of KHSRP protein25933445
C584509C646 compoundC646 compound results in decreased expression of KHSRP mRNA26191083
D002118CalciumCalcium deficiency inhibits the reaction [KHSRP protein binds to PTH 3' UTR]18583400
D002737ChloropreneChloroprene results in increased expression of KHSRP mRNA23125180
D003300CopperBetaine inhibits the reaction [Copper deficiency affects the expression of KHSRP protein]25150618
D003300CopperCopper deficiency affects the expression of KHSRP protein25150618
D016572CyclosporineCyclosporine results in increased expression of KHSRP mRNA21163907
D013759DronabinolDronabinol results in increased expression of KHSRP mRNA18454173
D003976DiazinonDiazinon results in increased methylation of KHSRP gene22964155
D002945CisplatinCisplatin results in increased expression of KHSRP protein20540955
C000944dicrotophosdicrotophos results in increased expression of KHSRP mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of KHSRP mRNA25016146
C039060dihydroartemisinindihydroartemisinin analog binds to KHSRP protein26340163
D004317DoxorubicinDoxorubicin affects the expression of KHSRP protein29385562
D004317DoxorubicinDoxorubicin results in increased expression of KHSRP mRNA16404146
D004317DoxorubicinKHSRP protein results in decreased susceptibility to Doxorubicin24675091
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of KHSRP protein23301498
D018120FinasterideFinasteride results in increased expression of KHSRP mRNA24136188
C020758indium trichlorideindium trichloride results in increased expression of KHSRP protein19539025
D007854LeadLead results in decreased expression of KHSRP mRNA19921347
D008070LipopolysaccharidesKHSRP gene mutant form inhibits the reaction [resveratrol inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of CXCL1 mRNA]]25352548
D008070LipopolysaccharidesKHSRP gene mutant form inhibits the reaction [resveratrol inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of NOS2 mRNA]]25352548
D008070LipopolysaccharidesKHSRP gene mutant form inhibits the reaction [resveratrol inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA]]25352548
D008070LipopolysaccharidesKHSRP gene mutant form promotes the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of CXCL1 mRNA]25352548
D008070LipopolysaccharidesKHSRP gene mutant form promotes the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of NOS2 mRNA]25352548
D008070LipopolysaccharidesKHSRP gene mutant form promotes the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA]25352548
D008345ManganeseKHSRP protein affects the reaction [Manganese results in increased expression of TP53 protein]25027559
D008345ManganeseManganese results in increased expression of KHSRP protein25027559
D008748MethylcholanthreneMethylcholanthrene results in increased expression of KHSRP mRNA18804290
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of KHSRP mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of KHSRP mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KHSRP mRNA"27188386
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of KHSRP protein26879310
D010758PhosphorusPhosphorus deficiency promotes the reaction [KHSRP protein binds to PTH 3' UTR]18583400
D011192Potassium DichromatePotassium Dichromate results in decreased expression of KHSRP protein18563748
D011794QuercetinQuercetin results in decreased expression of KHSRP protein14750173
C059514resveratrolKHSRP protein promotes the reaction [resveratrol inhibits the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of CXCL8 mRNA]]25352548
C059514resveratrolKHSRP protein promotes the reaction [resveratrol inhibits the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]]25352548
C059514resveratrolKHSRP protein promotes the reaction [resveratrol inhibits the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of TNF mRNA]]25352548
C059514resveratrolKHSRP protein promotes the reaction [resveratrol results in decreased stability of CXCL8 mRNA]25352548
C059514resveratrolKHSRP protein promotes the reaction [resveratrol results in decreased stability of NOS2 mRNA]25352548
C059514resveratrolKHSRP protein promotes the reaction [resveratrol results in decreased stability of TNF mRNA]25352548
