Gene: TP63

8626
AIS|B(p51A)|B(p51B)|EEC3|KET|LMS|NBP|OFC8|RHS|SHFM4|TP53CP|TP53L|TP73L|p40|p51|p53CP|p63|p73H|p73L
tumor protein p63
protein-coding
3q28
Ensembl:ENSG00000073282 MIM:603273 Vega:OTTHUMG00000156313 UniprotKB:Q9H3D4
NG_007550.1
PubMed
0   ANCO-SNPs
ND
15   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.953e-1 (AD)  2.132e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg16764781chr3:189347820TP632.900e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DSC30.83
NCCRP10.752
SIX10.725
FOXL10.712
PDE5A0.698
SERPINB50.69
GATA30.688
FMO10.688
OLFML10.686
FCRL30.685

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF835-0.424
OTUD7A-0.403
C16orf46-0.399
FAM171A2-0.399
MAGIX-0.397
KHDC1-0.396
CHST1-0.396
GGH-0.394
STPG1-0.393
CHRNA4-0.392

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0523831,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene"1,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene results in increased expression of TP63 mRNA"23373633
C50489712-(3-adamantan-1-ylureido)dodecanoic acid12-(3-adamantan-1-ylureido)dodecanoic acid affects the expression of TP63 mRNA19435785
C0144643,4-dichloroaniline"3,4-dichloroaniline results in decreased expression of TP63 mRNA"24172598
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of TP63 protein"25670856
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TP63 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TP63 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of TP63 protein15607904
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TP63 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TP63 mRNA"27188386
D020106AcrylamideAcrylamide results in increased expression of TP63 mRNA28959563
C016601afimoxifeneafimoxifene results in increased expression of TP63 mRNA23373633
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TP63 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TP63 mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in increased expression of TP63 protein16483693
D000970Antineoplastic AgentsAntineoplastic Agents results in increased expression of TP63 protein alternative form20043870
D000970Antineoplastic Agents[trichostatin A results in increased expression of and results in increased cleavage of and results in increased activity of TP63 protein alternative form] which affects the susceptibility to Antineoplastic Agents20043870
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TP63 mRNA24449571
D047310ApigeninApigenin results in increased expression of TP63 protein19397994
C006632arsenic trioxidearsenic trioxide results in decreased stability of and results in increased degradation of TP63 protein mutant form23271742
C006632arsenic trioxideRCHY1 protein promotes the reaction [arsenic trioxide results in increased degradation of TP63 protein mutant form]23271742
C015001arsenitearsenite results in increased expression of TP63 protein22011395
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of TP63 mRNA"17331233
D001564Benzo(a)pyreneTP63 protein affects the susceptibility to Benzo(a)pyrene28882572
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cisplatin promotes the reaction [RELA protein binds to TP63 protein alternative form]] which results in increased degradation of TP63 protein alternative form]21088498
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TP63 mRNA19619570
D004958EstradiolEstradiol results in increased expression of TP63 mRNA19619570|2337363
C006780bisphenol Abisphenol A affects the expression of TP63 mRNA25181051
D002087ButyratesButyrates results in increased expression of TP63 protein alternative form20043870
D002104CadmiumCadmium results in increased expression of TP63 protein20049202
D019256Cadmium ChlorideCadmium Chloride results in decreased activity of TP63 protein25446071
D019256Cadmium Chloride[Cadmium Chloride results in decreased activity of TP63 protein] inhibits the reaction [TP63 protein binds to TP53 gene]25446071
D019256Cadmium ChlorideEdetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP63 protein] inhibits the reaction [TP63 protein binds to TP53 gene]]25446071
C100187chloropicrinchloropicrin results in decreased expression of TP63 mRNA26352163|2847649
D004390ChlorpyrifosChlorpyrifos results in increased expression of TP63 mRNA21356183
C043561chrysinchrysin results in increased expression of TP63 protein18331776|1939799
C018021cobaltous chloridecobaltous chloride results in decreased activity of TP63 protein25446071
C018021cobaltous chloride[cobaltous chloride results in decreased activity of TP63 protein] inhibits the reaction [TP63 protein binds to TP53 gene]25446071
D003300CopperCopper results in decreased expression of TP63 mRNA16391388
D019327Copper SulfateCopper Sulfate results in increased expression of TP63 mRNA19549813
D003513CycloheximideCycloheximide inhibits the reaction [trichostatin A results in increased expression of TP63 protein alternative form]20043870
