Gene: CAV3

859
LGMD1C|LQT9|VIP-21|VIP21
caveolin 3
protein-coding
3p25.3
Ensembl:ENSG00000182533 MIM:601253 Vega:OTTHUMG00000090519 UniprotKB:P56539
NG_008797.2
PubMed
OD|ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.965e-2 (AD)  6.476e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C6orf1180.448
NKAIN30.443
PPP1R420.44
PARD30.438
TRDN0.425
PLEKHA70.419
MYBPC10.417
DLEC10.415
PON30.415
STK330.414

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CIDEA-0.303
NKD2-0.301
IGFBP2-0.295
ARL4D-0.294
DUSP2-0.291
GRASP-0.286
ADTRP-0.284
DUSP27-0.282
B3GNT4-0.28
C2orf91-0.28

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CAV3 mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CAV3 mRNA"18648102
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CAV3 gene27153756
D000638AmiodaroneAmiodarone results in increased expression of CAV3 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CAV3 mRNA16483693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of CAV3 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CAV3 mRNA22209252
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CAV3 mRNA23735875
D004958EstradiolEstradiol results in decreased expression of CAV3 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of CAV3 mRNA25181051|2717856
D002110CaffeineCaffeine results in decreased expression of CAV3 mRNA25868845
D002118CalciumCAV3 protein affects the reaction [Potassium Chloride results in increased uptake of Calcium]21294223
D002784CholesterolCAV3 protein affects the import of Cholesterol19221014
D002857Chromium[Niacin co-treated with Chromium] promotes the reaction [SLC2A4 protein binds to CAV3 protein]19027847
D002857Chromium[Niacin co-treated with Chromium] results in increased expression of CAV3 protein19027847
D002994ClofibrateClofibrate results in decreased expression of CAV3 mRNA22300585
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of CAV3 mRNA28962523
D004281Docosahexaenoic AcidsDocosahexaenoic Acids results in increased expression of CAV3 protein15560787
D004317Doxorubicin[CAV1 protein binds to CAV3 protein] promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]17982011
D015118Eicosapentaenoic AcidEicosapentaenoic Acid results in increased expression of CAV3 protein15560787
C069837fullerene C60fullerene C60 results in decreased expression of CAV3 mRNA19167457
D005947GlucoseCAV3 protein affects the reaction [resveratrol results in increased uptake of Glucose]22569348
D007545IsoproterenolIsoproterenol affects the localization of CAV3 protein19299911
D008345ManganeseManganese results in decreased expression of CAV3 mRNA23597857
D008345ManganeseManganese results in decreased expression of CAV3 protein23597857
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CAV3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CAV3 mRNA"25554681
D009525Niacin[Niacin co-treated with Chromium] promotes the reaction [SLC2A4 protein binds to CAV3 protein]19027847
D009525Niacin[Niacin co-treated with Chromium] results in increased expression of CAV3 protein19027847
C028007nickel monoxidenickel monoxide results in decreased expression of CAV3 mRNA19167457
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of CAV3 mRNA27935865
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CAV3 mRNA28126411
D010656PhenylephrineCAV3 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]12847114
D010656PhenylephrineCAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]12847114
D010656PhenylephrineCAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]12847114
D010656PhenylephrineCAV3 protein results in decreased susceptibility to Phenylephrine12847114
D010656PhenylephrinePhenylephrine affects the localization of CAV3 protein19299911
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of CAV3 mRNA27935865
D010936Plant ExtractsPlant Extracts results in decreased expression of CAV3 mRNA23557933
D011189Potassium ChlorideCAV3 protein affects the reaction [Potassium Chloride results in increased uptake of Calcium]21294223
D011374ProgesteroneCAV3 mutant form inhibits the reaction [Progesterone results in decreased expression of GNAI3 protein]19221014
D011374ProgesteroneCAV3 mutant form inhibits the reaction [Progesterone results in increased expression of GNAS protein]19221014
D011374ProgesteroneCAV3 protein affects the activity of Progesterone19221014
D011374ProgesteroneCAV3 mutant form inhibits the reaction [Progesterone results in decreased expression of GNAI3 protein]19221014
D011374ProgesteroneCAV3 mutant form inhibits the reaction [Progesterone results in increased expression of GNAS protein]19221014
