Gene: UNC5C

8633
UNC5H3
unc-5 netrin receptor C
protein-coding
4q22.3
Ensembl:ENSG00000182168 MIM:603610 Vega:OTTHUMG00000130989 UniprotKB:O95185
NC_000004.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.444e-1 (AD)  9.540e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3857231chr4:95445291 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRRC8D0.883
TTLL70.879
AGPAT40.876
CPOX0.87
NXPE30.863
CEP970.86
PXK0.857
CEP850.854
ABHD17B0.853
TLE40.851

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FOXL1-0.348
WNT7B-0.343
OR4F5-0.342
MAPKAPK3-0.339
MTRNR2L8-0.326
GJB2-0.318
OR4F29-0.318
LYN-0.316
DIO2-0.314
SLC2A4-0.314

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of UNC5C mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of UNC5C mRNA"25614096
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of UNC5C mRNA"20406850
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNC5C mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNC5C mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNC5C mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNC5C mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNC5C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNC5C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNC5C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNC5C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNC5C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNC5C mRNA"27188386
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in decreased expression of UNC5C mRNA"19936915
D000082Acetaminophen[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of UNC5C mRNA25607892
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of UNC5C gene27153756
D000726Androgen Antagonists[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of UNC5C mRNA25607892
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to UNC5C promoter]19654925
D004958EstradiolEstradiol results in increased expression of UNC5C mRNA19484750
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of UNC5C mRNA25607892
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of UNC5C mRNA25607892
C006780bisphenol Abisphenol A results in decreased expression of UNC5C mRNA25181051
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of UNC5C mRNA25607892
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of UNC5C mRNA25607892
D002220CarbamazepineCarbamazepine affects the expression of UNC5C mRNA25979313
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of UNC5C mRNA20971185
D003300CopperCopper deficiency results in increased expression of UNC5C mRNA26033743
D003976DiazinonDiazinon results in increased methylation of UNC5C gene22964155
D002945CisplatinUNC5C results in increased susceptibility to Cisplatin21600761
D004041Dietary FatsDietary Fats results in decreased expression of UNC5C mRNA25016146
D019422Dietary SucroseDietary Sucrose results in increased expression of UNC5C mRNA26033743
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of UNC5C mRNA25607892
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of UNC5C mRNA25607892
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of UNC5C mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UNC5C mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of UNC5C mRNA29097150
D005047EtoposideUNC5C results in increased susceptibility to Etoposide21600761
C039281furanfuran results in increased expression of UNC5C mRNA25539665
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of UNC5C mRNA22634610
C561695(+)-JQ1 compound(+)-JQ1 compound affects the expression of UNC5C mRNA26733615
C561695(+)-JQ1 compound(+)-JQ1 compound promotes the reaction [panobinostat affects the expression of UNC5C mRNA]26733615
C561695(+)-JQ1 compoundpanobinostat promotes the reaction [(+)-JQ1 compound affects the expression of UNC5C mRNA]26733615
D007649KetamineKetamine results in decreased expression of UNC5C mRNA20080153
C011890kojic acidkojic acid results in decreased expression of UNC5C mRNA16595896
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of UNC5C mRNA23103053
D008999MonocrotophosMonocrotophos affects the expression of UNC5C mRNA28645554
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of UNC5C mRNA"25554681
D009532NickelNickel results in decreased expression of UNC5C mRNA25583101
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of UNC5C mRNA20971185
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of UNC5C mRNA25607892
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of UNC5C mRNA25607892
D010100OxygenOxygen deficiency results in increased expression of UNC5C mRNA26516004
C496932panobinostat(+)-JQ1 compound promotes the reaction [panobinostat affects the expression of UNC5C mRNA]26733615
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNC5C mRNA"27188386
C496932panobinostatpanobinostat affects the expression of UNC5C mRNA26733615
C496932panobinostatpanobinostat promotes the reaction [(+)-JQ1 compound affects the expression of UNC5C mRNA]26733615
C496932panobinostatpanobinostat results in increased expression of UNC5C mRNA26272509
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of UNC5C mRNA26705709
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of UNC5C mRNA23602845
D010575PesticidesPesticides results in decreased methylation of UNC5C gene28396702
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNC5C mRNA"27188386
D011441PropylthiouracilPropylthiouracil results in increased expression of UNC5C mRNA24780913
C017947sodium arsenitesodium arsenite affects the methylation of UNC5C gene28589171
D012999SomanSoman results in increased expression of UNC5C mRNA19281266
D053260SootSoot results in decreased expression of UNC5C mRNA26551751
D013096SpermineSpermine results in increased expression of UNC5C mRNA18673383
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UNC5C mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UNC5C mRNA19933214
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNC5C mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of UNC5C mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNC5C mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of UNC5C mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of UNC5C gene29154799
D014635Valproic AcidValproic Acid results in increased expression of UNC5C mRNA24383497|2627250
D014640VancomycinVancomycin results in increased expression of UNC5C mRNA18930951
D001335Vehicle EmissionsVehicle Emissions affects the methylation of UNC5C gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNC5C mRNA"27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005042netrin receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IEA-  
GO:0007411axon guidance-TAS9126742  
GO:0007420brain development-IEA-  
GO:0030334regulation of cell migration-IEA-  
GO:0033564anterior/posterior axon guidance-IEA-  
GO:0038007netrin-activated signaling pathway-IEA-  
GO:0043065positive regulation of apoptotic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0043005neuron projection-IEA-  
GO:0045202synapse-IEA-  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-373752Netrin-1 signalingIEA
R-HSA-418886Netrin mediated repulsion signalsIEA
R-HSA-422475Axon guidanceIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal