Gene: CADPS

8618
CADPS1|CAPS|CAPS1|UNC-31
calcium dependent secretion activator
protein-coding
3p14.2
Ensembl:ENSG00000163618 MIM:604667 Vega:OTTHUMG00000158651 UniprotKB:Q9ULU8
NG_047093.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.551e-1 (AD)  3.037e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6445276chr3:62519585 (GRCh38.p7)T>A / T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NELL20.981
MAP7D20.98
DYNC1I10.98
SNAP910.979
PRKCE0.979
SYT40.979
NSF0.978
GLRB0.977
WDR70.977
SYT10.976

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.567
RNF135-0.558
REST-0.543
HEY2-0.536
YES1-0.535
CNN2-0.525
ASB4-0.524
RAI14-0.523
MYL3-0.522
CHST14-0.521

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB11093Calcium CitrateSmall Molecule813-94-5ApprovedTarget
DB11348Calcium PhosphateSmall Molecule10103-46-5ApprovedTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CADPS mRNA"19114083
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of CADPS mRNA"16984957
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CADPS mRNA"21346803
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of CADPS mRNA25088246
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of CADPS mRNA"16984957
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CADPS mRNA"20959002
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CADPS mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CADPS mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of CADPS mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CADPS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CADPS mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CADPS gene27153756
C015001arsenitearsenite results in increased methylation of CADPS promoter23974009
D001280AtrazineAtrazine results in decreased expression of CADPS mRNA25929836
C006780bisphenol Abisphenol A results in decreased expression of CADPS mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CADPS gene28505145
D002104CadmiumCadmium results in decreased expression of CADPS mRNA24376830
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CADPS gene20938992
C029892cupric chloridecupric chloride results in increased expression of CADPS protein22699969
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CADPS mRNA21266533
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in decreased expression of CADPS mRNA26924002
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of CADPS mRNA25374375
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of CADPS promoter25374375
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of CADPS mRNA26924002
C540355fenamidonefenamidone results in decreased expression of CADPS mRNA27029645
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CADPS gene20938992
C039281furanfuran results in increased expression of CADPS mRNA25539665
D007840LatexLatex analog results in decreased expression of CADPS mRNA24768652
D007854LeadLead affects the splicing of CADPS mRNA28903495
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CADPS mRNA26378955
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CADPS gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CADPS mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CADPS mRNA23179753
C517284monomethyl phthalatemonomethyl phthalate results in decreased expression of CADPS mRNA26924002
C570896NSC305787NSC305787 results in decreased expression of CADPS mRNA27137931
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of CADPS mRNA25374375
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of CADPS promoter25374375
D010656PhenylephrinePhenylephrine results in decreased expression of CADPS mRNA18158353
D010795Phthalic AcidsPhthalic Acids results in increased expression of CADPS mRNA15728792
C006253pirinixic acidpirinixic acid results in increased expression of CADPS mRNA20813756
D059808PolyphenolsPolyphenols results in decreased expression of CADPS mRNA16293270
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CADPS mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CADPS mRNA24680724
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CADPS mRNA20959002
D014212TretinoinTretinoin results in increased expression of CADPS mRNA21934132|2372400
C012589trichostatin Atrichostatin A results in decreased expression of CADPS mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of CADPS mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CADPS mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of CADPS mRNA23179753|2627250
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CADPS gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CADPS mRNA"27188386
C111237vorinostatvorinostat results in increased expression of CADPS mRNA26272509
D015032ZincZinc results in increased expression of CADPS mRNA17074742
D019287Zinc SulfateZinc Sulfate results in decreased expression of CADPS mRNA27215404
D019287Zinc SulfateZinc Sulfate results in increased expression of CADPS mRNA17074742

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17984325  
GO:0008289lipid binding-IEA-  
GO:0019901protein kinase binding-ISS-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006887exocytosis-TAS1516133  
GO:0015031protein transport-IEA-  
GO:0016050vesicle organization-IEA-  
GO:0016082synaptic vesicle priming-IEA-  
GO:0050432catecholamine secretion-IEA-  
GO:0099525presynaptic dense core vesicle exocytosis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS1516133  
GO:0030054cell junction-IEA-  
GO:0030659cytoplasmic vesicle membrane-IEA-  
GO:0098793presynapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal