Gene: NPFF

8620
FMRFAL
neuropeptide FF-amide peptide precursor
protein-coding
12q13.13
Ensembl:ENSG00000139574 MIM:604643 Vega:OTTHUMG00000169856 UniprotKB:O15130
NC_000012.12
PubMed
0   ANCO-SNPs
OD|ND
10   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.687e-1 (AD)  7.443e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ANKRD230.747
MUTYH0.743
LIME10.723
CRYGS0.722
CDK30.702
PRR140.693
FITM10.692
RNPEPL10.686
ABCD40.685
SAP250.682

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MTX3-0.434
APOOL-0.416
CDH7-0.412
SLC9A7-0.409
EPHA6-0.404
HS6ST3-0.401
NYAP2-0.401
KLHL11-0.397
PCDHAC1-0.393
CDKL5-0.393

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of NPFF mRNA"28903501
D000082AcetaminophenAcetaminophen affects the expression of NPFF mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of NPFF mRNA]22129741
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of NPFF mRNA22129741
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to NPFF promoter]19654925
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of NPFF mRNA28628672
C006780bisphenol Abisphenol A results in increased methylation of NPFF promoter27312807
C006780bisphenol Abisphenol A results in increased expression of NPFF mRNA25181051
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of NPFF mRNA28628672
D004052DiethylnitrosamineAcetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of NPFF mRNA]22129741
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of NPFF mRNA22129741
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of NPFF mRNA22129741
C016517indole-3-carbinolAcetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of NPFF mRNA]22129741
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of NPFF mRNA22129741
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of NPFF mRNA22129741
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of NPFF mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of NPFF mRNA28628672
C544151jinfukangjinfukang results in increased expression of NPFF mRNA27392435
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NPFF mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NPFF mRNA"25554681
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NPFF mRNA21570461
D014520UrethaneUrethane results in decreased expression of NPFF mRNA28818685

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001664G-protein coupled receptor binding-IBA21873635  
GO:0005102signaling receptor binding-TAS9224703  10851242  
GO:0005184neuropeptide hormone activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0002438acute inflammatory response to antigenic stimulus-IEA-  
GO:0003254regulation of membrane depolarization-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007204positive regulation of cytosolic calcium ion concentration-IEA-  
GO:0007218neuropeptide signaling pathway-IEA-  
GO:0007268chemical synaptic transmission-TAS9224703  
GO:0010459negative regulation of heart rate-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0021510spinal cord development-IEA-  
GO:0030103vasopressin secretion-IEA-  
GO:0032099negative regulation of appetite-IEA-  
GO:0043278response to morphine-IEA-  
GO:0045777positive regulation of blood pressure-IEA-  
GO:0046676negative regulation of insulin secretion-IEA-  
GO:0051930regulation of sensory perception of pain-IEA-  
GO:0060079excitatory postsynaptic potential-IBA21873635  
GO:0060135maternal process involved in female pregnancy-IEA-  
GO:0070253somatostatin secretion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0030425dendrite-IBA21873635  
GO:0031982vesicle-IEA-  
GO:0043204perikaryon-IBA21873635  
GO:0043679axon terminus-IBA21873635  
GO:0098794postsynapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-389397Orexin and neuropeptides FF and QRFP bind to their respective receptorsTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20803521Opioid-modulating properties of the neuropeptide FF system. (2010 Nov-Dec)Mouledous LBiofactors
8617406Opioid and anti-opioid peptides. (1995)Cesselin FFundam Clin Pharmacol
8746922Subcutaneous injection of an analog of neuropeptide FF prevents naloxone-precipitated morphine abstinence syndrome. (1995 Nov)Malin DHDrug Alcohol Depend
21718302Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments. (2012 Jan)Elhabazi KBr J Pharmacol
1491790Analog of neuropeptide FF attenuates morphine tolerance. (1992 Nov 9)Lake JRNeurosci Lett
8545244Changes in CNS neuropeptide FF-like material, pain sensitivity, and opiate dependence following chronic morphine treatment. (1995)Stinus LPeptides
15857316Opioid-modulating peptides: mechanisms of action. (2005)Mollereau CCurr Top Med Chem
10573293Modulation of naloxone-precipitated morphine withdrawal syndromes in rats by neuropeptide FF analogs. (1999)Tan PPPeptides
8743632Nicotine abstinence syndrome precipitated by an analog of neuropeptide FF. (1996 Jul)Malin DHPharmacol Biochem Behav
1800944Analog of neuropeptide FF attenuates morphine abstinence syndrome. (1991 Sep-Oct)Malin DHPeptides