Gene: SOCS1

8651
CIS1|CISH1|JAB|SOCS-1|SSI-1|SSI1|TIP-3|TIP3
suppressor of cytokine signaling 1
protein-coding
16p13.13
Ensembl:ENSG00000185338 MIM:603597 Vega:OTTHUMG00000129792 UniprotKB:O15524
NC_000016.10
PubMed
0   ANCO-SNPs
ND
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.090e-1 (AD)  8.164e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CXCL100.809
IRF10.801
BATF20.8
HELZ20.777
TAP10.757
CCL200.753
METRNL0.736
CXCL110.733
NFKB20.732
APOL60.728

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNK2-0.414
CASC15-0.413
MEPE-0.399
SLC7A4-0.396
ZC3H12B-0.391
VSTM5-0.389
B3GALT2-0.388
SNAP25-AS1-0.386
CACNA1F-0.385
REPS2-0.382

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of SOCS1 mRNA"12584205
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SOCS1 mRNA"25614096
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of SOCS1 mRNA"23829299
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOCS1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOCS1 mRNA"27188386
C0022024-oxoretinoic acid4-oxoretinoic acid results in decreased expression of SOCS1 mRNA15982314
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOCS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOCS1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SOCS1 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of SOCS1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of SOCS1 mRNA17562736
D000119Acetylmuramyl-Alanyl-IsoglutamineAcetylmuramyl-Alanyl-Isoglutamine results in decreased expression of SOCS1 protein19897531
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SOCS1 gene27153756
D000447AldehydesAldehydes results in increased expression of SOCS1 mRNA25014914
C103303alitretinoinalitretinoin results in decreased expression of SOCS1 mRNA15982314
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SOCS1 mRNA16483693
D000941AntigensAntigens results in increased expression of SOCS1 mRNA28935500
D000941Antigensdeoxynivalenol inhibits the reaction [Antigens results in increased expression of SOCS1 mRNA]28935500
D000941Antigensochratoxin A inhibits the reaction [Antigens results in increased expression of SOCS1 mRNA]28935500
C006632arsenic trioxidearsenic trioxide results in decreased methylation of SOCS1 gene19000444
C006632arsenic trioxidearsenic trioxide results in increased expression of SOCS1 mRNA18928596|1900044
C015001arsenitearsenite results in decreased expression of SOCS1 mRNA18191166
D001507BeclomethasoneBeclomethasone results in increased expression of SOCS1 mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SOCS1 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SOCS1 mRNA23735875
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SOCS1 mRNA"20382639
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of SOCS1 mRNA20404318
D004958EstradiolEstradiol inhibits the reaction [hydroxytamoxifen results in increased expression of SOCS1 mRNA]16849584
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of SOCS1 mRNA17404688
D004958EstradiolEstradiol affects the expression of SOCS1 mRNA15598610
D004958EstradiolEstradiol results in increased expression of SOCS1 mRNA25210133
D004958EstradiolEstradiol results in increased expression of SOCS1 mRNA18162529
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid results in decreased expression of SOCS1 mRNA18192240
C006780bisphenol Abisphenol A affects the expression of SOCS1 mRNA25181051
D001761BleomycinBleomycin results in decreased expression of SOCS1 mRNA17374387
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of SOCS1 mRNA15003993
C018475butyraldehydebutyraldehyde results in increased expression of SOCS1 mRNA26079696
C459604candoxincandoxin results in increased expression of SOCS1 mRNA16309724
D002330CarmustineCarmustine results in decreased expression of SOCS1 mRNA17374387
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in decreased expression of SOCS1 mRNA21356183
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SOCS1 protein20548288
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SOCS1 gene20938992
D002794Choline[[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MIR155 mRNA] which results in decreased expression of SOCS1 protein20548288
C007095cobaltiprotoporphyrincobaltiprotoporphyrin results in increased expression of SOCS1 protein25780291
