Gene: OASL

8638
OASL1|OASLd|TRIP-14|TRIP14|p59 OASL|p59-OASL|p59OASL
2'-5'-oligoadenylate synthetase like
protein-coding
12q24.31
Ensembl:ENSG00000135114 MIM:603281 Vega:OTTHUMG00000154981 UniprotKB:Q15646
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.520e-1 (AD)  9.491e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
USP180.908
OAS10.898
IFIH10.894
DDX60L0.892
ZBP10.891
CCL80.878
ETV70.874
DDX580.873
RSAD20.863
OAS30.859

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYADML2-0.26
HCN2-0.256
GABRA5-0.238
SCRT1-0.238
ATP6V1E2-0.234
NME5-0.23
HRH3-0.225
KCNN1-0.224
ADAMTSL2-0.222
GNG7-0.215

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in increased expression of OASL mRNA19041380
D000447AldehydesAldehydes results in increased expression of OASL mRNA25014914
D001151ArsenicArsenic results in increased methylation of OASL promoter21291286
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of OASL mRNA"25351596
C547126AZM551248AZM551248 results in decreased expression of OASL mRNA22323515
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of OASL mRNA19619570
D004958EstradiolEstradiol results in increased expression of OASL mRNA19619570|2118537
C006780bisphenol Abisphenol A affects the expression of OASL mRNA25181051
C006780bisphenol Abisphenol A affects the methylation of OASL promoter27415467
C018475butyraldehydebutyraldehyde results in increased expression of OASL mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of OASL mRNA25993096
D002737ChloropreneChloroprene results in decreased expression of OASL mRNA23125180
C023676chloroquine diphosphatechloroquine diphosphate results in decreased expression of OASL mRNA19192274
C018021cobaltous chloridecobaltous chloride results in increased expression of OASL mRNA19376846
D003300Copper[Disulfiram binds to Copper] which results in increased expression of OASL mRNA24690739
D016572CyclosporineCyclosporine results in increased expression of OASL mRNA22147139
D003907DexamethasoneDexamethasone results in increased expression of OASL mRNA25047013
D002117CalcitriolCalcitriol results in decreased expression of OASL mRNA12040012|1600243
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of OASL mRNA24690739
D011345FenofibrateFenofibrate results in increased expression of OASL mRNA25572481
D005557FormaldehydeFormaldehyde results in decreased expression of OASL mRNA28937961
C039281furanfuran results in decreased expression of OASL mRNA25539665
C007834genipingenipin inhibits the reaction [Lipopolysaccharides results in increased expression of OASL mRNA]22687549
D005839GentamicinsGentamicins results in increased expression of OASL mRNA22061828
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in decreased expression of OASL mRNA19192274
C082359imidaclopridimidacloprid results in increased expression of OASL mRNA27782041
C544151jinfukangjinfukang results in increased expression of OASL mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of OASL mRNA26752646
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of OASL mRNA15860229
D008070Lipopolysaccharidesgenipin inhibits the reaction [Lipopolysaccharides results in increased expression of OASL mRNA]22687549
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of OASL mRNA22687549
D008775MethylprednisoloneMethylprednisolone results in decreased expression of OASL mRNA19192274
D009151Mustard GasMustard Gas results in increased expression of OASL mRNA25102026
D009532NickelNickel results in increased expression of OASL mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in increased expression of OASL mRNA22714537
C558013NSC 689534NSC 689534 results in increased expression of OASL mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of OASL mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of OASL mRNA25729387
D010081OxazoloneOxazolone results in increased expression of OASL mRNA21893156
C046012pentanalpentanal results in increased expression of OASL mRNA26079696
D010634PhenobarbitalPhenobarbital affects the expression of OASL mRNA19159669
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of OASL mRNA19710929
D010938Plant OilsPlant Oils results in increased expression of OASL mRNA23370395
D011239PrednisolonePrednisolone results in decreased expression of OASL mRNA19192274
D011374ProgesteroneProgesterone results in increased expression of OASL mRNA19690047
C005556propionaldehydepropionaldehyde results in increased expression of OASL mRNA26079696
C059514resveratrolresveratrol results in increased expression of OASL mRNA25888808
C078903seocalcitolseocalcitol results in decreased expression of OASL mRNA12040012
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of OASL mRNA"24160326
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of OASL mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of OASL mRNA22300531|2535159
C061133tamibarotenetamibarotene results in increased expression of OASL mRNA15498508
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of OASL mRNA27914987
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of OASL mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of OASL mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of OASL mRNA23238561
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of OASL mRNA23238561
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of OASL mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of OASL mRNA25729387
D019772TopotecanTopotecan results in increased expression of OASL mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of OASL mRNA21893156
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of OASL mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of OASL mRNA25572481
D014635Valproic AcidValproic Acid results in increased expression of OASL mRNA29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00017302'-5'-oligoadenylate synthetase activity-IBA21873635  
GO:00017302'-5'-oligoadenylate synthetase activityNOTIDA9826176  
GO:0003677DNA binding-IDA9826176  
GO:0003723RNA binding-HDA22658674  
GO:0003725double-stranded RNA binding-IBA21873635  
GO:0003725double-stranded RNA binding-IDA9826176  
GO:0005524ATP binding-IEA-  
GO:0046966thyroid hormone receptor binding-TAS7776974  
GO ID GO Term Qualifier Evidence PubMed
GO:0009615response to virus-IDA18931074  20074559  
GO:0045071negative regulation of viral genome replication-IBA21873635  
GO:0045071negative regulation of viral genome replication-IDA18931074  20074559  
GO:0051607defense response to virus-IBA21873635  
GO:0051607defense response to virus-IDA21478870  
GO:0060333interferon-gamma-mediated signaling pathway-TAS-  
GO:0060337type I interferon signaling pathway-TAS-  
GO:0060700regulation of ribonuclease activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005730nucleolus-IDA9826176  
GO:0005737cytoplasm-IDA9826176  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016020membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-877300Interferon gamma signalingTAS
R-HSA-909733Interferon alpha/beta signalingTAS
R-HSA-913531Interferon SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25821920Sperm mRNAs and microRNAs as candidate markers for the impact of toxicants on human spermatogenesis: an application to tobacco smoking. (2015 Jun)Metzler-Guillemain CSyst Biol Reprod Med