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of TP63 mRNA24317228
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TP63 mRNA]27941970
D002945Cisplatinbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cisplatin promotes the reaction [RELA protein binds to TP63 protein alternative form]] which results in increased degradation of TP63 protein alternative form]21088498
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TP63 mRNA27392435
D002945CisplatinCisplatin inhibits the reaction [[HDAC1 protein co-treated with TP63 protein modified form] binds to BBC3 promoter]21527555
D002945CisplatinCisplatin promotes the reaction [DDIT3 protein binds to TP63 protein]20959455
D002945CisplatinCisplatin promotes the reaction [NFYA protein binds to TP63 protein]20959455
D002945CisplatinCisplatin promotes the reaction [RELA protein binds to TP63 protein alternative form]21088498
D002945Cisplatin[Cisplatin promotes the reaction [RELA protein binds to TP63 protein alternative form]] which results in increased degradation of TP63 protein alternative form21088498
D002945CisplatinCisplatin promotes the reaction [TP63 protein modified form binds to ADRM1 promoter]20959455
D002945CisplatinCisplatin promotes the reaction [TP63 protein modified form binds to TP63 protein]20959455
D002945CisplatinCisplatin promotes the reaction [TP63 protein modified form results in increased expression of MIR630]21274007
D002945CisplatinCisplatin results in decreased expression of TP63 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of TP63 mRNA alternative form21266360
D002945CisplatinCisplatin results in decreased expression of TP63 protein alternative form21266360
D002945Cisplatin[Cisplatin results in decreased expression of TP63 protein alternative form] which results in decreased expression of AKT121266360
D002945CisplatinCisplatin results in increased phosphorylation of and results in increased activity of TP63 protein alternative form21274007
D002945CisplatinCisplatin results in increased phosphorylation of TP63 protein20959455
D002945CisplatinCisplatin results in increased phosphorylation of TP63 protein alternative form21191146
D002945Cisplatin[Cisplatin results in increased phosphorylation of TP63 protein alternative form] promotes the reaction [ADRM1 protein binds to UCHL5 protein binds to TP63 protein alternative form]21191146
D002945Cisplatin[Cisplatin results in increased phosphorylation of TP63 protein alternative form] promotes the reaction [TP63 protein alternative form binds to ATM promoter]21191146
D002945Cisplatin[Cisplatin results in increased phosphorylation of TP63 protein alternative form] promotes the reaction [TP63 protein alternative form results in increased expression of ATM protein]21191146
D002945Cisplatin[Cisplatin results in increased phosphorylation of TP63 protein alternative form] promotes the reaction [TP63 protein modified form binds to DICER1 promoter]21274007
D002945Cisplatin[Cisplatin results in increased phosphorylation of TP63 protein alternative form] promotes the reaction [TP63 protein modified form binds to MIR630 promoter]21274007
D002945Cisplatin[Cisplatin results in increased phosphorylation of TP63 protein alternative form] promotes the reaction [TP63 protein modified form results in increased expression of DICER1 mRNA]21274007
D002945Cisplatin[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in decreased expression of MTOR protein21191146
D002945Cisplatin[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased activity of TSC2 protein21191146
D002945Cisplatin[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased degradation of STK11 protein alternative form21191146
D002945Cisplatin[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased degradation of TP63 protein alternative form21191146
D002945Cisplatin[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased expression of ADRM1 protein21191146
D002945Cisplatin[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased expression of MAP1LC3B protein21191146
D002945Cisplatinlactacystin inhibits the reaction [[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased degradation of STK11 protein]21191146
D002945Cisplatinlactacystin inhibits the reaction [[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased degradation of TP63 protein alternative form]21191146
D002945CisplatinSTK11 protein promotes the reaction [[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased expression of MAP1LC3B protein]21191146
D002945Cisplatin[TNFSF10 protein co-treated with Cisplatin] results in decreased expression of TP63 protein21252285
D002945CisplatinTP63 protein alternative form promotes the reaction [Cisplatin results in increased expression of ADRM1 mRNA]20959455
D002945CisplatinTP63 protein alternative form promotes the reaction [Cisplatin results in increased expression of DDIT3 protein]20959455
