Gene: NCOA1

8648
F-SRC-1|KAT13A|RIP160|SRC1|bHLHe42|bHLHe74
nuclear receptor coactivator 1
protein-coding
2p23.3
Ensembl:ENSG00000084676 MIM:602691 Vega:OTTHUMG00000125523 UniprotKB:Q15788
NG_029014.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.941e-1 (AD)  6.234e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KPNB10.928
ADNP0.926
SON0.926
RBBP40.921
JAK10.919
ARHGEF120.918
KDM3B0.911
CRKL0.911
SEC24B0.911
HP1BP30.91

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.74
OR4F29-0.704
NANOGNB-0.246
TNFRSF13B-0.222
C5orf64-0.197
SH2D1A-0.188
ANXA13-0.187
CTNNA3-0.185
OR6C74-0.184
FXYD4-0.183

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01645GenisteinSmall Molecule446-72-0InvestigationalTarget
DB04652CorticosteroneSmall Molecule50-22-6ExperimentalTarget
DB068322-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OLSmall MoleculeExperimentalTarget
DB068753-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXY-1-NAPHTHONITRILESmall MoleculeExperimentalTarget
DB06908(2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACIDSmall MoleculeExperimentalTarget
DB06927[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILESmall MoleculeExperimentalTarget
DB070092-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OLSmall MoleculeExperimentalTarget
DB07080N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDESmall MoleculeExperimentalTarget
DB071191-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOLSmall MoleculeExperimentalTarget
DB071504-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIMESmall MoleculeExperimentalTarget
DB071985-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILESmall MoleculeExperimentalTarget
DB072152-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACIDSmall MoleculeExperimentalTarget
DB072303-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONESmall MoleculeExperimentalTarget
DB072363-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OLSmall MoleculeExperimentalTarget
DB07530(1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diolSmall MoleculeExperimentalTarget
DB07557(5BETA)-PREGNANE-3,20-DIONESmall MoleculeExperimentalTarget
DB07724IndeglitazarSmall Molecule835619-41-5ExperimentalTarget
DB08220(8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acidSmall MoleculeExperimentalTarget
DB08231Myristic acidSmall Molecule544-63-8ExperimentalTarget
DB087421,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z)Small MoleculeExperimentalTarget
DB08915AleglitazarSmall Molecule475479-34-6InvestigationalTarget
ID Drug Name Action PubMed
C5244781,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole"1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [NCOA1 protein binds to CYP11A1 gene]]"18511507
C5244781,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole"1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [NCOA1 protein binds to HSD3B gene]]"18511507
C5244781,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole"1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to NCOA1 protein]]]"18511507
C5244781,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole"1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to NCOA1 protein]]"18511507
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with alitretinoin] promotes the reaction [[NR1I3 protein binds to RXRA protein] which binds to NCOA1 protein]"17223708
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[NR1I3 protein binds to RXRA protein] which binds to NCOA1 protein]"17223708
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Androstenedione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]]"18692084
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NR1I3 protein binds to NCOA1 protein]"15272053|1869208
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]"18973326
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of NCOA1 mRNA"25565004
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"NCOA1 protein promotes the reaction [2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of ESR2 protein]"27634370
C1040062',3',4',5'-tetrachloro-4-biphenylol"2',3',4',5'-tetrachloro-4-biphenylol promotes the reaction [ESR2 protein binds to NCOA1 protein]"10964929
C0388902,3,4,7,8-pentachlorodibenzofuran"2,3,4,7,8-pentachlorodibenzofuran promotes the reaction [NCOA1 protein binds to CYP1B1 promoter]"21703235
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran promotes the reaction [NCOA1 protein binds to CYP1B1 promoter]"21703235
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of NCOA1 mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of NCOA1 mRNA"21346803
C0149532-acetyltributylcitrate2-acetyltributylcitrate promotes the reaction [NCOA1 protein binds to NR1I2 protein]21742782
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NCOA1 mRNA"28973690
C5113033-benzylidene camphor3-benzylidene camphor affects the expression of NCOA1 mRNA19150460
C5495433-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid analog results in decreased expression of NCOA1 mRNA25716159
C0414773-hydroxyflavone3-hydroxyflavone promotes the reaction [NCOA1 protein binds to NR1I2 protein]26238175
C5830744,4'-hexafluorisopropylidene diphenol"[4,4'-hexafluorisopropylidene diphenol binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NCOA1 protein modified form]"28751236
C5830744,4'-hexafluorisopropylidene diphenol"NCOA1 protein promotes the reaction [4,4'-hexafluorisopropylidene diphenol results in increased expression of ESR2 protein]"27634370
C1052604-tert-octylphenol4-tert-octylphenol promotes the reaction [ESR1 protein binds to NCOA1 protein]10964929