D003300Copper[Copper co-treated with Chlorpyrifos] results in decreased expression of SOCS1 mRNA21356183
D003300CopperCopper results in decreased expression of SOCS1 mRNA21356183
D003300CopperCopper deficiency results in increased expression of SOCS1 mRNA26033743
D019327Copper SulfateCopper Sulfate results in decreased expression of SOCS1 mRNA19549813
C029892cupric chloridecupric chloride results in decreased expression of SOCS1 mRNA19174923
D003513Cycloheximide[hydroxytamoxifen co-treated with Cycloheximide] results in increased expression of SOCS1 mRNA16849584
D003513CycloheximideCycloheximide results in increased expression of SOCS1 mRNA23237828
D003520CyclophosphamideCyclophosphamide results in decreased expression of SOCS1 mRNA21041162
D016572CyclosporineCyclosporine results in decreased expression of SOCS1 mRNA25562108
D016572CyclosporineCyclosporine results in decreased methylation of SOCS1 promoter27989131
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of SOCS1 mRNA23914054
C014347decitabinedecitabine results in decreased methylation of SOCS1 promoter19551406
C014347decitabinedecitabine results in increased expression of SOCS1 mRNA19551406
C014347decitabine"decitabine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the methylation of SOCS1 promoter]"24440346
C007262deoxynivalenoldeoxynivalenol inhibits the reaction [Antigens results in increased expression of SOCS1 mRNA]28935500
C007262deoxynivalenoldeoxynivalenol results in increased expression of SOCS1 mRNA19625342
D003907DexamethasoneDexamethasone results in increased expression of SOCS1 mRNA21356098
D003907DexamethasoneDexamethasone results in increased expression of SOCS1 mRNA12732289|1278212
D003907DexamethasoneDexamethasone results in decreased expression of SOCS1 mRNA21041162
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SOCS1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of SOCS1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SOCS1 mRNA17374387
D002945CisplatinCisplatin results in increased expression of SOCS1 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of SOCS1 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SOCS1 mRNA26924002
D019422Dietary SucroseDietary Sucrose results in increased expression of SOCS1 mRNA26033743
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of SOCS1 mRNA21041162
C024629dimethyl phthalatedimethyl phthalate affects the expression of SOCS1 mRNA26924002
D015118Eicosapentaenoic Acid[Eicosapentaenoic Acid co-treated with Lipopolysaccharides] results in increased expression of SOCS1 mRNA22169119
C118739entinostatentinostat results in increased expression of SOCS1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOCS1 mRNA"27188386
D004967EstrogensEstrogens inhibits the reaction [PRL protein results in increased expression of SOCS1 mRNA]18325991
D004967EstrogensEstrogens results in increased expression of SOCS1 mRNA18325991
D004967EstrogensProgesterone inhibits the reaction [Estrogens results in increased expression of SOCS1 mRNA]18325991
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SOCS1 mRNA17942748
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of SOCS1 mRNA22213190
D005472FluorouracilFluorouracil results in increased expression of SOCS1 mRNA16557594
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SOCS1 protein20548288
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SOCS1 gene20938992
D005492Folic Acid[[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MIR155 mRNA] which results in decreased expression of SOCS1 protein20548288
D005557FormaldehydeFormaldehyde results in increased expression of SOCS1 mRNA23649840
C070081fulvestrantfulvestrant inhibits the reaction [hydroxytamoxifen results in increased expression of SOCS1 mRNA]16849584
C546771gardiquimodgardiquimod results in increased expression of SOCS1 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SOCS1 mRNA]28003376
C475919hydroxytamoxifenESR2 protein inhibits the reaction [hydroxytamoxifen results in increased expression of SOCS1 mRNA]16849584
C475919hydroxytamoxifenEstradiol inhibits the reaction [hydroxytamoxifen results in increased expression of SOCS1 mRNA]16849584
C475919hydroxytamoxifenfulvestrant inhibits the reaction [hydroxytamoxifen results in increased expression of SOCS1 mRNA]16849584
