Gene info: ID 8655

Gene: DYNLL1

GENE ID: 8655

Synonyms: DLC1|DLC8|DNCL1|DNCLC1|LC8|LC8a|PIN|hdlc1

Description: dynein light chain LC8-type 1

Gene type: protein-coding

Location: 12q24.31

dbXrefs: Ensembl:ENSG00000088986 MIM:601562 Vega:OTTHUMG00000169368 UniprotKB:P63167

RefSeq: NC_000012.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: OD|ND

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.919e-1 (AD) 4.352e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SOD1	0.964
NDUFA8	0.954
DYNLRB1	0.951
COPRS	0.944
SSU72	0.942
FAM32A	0.94
CUTA	0.936
VPS72	0.935
CCT7	0.935
RNF167	0.934

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.781
OR4F29	-0.743
IL18RAP	-0.362
TFPI2	-0.345
KLRF1	-0.339
KLRB1	-0.333
PZP	-0.331
IL2RB	-0.326
FZD10	-0.318
CXCR2	-0.314

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran affects the expression of DYNLL1 mRNA"	18343893
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of DYNLL1 mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of DYNLL1 mRNA"	21346803
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of DYNLL1 mRNA	12958071
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of DYNLL1 mRNA"	21346803
C105260	4-tert-octylphenol	4-tert-octylphenol results in decreased expression of DYNLL1 mRNA	17011747
C105260	4-tert-octylphenol	4-tert-octylphenol results in increased expression of DYNLL1 mRNA	17011747
C029370	4-toluidine	4-toluidine results in decreased expression of DYNLL1 mRNA	27638505
D000082	Acetaminophen	Acetaminophen affects the expression of DYNLL1 mRNA	17562736
C016601	afimoxifene	afimoxifene results in increased expression of DYNLL1 mRNA	12154049
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of DYNLL1 gene	27153756
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of DYNLL1 mRNA	17023530
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of DYNLL1 mRNA	16483693
D001280	Atrazine	Atrazine results in decreased expression of DYNLL1 mRNA	22378314
C061004	benidipine	benidipine affects the expression of DYNLL1 mRNA	15721868
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of DYNLL1 mRNA"	19150397
D004958	Estradiol	Estradiol results in increased expression of DYNLL1 mRNA	12154049
C044887	beta-methylcholine	beta-methylcholine affects the expression of DYNLL1 mRNA	21179406
C006780	bisphenol A	bisphenol A results in increased expression of DYNLL1 mRNA	24066056\|2518105
D002065	Buspirone	Buspirone results in decreased expression of DYNLL1 mRNA	24136188
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of DYNLL1 mRNA	12419474
D017272	Celiprolol	Celiprolol results in decreased expression of DYNLL1 mRNA	15262839
C100187	chloropicrin	chloropicrin results in decreased expression of DYNLL1 mRNA	26352163
C100187	chloropicrin	chloropicrin results in increased expression of DYNLL1 mRNA	26352163
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DYNLL1 mRNA	20938992
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of DYNLL1 mRNA	28472532
D002922	Ciguatoxins	Ciguatoxins affects the expression of DYNLL1 mRNA	18353800
D002995	Clofibric Acid	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of DYNLL1 mRNA	17602206
D003042	Cocaine	Cocaine affects the expression of DYNLL1 mRNA	20187946
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of DYNLL1 mRNA	19549813
D003474	Curcumin	Curcumin results in increased expression of DYNLL1 mRNA	17198877
D016572	Cyclosporine	Cyclosporine results in decreased expression of DYNLL1 mRNA	25562108
C014347	decitabine	decitabine results in increased expression of DYNLL1 mRNA	19151715
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of DYNLL1 mRNA]	27941970
D003907	Dexamethasone	Dexamethasone results in decreased expression of DYNLL1 mRNA	22733784
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of DYNLL1 mRNA	19850644
D004051	Diethylhexyl Phthalate	PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of DYNLL1 mRNA]	19850644
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of DYNLL1 mRNA	24535843
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of DYNLL1 mRNA	17602206
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of DYNLL1 mRNA	19041683
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of DYNLL1 mRNA	17011747
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of DYNLL1 mRNA	17011747
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in decreased expression of DYNLL1 mRNA	27638505
D004237	Diuron	Diuron results in decreased expression of DYNLL1 mRNA	21551480
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of DYNLL1 protein	23301498
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of DYNLL1 mRNA	14976129\|1755557
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DYNLL1 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of DYNLL1 mRNA	17108234\|1940095
D018120	Finasteride	Finasteride results in increased expression of DYNLL1 mRNA	24136188
D005485	Flutamide	Flutamide results in increased expression of DYNLL1 mRNA	24136188
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DYNLL1 mRNA	20938992
C070081	fulvestrant	fulvestrant results in increased expression of DYNLL1 mRNA	12154049
D005839	Gentamicins	Gentamicins results in decreased expression of DYNLL1 mRNA	22061828
