Gene: AOC3

8639
HPAO|SSAO|VAP-1|VAP1
amine oxidase, copper containing 3
protein-coding
17q21.31
Ensembl:ENSG00000131471 MIM:603735 Vega:OTTHUMG00000180656 UniprotKB:Q16853
NC_000017.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.790e-1 (AD)  7.667e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg21602160chr17:41003272AOC3Promoter3.638e-5Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ITIH30.853
PLN0.85
ACTA20.84
MYOCD0.817
KCNMB10.815
SLC13A40.811
COL8A10.811
TAGLN0.795
NEXN0.788
TRABD2B0.788

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.318
HAGHL-0.311
SLC25A10-0.305
ZSCAN1-0.301
CLDND2-0.287
NEU4-0.282
SFTPD-0.281
FGF22-0.279
C9orf24-0.272
BTBD17-0.267

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00780PhenelzineSmall Molecule51-71-8ApprovedTarget
DB01275HydralazineSmall Molecule86-54-4ApprovedTarget
DB043346-hydroxydopa quinoneSmall Molecule-ExperimentalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of AOC3 mRNA"27291303
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of AOC3 mRNA"21346803
D000499AllylamineAOC3 protein affects the metabolism of Allylamine11543647
D000499AllylamineAOC3 protein affects the metabolism of Allylamine11543647
D000499AllylamineAOC3 protein affects the metabolism of and results in increased oxidation of Allylamine10406932
D000499AllylamineAOC3 protein results in decreased susceptibility to Allylamine10406932
D000641AmmoniaAOC3 protein results in increased chemical synthesis of Ammonia16081681
C006632arsenic trioxidearsenic trioxide results in increased expression of AOC3 mRNA25258189
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AOC3 mRNA26238291
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of AOC3 mRNA25566086
C006780bisphenol Abisphenol A results in decreased expression of AOC3 mRNA27685785
C006780bisphenol Abisphenol A affects the expression of AOC3 mRNA25181051
D002101Cacodylic AcidCacodylic Acid results in increased expression of AOC3 mRNA17441966
D002101Cacodylic AcidOGG1 protein inhibits the reaction [Cacodylic Acid results in increased expression of AOC3 mRNA]17441966
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of AOC3 mRNA25993096
C010059carbamylhydrazinecarbamylhydrazine results in decreased activity of AOC3 protein11543647
C010059carbamylhydrazinecarbamylhydrazine results in decreased activity of AOC3 protein10406932|1154364
D060729Coal AshCoal Ash results in decreased expression of AOC3 mRNA19000753
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of AOC3 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of AOC3 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of AOC3 mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of AOC3 mRNA25562108
D003907DexamethasoneDexamethasone results in increased expression of AOC3 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AOC3 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of AOC3 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of AOC3 mRNA27392435
D004008DiclofenacDiclofenac results in decreased expression of AOC3 mRNA26934552
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of AOC3 mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of AOC3 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of AOC3 mRNA25016146
D002117CalcitriolCalcitriol results in increased expression of AOC3 mRNA26485663
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in decreased expression of AOC3 mRNA"27840820
D0198131,2-Dimethylhydrazine"APC protein affects the reaction [1,2-Dimethylhydrazine results in decreased expression of AOC3 mRNA]"27840820
C024629dimethyl phthalatedimethyl phthalate affects the expression of AOC3 mRNA26924002
D004237DiuronDiuron results in decreased expression of AOC3 mRNA25152437
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of AOC3 intron27776689
D005557FormaldehydeAOC3 protein affects the metabolism of Formaldehyde15128865
D005557FormaldehydeFormaldehyde results in increased expression of AOC3 mRNA23649840
C039281furanfuran results in increased expression of AOC3 mRNA27387713
D017313FenretinideFenretinide results in decreased expression of AOC3 mRNA28973697
D006861Hydrogen PeroxideAOC3 protein results in increased chemical synthesis of Hydrogen Peroxide16081681
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AOC3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AOC3 mRNA28628672
D007545IsoproterenolIsoproterenol results in increased expression of AOC3 mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of AOC3 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of AOC3 mRNA27392435
D008055Lipids[Methotrexate analog binds to Lipids] which results in decreased expression of AOC3 mRNA24065615
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of AOC3 mRNA"24972896
D008727Methotrexate[Methotrexate analog binds to Lipids] which results in decreased expression of AOC3 mRNA24065615
C027451methylamineAOC3 protein results in decreased amination of methylamine15128865
C027451methylaminemofegiline inhibits the reaction [AOC3 protein results in decreased amination of methylamine]15128865
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of AOC3 mRNA23649840
D015735MifepristoneMifepristone results in decreased expression of AOC3 mRNA25972201