C475919hydroxytamoxifen[hydroxytamoxifen co-treated with Cycloheximide] results in increased expression of SOCS1 mRNA16849584
C475919hydroxytamoxifenhydroxytamoxifen results in increased expression of SOCS1 mRNA16849584
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SOCS1 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of SOCS1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of SOCS1 mRNA24796395|2675264
C017461lead nitratelead nitrate affects the reaction [SOCS1 affects the expression of MT1 mRNA]11891201
C017461lead nitratelead nitrate affects the reaction [SOCS1 affects the expression of MT2 mRNA]11891201
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of SOCS1 mRNA"22546503
C433788lipopolysaccharide, E. coli O26-B6"Progesterone promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of SOCS1 mRNA]"22546503
C482199lipopolysaccharide, E coli O55-B5"decitabine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the methylation of SOCS1 promoter]"24440346
C482199lipopolysaccharide, E coli O55-B5"DNMT1 mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the expression of SOCS1 mRNA]"24440346
C482199lipopolysaccharide, E coli O55-B5"DNMT1 mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the expression of SOCS1 protein]"24440346
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 affects the expression of SOCS1 mRNA"24440346
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 affects the expression of SOCS1 protein"24440346
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 affects the methylation of SOCS1 promoter"24440346
C482199lipopolysaccharide, E coli O55-B5"SOCS1 mutant form inhibits the reaction [DNMT1 mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]]"24440346
C482199lipopolysaccharide, E coli O55-B5"SOCS1 mutant form inhibits the reaction [DNMT1 mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]"24440346
C482199lipopolysaccharide, E coli O55-B5"SOCS1 mutant form inhibits the reaction [DNMT1 mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of JAK2 protein]]"24440346
C482199lipopolysaccharide, E coli O55-B5"SOCS1 mutant form inhibits the reaction [DNMT1 mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of STAT3 protein]]"24440346
D008070Lipopolysaccharides[Eicosapentaenoic Acid co-treated with Lipopolysaccharides] results in increased expression of SOCS1 mRNA22169119
D008070LipopolysaccharidesIL4 protein promotes the reaction [Lipopolysaccharides results in increased expression of SOCS1 mRNA]22024136
D008070LipopolysaccharidesLipopolysaccharides affects the expression of SOCS1 mRNA22169119
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [IL4 results in increased expression of SOCS1 mRNA]22024136
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SOCS1 mRNA12057914|2202413
D008130LomustineLomustine results in decreased expression of SOCS1 mRNA17374387
C545385MequindoxMequindox affects the expression of SOCS1 mRNA21146578
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SOCS1 protein20548288
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SOCS1 gene20938992
D008715Methionine[[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MIR155 mRNA] which results in decreased expression of SOCS1 protein20548288
C517284monomethyl phthalatemonomethyl phthalate affects the expression of SOCS1 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of SOCS1 mRNA"23845593
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SOCS1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SOCS1 mRNA"25554681
D009532NickelNickel results in increased expression of SOCS1 mRNA25583101
C025589ochratoxin Aochratoxin A inhibits the reaction [Antigens results in increased expression of SOCS1 mRNA]28935500
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOCS1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of SOCS1 mRNA26272509
D052638Particulate MatterParticulate Matter results in decreased expression of SOCS1 mRNA23638009
C046012pentanalpentanal results in increased expression of SOCS1 mRNA26079696
D010938Plant OilsPlant Oils results in increased expression of SOCS1 mRNA23370395
D011070Poly I-CPoly I-C results in increased expression of SOCS1 mRNA22546503
