Gene: NUMB

8650
C14orf41|S171|c14_5527
NUMB, endocytic adaptor protein
protein-coding
14q24.2-q24.3
Ensembl:ENSG00000133961 MIM:603728 Vega:OTTHUMG00000171436 UniprotKB:P49757
NG_029061.2
PubMed
0   ANCO-SNPs
OD|ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.137e-2 (AD)  8.944e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEC31A0.904
DCAF50.901
DCP1A0.9
GAPVD10.896
YME1L10.893
TOP10.892
TNFAIP10.892
ASAP10.89
ZDHHC50.888
ADAR0.885

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.622
OR4F29-0.58
SOX3-0.271
CTNNA3-0.268
TNFRSF13B-0.256
KLRC2-0.25
PDE11A-0.247
PON1-0.245
C5orf64-0.244
SH2D1A-0.241

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in decreased expression of NUMB mRNA"26377693
C1053511-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene"[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of NUMB protein"23284745
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of NUMB mRNA"23829299
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of NUMB mRNA"19114083
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of NUMB mRNA"23829299
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of NUMB mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NUMB mRNA"15215175
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NUMB mRNA"28973690
D020106AcrylamideAcrylamide results in decreased expression of NUMB mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NUMB mRNA16483693
D001151ArsenicArsenic results in decreased expression of NUMB mRNA19654921
C006632arsenic trioxidearsenic trioxide results in decreased expression of NUMB mRNA19128835
C028559bathocuproine sulfonatebathocuproine sulfonate results in decreased expression of NUMB mRNA16973896
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of NUMB mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of NUMB mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NUMB mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NUMB mRNA22228805
C044887beta-methylcholinebeta-methylcholine affects the expression of NUMB mRNA21179406
C006780bisphenol Abisphenol A affects the methylation of NUMB promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of NUMB mRNA26063408
C006780bisphenol Abisphenol A affects the expression of NUMB mRNA25181051
D000069286BortezomibBortezomib results in increased expression of NUMB mRNA20977926
D000068579CelecoxibCelecoxib results in decreased expression of NUMB mRNA28201806
D003703DemecolcineDemecolcine results in increased expression of NUMB mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of NUMB mRNA21266533
D002945CisplatinCisplatin results in decreased expression of NUMB mRNA19561079
C042080diisodecyl phthalatediisodecyl phthalate results in decreased expression of NUMB mRNA25270620
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NUMB mRNA22079256
D018120FinasterideFinasteride results in increased expression of NUMB mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of NUMB mRNA20655997
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of NUMB mRNA17183730
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of NUMB protein25005833
D007213IndomethacinIndomethacin results in decreased expression of NUMB mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NUMB mRNA25613284
C017461lead nitratelead nitrate affects the reaction [NUMB affects the expression of MT1 mRNA]11891201
C017461lead nitratelead nitrate affects the reaction [NUMB affects the expression of MT2 mRNA]11891201
D008777MethyltestosteroneMethyltestosterone results in increased expression of NUMB mRNA29191790
D009532NickelNickel results in decreased expression of NUMB mRNA25583101
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of NUMB protein"25005833
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of NUMB mRNA25729387
C016030pantogabpantogab results in decreased expression of NUMB mRNA17379144
C410127PCB 180PCB 180 results in decreased expression of NUMB mRNA23829299
D010654Phenylbutyrates"[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of NUMB protein"23284745
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NUMB mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of NUMB mRNA22079256
D011441PropylthiouracilPropylthiouracil results in decreased expression of NUMB mRNA24780913
D011794QuercetinQuercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of NUMB mRNA]23117658
D018038Sodium SeleniteSodium Selenite results in increased expression of NUMB mRNA18175754
D013467SulindacSulindac results in increased expression of NUMB mRNA24136188
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of NUMB mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NUMB mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NUMB mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NUMB mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NUMB mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of NUMB mRNA25729387
D019772TopotecanTopotecan results in decreased expression of NUMB mRNA25729387
D014212Tretinoin"[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of NUMB protein"23284745
D014520UrethaneUrethane results in increased expression of NUMB mRNA28818685
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of NUMB mRNA17183730
D014750VincristineVincristine results in increased expression of NUMB mRNA23649840
D014812Vitamin KQuercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of NUMB mRNA]23117658
D014812Vitamin K[Warfarin co-treated with Vitamin K] results in increased expression of NUMB mRNA23117658
D024483Vitamin K 3Vitamin K 3 results in decreased expression of NUMB protein25005833
D014859WarfarinQuercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of NUMB mRNA]23117658
D014859Warfarin[Warfarin co-treated with Vitamin K] results in increased expression of NUMB mRNA23117658

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI9303539  18172499  23211419  24561623  
GO:0008013beta-catenin binding-IEA-  
GO:0045294alpha-catenin binding-IEA-  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0007409axonogenesis-IEA-  
GO:0021670lateral ventricle development-ISS-  
GO:0021849neuroblast division in subventricular zone-ISS-  
GO:0030335positive regulation of cell migration-IGI19581412  
GO:0030335positive regulation of cell migration-IMP19581412  
GO:0034332adherens junction organization-IEA-  
GO:0050769positive regulation of neurogenesis-ISS-  
GO:1903077negative regulation of protein localization to plasma membrane-IMP19581412  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005769early endosome-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005925focal adhesion-HDA21423176  
GO:0016323basolateral plasma membrane-IEA-  
GO:0019897extrinsic component of plasma membrane-IEA-  
GO:0030136clathrin-coated vesicle-IDA19581412  
GO:0045177apical part of cell-IEA-  
KEGG ID KEGG Term
hsa04330Notch signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-157118Signaling by NOTCHIEA
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-2122948Activated NOTCH1 Transmits Signal to the NucleusIEA
R-HSA-373760L1CAM interactionsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-437239Recycling pathway of L1TAS
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5610780Degradation of GLI1 by the proteasomeTAS
R-HSA-5610787Hedgehog 'off' stateTAS
R-HSA-5632684Hedgehog 'on' stateTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
7810463The numb arm and hand. (1995 Jan)Bracker MDAm Fam Physician
26264115Genetic variants of numb gene were associated with elevated total cholesterol level and low density lipoprotein cholesterol level in Chinese subjects, in Xinjiang, China. (2015 Aug 12)Abudoukelimu MDiagn Pathol