C058000mofegilinemofegiline inhibits the reaction [AOC3 protein results in decreased amination of methylamine]15128865
C058000mofegilinemofegiline results in decreased activity of AOC3 protein15128865
D009002MonomethylhydrazineMonomethylhydrazine results in decreased activity of AOC3 protein8583353
C517284monomethyl phthalatemonomethyl phthalate affects the expression of AOC3 mRNA26924002
C506836N'-(2-phenylallyl)hydrazineN'-(2-phenylallyl)hydrazine results in decreased activity of AOC3 protein16081681
D009532NickelNickel results in decreased expression of AOC3 mRNA25583101
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of AOC3 mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of AOC3 mRNA27935865
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of AOC3 mRNA20971185
C025589ochratoxin Aochratoxin A results in increased expression of AOC3 mRNA22124623
C025589ochratoxin Aochratoxin A results in increased expression of AOC3 mRNA22124623
D010100OxygenOxygen results in decreased expression of AOC3 mRNA22911455
D000073878Palm OilPalm Oil results in decreased expression of AOC3 mRNA18042831
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of AOC3 mRNA27935865
D011344ProcarbazineProcarbazine results in decreased activity of AOC3 protein8583353
D011374ProgesteroneProgesterone results in decreased expression of AOC3 mRNA19693291
C005556propionaldehydepropionaldehyde results in increased expression of AOC3 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of AOC3 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of AOC3 mRNA15309432|2163298
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of AOC3 mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in increased expression of AOC3 mRNA25351596
D012906SmokeSmoke affects the expression of AOC3 mRNA23693141
D053260SootSoot results in decreased expression of AOC3 mRNA26551751
D013739TestosteroneTestosterone results in increased expression of AOC3 mRNA19693291
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AOC3 mRNA21570461
C009495titanium dioxidetitanium dioxide results in decreased expression of AOC3 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of AOC3 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of AOC3 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of AOC3 mRNA28111298
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of AOC3 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of AOC3 mRNA12732648
C057693troglitazone[troglitazone co-treated with TNF protein] results in decreased expression of AOC3 mRNA12732648
D014639VanadiumVanadium results in decreased expression of AOC3 mRNA19000753
D001335Vehicle EmissionsVehicle Emissions affects the methylation of AOC3 gene25560391
C025643vinclozolinvinclozolin affects the expression of AOC3 mRNA19015723
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of AOC3 mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005507copper ion binding-IBA21873635  
GO:0005507copper ion binding-IDA19764817  
GO:0005509calcium ion binding-IDA19764817  
GO:0005515protein binding-IPI23349812  
GO:0008131primary amine oxidase activity-IBA21873635  
GO:0008131primary amine oxidase activity-IDA9653080  19764817  23349812  23474851  
GO:0008131primary amine oxidase activityNOTIDA23349812  
GO:0008131primary amine oxidase activity-TAS-  
GO:0042803protein homodimerization activity-TAS9653080  
GO:0046982protein heterodimerization activity-IPI23349812  
GO:0048038quinone binding-IDA9653080  
GO:0052593tryptamine:oxygen oxidoreductase (deaminating) activity-IEA-  
GO:0052594aminoacetone:oxygen oxidoreductase(deaminating) activity-IEA-  
GO:0052595aliphatic-amine oxidase activity-IEA-  
GO:0052596phenethylamine:oxygen oxidoreductase (deaminating) activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006805xenobiotic metabolic process-TAS-  
GO:0006954inflammatory response-TAS9653080  
GO:0007155cell adhesion-IDA9653080  
GO:0009308amine metabolic process-IBA21873635  
GO:0009308amine metabolic process-IDA9653080  
GO:0046677response to antibiotic-IBA21873635  
GO:0046677response to antibiotic-IDA19764817  
GO:0055114oxidation-reduction process-IEA-  
GO:1902283negative regulation of primary amine oxidase activity-IBA21873635  
GO:1902283negative regulation of primary amine oxidase activity-IDA23349812  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA23349812  
GO:0005769early endosome-IBA21873635  
GO:0005769early endosome-IDA23474851  
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005783endoplasmic reticulum-IDA23474851  
GO:0005794Golgi apparatus-IBA21873635  
GO:0005794Golgi apparatus-IDA23474851  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA9653080  
GO:0005886plasma membrane-TAS-  
GO:0005902microvillus-IDA23349812  
GO:0009986cell surface-IDA9653080  23349812  
GO:0016021integral component of membrane-IDA9653080  
KEGG ID KEGG Term
hsa00260Glycine, serine and threonine metabolism
hsa00350Tyrosine metabolism
hsa00360Phenylalanine metabolism
hsa00410beta-Alanine metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27378943Copper Deficiency in the Lungs of TNF-alpha Transgenic Mice. (2016)Liu LFront Physiol
25541553Adiposity is associated with DNA methylation profile in adipose tissue. (2015 Aug)Agha GInt J Epidemiol