Gene: TNFSF11

8600
CD254|ODF|OPGL|OPTB2|RANKL|TNLG6B|TRANCE|hRANKL2|sOdf
TNF superfamily member 11
protein-coding
13q14.11
Ensembl:ENSG00000120659 MIM:602642 Vega:OTTHUMG00000016807 UniprotKB:O14788
NG_008990.1
PubMed
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.730e-1 (AD)  1.128e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LHX90.821
CCDC1400.793
SIM10.776
SIX60.771
ELSPBP10.761
HMX30.749
PRDM130.743
ADAM20.722
OTX20.713
TSGA10IP0.711

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIAA1671-0.335
TNNT2-0.333
NEUROD2-0.332
SOHLH1-0.33
MPPED1-0.324
ADAMTS13-0.322
TESPA1-0.321
SKIDA1-0.316
TBR1-0.314
CA7-0.313

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00480LenalidomideSmall Molecule191732-72-6ApprovedTarget
DB06643DenosumabBiotechDrug615258-40-7ApprovedTarget
DB11582ThiocolchicosideSmall Molecule602-41-5Approved|InvestigationalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TNFSF11 mRNA"27291303
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]17306214
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNFSF11 protein results in increased phosphorylation of RPS6 protein]14502240
C0038982-anisidine2-anisidine results in increased expression of TNFSF11 mRNA28089782
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Freund's Adjuvant results in increased expression of TNFSF11 protein]27613480
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of TNFSF11 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFSF11 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFSF11 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFSF11 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TNFSF11 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFSF11 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFSF11 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of TNFSF11 protein"29127033
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"Sodium Fluoride inhibits the reaction [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of TNFSF11 protein]"29127033
C1081234-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [TNFSF11 protein results in increased phosphorylation of RPS6 protein]"14502240
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFSF11 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFSF11 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFSF11 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TNFSF11 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFSF11 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFSF11 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [PRKAA1 protein results in decreased activity of TNFSF11 protein]"20696287
D000082AcetaminophenAcetaminophen results in decreased expression of TNFSF11 mRNA21420995
D000171AcroleinAcrolein results in increased expression of TNFSF11 mRNA18515264
D000255Adenosine TriphosphateTNFSF11 protein results in increased abundance of Adenosine Triphosphate26287518
D019386AlendronateTNFSF11 inhibits the reaction [Alendronate results in increased expression of CASP9 protein]19405951
D019386AlendronateTNFSF11 inhibits the reaction [Alendronate results in decreased expression of MCL1 protein]19405951
D019386AlendronateAlendronate inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]27387537
D019386AlendronateAlendronate inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 protein]27387537
C035010alizarin 1-methyl etheralizarin 1-methyl ether inhibits the reaction [TNFSF11 protein results in increased phosphorylation of NFKBIA protein]21945525
C035010alizarin 1-methyl etheralizarin 1-methyl ether results in decreased expression of TNFSF11 mRNA21945525
C035010alizarin 1-methyl etheralizarin 1-methyl ether results in decreased expression of TNFSF11 protein21945525
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [norisoboldine inhibits the reaction [TNFSF11 protein results in increased expression of VEGFA mRNA]]26221077
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TNFSF11 mRNA16483693
D000677AmsacrineAmsacrine results in decreased expression of TNFSF11 mRNA11459812
D001151ArsenicArsenic affects the expression of TNFSF11 mRNA28793237
D001151Arsenic[Arsenic co-treated with Fluorides] results in decreased expression of TNFSF11 mRNA19962721
D001151Arsenic[Arsenic results in increased abundance of Cacodylic Acid] which affects the expression of TNFSF11 mRNA28793237
C006632arsenic trioxidearsenic trioxide results in decreased expression of TNFSF11 mRNA17530438
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in decreased expression of TNFSF11 mRNA15894607
C015001arsenitearsenite results in increased methylation of TNFSF11 promoter23974009
D001205Ascorbic Acid[Ascorbic Acid co-treated with TNFSF11 protein] results in decreased expression of CAR2 mRNA15730627
D001205Ascorbic Acid[Ascorbic Acid co-treated with TNFSF11 protein] results in decreased expression of TNFRSF11A mRNA15730627
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]15952411
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 protein]15952411
C547126AZM551248AZM551248 results in increased expression of TNFSF11 mRNA22323515
C060988baohuoside Ibaohuoside I results in decreased expression of TNFSF11 mRNA17764702
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFSF11 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TNFSF11 mRNA22316170
D004958EstradiolEstradiol results in increased expression of TNFSF11 mRNA19401787
C002070betulinic acidbetulinic acid inhibits the reaction [PTHLH protein results in increased expression of TNFSF11 protein]24463094
C002070betulinic acidbetulinic acid inhibits the reaction [TNFSF11 protein results in increased secretion of CTSK protein]24463094
C002070betulinic acidbetulinic acid inhibits the reaction [TNFSF11 protein results in increased secretion of MMP2 protein]24463094
C002070betulinic acidbetulinic acid inhibits the reaction [TNFSF11 protein results in increased secretion of MMP9 protein]24463094
C002070betulinic acidbetulinic acid results in decreased susceptibility to TNFSF11 protein24463094
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]17306214
C006780bisphenol Abisphenol A inhibits the reaction [TNFSF11 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]23900028
C006780bisphenol Abisphenol A inhibits the reaction [TNFSF11 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]23900028
C006780bisphenol Abisphenol A promotes the reaction [Progesterone results in increased expression of TNFSF11 mRNA]21903720
C006780bisphenol Abisphenol A results in decreased expression of TNFSF11 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of TNFSF11 mRNA25270620
D002101Cacodylic Acid[Arsenic results in increased abundance of Cacodylic Acid] which affects the expression of TNFSF11 mRNA28793237
D002104CadmiumCadmium results in increased expression of TNFSF11 protein23954550
D019256Cadmium Chloride[Cadmium Chloride co-treated with TNFSF11] results in increased activity of ACP5 protein21723911
D019256Cadmium Chloride[Cadmium Chloride co-treated with TNFSF11] results in increased expression of FOSL1 mRNA21723911
D019256Cadmium Chloride[Cadmium Chloride co-treated with TNFSF11] results in increased expression of FOS mRNA21723911
D019256Cadmium Chloride[Cadmium Chloride co-treated with TNFSF11] results in increased expression of SRC mRNA21723911