C1052604-tert-octylphenol4-tert-octylphenol promotes the reaction [ESR2 protein binds to NCOA1 protein]10964929
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [NCOA1 protein binds to and results in increased activity of NR1H3 protein]"27551952
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [NCOA1 protein binds to NR1I3 protein]"28289823
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]"21924250
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"21768169
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [NR1I3 protein binds to NCOA1 protein]"23015691
D000082AcetaminophenAcetaminophen results in increased expression of NCOA1 mRNA22230336
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of NCOA1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NCOA1 mRNA]17585979
C016601afimoxifeneafimoxifene inhibits the reaction [ESRRG protein binds to NCOA1 protein]11447273
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of NCOA1 mRNA22100608
C430898AGN 194204AGN 194204 inhibits the reaction [NCOA1 protein binds to EGFR promoter]21080969
C430898AGN 194204NCOA1 affects the susceptibility to AGN 19420421080969
C430898AGN 194204NCOA1 protein inhibits the reaction [AGN 194204 results in decreased expression of CDK1 protein]21080969
C430898AGN 194204NCOA1 protein inhibits the reaction [AGN 194204 results in decreased expression of CDK4 protein]21080969
C430898AGN 194204NCOA1 protein inhibits the reaction [AGN 194204 results in decreased expression of EGFR protein]21080969
C430898AGN 194204NCOA1 protein inhibits the reaction [AGN 194204 results in decreased expression of MAPK3 protein]21080969
C430898AGN 194204NCOA1 protein inhibits the reaction [AGN 194204 results in decreased expression of MYC protein]21080969
C430898AGN 194204NCOA1 affects the susceptibility to AGN 19420421080969
D000450Aldosterone[Aldosterone binds to NR3C2 protein] which binds to NCOA1 protein alternative form15761029
C008088alfacalcidolalfacalcidol promotes the reaction [[VDR protein binds to RXRA protein] which binds to NCOA1 protein modified form]20947021
C103303alitretinoin"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with alitretinoin] promotes the reaction [[NR1I3 protein binds to RXRA protein] which binds to NCOA1 protein]"17223708
C103303alitretinoin[alitretinoin co-treated with NCOA1 protein] results in increased activity of RXRB protein22227104
C103303alitretinoinalitretinoin promotes the reaction [[NR1I3 protein binds to RXRA protein] which binds to NCOA1 protein]17223708
D013196DihydrotestosteroneDihydrotestosterone promotes the reaction [NCOA1 protein binds to KLK3 promoter]16648561
D013196Dihydrotestosteronemethylselenic acid inhibits the reaction [Dihydrotestosterone promotes the reaction [NCOA1 protein binds to KLK3 promoter]]16648561
D013196DihydrotestosteroneNCOA1 protein promotes the reaction [Dihydrotestosterone results in increased expression of AR mRNA]16877366
D013196DihydrotestosteroneNCOA1 protein results in increased activity of [Dihydrotestosterone binds to AR protein]17804755
C000658androstan-3-olandrostan-3-ol inhibits the reaction [NR1I3 protein binds to NCOA1 protein]23015691
C000658androstan-3-olandrostan-3-ol promotes the reaction [NR1I2 protein binds to NCOA1 protein]15833898
D000735Androstenedione"1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Androstenedione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]]"18692084
D000735AndrostenedioneAndrostenedione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]18692084
D000735Androstenedioneisopimpinellin inhibits the reaction [Androstenedione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]]18692084
D000737AndrostenolsAndrostenols inhibits the reaction [NR1I3 protein binds to NCOA1 protein]23015691
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of NCOA1 mRNA"17331233
D001280AtrazineAtrazine results in decreased expression of NCOA1 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NCOA1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NCOA1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NCOA1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NCOA1 mRNA"19150397
D004958EstradiolESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA1 protein binds to H19 gene]]17962382
D004958EstradiolESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA1 protein binds to LLGL2 gene]]17962382
D004958EstradiolESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA1 protein binds to TMEM121B gene]]17962382
D004958EstradiolESR2 protein affects the reaction [Estradiol promotes the reaction [NCOA1 protein binds to NKD1 gene]]17962382
D004958EstradiolEstradiol analog promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]23383871
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of NCOA1 mRNA20404318
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of NCOA1 mRNA19619570
D004958Estradiol"Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"21768169
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]10964929|1681950
D004958EstradiolEstradiol promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]23383871
D004958EstradiolEstradiol promotes the reaction [ESR2 protein binds to NCOA1 protein]10964929
D004958EstradiolEstradiol promotes the reaction [NCOA1 protein binds to BRCA1 promoter]16489025
D004958EstradiolEstradiol promotes the reaction [NCOA1 protein binds to CTSD promoter]27366082
D004958EstradiolEstradiol promotes the reaction [NCOA1 protein binds to ESR1 protein]17135255|2715612
D004958EstradiolEstradiol promotes the reaction [NCOA1 protein binds to ESR2 protein]17135255
D004958EstradiolEstradiol promotes the reaction [NCOA1 protein binds to HOXA10 promoter]15236964