D005897	Glafenine	Glafenine results in increased expression of DYNLL1 mRNA	24136188
C401858	GW 7604	GW 7604 results in increased expression of DYNLL1 mRNA	12154049
D017313	Fenretinide	Fenretinide results in increased expression of DYNLL1 mRNA	28973697
D006830	Hydralazine	[Hydralazine co-treated with Valproic Acid] results in increased expression of DYNLL1 mRNA	17183730
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of DYNLL1 mRNA	26846883
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of DYNLL1 mRNA	12419474
C041508	indeno(1,2,3-cd)pyrene	"indeno(1,2,3-cd)pyrene results in decreased expression of DYNLL1 mRNA"	26377693
C410337	K 7174	K 7174 results in decreased expression of DYNLL1 mRNA	24086573
D007854	Lead	Lead affects the expression of DYNLL1 mRNA	28903495
C045463	leflunomide	leflunomide results in decreased expression of DYNLL1 mRNA	28988120
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DYNLL1 mRNA	20938992
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of DYNLL1 mRNA	17616710
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of DYNLL1 mRNA"	24096037
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of DYNLL1 mRNA"	24096037
D010126	Ozone	"[Water Pollutants, Chemical co-treated with Ozone] results in increased expression of DYNLL1 mRNA"	23246600
D010126	Ozone	Ozone results in decreased expression of DYNLL1 mRNA	28623178
D010269	Paraquat	Paraquat results in decreased expression of DYNLL1 mRNA	12595580
D010269	Paraquat	Paraquat results in decreased expression of DYNLL1 mRNA	16328009
D010269	Paraquat	Paraquat results in increased expression of DYNLL1 mRNA	20388547
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of DYNLL1 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital affects the expression of DYNLL1 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in increased expression of DYNLL1 mRNA	19482888
D010634	Phenobarbital	Phenobarbital results in decreased expression of DYNLL1 mRNA	19162173
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of DYNLL1 mRNA	22484513
C006253	pirinixic acid	pirinixic acid results in decreased expression of DYNLL1 mRNA	17426115\|1844570
C006253	pirinixic acid	pirinixic acid results in increased expression of DYNLL1 mRNA	18301758\|2381119
D010936	Plant Extracts	Plant Extracts results in decreased expression of DYNLL1 mRNA	23557933
C045950	propiconazole	propiconazole results in increased expression of DYNLL1 mRNA	21278054
D011794	Quercetin	Quercetin results in decreased expression of DYNLL1 mRNA	21632981
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased expression of DYNLL1 mRNA	12154049
C059514	resveratrol	resveratrol results in increased expression of DYNLL1 mRNA	12154049
D012524	Sarin	Sarin results in decreased expression of DYNLL1 mRNA	19522546
D012524	Sarin	Sarin results in increased expression of DYNLL1 mRNA	19522546
C009250	sevoflurane	sevoflurane affects the expression of DYNLL1 mRNA	15967596
D012834	Silver	Silver results in decreased expression of DYNLL1 mRNA	27131904
D013467	Sulindac	Sulindac results in decreased expression of DYNLL1 mRNA	24136188
C025462	sulindac sulfide	sulindac sulfide results in decreased expression of DYNLL1 mRNA	12734198
D013629	Tamoxifen	Tamoxifen affects the expression of DYNLL1 mRNA	17555576
D013629	Tamoxifen	Tamoxifen results in increased expression of DYNLL1 mRNA	19400957
D013629	Tamoxifen	Tamoxifen results in increased expression of DYNLL1 mRNA	19400957
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of DYNLL1 mRNA	18343893\|2157046
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of DYNLL1 mRNA	16214954
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DYNLL1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of DYNLL1 mRNA	15328365\|1696003
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of DYNLL1 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of DYNLL1 mRNA	16960034
C066340	tolcapone	tolcapone results in decreased expression of DYNLL1 mRNA	24136188
D014212	Tretinoin	Tretinoin results in increased expression of DYNLL1 mRNA	17045167
D014241	Trichloroethylene	Trichloroethylene results in increased expression of DYNLL1 mRNA	19448997
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of DYNLL1 gene	27618143
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of DYNLL1 mRNA"	26179874
C057693	troglitazone	troglitazone results in increased expression of DYNLL1 mRNA	28973697
C406224	valdecoxib	valdecoxib results in increased expression of DYNLL1 mRNA	24136188
D014635	Valproic Acid	[Hydralazine co-treated with Valproic Acid] results in increased expression of DYNLL1 mRNA	17183730
D014635	Valproic Acid	Valproic Acid results in increased expression of DYNLL1 mRNA	23179753
D014635	Valproic Acid	Valproic Acid results in increased methylation of DYNLL1 gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of DYNLL1 mRNA	17292431
D014640	Vancomycin	Vancomycin results in decreased expression of DYNLL1 mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of DYNLL1 mRNA	19165385
D014874	Water Pollutants, Chemical	"[Water Pollutants, Chemical co-treated with Ozone] results in increased expression of DYNLL1 mRNA"	23246600