D019256Cadmium Chloride[Cadmium Chloride co-treated with TNFSF11] results in increased expression of TNFRSF11A mRNA21723911
D019256Cadmium Chloride[Cadmium Chloride co-treated with TNFSF11] results in increased expression of TRAF6 mRNA21723911
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TNFSF11 protein23726800
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TNFSF11 protein modified form25656917
D019256Cadmium ChloridePlant Extracts inhibits the reaction [Cadmium Chloride results in increased expression of TNFSF11 protein]25656917
D019256Cadmium ChloridePolyphenols inhibits the reaction [Cadmium Chloride results in increased expression of TNFSF11 protein]25656917
D019256Cadmium Chloridezinc chloride inhibits the reaction [Cadmium Chloride results in increased expression of TNFSF11 protein]23726800
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]28363435
D002118CalciumTNFRSF11B protein inhibits the reaction [TNFSF11 protein results in increased abundance of Calcium]12110441
D002118CalciumTNFSF11 protein results in increased abundance of Calcium12110441
D002716ChlormequatChlormequat affects the expression of TNFSF11 mRNA28214531
D002746ChlorpromazineChlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]21869564
D002746ChlorpromazineChlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]21869564
D002746ChlorpromazineChlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]21869564
D002746ChlorpromazineChlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]21869564
D002746ChlorpromazineChlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]21869564
D002746ChlorpromazineChlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]21869564
D002746ChlorpromazineChlorpromazine results in decreased activity of TNFSF1121869564
D002746ChlorpromazineChlorpromazine results in decreased activity of TNFSF11 protein21869564
D002809Chondroitin Sulfates[Chondroitin Sulfates co-treated with Glucosamine] inhibits the reaction [Cholecalciferol results in increased expression of TNFSF11 mRNA]17996099
D002809Chondroitin SulfatesChondroitin Sulfates inhibits the reaction [Cholecalciferol results in increased expression of TNFSF11 mRNA]17996099
D002809Chondroitin SulfatesChondroitin Sulfates inhibits the reaction [Glucosamine results in increased expression of TNFSF11 mRNA]17996099
D002809Chondroitin SulfatesChondroitin Sulfates results in decreased expression of TNFSF11 mRNA17996099
C022990chromic chloride[cobaltous chloride co-treated with chromic chloride] results in increased expression of TNFSF11 mRNA25966675
D002858Chromium AlloysChromium Alloys results in increased expression of TNFSF11 mRNA25966675
C018021cobaltous chloride[cobaltous chloride co-treated with chromic chloride] results in increased expression of TNFSF11 mRNA25966675
C018021cobaltous chloridecobaltous chloride results in increased expression of TNFSF11 mRNA25966675
D003345Corticosterone[Corticosterone co-treated with PTH protein] results in decreased expression of TNFSF11 mRNA17476578
D003345CorticosteroneCorticosterone results in increased expression of TNFSF11 mRNA17476578
D065366CryptoxanthinsCryptoxanthins promotes the reaction [[Zinc Sulfate co-treated with CSF1 protein co-treated with TNFSF11 protein] results in decreased expression of CTSK mRNA]18636177
D065366CryptoxanthinsCryptoxanthins promotes the reaction [[Zinc Sulfate co-treated with CSF1 protein co-treated with TNFSF11 protein] results in decreased expression of NFATC1 mRNA]18636177
D065366Cryptoxanthins[CSF1 protein co-treated with TNFSF11 protein co-treated with Cryptoxanthins co-treated with Zinc Sulfate] results in decreased expression of ACP5 mRNA18636177
D065366Cryptoxanthins[CSF1 protein co-treated with TNFSF11 protein co-treated with Cryptoxanthins] promotes the reaction [Zinc Sulfate results in increased expression of CASP3 mRNA]18636177
D065366Cryptoxanthins[CSF1 protein co-treated with TNFSF11 protein co-treated with Zinc Sulfate] promotes the reaction [Cryptoxanthins results in increased expression of CASP3 mRNA]18636177
D065366CryptoxanthinsCycloheximide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Cryptoxanthins] promotes the reaction [Zinc Sulfate results in increased expression of CASP3 mRNA]]18636177
D065366CryptoxanthinsCycloheximide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Zinc Sulfate] promotes the reaction [Cryptoxanthins results in increased expression of CASP3 mRNA]]18636177
D065366CryptoxanthinsDichlororibofuranosylbenzimidazole inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Cryptoxanthins] promotes the reaction [Zinc Sulfate results in increased expression of CASP3 mRNA]]18636177
D065366CryptoxanthinsDichlororibofuranosylbenzimidazole inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Zinc Sulfate] promotes the reaction [Cryptoxanthins results in increased expression of CASP3 mRNA]]18636177
D003474CurcuminCurcumin inhibits the reaction [TNFSF11 protein results in increased activity of CHUK protein]15129424
D003474CurcuminCurcumin inhibits the reaction [TNFSF11 protein results in increased expression of PTGS2 protein]15129424
D003474CurcuminCurcumin inhibits the reaction [IL1A protein results in increased expression of TNFSF11 protein]18719352
C038459curdlancurdlan inhibits the reaction [TNFSF11 protein results in increased expression of FOS]24821724
C038459curdlancurdlan inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1]24821724
D003513CycloheximideCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TNFSF11 mRNA]11007951
D003513CycloheximideCycloheximide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Cryptoxanthins] promotes the reaction [Zinc Sulfate results in increased expression of CASP3 mRNA]]18636177
D003513CycloheximideCycloheximide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Zinc Sulfate] promotes the reaction [Cryptoxanthins results in increased expression of CASP3 mRNA]]18636177
D003513CycloheximideCycloheximide inhibits the reaction [Genistein promotes the reaction [[Zinc Sulfate co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 mRNA]]17295206
D003513CycloheximideCycloheximide inhibits the reaction [Zinc Sulfate results in increased expression of TNFSF11 mRNA]18327666
D016572CyclosporineCyclosporine results in decreased expression of TNFSF11 mRNA27989131
D016572CyclosporineCyclosporine inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]15207740
C045571cyclosporin Gcyclosporin G inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]15207740
C050025cyclosporin Hcyclosporin H inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]15207740
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of TNFSF11 mRNA23640034
C017180decamethrindecamethrin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK1 protein]22634059
C017180decamethrindecamethrin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein]22634059
C017180decamethrindecamethrin results in decreased susceptibility to TNFSF11 protein22634059
C014347decitabinedecitabine promotes the reaction [Cholecalciferol results in increased expression of TNFSF11 mRNA]17008384
C014347decitabinedecitabine results in increased expression of TNFSF11 mRNA17008384
C083030dehydrocostus lactonedehydrocostus lactone inhibits the reaction [Hydrogen Peroxide results in increased secretion of TNFSF11 protein]19457452