D011441PropylthiouracilPropylthiouracil results in increased expression of CAV3 mRNA24780913
C059514resveratrolresveratrol inhibits the reaction [Streptozocin inhibits the reaction [CAV3 protein binds to SLC2A4 protein]]18266981
C059514resveratrolresveratrol inhibits the reaction [Streptozocin results in decreased expression of CAV3 protein]18266981
C059514resveratrolresveratrol results in increased expression of CAV3 protein18266981
C059514resveratrolCAV3 protein affects the reaction [resveratrol affects the localization of SLC2A4 protein]22569348
C059514resveratrolCAV3 protein affects the reaction [resveratrol results in increased uptake of Glucose]22569348
C059514resveratrol[resveratrol results in increased activity of ESR1 protein] which results in increased expression of CAV3 protein22569348
C059514resveratrol[[resveratrol results in increased activity of ESR1 protein] which results in increased expression of CAV3 protein] which affects the localization of SLC2A4 protein22569348
C059514resveratrolresveratrol results in increased expression of CAV3 protein22569348
C059514resveratrol[resveratrol results in increased expression of CAV3 protein] which affects the localization of SLC2A4 protein22569348
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CAV3 mRNA25895662
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of CAV3 mRNA]21245298
C017947sodium arsenitesodium arsenite results in increased expression of CAV3 protein19072884
C016104sodium bichromatesodium bichromate results in decreased expression of CAV3 mRNA22155349
D013311Streptozocinresveratrol inhibits the reaction [Streptozocin inhibits the reaction [CAV3 protein binds to SLC2A4 protein]]18266981
D013311Streptozocinresveratrol inhibits the reaction [Streptozocin results in decreased expression of CAV3 protein]18266981
D013311StreptozocinStreptozocin inhibits the reaction [CAV3 protein binds to SLC2A4 protein]18266981
D013311StreptozocinStreptozocin results in decreased expression of CAV3 protein18266981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CAV3 mRNA16714409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CAV3 mRNA22298810
C009495titanium dioxidetitanium dioxide results in decreased expression of CAV3 mRNA23557971
C012589trichostatin Atrichostatin A results in decreased expression of CAV3 mRNA15901671
C012589trichostatin Atrichostatin A results in decreased expression of CAV3 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CAV3 mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased expression of CAV3 mRNA15901671
D014635Valproic AcidValproic Acid results in increased methylation of CAV3 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of CAV3 mRNA15901671

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005198structural molecule activity-IBA21873635  
GO:0005246calcium channel regulator activity-IDA21084288  
GO:0005515protein binding-IPI10988290  24567387  25556234  26497963  
GO:0008022protein C-terminus binding-IDA10988290  
GO:0017080sodium channel regulator activity-IDA17060380  
GO:0017080sodium channel regulator activity-IMP17275750  
GO:0019870potassium channel inhibitor activity-ISS22879586  
GO:0032947protein-containing complex scaffold activity-IBA21873635  
GO:0032947protein-containing complex scaffold activity-IPI17060380  
GO:0032947protein-containing complex scaffold activity-ISS-  
GO:0043014alpha-tubulin binding-IEA-  
GO:0044325ion channel binding-IBA21873635  
GO:0044325ion channel binding-IPI17060380  21084288  
GO:0044877protein-containing complex binding-IDA10988290  
GO:0050998nitric-oxide synthase binding-IEA-  
GO:0071253connexin binding-IBA21873635  
GO:0071253connexin binding-IDA19544087  
GO ID GO Term Qualifier Evidence PubMed
GO:0001778plasma membrane repair-IEA-  
GO:0002027regulation of heart rate-IMP17060380  
GO:0006469negative regulation of protein kinase activity-ISS-  
GO:0006641triglyceride metabolic process-ISS-  
GO:0006869lipid transport-IBA21873635  
GO:0006897endocytosis-ISS-  
GO:0006936muscle contraction-TAS-  
GO:0007009plasma membrane organization-ISS-  
GO:0007015actin filament organization-IEA-  
GO:0007204positive regulation of cytosolic calcium ion concentration-ISS-  
GO:0007517muscle organ development-TAS10988290  
GO:0007520myoblast fusion-IEA-  
GO:0008016regulation of heart contraction-ISS-  
GO:0008104protein localization-ISS-  
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0010614negative regulation of cardiac muscle hypertrophy-IMP12847114  
GO:0010831positive regulation of myotube differentiation-IEA-  
GO:0014819regulation of skeletal muscle contraction-IMP17524427  
GO:0017015regulation of transforming growth factor beta receptor signaling pathway-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0030154cell differentiation-ISS-  
GO:0031116positive regulation of microtubule polymerization-ISS-  
GO:0031122cytoplasmic microtubule organization-IEA-  
GO:0031579membrane raft organization-ISS-  
GO:0033292T-tubule organization-TAS12847114  
GO:0035995detection of muscle stretch-IEA-  
GO:0038009regulation of signal transduction by receptor internalization-IMP20472890  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0042391regulation of membrane potential-IDA21084288  
GO:0042593glucose homeostasis-ISS-  
GO:0042632cholesterol homeostasis-ISS-  
GO:0043407negative regulation of MAP kinase activity-IMP12847114  
GO:0043409negative regulation of MAPK cascade-ISS-  
GO:0045792negative regulation of cell size-IMP12847114  
GO:0046716muscle cell cellular homeostasis-ISS-  
GO:0051001negative regulation of nitric-oxide synthase activity-ISS-  
GO:0051394regulation of nerve growth factor receptor activity-IMP20472890  
GO:0051647nucleus localization-IEA-  
GO:0051896regulation of protein kinase B signaling-IEA-  
GO:0051926negative regulation of calcium ion transport-IDA21084288  
GO:0055013cardiac muscle cell development-IEA-  
GO:0055117regulation of cardiac muscle contraction-IMP17275750  
GO:0060299negative regulation of sarcomere organization-IMP12847114  
GO:0060307regulation of ventricular cardiac muscle cell membrane repolarization-IMP17060380  
GO:0060347heart trabecula formation-IEA-  
GO:0060373regulation of ventricular cardiac muscle cell membrane depolarization-IDA17060380  
GO:0060762regulation of branching involved in mammary gland duct morphogenesis-IEA-  
GO:0061052negative regulation of cell growth involved in cardiac muscle cell development-IEA-  
GO:0070836caveola assembly-IBA21873635  
GO:0070836caveola assembly-IDA18936328  
GO:0071417cellular response to organonitrogen compound-IEA-  
GO:0072659protein localization to plasma membrane-ISS-  
GO:0086005ventricular cardiac muscle cell action potential-ISS22879586  
GO:0090279regulation of calcium ion import-IDA21084288  
GO:0098909regulation of cardiac muscle cell action potential involved in regulation of contraction-IMP17060380  
GO:1900744regulation of p38MAPK cascade-IEA-  
GO:1900825regulation of membrane depolarization during cardiac muscle cell action potential-IBA21873635  
GO:1900825regulation of membrane depolarization during cardiac muscle cell action potential-IMP17275750  
GO:1900826negative regulation of membrane depolarization during cardiac muscle cell action potential-IEA-  
GO:1901017negative regulation of potassium ion transmembrane transporter activity-ISS22879586  
GO:1901019regulation of calcium ion transmembrane transporter activity-IDA21084288  
GO:1901380negative regulation of potassium ion transmembrane transport-ISS22879586  
GO:2000009negative regulation of protein localization to cell surface-NAS22879586  
GO:2000060positive regulation of ubiquitin-dependent protein catabolic process-NAS22879586  
GO:2000649regulation of sodium ion transmembrane transporter activity-IDA17060380  17275750  
GO:2001288positive regulation of caveolin-mediated endocytosis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005737cytoplasmCOLOCALIZES_WITHIBA21873635  
GO:0005783endoplasmic reticulum-IDA22792322  
GO:0005886plasma membrane-IDA17060380  20472890  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005901caveolaCOLOCALIZES_WITHIBA21873635  
GO:0005901caveola-ISS-  
GO:0005925focal adhesionCOLOCALIZES_WITHIBA21873635  
GO:0009986cell surface-IEA-  
GO:0014704intercalated disc-IEA-  
GO:0016010dystrophin-associated glycoprotein complex-IDA10988290  
GO:0030018Z disccolocalizes_withISS-  
GO:0030315T-tubule-ISS-  
GO:0031594neuromuscular junction-ISS-  
GO:0031982vesicle-IEA-  
GO:0042383sarcolemmaCOLOCALIZES_WITHIBA21873635  
GO:0042383sarcolemma-IDA12847114  17060380  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0045121membrane raft-ISS-  
KEGG ID KEGG Term
hsa04144Endocytosis
hsa04510Focal adhesion
hsa05100Bacterial invasion of epithelial cells
Reactome ID Reactome Term Evidence
R-HSA-397014Muscle contractionTAS
R-HSA-397014Muscle contractionIEA
R-HSA-445355Smooth Muscle ContractionTAS
R-HSA-445355Smooth Muscle ContractionIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20346360Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (2010 Jul)Roberts KEGastroenterology
27919294Heantos-4, a natural plant extract used in the treatment of drug addiction, modulates T-type calcium channels and thalamocortical burst-firing. (2016 Dec 5)Cain SMMol Brain