D011070Poly I-CProgesterone promotes the reaction [Poly I-C results in increased expression of SOCS1 mRNA]22546503
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of SOCS1 mRNA17404688
D011374Progesterone[Progesterone co-treated with TGFB1 protein] results in decreased expression of SOCS1 mRNA21768398
D011374ProgesteroneProgesterone results in decreased expression of SOCS1 mRNA21768398
D011374Progesterone"Progesterone promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of SOCS1 mRNA]"22546503
D011374ProgesteroneProgesterone promotes the reaction [Poly I-C results in increased expression of SOCS1 mRNA]22546503
D011374ProgesteroneProgesterone inhibits the reaction [Estrogens results in increased expression of SOCS1 mRNA]18325991
D011374ProgesteroneProgesterone inhibits the reaction [PRL protein results in increased expression of SOCS1 mRNA]18325991
C005556propionaldehydepropionaldehyde results in increased expression of SOCS1 mRNA26079696
D015237DinoprostDinoprost results in increased expression of SOCS1 mRNA21654155
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SOCS1 mRNA]28003376
C428725pyridabenpyridaben results in decreased expression of SOCS1 mRNA22563483
D011794QuercetinQuercetin results in increased expression of SOCS1 mRNA21356098
D017382Reactive Oxygen Species[[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of SOCS1 mRNA27634759
C059514resveratrolresveratrol results in increased expression of SOCS1 mRNA27064016
C059514resveratrolresveratrol results in increased expression of SOCS1 protein27064016
C059514resveratrolSOCS1 protein affects the reaction [resveratrol results in decreased phosphorylation of STAT3 protein]27064016
D015474IsotretinoinIsotretinoin results in decreased expression of SOCS1 mRNA15982314
C089730rosiglitazonerosiglitazone results in increased expression of SOCS1 mRNA12584205
D012822Silicon DioxideSilicon Dioxide results in increased expression of SOCS1 mRNA25351596
D012834SilverSilver results in decreased expression of SOCS1 mRNA27131904
C017947sodium arsenitesodium arsenite inhibits the reaction [IL6 protein results in increased expression of SOCS1 mRNA]15116095
C017947sodium arsenitesodium arsenite results in decreased expression of SOCS117224793
D013469SulpirideSulpiride results in increased expression of SOCS1 mRNA18162529
D013739TestosteroneTestosterone results in increased expression of SOCS1 mRNA15788153
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SOCS1 mRNA21632981|2623829
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SOCS1 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SOCS1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SOCS1 mRNA27913140
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SOCS1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of SOCS1 mRNA23557971
C082097tocotrienol, delta"tocotrienol, delta results in increased expression of SOCS1 mRNA"21356098
C483909torcetrapibtorcetrapib results in increased expression of SOCS1 mRNA23228038
D014118Toxins, Biological"Toxins, Biological affects the expression of SOCS1 mRNA"19682533
D014212TretinoinTretinoin metabolite results in decreased expression of SOCS1 mRNA15982314
D014212TretinoinTretinoin results in decreased expression of SOCS1 mRNA15982314
C012589trichostatin Atrichostatin A results in increased expression of SOCS1 mRNA24935251
C001899triptolidetriptolide results in increased expression of SOCS1 mRNA23639586
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SOCS1 mRNA"26179874
D014520UrethaneUrethane results in increased expression of SOCS1 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of SOCS1 mRNA24935251
D014635Valproic AcidValproic Acid results in increased methylation of SOCS1 gene29154799
C066075vanadium pentoxidevanadium pentoxide results in decreased expression of SOCS1 mRNA17459161
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SOCS1 gene25560391
D012256RiboflavinRiboflavin results in increased expression of SOCS1 mRNA21356098
C088658zoledronic acidzoledronic acid results in increased expression of SOCS1 mRNA24714768
D015054ZymosanSTAT1 protein affects the reaction [Zymosan results in increased expression of SOCS1 mRNA]15188379
D015054ZymosanZymosan results in increased expression of SOCS1 mRNA15188379