D003907Dexamethasone[Thalidomide co-treated with Dexamethasone] results in decreased expression of TNFSF11 protein16079895
D003907DexamethasoneAlendronate inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]27387537
D003907DexamethasoneAlendronate inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 protein]27387537
D003907Dexamethasonecaffeic acid phenethyl ester inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]28363435
D003907DexamethasoneDexamethasone results in decreased expression of TNFSF11 mRNA20032058
D003907DexamethasoneDexamethasone results in increased expression of TNFSF11 mRNA27387537|2836343
D003907DexamethasoneDexamethasone results in increased expression of TNFSF11 protein27387537
D003907Dexamethasoneginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]27387537
D003907Dexamethasoneginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 protein]27387537
D003907DexamethasoneNOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]]27387537
D003907DexamethasoneNOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 protein]]27387537
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of TNFSF11 mRNA]20032058
D004004DichlororibofuranosylbenzimidazoleDichlororibofuranosylbenzimidazole inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Cryptoxanthins] promotes the reaction [Zinc Sulfate results in increased expression of CASP3 mRNA]]18636177
D004004DichlororibofuranosylbenzimidazoleDichlororibofuranosylbenzimidazole inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Zinc Sulfate] promotes the reaction [Cryptoxanthins results in increased expression of CASP3 mRNA]]18636177
D004004DichlororibofuranosylbenzimidazoleDichlororibofuranosylbenzimidazole inhibits the reaction [Genistein promotes the reaction [[Zinc Sulfate co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 mRNA]]17295206
D004004DichlororibofuranosylbenzimidazoleDichlororibofuranosylbenzimidazole inhibits the reaction [Zinc Sulfate results in increased expression of TNFSF11 mRNA]18327666
D004052Diethylnitrosamine[DMU-212 co-treated with Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TNFSF11 mRNA27048571
D002117CalcitriolCalcitriol results in increased expression of TNFSF11 mRNA17293108
D002117CalcitriolCalcitriol results in increased expression of TNFSF11 mRNA11113387|1681352
D002117Calcitriolmenatetrenone inhibits the reaction [Calcitriol results in increased expression of TNFSF11 mRNA]11113387
D002117CalcitriolCalcitriol results in increased expression of TNFSF11 mRNA17352647
D002117CalcitriolCalcitriol results in increased expression of TNFSF11 protein17352647
D004144DiosgeninDiosgenin inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]16331273
D004144DiosgeninDiosgenin results in decreased activity of TNFSF11 protein16331273
C521792DMU-212[DMU-212 co-treated with Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TNFSF11 mRNA27048571
C521792DMU-212DMU-212 results in increased expression of TNFSF11 mRNA27048571
C118739entinostatentinostat results in increased expression of TNFSF11 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFSF11 mRNA"27188386
C028044epoxy resin AH-26epoxy resin AH-26 results in increased expression of TNFSF11 mRNA19249596
C028044epoxy resin AH-26epoxy resin AH-26 results in increased expression of TNFSF11 protein19249596
D004967EstrogensEstrogens results in decreased expression of TNFSF11 mRNA16005483
D004967Estrogens[Progesterone co-treated with Estrogens] results in increased expression of TNFSF11 mRNA21258428
D000431EthanolEthanol results in increased expression of TNFSF11 mRNA22892342|2487243
D000431EthanolEthanol results in increased expression of TNFSF11 protein24872432
D000431EthanolGenistein promotes the reaction [Ethanol results in increased expression of TNFSF11 mRNA]24872432
D000431EthanolGenistein promotes the reaction [Ethanol results in increased expression of TNFSF11 protein]24872432
D000431EthanolVitamin D inhibits the reaction [Ethanol results in increased expression of TNFSF11 mRNA]22892342
D000431EthanolEthanol promotes the reaction [lead acetate results in increased expression of TNFSF11 protein]23376407
D005047EtoposideEtoposide results in decreased expression of TNFSF11 mRNA11459812
C074031exenatideexenatide results in decreased expression of TNFSF11 mRNA19586609
D005395Fish OilsFish Oils inhibits the reaction [Valproic Acid results in increased expression of TNFSF11 protein]18455911
D005459Fluorides[Arsenic co-treated with Fluorides] results in decreased expression of TNFSF11 mRNA19962721
D005459FluoridesFluorides affects the expression of TNFSF11 mRNA20709135
D005473FluoxetineFluoxetine inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]15312242
D005473FluoxetineFluoxetine inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]15312242
D005473FluoxetineFluoxetine inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]15312242
D005557FormaldehydeFormaldehyde results in decreased expression of TNFSF11 mRNA27664576
D005620Freund's Adjuvant3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Freund's Adjuvant results in increased expression of TNFSF11 protein]27613480
D005620Freund's AdjuvantFreund's Adjuvant results in increased expression of TNFSF11 mRNA25698669|2761348
D005620Freund's AdjuvantFreund's Adjuvant results in increased expression of TNFSF11 protein27613480
D005620Freund's AdjuvantIndomethacin inhibits the reaction [Freund's Adjuvant results in increased expression of TNFSF11 mRNA]25698669
D005620Freund's AdjuvantMethotrexate inhibits the reaction [Freund's Adjuvant results in increased expression of TNFSF11 mRNA]27613480
D005620Freund's AdjuvantMethotrexate inhibits the reaction [Freund's Adjuvant results in increased expression of TNFSF11 protein]27613480
D005620Freund's Adjuvant[morin co-treated with Indomethacin] inhibits the reaction [Freund's Adjuvant results in increased expression of TNFSF11 mRNA]25698669
D005620Freund's Adjuvantmorin inhibits the reaction [Freund's Adjuvant results in increased expression of TNFSF11 mRNA]25698669
D005620Freund's Adjuvanttrikatu inhibits the reaction [Freund's Adjuvant results in increased expression of TNFSF11 mRNA]27613480
D005620Freund's Adjuvanttrikatu inhibits the reaction [Freund's Adjuvant results in increased expression of TNFSF11 protein]27613480
D005665FurosemideFurosemide affects the expression of TNFSF11 mRNA17497460
C038958gadolinium chloridegadolinium chloride results in decreased expression of TNFSF11 mRNA21605080
D019833Genistein[CSF1 protein co-treated with TNFSF11 protein co-treated with Genistein] results in decreased expression of CTSK mRNA17295206
D019833GenisteinCycloheximide inhibits the reaction [Genistein promotes the reaction [[Zinc Sulfate co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 mRNA]]17295206
D019833GenisteinDichlororibofuranosylbenzimidazole inhibits the reaction [Genistein promotes the reaction [[Zinc Sulfate co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 mRNA]]17295206
D019833GenisteinGenistein promotes the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Zinc Sulfate] results in decreased expression of CTSK mRNA]17295206
D019833GenisteinGenistein promotes the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Zinc Sulfate] results in decreased expression of NFATC1 mRNA]17295206