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	14607844 15891768 16684779 17353931 18420585 18579519 19615732 20133940 20412299 20562859 21094642 22167198 24255178 24366813 25416956 25852190 26496610 26638075 27173435
GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	CONTRIBUTES_TO	IBA	21873635
GO:0019899	enzyme binding	-	IEA	-
GO:0030235	nitric-oxide synthase regulator activity	-	IEA	-
GO:0042803	protein homodimerization activity	-	IEA	-
GO:0045505	dynein intermediate chain binding	-	IBA	21873635
GO:0046982	protein heterodimerization activity	-	IEA	-
GO:0051959	dynein light intermediate chain binding	-	IBA	21873635
GO:0097110	scaffold protein binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000086	G2/M transition of mitotic cell cycle	-	TAS	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006355	regulation of transcription, DNA-templated	-	IEA	-
GO:0006888	ER to Golgi vesicle-mediated transport	-	TAS	-
GO:0006915	apoptotic process	-	IEA	-
GO:0007286	spermatid development	-	IEA	-
GO:0010389	regulation of G2/M transition of mitotic cell cycle	-	TAS	-
GO:0016032	viral process	-	IEA	-
GO:0016236	macroautophagy	-	TAS	-
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	-	TAS	-
GO:0021762	substantia nigra development	-	HEP	22926577
GO:0035735	intraciliary transport involved in cilium assembly	-	TAS	-
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	-	IEA	-
GO:0042326	negative regulation of phosphorylation	-	IDA	18579519
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0060271	cilium assembly	-	IBA	21873635
GO:0097711	ciliary basal body-plasma membrane docking	-	TAS	-
GO:2000582	positive regulation of ATP-dependent microtubule motor activity, plus-end-directed	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000776	kinetochore	-	IDA	20133940
GO:0005634	nucleus	-	IDA	15891768
GO:0005737	cytoplasm	-	IDA	8628263 15891768
GO:0005739	mitochondrion	-	IEA	-
GO:0005813	centrosome	-	IDA	21399614
GO:0005829	cytosol	-	TAS	-
GO:0005868	cytoplasmic dynein complex	-	IBA	21873635
GO:0005868	cytoplasmic dynein complex	-	IDA	25830415
GO:0005868	cytoplasmic dynein complex	-	ISS	-
GO:0005874	microtubule	-	IEA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005929	cilium	-	TAS	-
GO:0008180	COP9 signalosome	colocalizes_with	IDA	18850735
GO:0016020	membrane	-	HDA	19946888
GO:0030286	dynein complex	-	IBA	21873635
GO:0070821	tertiary granule membrane	-	TAS	-
GO:0072686	mitotic spindle	-	IDA	20133940
GO:0097542	ciliary tip	-	TAS	-
GO:0101003	ficolin-1-rich granule membrane	-	TAS	-
GO:1904115	axon cytoplasm	-	IEA	-

KEGG ID	KEGG Term
hsa04962	Vasopressin-regulated water reabsorption

Reactome ID	Reactome Term	Evidence
R-HSA-109581	Apoptosis	TAS
R-HSA-109606	Intrinsic Pathway for Apoptosis	TAS
R-HSA-111446	Activation of BIM and translocation to mitochondria	TAS
R-HSA-114452	Activation of BH3-only proteins	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-141424	Amplification of signal from the kinetochores	TAS
R-HSA-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-1632852	Macroautophagy	TAS
R-HSA-1640170	Cell Cycle	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-1852241	Organelle biogenesis and maintenance	TAS
R-HSA-194315	Signaling by Rho GTPases	TAS
R-HSA-195258	RHO GTPase Effectors	TAS
R-HSA-199977	ER to Golgi Anterograde Transport	TAS
R-HSA-199991	Membrane Trafficking	TAS
R-HSA-2132295	MHC class II antigen presentation	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-2467813	Separation of Sister Chromatids	TAS
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	TAS
R-HSA-2555396	Mitotic Metaphase and Anaphase	TAS
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	TAS
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR)	TAS
R-HSA-380259	Loss of Nlp from mitotic centrosomes	TAS
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes	TAS
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centrosome	TAS
R-HSA-380287	Centrosome maturation	TAS
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-446203	Asparagine N-linked glycosylation	TAS
R-HSA-453274	Mitotic G2-G2/M phases	TAS
R-HSA-5357801	Programmed Cell Death	TAS
R-HSA-5617833	Cilium Assembly	TAS
R-HSA-5620912	Anchoring of the basal body to the plasma membrane	TAS
R-HSA-5620924	Intraflagellar transport	TAS
R-HSA-5653656	Vesicle-mediated transport	TAS
R-HSA-5663220	RHO GTPases Activate Formins	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-6807878	COPI-mediated anterograde transport	TAS
R-HSA-6811436	COPI-independent Golgi-to-ER retrograde traffic	TAS
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	TAS
R-HSA-68877	Mitotic Prometaphase	TAS
R-HSA-68882	Mitotic Anaphase	TAS
R-HSA-68886	M Phase	TAS
R-HSA-69275	G2/M Transition	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS
R-HSA-69618	Mitotic Spindle Checkpoint	TAS
R-HSA-69620	Cell Cycle Checkpoints	TAS
R-HSA-8854518	AURKA Activation by TPX2	TAS
R-HSA-8856688	Golgi-to-ER retrograde transport	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-948021	Transport to the Golgi and subsequent modification	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal