Gene: PDE8B

8622
ADSD|PPNAD3
phosphodiesterase 8B
protein-coding
5q13.3
Ensembl:ENSG00000284762 MIM:603390 Vega:OTTHUMG00000102170 UniprotKB:O95263
NG_023364.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.274e-1 (AD)  1.920e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPIN10.892
VMA210.885
IPO50.885
RNF110.88
PUM20.88
ACTR20.877
MCFD20.875
CNOT70.874
MAPK60.874
RAB6A0.872

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.695
OR4F29-0.655
CSAG1-0.25
ZBTB20-0.236
EVC2-0.236
WDR38-0.222
CNN2-0.219
ANXA13-0.215
RHOD-0.215
FXYD4-0.213

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00201CaffeineSmall Molecule58-08-2ApprovedTarget
DB09283TrapidilSmall Molecule15421-84-8ApprovedTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of PDE8B mRNA"26377693
C0101929-(2-hydroxy-3-nonyl)adenine9-(2-hydroxy-3-nonyl)adenine inhibits the reaction [PDE8B protein results in increased metabolism of Cyclic AMP]12681444
D000082AcetaminophenAcetaminophen results in decreased expression of PDE8B mRNA29067470
D000242Cyclic AMP9-(2-hydroxy-3-nonyl)adenine inhibits the reaction [PDE8B protein results in increased metabolism of Cyclic AMP]12681444
D000242Cyclic AMPDipyridamole inhibits the reaction [PDE8B protein results in increased hydrolysis of Cyclic AMP]9784418
D000242Cyclic AMPDipyridamole inhibits the reaction [PDE8B protein results in increased metabolism of Cyclic AMP]12681444
D000242Cyclic AMPE 4021 inhibits the reaction [PDE8B protein results in increased metabolism of Cyclic AMP]12681444
D000242Cyclic AMPPDE8B protein results in increased hydrolysis of Cyclic AMP9784418
D000242Cyclic AMPPDE8B protein results in increased metabolism of Cyclic AMP12681444
D000242Cyclic AMPSildenafil Citrate inhibits the reaction [PDE8B protein results in increased metabolism of Cyclic AMP]12681444
D000242Cyclic AMPPDE8B protein results in increased degradation of Cyclic AMP20085714
D000242Cyclic AMP[PDE8B protein results in increased degradation of Cyclic AMP] which affects the activity of Dopamine20085714
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PDE8B protein20106945
D001280AtrazineAtrazine results in decreased expression of PDE8B mRNA25929836
C547126AZM551248AZM551248 results in decreased expression of PDE8B mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PDE8B mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PDE8B mRNA21569818
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PDE8B mRNA"19150397|2001819
C018475butyraldehydebutyraldehyde results in decreased expression of PDE8B mRNA26079696
D016572CyclosporineCyclosporine results in decreased expression of PDE8B mRNA20106945
D003907DexamethasoneDexamethasone results in increased expression of PDE8B mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PDE8B mRNA28628672
D004176DipyridamoleDipyridamole inhibits the reaction [PDE8B protein results in increased hydrolysis of Cyclic AMP]9784418
D004176DipyridamoleDipyridamole inhibits the reaction [PDE8B protein results in increased metabolism of Cyclic AMP]12681444
D004298Dopamine[PDE8B protein results in increased degradation of Cyclic AMP] which affects the activity of Dopamine20085714
C091517E 4021E 4021 inhibits the reaction [PDE8B protein results in increased metabolism of Cyclic AMP]12681444
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PDE8B mRNA26159488
D005473FluoxetineFluoxetine results in increased expression of PDE8B mRNA22291481
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PDE8B mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PDE8B mRNA28628672
C544151jinfukangjinfukang results in decreased expression of PDE8B mRNA27392435
C459562L-826,141"L-826,141 results in decreased activity of PDE8B protein"15901792
D008094LithiumLithium results in decreased expression of PDE8B mRNA20222156
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PDE8B mRNA26378955
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PDE8B mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PDE8B mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PDE8B mRNA"25554681
D009532NickelNickel results in decreased expression of PDE8B mRNA24768652|2558310
C076029olanzapineolanzapine results in increased expression of PDE8B mRNA20222156
D011441PropylthiouracilPropylthiouracil results in decreased expression of PDE8B mRNA24780913
C424423RoflumilastRoflumilast results in decreased activity of PDE8B protein15901792
D000068677Sildenafil CitrateSildenafil Citrate inhibits the reaction [PDE8B protein results in increased metabolism of Cyclic AMP]12681444
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PDE8B mRNA23806026|2589566
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PDE8B mRNA25351596
D012906SmokeSmoke results in decreased expression of PDE8B mRNA21095227
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PDE8B mRNA26378955
C004648testosterone enanthatetestosterone enanthate results in increased expression of PDE8B mRNA21427060
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PDE8B mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PDE8B mRNA20106945
C009495titanium dioxidetitanium dioxide results in decreased expression of PDE8B mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PDE8B mRNA28065790
C035964trequinsintrequinsin results in decreased activity of PDE8B protein15901792
D014415TunicamycinTunicamycin results in increased expression of PDE8B mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of PDE8B mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PDE8B mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of PDE8B gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PDE8B gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity-NAS9784418  
GO:00041153',5'-cyclic-AMP phosphodiesterase activity-TAS-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006198cAMP catabolic process-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0009187cyclic nucleotide metabolic process-NAS9784418  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00230Purine metabolism
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418555G alpha (s) signalling eventsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23237535Phosphodiesterase 8B gene polymorphism in women with recurrent miscarriage: a retrospective case control study. (2012 Dec 13)Granfors MBMC Med Genet