D019833GenisteinGenistein promotes the reaction [Ethanol results in increased expression of TNFSF11 mRNA]24872432
D019833GenisteinGenistein promotes the reaction [Ethanol results in increased expression of TNFSF11 protein]24872432
D019833GenisteinGenistein promotes the reaction [[Zinc Sulfate co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 mRNA]17295206
D019833GenisteinGenistein results in decreased expression of TNFSF11 mRNA11459812|1940178
D019833GenisteinGenistein results in increased expression of TNFSF11 mRNA19401787|2487243
D019833GenisteinGenistein results in increased expression of TNFSF11 protein24872432
D019833Genistein[Zinc Sulfate co-treated with Genistein co-treated with CSF1 protein co-treated with TNFSF11 protein] results in decreased expression of ACP5 mRNA17295206
D019833GenisteinZinc Sulfate promotes the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Genistein] results in decreased expression of CTSK mRNA]17295206
D005839GentamicinsGentamicins results in decreased expression of TNFSF11 protein25051504
C442759ginsenoside Rb1ginsenoside Rb1 inhibits the reaction [TNFSF11 protein affects the localization of RELA protein]22386813
C442759ginsenoside Rb1ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]22386813
C442759ginsenoside Rb1ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]22386813
C442759ginsenoside Rb1ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of TNF mRNA]22386813
C442759ginsenoside Rb1ginsenoside Rb1 results in decreased susceptibility to TNFSF11 protein22386813
C097367ginsenoside Rg3ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]27387537
C097367ginsenoside Rg3ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 protein]27387537
C097367ginsenoside Rg3NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]]27387537
C097367ginsenoside Rg3NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 protein]]27387537
D005944Glucosamine[Chondroitin Sulfates co-treated with Glucosamine] inhibits the reaction [Cholecalciferol results in increased expression of TNFSF11 mRNA]17996099
D005944GlucosamineChondroitin Sulfates inhibits the reaction [Glucosamine results in increased expression of TNFSF11 mRNA]17996099
D005944GlucosamineGlucosamine results in increased expression of TNFSF11 mRNA17996099
D019812Heparan Sulfate Proteoglycans[Heparan Sulfate Proteoglycans binds to and results in increased activity of FGF2 protein] which results in increased expression of TNFSF11 protein15334457
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of TNFSF11 protein25130202
D006861Hydrogen Peroxidemyricitrin inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFSF11 protein]25130202
D006861Hydrogen Peroxidedehydrocostus lactone inhibits the reaction [Hydrogen Peroxide results in increased secretion of TNFSF11 protein]19457452
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of TNFSF11 protein25130202
D006861Hydrogen PeroxideHydrogen Peroxide results in increased secretion of TNFSF11 protein19457452
D006861Hydrogen Peroxidemyricitrin inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFSF11 protein]25130202
C056599icariinicariin results in decreased expression of TNFSF11 mRNA19747809
C056599icariinNOG protein inhibits the reaction [icariin results in decreased expression of TNFSF11 mRNA]19747809
C499403icaritinicaritin results in decreased expression of TNFSF11 mRNA17764702
D007213IndomethacinIndomethacin inhibits the reaction [Freund's Adjuvant results in increased expression of TNFSF11 mRNA]25698669
D007213Indomethacin[morin co-treated with Indomethacin] inhibits the reaction [Freund's Adjuvant results in increased expression of TNFSF11 mRNA]25698669
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNFSF11 mRNA25613284
D007505Iron-Dextran ComplexIron-Dextran Complex results in increased expression of TNFSF11 mRNA29122540
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TNFSF11 protein promotes the reaction [BRD4 protein binds to MMP9 promoter]]24646477
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TNFSF11 protein promotes the reaction [BRD4 protein binds to NFATC1 promoter]]24646477
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]24646477
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]24646477
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]24646477
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with TNFSF11 protein] results in decreased expression of FOS mRNA24799421
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TNFSF11 protein promotes the reaction [BRD4 protein binds to FOS promoter]]24799421
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TNFSF11 protein promotes the reaction [BRD4 protein binds to NFATC1 promoter]]24799421
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]24799421
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]24799421
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]24799421
C006552kaempferolkaempferol inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]16434028
C006552kaempferolkaempferol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]16434028
C006552kaempferolkaempferol inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA]16434028
C072105KN 93KN 93 inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]21869564
C008261lead acetateEthanol promotes the reaction [lead acetate results in increased expression of TNFSF11 protein]23376407
C008261lead acetatelead acetate results in increased expression of TNFSF11 protein23376407
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 affects the expression of TNFSF11 mRNA"21793936
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 affects the expression of TNFSF11 protein"21793936
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with TNFSF11 protein] results in increased degradation of TRAF6 protein21127049
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with TNFSF11 protein] results in increased expression of TNFAIP3 protein21127049
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TNFSF11 mRNA20682337|2544633
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TNFSF11 mRNA25446332
D008070LipopolysaccharidesTitanium promotes the reaction [Lipopolysaccharides results in increased expression of TNFSF11 mRNA]25446332
D008095Lithocholic AcidLithocholic Acid inhibits the reaction [Vitamin D results in increased expression of TNFSF11 mRNA]20055894
C013592mangiferinmangiferin inhibits the reaction [TNFSF11 protein results in increased degradation of NFKBIA protein]20683903
C013592mangiferinmangiferin inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]20683903
C013592mangiferinmangiferin inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA]20683903
C013592mangiferinmangiferin inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]20683903
C013592mangiferinmangiferin inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]20683903
C013592mangiferinmangiferin inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]20683903
C013592mangiferinmangiferin inhibits the reaction [TNFSF11 protein results in increased localization of RELA protein]20683903
C013592mangiferinmangiferin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK1 protein]20683903
C013592mangiferinmangiferin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein]20683903
