Gene info: ID 859

Gene: CAV3

GENE ID: 859

Synonyms: LGMD1C|LQT9|VIP-21|VIP21

Description: caveolin 3

Gene type: protein-coding

Location: 3p25.3

dbXrefs: Ensembl:ENSG00000182533 MIM:601253 Vega:OTTHUMG00000090519 UniprotKB:P56539

RefSeq: NG_008797.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: OD|ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.965e-2 (AD) 6.476e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
C6orf118	0.448
NKAIN3	0.443
PPP1R42	0.44
PARD3	0.438
TRDN	0.425
PLEKHA7	0.419
MYBPC1	0.417
DLEC1	0.415
PON3	0.415
STK33	0.414

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CIDEA	-0.303
NKD2	-0.301
IGFBP2	-0.295
ARL4D	-0.294
DUSP2	-0.291
GRASP	-0.286
ADTRP	-0.284
DUSP27	-0.282
B3GNT4	-0.28
C2orf91	-0.28

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CAV3 mRNA"	19114083
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of CAV3 mRNA"	18648102
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of CAV3 gene	27153756
D000638	Amiodarone	Amiodarone results in increased expression of CAV3 mRNA	19774075
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CAV3 mRNA	16483693
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of CAV3 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CAV3 mRNA	22209252
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CAV3 mRNA	23735875
D004958	Estradiol	Estradiol results in decreased expression of CAV3 mRNA	19484750
C006780	bisphenol A	bisphenol A results in decreased expression of CAV3 mRNA	25181051\|2717856
D002110	Caffeine	Caffeine results in decreased expression of CAV3 mRNA	25868845
D002118	Calcium	CAV3 protein affects the reaction [Potassium Chloride results in increased uptake of Calcium]	21294223
D002784	Cholesterol	CAV3 protein affects the import of Cholesterol	19221014
D002857	Chromium	[Niacin co-treated with Chromium] promotes the reaction [SLC2A4 protein binds to CAV3 protein]	19027847
D002857	Chromium	[Niacin co-treated with Chromium] results in increased expression of CAV3 protein	19027847
D002994	Clofibrate	Clofibrate results in decreased expression of CAV3 mRNA	22300585
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in decreased expression of CAV3 mRNA	28962523
D004281	Docosahexaenoic Acids	Docosahexaenoic Acids results in increased expression of CAV3 protein	15560787
D004317	Doxorubicin	[CAV1 protein binds to CAV3 protein] promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]	17982011
D015118	Eicosapentaenoic Acid	Eicosapentaenoic Acid results in increased expression of CAV3 protein	15560787
C069837	fullerene C60	fullerene C60 results in decreased expression of CAV3 mRNA	19167457
D005947	Glucose	CAV3 protein affects the reaction [resveratrol results in increased uptake of Glucose]	22569348
D007545	Isoproterenol	Isoproterenol affects the localization of CAV3 protein	19299911
D008345	Manganese	Manganese results in decreased expression of CAV3 mRNA	23597857
D008345	Manganese	Manganese results in decreased expression of CAV3 protein	23597857
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of CAV3 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CAV3 mRNA"	25554681
D009525	Niacin	[Niacin co-treated with Chromium] promotes the reaction [SLC2A4 protein binds to CAV3 protein]	19027847
D009525	Niacin	[Niacin co-treated with Chromium] results in increased expression of CAV3 protein	19027847
C028007	nickel monoxide	nickel monoxide results in decreased expression of CAV3 mRNA	19167457
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of CAV3 mRNA	27935865
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of CAV3 mRNA	28126411
D010656	Phenylephrine	CAV3 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]	12847114
D010656	Phenylephrine	CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]	12847114
D010656	Phenylephrine	CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]	12847114
D010656	Phenylephrine	CAV3 protein results in decreased susceptibility to Phenylephrine	12847114