D004958EstradiolEstradiol promotes the reaction [NCOA1 protein binds to IGF1 promoter]17872375
D004958EstradiolEstradiol promotes the reaction [NCOA1 protein binds to TFF1 promoter]19838210
D004958EstradiolEstradiol promotes the reaction [NR1I2 protein binds to NCOA1 protein]15650019
D004958EstradiolEstradiol results in decreased expression of NCOA1 mRNA19167446|1961957
D004958EstradiolEstradiol results in increased expression of NCOA1 mRNA19432593
D004958Estradiol[NCOA1 protein binds to ESR1 protein] which results in increased susceptibility to Estradiol20332105
D004958Estradiol"[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"21768169
D004958EstradiolTetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [NCOA1 protein binds to BRCA1 promoter]]16489025
D004958EstradiolEstradiol affects the localization of NCOA1 protein17556502
D004958EstradiolEstradiol promotes the reaction [NR1I3 protein binds to NCOA1 protein]23015691
D004958EstradiolNCOA1 protein promotes the reaction [Estradiol results in increased expression of ESR2 protein]27634370
D004958EstradiolNCOA1 protein promotes the reaction [Estradiol results in increased expression of ESR2 protein alternative form]27634370
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]19460436
D004958Estradiolormeloxifene inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]]19460436
D004958EstradiolTamoxifen inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]]19460436
D004958EstradiolEstradiol promotes the reaction [NCOA1 protein binds to ESR1 protein]17910454
D001629BezafibrateBezafibrate promotes the reaction [PPARA protein binds to NCOA1 protein]19263263
C053541bicalutamidebicalutamide inhibits the reaction [AR protein binds to NCOA1 protein]11981028
C004541biochanin Abiochanin A promotes the reaction [RORC protein binds to NCOA1 protein]25583575
C006780bisphenol A[bisphenol A binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NCOA1 protein modified form]28751236
C006780bisphenol Abisphenol A inhibits the reaction [[Triiodothyronine co-treated with NCOA1 protein] results in increased activity of THRB protein]22227104
C006780bisphenol Abisphenol A promotes the reaction [ESR1 protein binds to NCOA1 protein]10964929
C006780bisphenol Abisphenol A promotes the reaction [ESR2 protein binds to NCOA1 protein]10964929
C006780bisphenol Abisphenol A promotes the reaction [NCOA1 protein binds to and results in increased activity of NR1I2 protein]22214767
C006780bisphenol Abisphenol A promotes the reaction [NCOA1 protein binds to CTSD promoter]27366082
C006780bisphenol Abisphenol A promotes the reaction [NCOA1 protein binds to ESR1 protein]27156127
C006780bisphenol Abisphenol A promotes the reaction [NCOA1 protein binds to NR1I2 protein]11581012
C006780bisphenol Abisphenol A promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]11581012
C006780bisphenol Abisphenol A results in decreased expression of NCOA1 mRNA25912373
C006780bisphenol Abisphenol A results in decreased expression of NCOA1 mRNA22687993
C006780bisphenol Abisphenol A results in increased expression of NCOA1 mRNA17412439
C006780bisphenol Abisphenol A results in increased expression of NCOA1 protein17412439
C006780bisphenol ANCOA1 protein promotes the reaction [bisphenol A results in increased expression of ESR2 protein]27634370
C006780bisphenol Abisphenol A affects the expression of NCOA1 mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of NCOA1 protein19379760|2362020
C006780bisphenol Abisphenol A results in increased expression of NCOA1 protein19590682
C004605butambenbutamben promotes the reaction [NR1I2.L protein binds to NCOA1 protein]12198127
C004605butambenbutamben promotes the reaction [NR1I2.S protein binds to NCOA1 protein]12198127
C018475butyraldehydebutyraldehyde results in decreased expression of NCOA1 mRNA26079696
D002635Chenodeoxycholic AcidChenodeoxycholic Acid analog promotes the reaction [NR1H4 protein binds to NCOA1 protein]13130122
D002635Chenodeoxycholic AcidChenodeoxycholic Acid promotes the reaction [NR1H4 protein binds to NCOA1 protein]13130122|1468475
D002635Chenodeoxycholic AcidKetoconazole inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein binds to NCOA1 protein]]16819505
D002635Chenodeoxycholic AcidChenodeoxycholic Acid promotes the reaction [NR1H4 protein binds to NCOA1 protein]15307955
C039671ciglitazoneciglitazone inhibits the reaction [NCOA1 protein binds to EGFR promoter]21080969
C039671ciglitazoneNCOA1 affects the susceptibility to ciglitazone21080969
C039671ciglitazoneNCOA1 protein inhibits the reaction [ciglitazone results in decreased expression of CDK1 protein]21080969
C039671ciglitazoneNCOA1 protein inhibits the reaction [ciglitazone results in decreased expression of CDK4 protein]21080969
C039671ciglitazoneNCOA1 protein inhibits the reaction [ciglitazone results in decreased expression of EGFR protein]21080969
C039671ciglitazoneNCOA1 protein inhibits the reaction [ciglitazone results in decreased expression of MAPK3 protein]21080969
C039671ciglitazoneNCOA1 protein inhibits the reaction [ciglitazone results in decreased expression of MYC protein]21080969
C039671ciglitazoneNCOA1 affects the susceptibility to ciglitazone21080969
D002994ClofibrateClofibrate inhibits the reaction [NCOA1 protein binds to EGFR promoter]21080969
D002994ClofibrateNCOA1 affects the susceptibility to Clofibrate21080969
D002994ClofibrateNCOA1 protein inhibits the reaction [Clofibrate results in decreased expression of CDK1 protein]21080969
D002994ClofibrateNCOA1 protein inhibits the reaction [Clofibrate results in decreased expression of CDK4 protein]21080969