C030814menatetrenonemenatetrenone inhibits the reaction [Calcitriol results in increased expression of TNFSF11 mRNA]11113387
D008713MethimazoleMethimazole results in increased expression of TNFSF11 mRNA22504374
D008727MethotrexateMethotrexate results in decreased expression of TNFSF11 mRNA15593184
D008727MethotrexateMethotrexate results in decreased expression of TNFSF11 protein15593184
D008727MethotrexateMethotrexate inhibits the reaction [Freund's Adjuvant results in increased expression of TNFSF11 mRNA]27613480
D008727MethotrexateMethotrexate inhibits the reaction [Freund's Adjuvant results in increased expression of TNFSF11 protein]27613480
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TNFSF11 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TNFSF11 mRNA26011545
C008548morin[morin co-treated with Indomethacin] inhibits the reaction [Freund's Adjuvant results in increased expression of TNFSF11 mRNA]25698669
C008548morinmorin inhibits the reaction [Freund's Adjuvant results in increased expression of TNFSF11 mRNA]25698669
C008577myricitrinmyricitrin inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFSF11 protein]25130202
C008577myricitrinmyricitrin inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFSF11 protein]25130202
C003799N2 Dental CementN2 Dental Cement results in increased expression of TNFSF11 mRNA19249596
C003799N2 Dental CementN2 Dental Cement results in increased expression of TNFSF11 protein19249596
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TNFSF11 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TNFSF11 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of TNFSF11 protein25051504
C005274naringinnaringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ACP5 mRNA]21835177
C005274naringinnaringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ATP6V0D2 mRNA]21835177
C005274naringinnaringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CALCR mRNA]21835177
C005274naringinnaringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CTSK mRNA]21835177
C005274naringinnaringin inhibits the reaction [TNFSF11 protein results in increased degradation of NFKBIA protein]21835177
C005274naringinnaringin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK1 protein]21835177
C005274naringinnaringin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein]21835177
D009532NickelNickel results in increased expression of TNFSF11 mRNA25583101
D009534NiclosamideNiclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]26792726
D009534NiclosamideNiclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA]26792726
D009534NiclosamideNiclosamide inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]26792726
D009534NiclosamideNiclosamide inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]26792726
D009534NiclosamideNiclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGAV mRNA]26792726
D009534NiclosamideNiclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGB3 mRNA]26792726
D009534NiclosamideNiclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]26792726
D009534NiclosamideNiclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]26792726
D009534NiclosamideNiclosamide inhibits the reaction [TNFSF11 protein results in increased expression of OSCAR mRNA]26792726
D009534NiclosamideNiclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of AKT1 protein]26792726
D009534NiclosamideNiclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of STAT3 protein]26792726
C012655nimesulide[nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of TNFSF11 mRNA22561872
D0151124-Nitroquinoline-1-oxide4-Nitroquinoline-1-oxide results in decreased expression of TNFSF11 mRNA22561872
D016912LevonorgestrelLevonorgestrel results in decreased expression of TNFSF11 mRNA16114553
C464745norisoboldinealpha-naphthoflavone inhibits the reaction [norisoboldine inhibits the reaction [TNFSF11 protein results in increased expression of VEGFA mRNA]]26221077
C464745norisoboldinenorisoboldine inhibits the reaction [TNFSF11 protein affects the localization of RELA protein]26221077
C464745norisoboldinenorisoboldine inhibits the reaction [TNFSF11 protein inhibits the reaction [RELA protein binds to AHR protein]]26221077
C464745norisoboldinenorisoboldine inhibits the reaction [TNFSF11 protein promotes the reaction [HIF1A protein binds to AHR protein]]26221077
C464745norisoboldinenorisoboldine inhibits the reaction [TNFSF11 protein results in increased expression of VEGFA mRNA]26221077
C464745norisoboldineresveratrol inhibits the reaction [norisoboldine inhibits the reaction [TNFSF11 protein results in increased expression of VEGFA mRNA]]26221077
C010722nylestriolnylestriol results in decreased expression of TNFSF11 mRNA16114553
C034364ozagrelozagrel results in decreased expression of TNFSF11 mRNA18264100
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFSF11 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of TNFSF11 mRNA26272509
C084656paricalcitolparicalcitol results in increased expression of TNFSF11 mRNA17352647
C084656paricalcitolparicalcitol results in increased expression of TNFSF11 protein17352647
D010424PentobarbitalPentobarbital results in decreased expression of TNFSF11 mRNA16978161
D010634PhenobarbitalPhenobarbital affects the expression of TNFSF11 mRNA19159669
D010634PhenobarbitalPhenobarbital results in increased expression of TNFSF11 mRNA19084549
D010634Phenobarbital[DMU-212 co-treated with Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TNFSF11 mRNA27048571
D010634PhenobarbitalPhenobarbital results in increased expression of TNFSF11 protein25051504
D010656Phenylephrine2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]17306214
D010656Phenylephrinebisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]17306214
D010656PhenylephrinePhenylephrine results in increased expression of TNFSF11 mRNA17306214
D010656PhenylephrinePrazosin inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]17306214
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TNFSF11 mRNA"27188386
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TNFSF11 mRNA19710929
D010936Plant ExtractsPlant Extracts inhibits the reaction [Cadmium Chloride results in increased expression of TNFSF11 protein]25656917
D020959PolyethylenePolyethylene affects the secretion of TNFSF11 protein15046894
D020959PolyethylenePolyethylene results in increased secretion of TNFSF11 protein15585240
D059808PolyphenolsPolyphenols inhibits the reaction [Cadmium Chloride results in increased expression of TNFSF11 protein]25656917
D059808PolyphenolsPolyphenols results in decreased expression of TNFSF11 mRNA16293270
D011224PrazosinPrazosin inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]17306214
D011374Progesteronebisphenol A promotes the reaction [Progesterone results in increased expression of TNFSF11 mRNA]21903720
D011374ProgesteroneProgesterone results in increased expression of TNFSF11 mRNA21903720
D011374Progesterone[Progesterone co-treated with Estrogens] results in increased expression of TNFSF11 mRNA21258428
D011398PromethazinePromethazine results in decreased activity of TNFSF1121869564
D011429PropolisPropolis inhibits the reaction [Valproic Acid results in increased expression of TNFSF11 protein]18455911
D011441PropylthiouracilPropylthiouracil results in increased expression of TNFSF11 mRNA22504374
D011794QuercetinQuercetin inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]16434028|1949592
D011794QuercetinQuercetin inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]19495926
D011794QuercetinQuercetin inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]16434028
D011794QuercetinQuercetin inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]19495926
D011794QuercetinQuercetin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]19495926
D011794QuercetinQuercetin inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA]16434028
D011794QuercetinQuercetin results in decreased activity of TNFSF11 protein19495926
C443401quercetin 3-O-glucuronidequercetin 3-O-glucuronide results in decreased activity of TNFSF11 protein19495926
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of TNFSF11 mRNA16005483
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of TNFSF11 mRNA19401787
C059514resveratrolresveratrol inhibits the reaction [TNFSF11 protein results in decreased expression of RUNX2 protein]21239502
C059514resveratrolresveratrol inhibits the reaction [TNFSF11 protein results in decreased expression of SIRT1 protein]21239502
C059514resveratrolresveratrol inhibits the reaction [TNFSF11 protein results in increased acetylation of and results in increased localization of and results in increased activity of RELA protein]21239502
C059514resveratrolresveratrol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]21239502
C059514resveratrolresveratrol inhibits the reaction [TNFSF11 protein results in increased localization of and results in increased activity of RELA protein]21239502
C059514resveratrolresveratrol inhibits the reaction [TNFSF11 protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]21239502
C059514resveratrol[resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] inhibits the reaction [TNFSF11 protein results in increased acetylation of and results in increased activity of RELA protein]21239502
C059514resveratrolresveratrol results in decreased susceptibility to TNFSF11 protein21239502
C059514resveratrol[resveratrol co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CD14 mRNA16267019
C059514resveratrol[resveratrol co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CSF1R mRNA16267019
C059514resveratrolresveratrol inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in decreased expression of ITGAL mRNA]16267019
C059514resveratrolresveratrol inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased activity of ACP5 protein]16267019
C059514resveratrolresveratrol inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA]16267019
C059514resveratrolresveratrol inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]16267019
C059514resveratrolresveratrol inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TNFRSF11A mRNA]16267019
C059514resveratrolresveratrol inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TNFRSF11A protein]16267019
C059514resveratrolresveratrol inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased localization of RELA protein]16267019
C059514resveratrolresveratrol inhibits the reaction [norisoboldine inhibits the reaction [TNFSF11 protein results in increased expression of VEGFA mRNA]]26221077
C059514resveratrolresveratrol results in increased expression of TNFSF11 mRNA16813520
C059514resveratrolresveratrol affects the expression of TNFSF11 mRNA24066520
C084904Ro 41-5253Ro 41-5253 inhibits the reaction [Tretinoin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]17291456
C084904Ro 41-5253Ro 41-5253 inhibits the reaction [tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]17291456
C089730rosiglitazone[rosiglitazone co-treated with TNFSF11 protein] results in increased expression of PPARG mRNA22286232
C089730rosiglitazonerosiglitazone inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA]22286232
C089730rosiglitazonerosiglitazone inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A protein]22286232
C089730rosiglitazonerosiglitazone inhibits the reaction [TNFSF11 protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]22286232
D012402RotenoneRotenone inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]19900598
D012402RotenoneRotenone inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]19900598
D012402RotenoneRotenone inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]19900598
D012402RotenoneRotenone inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]19900598
D012402RotenoneRotenone inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]19900598
D012402RotenoneRotenone inhibits the reaction [TNFSF11 protein results in increased expression of OSCAR mRNA]19900598
C072500rubiadinrubiadin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of NFKBIA protein]21945525
C072500rubiadinrubiadin results in decreased expression of TNFSF11 mRNA21945525
C072500rubiadinrubiadin results in decreased expression of TNFSF11 protein21945525
C577249sargachromanol Gsargachromanol G inhibits the reaction [IL1B protein results in increased expression of TNFSF11 protein]22727857
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of TNFSF11 mRNA25895662
D020123SirolimusSirolimus inhibits the reaction [TNFSF11 protein results in increased phosphorylation of EIF4EBP1 protein]14502240
D020123SirolimusSirolimus inhibits the reaction [TNFSF11 protein results in increased phosphorylation of RPS6 protein]14502240
C017947sodium arsenitesodium arsenite results in decreased expression of TNFSF11 mRNA16014739
D012969Sodium FluorideSodium Fluoride results in decreased expression of TNFSF11 mRNA26339601
D012969Sodium Fluoride"Sodium Fluoride inhibits the reaction [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of TNFSF11 protein]"29127033
D012969Sodium FluorideSodium Fluoride affects the expression of TNFSF11 mRNA25132241
D012969Sodium FluorideSodium Fluoride results in increased expression of TNFSF11 mRNA17190191
C000601293SRT3025SRT3025 inhibits the reaction [TNFSF11 protein results in increased acetylation of FOXO1 protein]26287518
D012460SulfasalazineSulfasalazine results in decreased expression of TNFSF11 mRNA15593184
D012460SulfasalazineSulfasalazine results in decreased expression of TNFSF11 protein15593184
D016559TacrolimusTacrolimus inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]15207740
D016559TacrolimusTacrolimus inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]21869564
C099410TAPI-2TAPI-2 inhibits the reaction [zoledronic acid results in decreased expression of TNFSF11 protein]14753746
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of TNFSF11 mRNA]20032058
D013749TetrachlorodibenzodioxinCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TNFSF11 mRNA]11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TNFSF11 mRNA11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TNFSF11 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TNFSF11 mRNA15310856|1597263
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of TNFSF11 mRNA17306214
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNFSF11 mRNA25613284
D013792Thalidomide[Thalidomide co-treated with Dexamethasone] results in decreased expression of TNFSF11 protein16079895
C024587thromboxane A2, carbocyclic"thromboxane A2, carbocyclic results in increased expression of TNFSF11 mRNA"18264100