D002945CisplatinTP63 protein alternative form promotes the reaction [Cisplatin results in increased expression of NFYA protein]20959455
D002945CisplatinTP63 protein alternative form results in decreased susceptibility to Cisplatin21266360
D002945CisplatinTP63 protein promotes the reaction [Cisplatin inhibits the reaction [IFNG protein results in increased expression of and results in increased activity of NOS2 protein]]20959455
D002945CisplatinTP63 protein promotes the reaction [Cisplatin promotes the reaction [NOS2 protein binds to ADRM1 protein binds to UCHL5 protein]]20959455
D002945CisplatinTP63 protein promotes the reaction [Cisplatin results in increased degradation of NOS2 protein]20959455
D002945CisplatinTP63 protein promotes the reaction [Cisplatin results in increased expression of ADRM1 protein]20959455
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of TP63 protein16439099
D002117CalcitriolCalcitriol results in increased expression of TP63 mRNA26485663
D004147DioxinsDioxins affects the expression of TP63 mRNA20463971
D004237DiuronDiuron metabolite results in decreased expression of TP63 mRNA24172598
D004492Edetic AcidEdetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP63 protein] inhibits the reaction [TP63 protein binds to TP53 gene]]25446071
C118739entinostatentinostat results in increased expression of TP63 protein alternative form20043870
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of TP63 mRNA23649840
D005054EugenolEugenol results in decreased expression of TP63 mRNA17936526
D005557FormaldehydeFormaldehyde results in decreased expression of TP63 mRNA23649840
D019833GenisteinGenistein results in increased expression of TP63 mRNA15256057
D019833GenisteinGenistein results in decreased expression of TP6312929590
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TP63 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TP63 mRNA27392435
C006552kaempferolkaempferol results in increased expression of TP63 protein18331776|1939799
C067713lactacystinlactacystin inhibits the reaction [[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased degradation of STK11 protein]21191146
C067713lactacystinlactacystin inhibits the reaction [[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased degradation of TP63 protein alternative form]21191146
C554430LDN 193189LDN 193189 results in decreased expression of TP63 protein alternative form23243027
C038753leptomycin B[leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of TP63 mRNA20803015
C038753leptomycin Bleptomycin B results in decreased expression of TP63 mRNA20803015
D018021Lithium ChlorideLithium Chloride results in increased expression of TP63 mRNA23527032
D047311LuteolinLuteolin results in increased expression of TP63 protein18331776|1939799
D008558MelphalanMelphalan results in decreased expression of TP63 mRNA22363485
C004925methylmercuric chloridemethylmercuric chloride affects the expression of TP63 mRNA20864626
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TP63 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TP63 mRNA23649840
C040015myricetinmyricetin results in increased expression of TP63 protein19397994
C022838nickel chlorideIKBKB gene mutant form inhibits the reaction [nickel chloride results in decreased expression of TP63 mRNA alternative form]21466819
C022838nickel chlorideIRF3 protein inhibits the reaction [nickel chloride results in decreased expression of TP63 mRNA alternative form]21466819
C022838nickel chloridenickel chloride promotes the reaction [TP63 mutant form results in increased expression of CDKN1A mRNA]21466819
C022838nickel chloridenickel chloride results in decreased activity of TP63 protein25446071
C022838nickel chloride[nickel chloride results in decreased activity of TP63 protein] inhibits the reaction [TP63 protein binds to TP53 gene]25446071
C022838nickel chloridenickel chloride results in decreased expression of TP63 mRNA alternative form21466819
C022838nickel chloridenickel chloride results in decreased expression of TP63 protein alternative form21466819
C022838nickel chlorideTP63 protein mutant form inhibits the reaction [nickel chloride results in increased expression of CDKN1A mRNA]21466819
C022838nickel chlorideTP63 protein mutant form inhibits the reaction [nickel chloride results in increased expression of CDKN1A protein]21466819
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of TP63 mRNA17616710
C016340o,p'-DDT"o,p'-DDT analog results in decreased expression of TP63 mRNA"22937105
C016340o,p'-DDT"o,p'-DDT results in increased expression of TP63 mRNA"22937105
C496932panobinostatpanobinostat results in increased expression of TP63 protein alternative form20043870
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TP63 mRNA"27188386
D011374ProgesteroneProgesterone results in decreased expression of TP63 mRNA21795739
D011794QuercetinQuercetin results in increased expression of TP63 protein18331776|1939799