D002994ClofibrateNCOA1 protein inhibits the reaction [Clofibrate results in decreased expression of EGFR protein]21080969
D002994ClofibrateNCOA1 protein inhibits the reaction [Clofibrate results in decreased expression of MAPK3 protein]21080969
D002994ClofibrateNCOA1 protein inhibits the reaction [Clofibrate results in decreased expression of MYC protein]21080969
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of NCOA1 mRNA17585979
D002994ClofibrateNCOA1 affects the susceptibility to Clofibrate21080969
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NCOA1 mRNA]17585979
D003022ClotrimazoleClotrimazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]17998298
D003022ClotrimazoleClotrimazole promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]21924250
D003022ClotrimazoleClotrimazole promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]18973326
D003345CorticosteroneCorticosterone promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]11581012
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of NCOA1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of NCOA1 mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of NCOA1 mRNA19167446
D003474CurcuminCurcumin promotes the reaction [VDR protein binds to NCOA1 protein]20153625
D016572CyclosporineCyclosporine results in increased expression of NCOA1 mRNA19770486
C017160cypermethrincypermethrin inhibits the reaction [AR protein binds to NCOA1 protein]22664485
D017373Cyproterone AcetateNCOA1 protein results in increased activity of [Cyproterone Acetate binds to AR protein]17804755
D003840Deoxycholic AcidDeoxycholic Acid metabolite promotes the reaction [NR1I2 protein binds to NCOA1 protein]27871908
D003907Dexamethasone[Dexamethasone co-treated with NCOA1 protein] results in increased activity of NR3C1 protein22227104
D003907DexamethasoneDexamethasone results in increased expression of NCOA1 mRNA19022236
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]11581012
D004054DiethylstilbestrolDiethylstilbestrol promotes the reaction [ESR1 protein binds to NCOA1 protein]10964929
D004054DiethylstilbestrolDiethylstilbestrol promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]23383871
D004054DiethylstilbestrolDiethylstilbestrol promotes the reaction [ESR2 protein binds to NCOA1 protein]10964929
D004054DiethylstilbestrolDiethylstilbestrol promotes the reaction [NCOA1 protein binds to HOXA10 promoter]15236964
D004054DiethylstilbestrolDiethylstilbestrol promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]21924250
D002117CalcitriolCalcitriol promotes the reaction [NCOA1 protein binds to CYP24A1 promoter]21917910
D002117CalcitriolCalcitriol promotes the reaction [NCOA1 protein binds to VDRALPHA protein]25279795
D002117CalcitriolCalcitriol promotes the reaction [NCOA1 protein binds to VDRA protein]25279795
D002117CalcitriolCalcitriol promotes the reaction [NCOA1 protein binds to VDRB protein]25279795
D002117CalcitriolCalcitriol promotes the reaction [NCOA1 protein binds to VDR protein]25279795
D002117CalcitriolCalcitriol promotes the reaction [VDR protein binds to NCOA1 protein]15489543|1557859
D002117CalcitriolNCOA1 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein binds to and results in increased activity of VDRALPHA protein]]25279795
D002117CalcitriolNCOA1 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein binds to and results in increased activity of VDRA protein]]25279795
D002117CalcitriolNCOA1 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein binds to and results in increased activity of VDRB protein]]25279795
D002117CalcitriolNCOA1 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein binds to and results in increased activity of VDR protein]]25279795
D002117CalcitriolNCOA1 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein mutant form binds to VDRALPHA protein]]25279795
D002117CalcitriolNCOA1 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein mutant form binds to VDRA protein]]25279795
D002117CalcitriolNCOA1 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein mutant form binds to VDRB protein]]25279795
D002117CalcitriolNCOA1 protein promotes the reaction [Calcitriol promotes the reaction [VDR protein binds to HNF4A protein]]20371703
D002117CalcitriolNCOA1 protein results in increased susceptibility to Calcitriol25279795
D002117CalcitriolRXRA protein inhibits the reaction [Calcitriol promotes the reaction [NCOA1 protein binds to VDRALPHA protein]]25279795
D002117CalcitriolRXRA protein inhibits the reaction [Calcitriol promotes the reaction [NCOA1 protein binds to VDRA protein]]25279795
D002117CalcitriolRXRA protein promotes the reaction [Calcitriol promotes the reaction [NCOA1 protein binds to VDRB protein]]25279795
D002117CalcitriolRXRA protein promotes the reaction [Calcitriol promotes the reaction [NCOA1 protein binds to VDR protein]]25279795
D002117CalcitriolCalcitriol affects the localization of NCOA1 protein15647825
D002117CalcitriolCalcitriol promotes the reaction [NCOA1 protein binds to CYP24A1 promoter]15647825
D002117CalcitriolCalcitriol promotes the reaction [NCOA1 protein binds to SPP1 promoter]15647825
C118756dihydroxy-vitamin D3dihydroxy-vitamin D3 promotes the reaction [[VDR protein binds to RXRA protein] which binds to NCOA1 protein modified form]20947021
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of NCOA1 mRNA27638505
D004237DiuronDiuron results in decreased expression of NCOA1 mRNA21551480
D004464EconazoleEconazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]17998298
C547512eldecalcitoleldecalcitol promotes the reaction [[VDR protein binds to RXRA protein] which binds to NCOA1 protein modified form]20947021