D010656	Phenylephrine	Phenylephrine affects the localization of CAV3 protein	19299911
C060836	pioglitazone	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of CAV3 mRNA	27935865
D010936	Plant Extracts	Plant Extracts results in decreased expression of CAV3 mRNA	23557933
D011189	Potassium Chloride	CAV3 protein affects the reaction [Potassium Chloride results in increased uptake of Calcium]	21294223
D011374	Progesterone	CAV3 mutant form inhibits the reaction [Progesterone results in decreased expression of GNAI3 protein]	19221014
D011374	Progesterone	CAV3 mutant form inhibits the reaction [Progesterone results in increased expression of GNAS protein]	19221014
D011374	Progesterone	CAV3 protein affects the activity of Progesterone	19221014
D011374	Progesterone	CAV3 mutant form inhibits the reaction [Progesterone results in decreased expression of GNAI3 protein]	19221014
D011374	Progesterone	CAV3 mutant form inhibits the reaction [Progesterone results in increased expression of GNAS protein]	19221014
D011441	Propylthiouracil	Propylthiouracil results in increased expression of CAV3 mRNA	24780913
C059514	resveratrol	resveratrol inhibits the reaction [Streptozocin inhibits the reaction [CAV3 protein binds to SLC2A4 protein]]	18266981
C059514	resveratrol	resveratrol inhibits the reaction [Streptozocin results in decreased expression of CAV3 protein]	18266981
C059514	resveratrol	resveratrol results in increased expression of CAV3 protein	18266981
C059514	resveratrol	CAV3 protein affects the reaction [resveratrol affects the localization of SLC2A4 protein]	22569348
C059514	resveratrol	CAV3 protein affects the reaction [resveratrol results in increased uptake of Glucose]	22569348
C059514	resveratrol	[resveratrol results in increased activity of ESR1 protein] which results in increased expression of CAV3 protein	22569348
C059514	resveratrol	[[resveratrol results in increased activity of ESR1 protein] which results in increased expression of CAV3 protein] which affects the localization of SLC2A4 protein	22569348
C059514	resveratrol	resveratrol results in increased expression of CAV3 protein	22569348
C059514	resveratrol	[resveratrol results in increased expression of CAV3 protein] which affects the localization of SLC2A4 protein	22569348
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of CAV3 mRNA	25895662
D020123	Sirolimus	Sirolimus inhibits the reaction [TP73 protein results in increased expression of CAV3 mRNA]	21245298
C017947	sodium arsenite	sodium arsenite results in increased expression of CAV3 protein	19072884
C016104	sodium bichromate	sodium bichromate results in decreased expression of CAV3 mRNA	22155349
D013311	Streptozocin	resveratrol inhibits the reaction [Streptozocin inhibits the reaction [CAV3 protein binds to SLC2A4 protein]]	18266981
D013311	Streptozocin	resveratrol inhibits the reaction [Streptozocin results in decreased expression of CAV3 protein]	18266981
D013311	Streptozocin	Streptozocin inhibits the reaction [CAV3 protein binds to SLC2A4 protein]	18266981
D013311	Streptozocin	Streptozocin results in decreased expression of CAV3 protein	18266981
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CAV3 mRNA	16714409
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CAV3 mRNA	22298810
C009495	titanium dioxide	titanium dioxide results in decreased expression of CAV3 mRNA	23557971
C012589	trichostatin A	trichostatin A results in decreased expression of CAV3 mRNA	15901671
C012589	trichostatin A	trichostatin A results in decreased expression of CAV3 mRNA	15901671
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CAV3 mRNA"	26179874
D014635	Valproic Acid	Valproic Acid results in decreased expression of CAV3 mRNA	15901671
D014635	Valproic Acid	Valproic Acid results in increased methylation of CAV3 gene	29154799
D014635	Valproic Acid	Valproic Acid results in decreased expression of CAV3 mRNA	15901671