C012526quercitrinquercitrin results in decreased expression of TP63 mRNA25193878
C059514resveratrolresveratrol results in increased expression of TP63 mRNA18347188
C059514resveratrolresveratrol results in increased expression of TP63 protein18347188
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of TP63 mRNA23806026|2589566
D012822Silicon DioxideSilicon Dioxide results in decreased expression of TP63 mRNA25351596
D020123SirolimusSirolimus results in decreased expression of TP63 protein20038814
D012906SmokeSmoke results in decreased expression of TP63 mRNA21095227
C017947sodium arsenitesodium arsenite affects the expression of TP63 mRNA20056578
C017947sodium arsenitesodium arsenite affects the expression of TP63 protein20056578
C017947sodium arsenitesodium arsenite results in decreased expression of TP63 mRNA25199682
D014284TriiodothyronineTriiodothyronine results in increased expression of TP63 mRNA22281776
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TP63 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TP63 mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TP63 mRNA19619570
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TP63 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of TP63 mRNA27865774
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TP63 mRNA25788831
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TP63 protein27865774
C012589trichostatin ACycloheximide inhibits the reaction [trichostatin A results in increased expression of TP63 protein alternative form]20043870
C012589trichostatin ATP53 protein affects the reaction [trichostatin A results in increased expression of TP63 protein alternative form]20043870
C012589trichostatin ATP63 protein modified form results in increased susceptibility to trichostatin A21527555
C012589trichostatin Atrichostatin A results in increased expression of and results in increased cleavage of and results in increased activity of TP63 protein alternative form20043870
C012589trichostatin A[trichostatin A results in increased expression of and results in increased cleavage of and results in increased activity of TP63 protein alternative form] which affects the susceptibility to Antineoplastic Agents20043870
C012589trichostatin Atrichostatin A results in increased expression of TP63 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of TP63 mRNA alternative form20043870
D014520UrethaneUrethane results in decreased expression of TP63 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TP63 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of TP63 mRNA24383497|2627250
D014635Valproic AcidValproic Acid results in increased expression of TP63 protein alternative form20043870

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0000989transcription factor activity, transcription factor binding-IEA-  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0002039p53 binding-IPI25417702  
GO:0003677DNA binding-NAS9662346  
GO:0003700DNA-binding transcription factor activity-IMP25417702  
GO:0005515protein binding-IPI14729977  16908849  18275817  19345189  20085233  21741598  
21988832  26112605  
GO:0042802identical protein binding-IPI12446779  19815500  21335238  21464285  
GO:0044212transcription regulatory region DNA binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO:0050699WW domain binding-IPI19451233  
GO:0097371MDM2/MDM4 family protein binding-IPI25417702  
GO ID GO Term Qualifier Evidence PubMed
GO:0001302replicative cell aging-IEA-  
GO:0001501skeletal system development-IEA-  
GO:0001736establishment of planar polarity-IEA-  
GO:0002053positive regulation of mesenchymal cell proliferation-IEA-  
GO:0002064epithelial cell development-IEA-  
GO:0006338chromatin remodeling-IEA-  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0006915apoptotic process-TAS9662378  
GO:0007219Notch signaling pathway-IEA-  
GO:0007283spermatogenesis-IEA-  
GO:0007499ectoderm and mesoderm interaction-IEA-  
GO:0009954proximal/distal pattern formation-IEA-  
GO:0010259multicellular organism aging-IEA-  
GO:0010481epidermal cell division-IEA-  
GO:0010482regulation of epidermal cell division-ISS-  
GO:0010838positive regulation of keratinocyte proliferation-IEA-  
GO:0030216keratinocyte differentiation-IEA-  
GO:0030859polarized epithelial cell differentiation-IEA-  
GO:0031069hair follicle morphogenesis-IEA-  
GO:0033147negative regulation of intracellular estrogen receptor signaling pathway-IEA-  
GO:0035115embryonic forelimb morphogenesis-IEA-  
GO:0035116embryonic hindlimb morphogenesis-IEA-  
GO:0036342post-anal tail morphogenesis-IEA-  
GO:0042475odontogenesis of dentin-containing tooth-IEA-  
GO:0042981regulation of apoptotic process-TAS-  
GO:0043281regulation of cysteine-type endopeptidase activity involved in apoptotic process-IEA-  
GO:0043589skin morphogenesis-IEA-  
GO:0043616keratinocyte proliferation-IEA-  
GO:0045617negative regulation of keratinocyte differentiation-IEA-  