D004726EndosulfanEndosulfan results in decreased expression of NCOA1 protein25486513
C038939enzacameneenzacamene results in increased expression of NCOA1 mRNA19150460
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of NCOA1 mRNA22079256
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NCOA1 mRNA22079256
D004970EstroneEstrone promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]23383871
D004970EstroneEstrone promotes the reaction [NR1I3 protein binds to NCOA1 protein]23015691
D004997Ethinyl EstradiolEthinyl Estradiol analog promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]23383871
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NCOA1 mRNA16183386
C000611514ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate"ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate inhibits the reaction [NCOA1 protein binds to NR1I3 protein]"28289823
C000611514ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate"ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate promotes the reaction [NCOA1 protein binds to NR1I2 protein]"28289823
C070081fulvestrantfulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [NCOA1 protein binds to CYP11A1 gene]]18511507
C070081fulvestrantfulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [NCOA1 protein binds to HSD3B gene]]18511507
C070081fulvestrantfulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to NCOA1 protein]]]18511507
C070081fulvestrantfulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to NCOA1 protein]]18511507
C037032galangingalangin promotes the reaction [NCOA1 protein binds to NR1I2 protein]26238175
D019833GenisteinGenistein promotes the reaction [ESR1 protein binds to NCOA1 protein]10964929
D019833GenisteinGenistein promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]23383871
D019833GenisteinGenistein promotes the reaction [ESR2 protein binds to NCOA1 protein]10964929
D019833GenisteinGenistein promotes the reaction [NCOA1 protein binds to ESR1 protein]27156127
D019833GenisteinNCOA1 protein promotes the reaction [Genistein results in increased expression of ESR2 protein]27634370
D005839GentamicinsGentamicins results in increased expression of NCOA1 mRNA22061828
C558292GSK 2324GSK 2324 promotes the reaction [NCOA1 protein binds to NR1H4 protein]21256005
C412815GW 4064GW 4064 promotes the reaction [NCOA1 protein binds to NR1H4 protein]21256005
C412815GW 4064GW 4064 promotes the reaction [NR1H4 protein binds to NCOA1 protein]14684751
C412815GW 4064GW 4064 promotes the reaction [NR1H4 protein binds to NCOA1 protein]15307955
D006589HexestrolHexestrol promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]23383871
D017313FenretinideFenretinide results in decreased expression of NCOA1 mRNA28973697
C492448ICG 001ICG 001 results in increased expression of NCOA1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NCOA1 mRNA25613284
C051890irinotecanirinotecan metabolite results in increased expression of NCOA1 mRNA15956246
C051890irinotecanirinotecan results in increased expression of NCOA1 mRNA15956246
C015304isopimpinellinisopimpinellin inhibits the reaction [Androstenedione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]]18692084
C015304isopimpinellinisopimpinellin promotes the reaction [NR1I3 protein binds to NCOA1 protein]18692084
C015304isopimpinellinisopimpinellin promotes the reaction [NR1I2 protein binds to NCOA1 protein]18692084
D007555IsoxazolesIsoxazoles analog promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]21924250
D017964ItraconazoleItraconazole promotes the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]17998298
D007654KetoconazoleKetoconazole inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein binds to NCOA1 protein]]16819505
D007654KetoconazoleKetoconazole inhibits the reaction [NR1I2 protein binds to NCOA1 protein]12072427|1799829
D007654KetoconazoleKetoconazole inhibits the reaction [Paclitaxel promotes the reaction [NR1I2 protein binds to NCOA1 protein]]16819505
D007654KetoconazoleKetoconazole inhibits the reaction [piperine promotes the reaction [NCOA1 protein binds to NR1I2 protein]]23707768
D007654KetoconazoleKetoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]16819505|1743810
D007657Ketone BodiesKetone Bodies results in increased expression of NCOA1 mRNA16807920
D007854LeadLead affects the splicing of NCOA1 mRNA28903495
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of NCOA1 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of NCOA1 mRNA16847310
D008095Lithocholic AcidLithocholic Acid promotes the reaction [VDR protein binds to NCOA1 protein]15489543|2191791
D008095Lithocholic AcidLithocholic Acid inhibits the reaction [NR1I3 protein binds to NCOA1 protein]23015691
D008095Lithocholic AcidLithocholic Acid inhibits the reaction [NR1I3 protein binds to NCOA1 protein]23015691
C502354lithocholic acid acetatelithocholic acid acetate promotes the reaction [VDR protein binds to NCOA1 protein]20371703
C502354lithocholic acid acetateNCOA1 protein promotes the reaction [lithocholic acid acetate promotes the reaction [VDR protein binds to HNF4A protein]]20371703
C115121LY 353381[LY 353381 co-treated with CCND1 protein] results in increased stability of [ESR1 protein binds to NCOA1 protein]19477949
D008468MeclizineMeclizine inhibits the reaction [NR1I3 protein binds to NCOA1 protein]15272053
D008468MeclizineMeclizine promotes the reaction [NR1I3 protein binds to NCOA1 protein]15272053
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate promotes the reaction [PGR protein binds to NCOA1 protein]15937332