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005198	structural molecule activity	-	IBA	21873635
GO:0005246	calcium channel regulator activity	-	IDA	21084288
GO:0005515	protein binding	-	IPI	10988290 24567387 25556234 26497963
GO:0008022	protein C-terminus binding	-	IDA	10988290
GO:0017080	sodium channel regulator activity	-	IDA	17060380
GO:0017080	sodium channel regulator activity	-	IMP	17275750
GO:0019870	potassium channel inhibitor activity	-	ISS	22879586
GO:0032947	protein-containing complex scaffold activity	-	IBA	21873635
GO:0032947	protein-containing complex scaffold activity	-	IPI	17060380
GO:0032947	protein-containing complex scaffold activity	-	ISS	-
GO:0043014	alpha-tubulin binding	-	IEA	-
GO:0044325	ion channel binding	-	IBA	21873635
GO:0044325	ion channel binding	-	IPI	17060380 21084288
GO:0044877	protein-containing complex binding	-	IDA	10988290
GO:0050998	nitric-oxide synthase binding	-	IEA	-
GO:0071253	connexin binding	-	IBA	21873635
GO:0071253	connexin binding	-	IDA	19544087

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001778	plasma membrane repair	-	IEA	-
GO:0002027	regulation of heart rate	-	IMP	17060380
GO:0006469	negative regulation of protein kinase activity	-	ISS	-
GO:0006641	triglyceride metabolic process	-	ISS	-
GO:0006869	lipid transport	-	IBA	21873635
GO:0006897	endocytosis	-	ISS	-
GO:0006936	muscle contraction	-	TAS	-
GO:0007009	plasma membrane organization	-	ISS	-
GO:0007015	actin filament organization	-	IEA	-
GO:0007204	positive regulation of cytosolic calcium ion concentration	-	ISS	-
GO:0007517	muscle organ development	-	TAS	10988290
GO:0007520	myoblast fusion	-	IEA	-
GO:0008016	regulation of heart contraction	-	ISS	-
GO:0008104	protein localization	-	ISS	-
GO:0008284	positive regulation of cell proliferation	-	IEA	-
GO:0010614	negative regulation of cardiac muscle hypertrophy	-	IMP	12847114
GO:0010831	positive regulation of myotube differentiation	-	IEA	-
GO:0014819	regulation of skeletal muscle contraction	-	IMP	17524427
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	-	IEA	-
GO:0030154	cell differentiation	-	IBA	21873635
GO:0030154	cell differentiation	-	ISS	-
GO:0031116	positive regulation of microtubule polymerization	-	ISS	-
GO:0031122	cytoplasmic microtubule organization	-	IEA	-
GO:0031579	membrane raft organization	-	ISS	-
GO:0033292	T-tubule organization	-	TAS	12847114
GO:0035995	detection of muscle stretch	-	IEA	-
GO:0038009	regulation of signal transduction by receptor internalization	-	IMP	20472890
GO:0042391	regulation of membrane potential	-	IBA	21873635
GO:0042391	regulation of membrane potential	-	IDA	21084288
GO:0042593	glucose homeostasis	-	ISS	-
GO:0042632	cholesterol homeostasis	-	ISS	-
GO:0043407	negative regulation of MAP kinase activity	-	IMP	12847114
GO:0043409	negative regulation of MAPK cascade	-	ISS	-
GO:0045792	negative regulation of cell size	-	IMP	12847114
GO:0046716	muscle cell cellular homeostasis	-	ISS	-
GO:0051001	negative regulation of nitric-oxide synthase activity	-	ISS	-
GO:0051394	regulation of nerve growth factor receptor activity	-	IMP	20472890
GO:0051647	nucleus localization	-	IEA	-
GO:0051896	regulation of protein kinase B signaling	-	IEA	-
GO:0051926	negative regulation of calcium ion transport	-	IDA	21084288
GO:0055013	cardiac muscle cell development	-	IEA	-
GO:0055117	regulation of cardiac muscle contraction	-	IMP	17275750
GO:0060299	negative regulation of sarcomere organization	-	IMP	12847114
GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	-	IMP	17060380
GO:0060347	heart trabecula formation	-	IEA	-
GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization	-	IDA	17060380
GO:0060762	regulation of branching involved in mammary gland duct morphogenesis	-	IEA	-
GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development	-	IEA	-
GO:0070836	caveola assembly	-	IBA	21873635
GO:0070836	caveola assembly	-	IDA	18936328
GO:0071417	cellular response to organonitrogen compound	-	IEA	-
GO:0072659	protein localization to plasma membrane	-	ISS	-
GO:0086005	ventricular cardiac muscle cell action potential	-	ISS	22879586
GO:0090279	regulation of calcium ion import	-	IDA	21084288
GO:0098909	regulation of cardiac muscle cell action potential involved in regulation of contraction	-	IMP	17060380
GO:1900744	regulation of p38MAPK cascade	-	IEA	-
GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential	-	IBA	21873635
GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential	-	IMP	17275750
GO:1900826	negative regulation of membrane depolarization during cardiac muscle cell action potential	-	IEA	-
GO:1901017	negative regulation of potassium ion transmembrane transporter activity	-	ISS	22879586
GO:1901019	regulation of calcium ion transmembrane transporter activity	-	IDA	21084288
GO:1901380	negative regulation of potassium ion transmembrane transport	-	ISS	22879586
GO:2000009	negative regulation of protein localization to cell surface	-	NAS	22879586
GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	-	NAS	22879586
GO:2000649	regulation of sodium ion transmembrane transporter activity	-	IDA	17060380 17275750
GO:2001288	positive regulation of caveolin-mediated endocytosis	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000139	Golgi membrane	-	IEA	-
GO:0005737	cytoplasm	COLOCALIZES_WITH	IBA	21873635
GO:0005783	endoplasmic reticulum	-	IDA	22792322
GO:0005886	plasma membrane	-	IDA	17060380 20472890
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005901	caveola	COLOCALIZES_WITH	IBA	21873635
GO:0005901	caveola	-	ISS	-
GO:0005925	focal adhesion	COLOCALIZES_WITH	IBA	21873635
GO:0009986	cell surface	-	IEA	-
GO:0014704	intercalated disc	-	IEA	-
GO:0016010	dystrophin-associated glycoprotein complex	-	IDA	10988290
GO:0030018	Z disc	colocalizes_with	ISS	-
GO:0030315	T-tubule	-	ISS	-
GO:0031594	neuromuscular junction	-	ISS	-
GO:0031982	vesicle	-	IEA	-
GO:0042383	sarcolemma	COLOCALIZES_WITH	IBA	21873635
GO:0042383	sarcolemma	-	IDA	12847114 17060380
GO:0043231	intracellular membrane-bounded organelle	-	IDA	-
GO:0045121	membrane raft	-	ISS	-

KEGG ID	KEGG Term
hsa04144	Endocytosis
hsa04510	Focal adhesion
hsa05100	Bacterial invasion of epithelial cells

Reactome ID	Reactome Term	Evidence
R-HSA-397014	Muscle contraction	TAS
R-HSA-397014	Muscle contraction	IEA
R-HSA-445355	Smooth Muscle Contraction	TAS
R-HSA-445355	Smooth Muscle Contraction	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
20346360	Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (2010 Jul)	Roberts KE	Gastroenterology
27919294	Heantos-4, a natural plant extract used in the treatment of drug addiction, modulates T-type calcium channels and thalamocortical burst-firing. (2016 Dec 5)	Cain SM	Mol Brain