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004860protein kinase inhibitor activity-TAS9202125  
GO:0005159insulin-like growth factor receptor binding-IPI9727029  
GO:0005515protein binding-IPI16273093  16643902  17183367  18172216  
GO:0019210kinase inhibitor activity-ISS-  
GO:0019901protein kinase binding-IPI9727029  
GO:00469351-phosphatidylinositol-3-kinase regulator activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001932regulation of protein phosphorylation-ISS-  
GO:0006469negative regulation of protein kinase activity-IEA-  
GO:0016567protein ubiquitination-IEA-  
GO:0019221cytokine-mediated signaling pathway-ISS-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0035556intracellular signal transduction-IEA-  
GO:0038111interleukin-7-mediated signaling pathway-TAS-  
GO:0040008regulation of growth-IEA-  
GO:0042532negative regulation of tyrosine phosphorylation of STAT protein-IMP25019494  
GO:0042532negative regulation of tyrosine phosphorylation of STAT protein-ISS-  
GO:0043372positive regulation of CD4-positive, alpha-beta T cell differentiation-ISS-  
GO:0043377negative regulation of CD8-positive, alpha-beta T cell differentiation-ISS-  
GO:0045591positive regulation of regulatory T cell differentiation-IMP22387553  
GO:0046426negative regulation of JAK-STAT cascade-IMP25019494  
GO:0046426negative regulation of JAK-STAT cascade-ISS-  
GO:0046426negative regulation of JAK-STAT cascade-NAS9727029  
GO:0046627negative regulation of insulin receptor signaling pathway-IBA21873635  
GO:0046627negative regulation of insulin receptor signaling pathway-ISS-  
GO:0046854phosphatidylinositol phosphorylation-IBA21873635  
GO:0060334regulation of interferon-gamma-mediated signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-TAS9202126  
GO:0005829cytosol-TAS-  
GO:0005942phosphatidylinositol 3-kinase complex-IBA21873635  
GO:0031410cytoplasmic vesicle-IEA-  
GO:0036464cytoplasmic ribonucleoprotein granule-IDA-  
KEGG ID KEGG Term
hsa04120Ubiquitin mediated proteolysis
hsa04380Osteoclast differentiation
hsa04630Jak-STAT signaling pathway
hsa04910Insulin signaling pathway
hsa04930Type II diabetes mellitus
hsa05145Toxoplasmosis
Reactome ID Reactome Term Evidence
R-HSA-1266695Interleukin-7 signalingTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1433557Signaling by SCF-KITIEA
R-HSA-1433559Regulation of KIT signalingIEA
R-HSA-162582Signal TransductionIEA
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166058MyD88:Mal cascade initiated on plasma membraneTAS
R-HSA-168179Toll Like Receptor TLR1:TLR2 CascadeTAS
R-HSA-168188Toll Like Receptor TLR6:TLR2 CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-181438Toll Like Receptor 2 (TLR2) CascadeTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-877300Interferon gamma signalingTAS
R-HSA-877312Regulation of IFNG signalingTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA
R-HSA-909733Interferon alpha/beta signalingTAS
R-HSA-909733Interferon alpha/beta signalingIEA
R-HSA-912694Regulation of IFNA signalingIEA
R-HSA-913531Interferon SignalingTAS
R-HSA-913531Interferon SignalingIEA
R-HSA-982772Growth hormone receptor signalingIEA
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26199896Association of SOCS1 (- 820) (rs33977706) gene polymorphism with chronic periodontitis: A case-control study in Brazilians. (2015 Sep)Guedes RAMeta Gene
25847945Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling. (2015 May 4)Bourdonnay EJ Exp Med
25104439Genetic variation in the JAK/STAT/SOCS signaling pathway influences breast cancer-specific mortality through interaction with cigarette smoking and use of aspirin/NSAIDs: the Breast Cancer Health Disparities Study. (2014 Aug)Slattery MLBreast Cancer Res Treat
22121102JAK/STAT/SOCS-signaling pathway and colon and rectal cancer. (2013 Feb)Slattery MLMol Carcinog
24997329Association of the suppressor of cytokine signaling 1 (SOCS1) gene polymorphisms with acute coronary syndrome in Mexican patients. (2014 Nov)Vargas-Alarcon GMol Immunol
23539450Genomic aberrations occurring in subsets of serrated colorectal lesions but not conventional adenomas. (2013 May 1)Burnett-Hartman ANCancer Res
26730186Cigarette smoke-induced lung inflammation in COPD mediated via LTB4/BLT1/SOCS1 pathway. (2016)Dong RInt J Chron Obstruct Pulmon Dis