D008687MetforminMetformin inhibits the reaction [NR1I2 protein binds to NCOA1 protein]21920351
D008731MethoxychlorMethoxychlor promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]21924250
D008731MethoxychlorMethoxychlor promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]18973326
D008731MethoxychlorMethoxychlor metabolite promotes the reaction [ESR1 protein binds to NCOA1 protein]14613717
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of NCOA1 mRNA26558463
C008493methylselenic acidmethylselenic acid inhibits the reaction [Dihydrotestosterone promotes the reaction [NCOA1 protein binds to KLK3 promoter]]16648561
D008777MethyltestosteroneMethyltestosterone promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]23383871
D015741Metribolone[Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA1 protein modified form]28751236
D015741MetriboloneMetribolone inhibits the reaction [NCOA1 protein results in increased activity of AR protein]11981028
D008825MiconazoleMiconazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]17998298
D008825MiconazoleMiconazole promotes the reaction [Rifampin results in increased expression of NCOA1 mRNA]17998298
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate promotes the reaction [NCOA1 protein binds to and results in increased activity of NR1H2 protein]27551952
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate promotes the reaction [NCOA1 protein binds to and results in increased activity of NR1H3 protein]27551952
C471400monoisononylphthalatemonoisononylphthalate promotes the reaction [NCOA1 protein binds to and results in increased activity of NR1H2 protein]27551952
C471400monoisononylphthalatemonoisononylphthalate promotes the reaction [NCOA1 protein binds to and results in increased activity of NR1H3 protein]27551952
D009151Mustard GasMustard Gas results in decreased expression of NCOA1 mRNA26392148
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NCOA1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NCOA1 mRNA"25554681
D009281NaphthalenesNaphthalenes analog promotes the reaction [NCOA1 protein binds to NR1H4 protein]21256005
C025256nonylphenolnonylphenol promotes the reaction [NCOA1 protein binds to CTSD promoter]27366082
C025256nonylphenolnonylphenol promotes the reaction [NCOA1 protein binds to NR1I2 protein]10707959
D019787Linoleic AcidLinoleic Acid promotes the reaction [PPARA protein binds to NCOA1 protein]19263263
D009853OmeprazoleOmeprazole promotes the reaction [NCOA1 protein binds to CYP1A1 promoter]21703235
D009853OmeprazoleOmeprazole promotes the reaction [NCOA1 protein binds to CYP1B1 promoter]21703235
C016340o,p'-DDT"o,p'-DDT promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]"21924250
C508548ormeloxifeneormeloxifene inhibits the reaction [ESR2 protein binds to NCOA1 protein]19460436
C508548ormeloxifeneormeloxifene inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]]19460436
D008939MitotaneMitotane promotes the reaction [NCOA1 protein binds to NR1I2 protein]23179081
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of NCOA1 mRNA25729387
C022155oxiconazoleoxiconazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]17998298
C022155oxiconazoleoxiconazole promotes the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]17998298
C022155oxiconazoleRifampin inhibits the reaction [oxiconazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]]17998298
D017239PaclitaxelKetoconazole inhibits the reaction [Paclitaxel promotes the reaction [NR1I2 protein binds to NCOA1 protein]]16819505
D017239PaclitaxelPaclitaxel promotes the reaction [NR1I2 protein binds to NCOA1 protein]16819505
D026023PermethrinPermethrin promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]21924250
D010672PhenytoinPhenytoin promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]21924250
C032279phthalic acidphthalic acid promotes the reaction [NR1I2 protein binds to NCOA1 protein]15650019
C032279phthalic acidphthalic acid promotes the reaction [NCOA1 protein binds to NR1I2 protein]10707959
C008922piperineKetoconazole inhibits the reaction [piperine promotes the reaction [NCOA1 protein binds to NR1I2 protein]]23707768
C008922piperinepiperine promotes the reaction [NCOA1 protein binds to NR1I2 protein]23707768
C006253pirinixic acidpirinixic acid promotes the reaction [NCOA1 protein binds to and results in increased activity of PPARA protein]27551952
C006253pirinixic acidpirinixic acid promotes the reaction [PPARA protein binds to NCOA1 protein]19263263
C037850PK 11195PK 11195 inhibits the reaction [NR1I3 protein binds to NCOA1 protein]23665929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NCOA1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of NCOA1 mRNA22079256
C023617pregna-4,17-diene-3,16-dione"pregna-4,17-diene-3,16-dione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]"15833898
C023617pregna-4,17-diene-3,16-dione"pregna-4,17-diene-3,16-dione promotes the reaction [NR1I2 protein binds to NCOA1 protein]"15833898
C023617pregna-4,17-diene-3,16-dione"pregna-4,17-diene-3,16-dione promotes the reaction [NR1I2 protein binds to NCOA1 protein]"15075359
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to NCOA1 protein]18692084
D011374ProgesteroneProgesterone results in increased expression of NCOA1 mRNA23012394
D011374Progesterone"[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"21768169
D011374Progesterone"Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]"21768169
D011374ProgesteroneProgesterone results in increased expression of NCOA1 protein17556502
D011374ProgesteroneProgesterone promotes the reaction [NCOA1 protein binds to NR1I2 protein]10707959