GO:0045669positive regulation of osteoblast differentiation-IMP22521434  
GO:0045747positive regulation of Notch signaling pathway-IDA11641404  
GO:0045892negative regulation of transcription, DNA-templated-IDA12446784  
GO:0045893positive regulation of transcription, DNA-templated-IDA12446784  16343436  
GO:0045893positive regulation of transcription, DNA-templated-IMP25417702  
GO:0045893positive regulation of transcription, DNA-templated-NAS9774969  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA22521434  
GO:0048485sympathetic nervous system development-IEA-  
GO:0048745smooth muscle tissue development-IEA-  
GO:0048807female genitalia morphogenesis-IEA-  
GO:0051289protein homotetramerization-IPI10373484  
GO:0051402neuron apoptotic process-IEA-  
GO:0060157urinary bladder development-IEA-  
GO:0060197cloacal septation-IEA-  
GO:0060513prostatic bud formation-IEA-  
GO:0060529squamous basal epithelial stem cell differentiation involved in prostate gland acinus development-IEA-  
GO:0061436establishment of skin barrier-ISS-  
GO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway-TAS-  
GO:1901796regulation of signal transduction by p53 class mediator-TAS-  
GO:1904674positive regulation of somatic stem cell population maintenance-IEA-  
GO:1904888cranial skeletal system development-IEA-  
GO:2000271positive regulation of fibroblast apoptotic process-IDA9774969  
GO:2000381negative regulation of mesoderm development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA22521434  
GO:0005634nucleus-IDA10657951  11106548  12446779  
GO:0005634nucleus-NAS9774969  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA10657951  
GO:0005739mitochondrion-IEA-  
GO:0005791rough endoplasmic reticulum-IEA-  
GO:0005794Golgi apparatus-IDA-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisTAS
R-HSA-109606Intrinsic Pathway for ApoptosisTAS
R-HSA-114452Activation of BH3-only proteinsTAS
R-HSA-139915Activation of PUMA and translocation to mitochondriaTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5357801Programmed Cell DeathTAS
R-HSA-5628897TP53 Regulates Metabolic GenesTAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5633008TP53 Regulates Transcription of Cell Death GenesTAS
R-HSA-6803204TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseTAS
R-HSA-6803205TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertainTAS
R-HSA-6803207TP53 Regulates Transcription of Caspase Activators and CaspasesTAS
R-HSA-6803211TP53 Regulates Transcription of Death Receptors and LigandsTAS
R-HSA-6804759Regulation of TP53 Activity through Association with Co-factorsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27063419Association of Single Nucleotide Polymorphisms in the Apoptosis-Related Genes TP63 and CD40 with Risk for Lung Cancer in a Chinese Han Population. (2016 Apr)Tang WTohoku J Exp Med
24790730Apoptosis-Related Single Nucleotide Polymorphisms and the Risk of Non-Small Cell Lung Cancer in Women. (2014)Pathak AJ Cancer Ther Res
24377560TP63 gene polymorphisms, cooking oil fume exposure and risk of lung adenocarcinoma in Chinese non-smoking females. (2014 Jan)Yin ZHAsian Pac J Cancer Prev
19843673Sequence variant on 3q28 and urinary bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study. (2009 Nov)Stern MCCancer Epidemiol Biomarkers Prev
20153630Common predisposition alleles for moderately common cancers: bladder cancer. (2010 Jun)Kiltie AECurr Opin Genet Dev
22310392Association between C3orf21, TP63 polymorphisms and environment and NSCLC in never-smoking Chinese population. (2012 Apr 10)Zhang YGene
24163739Genetic susceptibility to lung cancer and co-morbidities. (2013 Oct)Yang IAJ Thorac Dis
28449811Effects of polymorphisms identified in genome-wide association studies of never-smoking females on the prognosis of non-small cell lung cancer. (2017 Apr)Yoo SSCancer Genet
24278325Distinct effects of alcohol consumption and smoking on genetic alterations in head and neck carcinoma. (2013)Urashima MPLoS One
25218545Interaction between TP63 and MDM2 genes and the risk of recurrent pregnancy loss. (2014 Nov)Fraga LREur J Obstet Gynecol Reprod Biol
25566987Interactions between household air pollution and GWAS-identified lung cancer susceptibility markers in the Female Lung Cancer Consortium in Asia (FLCCA). (2015 Mar)Hosgood HD 3rdHum Genet
27750372Copy number gain of 11q13.3 genes associates with pathological stage in hypopharyngeal squamous cell carcinoma. (2017 Mar)Pattle SBGenes Chromosomes Cancer
21063684Rs710521[A] on chromosome 3q28 close to TP63 is associated with increased urinary bladder cancer risk. (2010 Dec)Lehmann MLArch Toxicol
28464886A lung cancer risk classifier comprising genome maintenance genes measured in normal bronchial epithelial cells. (2017 May 2)Yeo JBMC Cancer
25144241A functional polymorphism in CSF1R gene is a novel susceptibility marker for lung cancer among never-smoking females. (2014 Nov)Kang HGJ Thorac Oncol