D014025TitaniumTitanium promotes the reaction [Lipopolysaccharides results in increased expression of TNFSF11 mRNA]25446332
C479163tofacitinibtofacitinib results in decreased expression of and results in decreased secretion of TNFSF11 protein22899318
C479163tofacitinibtofacitinib inhibits the reaction [IL6 protein results in increased expression of TNFSF11 mRNA]21937456
C479163tofacitinibtofacitinib inhibits the reaction [OSM protein results in increased expression of TNFSF11 mRNA]21937456
C479163tofacitinibtofacitinib inhibits the reaction [TNF protein results in increased expression of TNFSF11 mRNA]21937456
C479163tofacitinibtofacitinib results in decreased expression of TNFSF11 protein21937456
C479163tofacitinibtofacitinib results in decreased expression of and results in decreased secretion of TNFSF11 protein22899318
C479163tofacitinibtofacitinib results in decreased expression of TNFSF11 mRNA22899318
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in decreased expression of TNFSF11 mRNA15894607
D014212TretinoinRo 41-5253 inhibits the reaction [Tretinoin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]17291456
D014212TretinoinTretinoin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]17291456
C011559tributyltinRo 41-5253 inhibits the reaction [tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]17291456
C011559tributyltintributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]17291456
C012589trichostatin Atrichostatin A results in increased expression of TNFSF11 mRNA24935251
D014268TrifluoperazineTrifluoperazine results in decreased activity of TNFSF1121869564
C540456trikatutrikatu inhibits the reaction [Freund's Adjuvant results in increased expression of TNFSF11 mRNA]27613480
C540456trikatutrikatu inhibits the reaction [Freund's Adjuvant results in increased expression of TNFSF11 protein]27613480
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in decreased expression of TNFSF11 protein23747339
C030665triphenyltintriphenyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]17291456
C057693troglitazonetroglitazone results in decreased expression of TNFSF11 mRNA16813520
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFSF11 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TNFSF11 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TNFSF11 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of TNFSF11 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of TNFSF11 mRNA17963808
D014635Valproic AcidFish Oils inhibits the reaction [Valproic Acid results in increased expression of TNFSF11 protein]18455911
D014635Valproic AcidPropolis inhibits the reaction [Valproic Acid results in increased expression of TNFSF11 protein]18455911
D014635Valproic AcidValproic Acid results in increased expression of TNFSF11 protein18455911
D012256RiboflavinRiboflavin analog affects the expression of TNFSF11 protein20688149
D009536NiacinamideNiacinamide results in decreased expression of TNFSF11 mRNA16813520
D014807Vitamin DLithocholic Acid inhibits the reaction [Vitamin D results in increased expression of TNFSF11 mRNA]20055894
D014807Vitamin DVitamin D results in increased expression of TNFSF11 mRNA20055894
D014807Vitamin DVitamin D inhibits the reaction [Ethanol results in increased expression of TNFSF11 mRNA]22892342
D002762CholecalciferolCholecalciferol results in increased expression of TNFSF11 mRNA17996099
D002762Cholecalciferol[Chondroitin Sulfates co-treated with Glucosamine] inhibits the reaction [Cholecalciferol results in increased expression of TNFSF11 mRNA]17996099
D002762CholecalciferolChondroitin Sulfates inhibits the reaction [Cholecalciferol results in increased expression of TNFSF11 mRNA]17996099
D002762CholecalciferolCholecalciferol promotes the reaction [[RXRB protein binds to VDR protein] which binds to TNFSF11 promoter]17008384
D002762CholecalciferolCholecalciferol results in increased expression of TNFSF11 mRNA17008384
D002762Cholecalciferoldecitabine promotes the reaction [Cholecalciferol results in increased expression of TNFSF11 mRNA]17008384
D024482Vitamin K 2Vitamin K 2 results in decreased expression of TNFSF11 mRNA19675304
D024483Vitamin K 3Vitamin K 3 results in decreased expression of TNFSF11 mRNA19675304
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFSF11 mRNA"27188386
C017967W 7W 7 inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]21869564
C017967W 7W 7 inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]21869564
C017967W 7W 7 inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]21869564
C017967W 7W 7 inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]21869564
C017967W 7W 7 inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]21869564
C017967W 7W 7 inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]21869564
C017967W 7W 7 results in decreased activity of TNFSF11 protein21869564
C104536xanthohumolxanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of AKT2 mRNA]23994090
C104536xanthohumolxanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]23994090
C104536xanthohumolxanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CLCN7 mRNA]23994090
C104536xanthohumolxanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]23994090
C104536xanthohumolxanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]23994090
C104536xanthohumolxanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of GAB2 mRNA]23994090
C104536xanthohumolxanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of MAPK3 mRNA]23994090
C104536xanthohumolxanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]23994090
C104536xanthohumolxanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]23994090
C104536xanthohumolxanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of OSTM1 mRNA]23994090
C104536xanthohumolxanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of PIK3CG mRNA]23994090
C104536xanthohumolxanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA]23994090
C104536xanthohumolxanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TCIRG1 mRNA]23994090
C104536xanthohumolxanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TRAF6 mRNA]23994090
C104536xanthohumolxanthohumol results in decreased susceptibility to TNFSF11 protein23994090
C016837zinc chloridezinc chloride inhibits the reaction [Cadmium Chloride results in increased expression of TNFSF11 protein]23726800
D019287Zinc SulfateCryptoxanthins promotes the reaction [[Zinc Sulfate co-treated with CSF1 protein co-treated with TNFSF11 protein] results in decreased expression of CTSK mRNA]18636177
D019287Zinc SulfateCryptoxanthins promotes the reaction [[Zinc Sulfate co-treated with CSF1 protein co-treated with TNFSF11 protein] results in decreased expression of NFATC1 mRNA]18636177
D019287Zinc Sulfate[CSF1 protein co-treated with TNFSF11 protein co-treated with Cryptoxanthins co-treated with Zinc Sulfate] results in decreased expression of ACP5 mRNA18636177
D019287Zinc Sulfate[CSF1 protein co-treated with TNFSF11 protein co-treated with Cryptoxanthins] promotes the reaction [Zinc Sulfate results in increased expression of CASP3 mRNA]18636177
D019287Zinc Sulfate[CSF1 protein co-treated with TNFSF11 protein co-treated with Zinc Sulfate] promotes the reaction [Cryptoxanthins results in increased expression of CASP3 mRNA]18636177