D011794QuercetinQuercetin results in decreased expression of NCOA1 mRNA15309432
D011804QuinolinesQuinolines analog promotes the reaction [NCOA1 protein binds to NR1H4 protein]21256005
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NCOA1 mRNA19059307
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride promotes the reaction [NCOA1 protein binds to IGF1 promoter]17872375
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of NCOA1 mRNA19432593
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of NCOA1 mRNA19167446
C059514resveratrolresveratrol inhibits the reaction [ESR1 protein binds to NCOA1 protein]24771768
D012293RifampinItraconazole promotes the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]17998298
D012293RifampinKetoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]16819505|1743810
D012293RifampinMiconazole promotes the reaction [Rifampin results in increased expression of NCOA1 mRNA]17998298
D012293RifampinNCOA1 protein inhibits the reaction [[NR1I2 protein co-treated with Rifampin] results in decreased expression of SLC22A1 mRNA]26920453
D012293RifampinNCOA1 protein inhibits the reaction [[NR1I2 protein results in increased susceptibility to Rifampin] which results in decreased expression of SLC22A1 mRNA]26920453
D012293Rifampinoxiconazole promotes the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]17998298
D012293RifampinRifampin inhibits the reaction [NCOA1 protein binds to SLC22A1 promoter]26920453
D012293RifampinRifampin inhibits the reaction [oxiconazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]]17998298
D012293RifampinRifampin promotes the reaction [NCOA1 protein binds to and results in increased activity of NR1I2 protein]22214767
D012293RifampinRifampin promotes the reaction [NCOA1 protein binds to HNF4A protein]21292004
D012293RifampinRifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]11581012|2828982
D012293RifampinRifampin promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]11581012
D012293RifampinRifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]12072427|1681950
D012293RifampinRifampin promotes the reaction [[NR1I2 protein binds to NCOA1 protein] which binds to CYP27A1 gene]17088262
C057006Ro 21-5104Ro 21-5104 promotes the reaction [NR1I2 protein binds to NCOA1 protein]25313206
C089730rosiglitazone[rosiglitazone binds to PPARG protein] which affects the localization of NCOA1 protein10871190
D014284Triiodothyroninebisphenol A inhibits the reaction [[Triiodothyronine co-treated with NCOA1 protein] results in increased activity of THRB protein]22227104
D014284Triiodothyronine[Triiodothyronine co-treated with NCOA1 protein] results in increased activity of THRB protein22227104
D013629Tamoxifen[NCOA1 protein binds to ESR1 protein] which results in increased susceptibility to Tamoxifen20332105
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of NCOA1 mRNA19059307
D013629TamoxifenTamoxifen inhibits the reaction [ESR1 protein binds to NCOA1 protein]23665804
D013629TamoxifenTamoxifen results in increased expression of NCOA1 mRNA19432593|2033231
D013629TamoxifenTamoxifen inhibits the reaction [ESR2 protein binds to NCOA1 protein]19460436
D013629TamoxifenTamoxifen inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]]19460436
C503890tanoprogettanoproget promotes the reaction [PGR protein binds to NCOA1 protein]15937332
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of NCOA1 mRNA20189893
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of NCOA1 mRNA19619570
D013749TetrachlorodibenzodioxinNCOA1 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]]12024042
D013749TetrachlorodibenzodioxinNCOA1 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]12024042
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [NCOA1 protein binds to BRCA1 promoter]]16489025
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [NCOA1 protein binds to CYP1A1 enhancer]12024042|1884262
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [NCOA1 protein binds to CYP1A1 promoter]18842620|2170323
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [NCOA1 protein binds to CYP1B1 enhancer]18842620
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [NCOA1 protein binds to CYP1B1 promoter]18842620|2170323
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NCOA1 mRNA19619570
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NCOA1 mRNA25613284
C423915TO-901317TO-901317 inhibits the reaction [NR1I3 protein binds to NCOA1 protein]23665929
C423915TO-901317TO-901317 promotes the reaction [NCOA1 protein binds to and results in increased activity of NR1I2 protein]27551952
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of NCOA1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of NCOA1 mRNA25729387
D014212TretinoinTretinoin promotes the reaction [RARA protein binds to NCOA1 protein]15578590
D014212TretinoinNCOA1 protein affects the reaction [Tretinoin results in increased expression of RARB mRNA alternative form]16723356
D014212TretinoinNCOA1 protein affects the susceptibility to Tretinoin16723356
C050319trimegestonetrimegestone promotes the reaction [PGR protein binds to NCOA1 protein]15937332
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of NCOA1 mRNA"23306105
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of NCOA1 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate results in decreased expression of NCOA1 mRNA26562049
C031324tris(chloroethyl)phosphatetris(chloroethyl)phosphate results in increased expression of NCOA1 mRNA27776230
C057693troglitazoneNCOA1 protein inhibits the reaction [RXRA protein results in decreased susceptibility to troglitazone]15581905