C059514resveratrolresveratrol binds to and results in decreased phosphorylation of KHSRP protein25352548
C059514resveratrolresveratrol promotes the reaction [KHSRP protein binds to and results in decreased stability of CXCL8 mRNA]25352548
C059514resveratrolresveratrol promotes the reaction [KHSRP protein binds to and results in decreased stability of NOS2 mRNA]25352548
C059514resveratrolresveratrol promotes the reaction [KHSRP protein binds to and results in decreased stability of TNF mRNA]25352548
C059514resveratrolresveratrol promotes the reaction [KHSRP protein binds to EXOSC10 protein]25352548
C059514resveratrolKHSRP gene mutant form inhibits the reaction [resveratrol inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of CXCL1 mRNA]]25352548
C059514resveratrolKHSRP gene mutant form inhibits the reaction [resveratrol inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of NOS2 mRNA]]25352548
C059514resveratrolKHSRP gene mutant form inhibits the reaction [resveratrol inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA]]25352548
C059514resveratrolresveratrol results in decreased expression of KHSRP protein25505154
D018038Sodium SeleniteSodium Selenite results in increased expression of KHSRP mRNA18175754
D053260SootSoot results in increased expression of KHSRP protein24464499
D013467SulindacSulindac results in increased expression of KHSRP mRNA24136188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KHSRP mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KHSRP protein16548065
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KHSRP mRNA19490992
C009495titanium dioxidetitanium dioxide analog results in increased expression of KHSRP mRNA25111187
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of KHSRP mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of KHSRP mRNA28973697
D014415TunicamycinTunicamycin results in increased expression of KHSRP mRNA17127020
D014635Valproic AcidValproic Acid results in increased expression of KHSRP mRNA23179753
C025643vinclozolinvinclozolin affects the expression of KHSRP mRNA19015723
D000225AdenineAdenine inhibits the reaction [KHSRP protein binds to PTH 3' UTR]18583400

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0005515protein binding-IPI16126846  17353931  19458619  20562859  
GO:0035925mRNA 3'-UTR AU-rich region binding-IDA16126846  
GO ID GO Term Qualifier Evidence PubMed
GO:0000375RNA splicing, via transesterification reactions-TAS10911989  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0006397mRNA processing-IEA-  
GO:0006402mRNA catabolic process-IEA-  
GO:0008380RNA splicing-TAS10911989  
GO:0010586miRNA metabolic process-IMP27478153  
GO:0010989negative regulation of low-density lipoprotein particle clearance-IGI26523989  
GO:0043488regulation of mRNA stability-IDA16126846  
GO:0043488regulation of mRNA stability-TAS-  
GO:0045019negative regulation of nitric oxide biosynthetic process-IDA16126846  
GO:0051028mRNA transport-IEA-  
GO:0061014positive regulation of mRNA catabolic process-IDA16126846  
GO:00611583'-UTR-mediated mRNA destabilization-IDA16126846  
GO:0071345cellular response to cytokine stimulus-IMP16126846  
GO:2000628regulation of miRNA metabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000178exosome (RNase complex)colocalizes_withNAS16126846  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-TAS-  
GO:0010494cytoplasmic stress granule-IEA-  
GO:0016020membrane-HDA19946888  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-380994ATF4 activates genesTAS
R-HSA-381042PERK regulates gene expressionTAS
R-HSA-381119Unfolded Protein Response (UPR)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-450531Regulation of mRNA stability by proteins that bind AU-rich elementsTAS
R-HSA-450531Regulation of mRNA stability by proteins that bind AU-rich elementsIEA
R-HSA-450604KSRP (KHSRP) binds and destabilizes mRNATAS
R-HSA-450604KSRP (KHSRP) binds and destabilizes mRNAIEA
R-HSA-8953854Metabolism of RNATAS
R-HSA-8953854Metabolism of RNAIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23988199Cigarette smoke enhances human rhinovirus-induced CXCL8 production via HuR-mediated mRNA stabilization in human airway epithelial cells. (2013 Aug 30)Hudy MHRespir Res