D019287Zinc Sulfate[CSF1 protein co-treated with TNFSF11 protein co-treated with Zinc Sulfate] results in decreased expression of CTSK mRNA17295206
D019287Zinc Sulfate[CSF1 protein co-treated with TNFSF11 protein co-treated with Zinc Sulfate] results in decreased expression of NFATC1 mRNA17295206
D019287Zinc SulfateCycloheximide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Cryptoxanthins] promotes the reaction [Zinc Sulfate results in increased expression of CASP3 mRNA]]18636177
D019287Zinc SulfateCycloheximide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Zinc Sulfate] promotes the reaction [Cryptoxanthins results in increased expression of CASP3 mRNA]]18636177
D019287Zinc SulfateCycloheximide inhibits the reaction [Genistein promotes the reaction [[Zinc Sulfate co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 mRNA]]17295206
D019287Zinc SulfateCycloheximide inhibits the reaction [Zinc Sulfate results in increased expression of TNFSF11 mRNA]18327666
D019287Zinc SulfateDichlororibofuranosylbenzimidazole inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Cryptoxanthins] promotes the reaction [Zinc Sulfate results in increased expression of CASP3 mRNA]]18636177
D019287Zinc SulfateDichlororibofuranosylbenzimidazole inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Zinc Sulfate] promotes the reaction [Cryptoxanthins results in increased expression of CASP3 mRNA]]18636177
D019287Zinc SulfateDichlororibofuranosylbenzimidazole inhibits the reaction [Genistein promotes the reaction [[Zinc Sulfate co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 mRNA]]17295206
D019287Zinc SulfateDichlororibofuranosylbenzimidazole inhibits the reaction [Zinc Sulfate results in increased expression of TNFSF11 mRNA]18327666
D019287Zinc SulfateGenistein promotes the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Zinc Sulfate] results in decreased expression of CTSK mRNA]17295206
D019287Zinc SulfateGenistein promotes the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Zinc Sulfate] results in decreased expression of NFATC1 mRNA]17295206
D019287Zinc SulfateGenistein promotes the reaction [[Zinc Sulfate co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 mRNA]17295206
D019287Zinc Sulfate[Zinc Sulfate co-treated with CSF1 protein co-treated with TNFSF11 protein] results in decreased expression of CTSK mRNA18636177
D019287Zinc Sulfate[Zinc Sulfate co-treated with CSF1 protein co-treated with TNFSF11 protein] results in decreased expression of NFATC1 mRNA18636177
D019287Zinc Sulfate[Zinc Sulfate co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 mRNA17295206
D019287Zinc Sulfate[Zinc Sulfate co-treated with Genistein co-treated with CSF1 protein co-treated with TNFSF11 protein] results in decreased expression of ACP5 mRNA17295206
D019287Zinc SulfateZinc Sulfate promotes the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Genistein] results in decreased expression of CTSK mRNA]17295206
D019287Zinc SulfateZinc Sulfate results in increased expression of TNFSF11 mRNA18327666
C088658zoledronic acidADAM17 protein promotes the reaction [zoledronic acid results in decreased expression of TNFSF11 protein]14753746
C088658zoledronic acidTAPI-2 inhibits the reaction [zoledronic acid results in decreased expression of TNFSF11 protein]14753746
C088658zoledronic acidzoledronic acid affects the expression of TNFSF11 protein17041912
C088658zoledronic acidzoledronic acid results in decreased expression of TNFSF11 protein14753746
D015054ZymosanNCF1 protein affects the reaction [Zymosan affects the expression of TNFSF11 mRNA]14507659

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-IDA9367155  15248232  
GO:0005125cytokine activity-NAS9568710  
GO:0005164tumor necrosis factor receptor binding-NAS9312132  9367155  
GO:0005515protein binding-IPI18586671  22664871  
GO:0032813tumor necrosis factor receptor superfamily binding-IC19940926  
GO ID GO Term Qualifier Evidence PubMed
GO:0001503ossification-IEA-  
GO:0002158osteoclast proliferation-IEA-  
GO:0002548monocyte chemotaxis-IDA15248232  
GO:0006955immune response-NAS9312132  
GO:0007257activation of JUN kinase activity-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0019221cytokine-mediated signaling pathway-IDA15248232  
GO:0019722calcium-mediated signaling-ISS-  
GO:0030316osteoclast differentiation-IDA18606301  
GO:0030316osteoclast differentiation-ISS-  
GO:0030316osteoclast differentiation-NAS9568710  
GO:0033209tumor necrosis factor-mediated signaling pathway-ISS19940926  
GO:0033209tumor necrosis factor-mediated signaling pathway-TAS-  
GO:0033598mammary gland epithelial cell proliferation-IEA-  
GO:0034112positive regulation of homotypic cell-cell adhesion-IDA9367155  
GO:0036035osteoclast development-IEA-  
GO:0038001paracrine signaling-IEA-  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IEA-  
GO:0043406positive regulation of MAP kinase activity-IDA15304486  
GO:0044691tooth eruption-IEA-  
GO:0045453bone resorption-IEA-  
GO:0045672positive regulation of osteoclast differentiation-IDA15304486  17241109  19560569  
GO:0045780positive regulation of bone resorption-IDA17241109  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA15304486  
GO:0050870positive regulation of T cell activation-IDA9367155  
GO:0051091positive regulation of DNA-binding transcription factor activity-ISS19940926  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IDA9367155  
GO:0051260protein homooligomerization-IEA-  
GO:0051466positive regulation of corticotropin-releasing hormone secretion-ISS19940926  
GO:0051897positive regulation of protein kinase B signaling-IEA-  
GO:0055074calcium ion homeostasis-IEA-  
GO:0060749mammary gland alveolus development-IEA-  
GO:0070371ERK1 and ERK2 cascade-IEA-  
GO:0071812positive regulation of fever generation by positive regulation of prostaglandin secretion-ISS19940926  
GO:0071847TNFSF11-mediated signaling pathway-IDA18606301  
GO:0071848positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling-IDA18606301  
GO:1902533positive regulation of intracellular signal transduction-IDA15248232  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO:2001206positive regulation of osteoclast development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS9568710  10708588  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IEA-  
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-NAS9312132  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04380Osteoclast differentiation
hsa05323Rheumatoid arthritis
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-5668541TNFR2 non-canonical NF-kB pathwayTAS
R-HSA-5669034TNFs bind their physiological receptorsTAS
R-HSA-5676594TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28893037Periodontal Initial Radiological Findings of Genetically Predisposed Finnish Adolescents. (2017 Jul)Heikkinen AMJ Clin Diagn Res
23919740Comparison of circulating tumour necrosis factor superfamily cytokines in periodontitis patients undergoing supportive therapy: a case-controlled cross-sectional study comparing smokers and non-smokers in health and disease. (2013 Sep)Nile CJJ Clin Periodontol
20531232TNFRSF11A and TNFSF11 are associated with age at menarche and natural menopause in white women. (2010 Sep-Oct)Lu YMenopause