C057693troglitazoneNCOA1 protein results in increased susceptibility to troglitazone15581905
C057693troglitazoneRXRA protein inhibits the reaction [NCOA1 protein results in increased susceptibility to troglitazone]15581905
C057693troglitazone[troglitazone binds to PPARG protein] which affects the localization of NCOA1 protein10871190
C057693troglitazonetroglitazone promotes the reaction [NCOA1 protein binds to and results in increased activity of PPARG protein]27551952
C057693troglitazonetroglitazone results in decreased expression of NCOA1 mRNA28973697
D014520UrethaneUrethane results in increased expression of NCOA1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of NCOA1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of NCOA1 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of NCOA1 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of NCOA1 mRNA26682919
D014801Vitamin AVitamin A affects the reaction [NCOA1 protein binds to PCK1 promoter]16317119
D014807Vitamin DVitamin D analog promotes the reaction [VDR protein binds to NCOA1 protein]21917910
C111237vorinostatvorinostat results in decreased expression of NCOA1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0003677DNA binding-IEA-  
GO:0003682chromatin binding-IEA-  
GO:0003713transcription coactivator activity-IDA10207113  
GO:0003713transcription coactivator activity-NAS15572661  15774904  
GO:0004402histone acetyltransferase activity-IEA-  
GO:0005515protein binding-IPI9556555  10207113  11113179  11682626  11971985  12482968  
12578355  12917342  14684751  14698205  15367689  16456540  
16606617  16957778  17254542  17363140  17476305  17627277  
17641689  17673910  18391212  19039327  19786558  20203100  
20543827  20682316  21454491  21478865  23602807  25219498  
25962847  
GO:0016922ligand-dependent nuclear receptor binding-IBA21873635  
GO:0016922ligand-dependent nuclear receptor binding-IPI17363140  18798693  
GO:0017162aryl hydrocarbon receptor binding-IPI15641800  
GO:0019899enzyme binding-IPI12039952  
GO:0030331estrogen receptor binding-IPI18563714  
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity-IBA21873635  
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity-IDA15919756  17363140  
GO:0035257nuclear hormone receptor binding-IBA21873635  
GO:0035257nuclear hormone receptor binding-IDA10207113  
GO:0046983protein dimerization activity-IEA-  
GO:0047485protein N-terminus binding-IPI12917342  
GO:0050681androgen receptor binding-NAS15572661  
GO ID GO Term Qualifier Evidence PubMed
GO:0000435positive regulation of transcription from RNA polymerase II promoter by galactose-IDA10207113  
GO:0002155regulation of thyroid hormone mediated signaling pathway-IEA-  
GO:0006351transcription, DNA-templated-IDA9223431  
GO:0015721bile acid and bile salt transport-TAS-  
GO:0019216regulation of lipid metabolic process-TAS-  
GO:0030521androgen receptor signaling pathway-NAS15572661  
GO:0032870cellular response to hormone stimulus-IBA21873635  
GO:0043065positive regulation of apoptotic process-IEA-  
GO:0043967histone H4 acetylation-IEA-  
GO:0045666positive regulation of neuron differentiation-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IDA11891224  15367689  
GO:0045893positive regulation of transcription, DNA-templated-NAS15572661  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA15919756  
GO:0045944positive regulation of transcription by RNA polymerase II-NAS15774904  
GO:0060713labyrinthine layer morphogenesis-IEA-  
GO:1904017cellular response to Thyroglobulin triiodothyronine-IEA-  
GO:2001038regulation of cellular response to drug-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA15831516  17363140  
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA-  
GO:0032991protein-containing complex-IMP15641800  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1368082RORA activates gene expressionTAS
R-HSA-1368108BMAL1:CLOCK,NPAS2 activates circadian gene expressionIEA
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-1592230Mitochondrial biogenesisTAS
R-HSA-159418Recycling of bile acids and saltsTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)TAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-192105Synthesis of bile acids and bile saltsTAS
R-HSA-193368Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterolTAS
R-HSA-193807Synthesis of bile acids and bile salts via 27-hydroxycholesterolTAS
R-HSA-194068Bile acid and bile salt metabolismTAS
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-1989781PPARA activates gene expressionIEA
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-211976Endogenous sterolsTAS
R-HSA-2151201Transcriptional activation of mitochondrial biogenesisTAS
R-HSA-2426168Activation of gene expression by SREBF (SREBP)TAS
R-HSA-3214847HATs acetylate histonesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-381340Transcriptional regulation of white adipocyte differentiationTAS
R-HSA-381340Transcriptional regulation of white adipocyte differentiationIEA
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)IEA
R-HSA-400253Circadian ClockTAS
R-HSA-400253Circadian ClockIEA
R-HSA-4839726Chromatin organizationTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-556833Metabolism of lipidsIEA
R-HSA-8939211ESR-mediated signalingTAS
R-HSA-8957322Metabolism of steroidsTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS
R-HSA-9018519Estrogen-dependent gene expressionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26202054Interaction between smoking history and gene expression levels impacts survival of breast cancer patients. (2015 Aug)Andres SABreast Cancer Res Treat