Gene: TNKS

8658
ARTD5|PARP-5a|PARP5A|PARPL|TIN1|TINF1|TNKS1|pART5
tankyrase
protein-coding
8p23.1
Ensembl:ENSG00000173273 MIM:603303 Vega:OTTHUMG00000090481 UniprotKB:O95271
NC_000008.11
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.679e-1 (AD)  7.979e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4128324chr8:9651369 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HECTD10.933
ATG2B0.923
PUM10.923
AP1G10.923
ANKRD170.92
ZNF6550.92
CPSF60.919
MAP3K70.918
RPS6KB10.917
APPBP20.917

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.606
OR4F29-0.561
PLA2G5-0.318
S100A14-0.28
SLC22A6-0.264
TTLL10-0.263
OR4F16-0.257
AQP5-0.257
MTRNR2L10-0.246
FOXS1-0.246

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of TNKS mRNA"28903501
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TNKS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TNKS mRNA"27188386
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TNKS mRNA24449571
C015001arsenitearsenite results in increased methylation of TNKS promoter23974009
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TNKS mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of TNKS mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of TNKS mRNA26063408
C006780bisphenol Abisphenol A affects the expression of TNKS mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of TNKS mRNA29097150
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in decreased expression of TNKS mRNA25522274
C018475butyraldehydebutyraldehyde results in decreased expression of TNKS mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TNKS mRNA16973896
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of TNKS promoter22457795
C018021cobaltous chloridecobaltous chloride results in increased expression of TNKS mRNA19320972
D003300CopperCopper affects the expression of TNKS mRNA23825565
D019327Copper SulfateCopper Sulfate results in increased expression of TNKS mRNA19549813
D003474CurcuminCurcumin analog results in decreased expression of TNKS mRNA26409325
D016572CyclosporineCyclosporine results in decreased expression of TNKS mRNA25562108
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TNKS mRNA28628672
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TNKS mRNA29097150
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of TNKS mRNA23649840
D005047EtoposideTNKS protein affects the susceptibility to Etoposide16217747
D017313FenretinideFenretinide results in decreased expression of TNKS mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TNKS mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TNKS mRNA28628672
D007545IsoproterenolIsoproterenol results in increased expression of TNKS mRNA20003209
C544151jinfukangjinfukang results in decreased expression of TNKS mRNA27392435
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TNKS mRNA23649840
D008942MitoxantroneTNKS protein affects the susceptibility to Mitoxantrone16217747
D010433PentylenetetrazolePentylenetetrazole affects the expression of TNKS mRNA21503142
D010936Plant ExtractsPlant Extracts results in increased expression of TNKS mRNA23557933
D011794QuercetinQuercetin results in increased expression of TNKS mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TNKS mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TNKS mRNA22298810
D014520UrethaneUrethane results in increased expression of TNKS mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TNKS mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TNKS mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TNKS mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in decreased methylation of TNKS gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of TNKS gene25560391
C025643vinclozolinvinclozolin affects the expression of TNKS mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003950NAD+ ADP-ribosyltransferase activity-IBA21873635  
GO:0003950NAD+ ADP-ribosyltransferase activity-IDA9822378  11854288  16076287  19759537  21270334  21478859  
22864114  
GO:0003950NAD+ ADP-ribosyltransferase activity-TAS-  
GO:0005515protein binding-IPI9822378  11854288  12080061  12768206  14596906  15133513  
16076287  17003112  19759537  20696165  21251231  21478859  
22699936  22864114  25327252  26373281  26496610  26972000  
GO:0008270zinc ion binding-IDA18436240  
GO:0042393histone binding-IPI26373281  
GO ID GO Term Qualifier Evidence PubMed
GO:0000209protein polyubiquitination-IDA19759537  21478859  
GO:0006471protein ADP-ribosylation-IBA21873635  
GO:0006471protein ADP-ribosylation-IDA9822378  15133513  21270334  
GO:0007052mitotic spindle organization-TAS17026964  
GO:0015031protein transport-IEA-  
GO:0016055Wnt signaling pathway-IEA-  
GO:0018105peptidyl-serine phosphorylation-IDA17026964  
GO:0018107peptidyl-threonine phosphorylation-IDA17026964  
GO:0032210regulation of telomere maintenance via telomerase-IC9822378  
GO:0032212positive regulation of telomere maintenance via telomerase-IDA12782650  18221737  
GO:0032212positive regulation of telomere maintenance via telomerase-IMP11739745  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA19245366  
GO:0051028mRNA transport-IEA-  
GO:0051225spindle assembly-TAS17026964  
GO:0051301cell division-IEA-  
GO:0051973positive regulation of telomerase activity-IDA12782650  
GO:0070198protein localization to chromosome, telomeric region-IBA21873635  
GO:0070198protein localization to chromosome, telomeric region-IMP15133513  18221737  
GO:0070212protein poly-ADP-ribosylation-IDA9822378  16076287  
GO:0070212protein poly-ADP-ribosylation-IMP25939383  
GO:0070213protein auto-ADP-ribosylation-IDA9822378  15133513  19759537  21478859  
GO:0090263positive regulation of canonical Wnt signaling pathway-IBA21873635  
GO:0090263positive regulation of canonical Wnt signaling pathway-IMP19759537  25939383  
GO:0090263positive regulation of canonical Wnt signaling pathway-TAS-  
GO:1904355positive regulation of telomere capping-IBA21873635  
GO:1904355positive regulation of telomere capping-IDA21531765  
GO:1904355positive regulation of telomere capping-IMP25939383  
GO:1904357negative regulation of telomere maintenance via telomere lengthening-IMP25939383  
GO:1904743negative regulation of telomeric DNA binding-IDA9822378  
GO:1904743negative regulation of telomeric DNA binding-IMP25939383  
GO:1904908negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric-IMP26373281  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0000242pericentriolar material-TAS11454873  
GO:0000775chromosome, centromeric region-IEA-  
GO:0000781chromosome, telomeric region-IDA9822378  
GO:0000784nuclear chromosome, telomeric region-IDA9822378  11739745  
GO:0005634nucleus-IBA21873635  
GO:0005643nuclear pore-TAS11454873  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005794Golgi apparatus-IDA22864114  
GO:0005829cytosol-TAS-  
GO:0016604nuclear body-IDA-  
GO:0031965nuclear membrane-IDA-  
GO:0031965nuclear membrane-TAS11454873  
GO:0097431mitotic spindle pole-IDA16076287  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4641257Degradation of AXINTAS
R-HSA-4791275Signaling by WNT in cancerTAS
R-HSA-5545619XAV939 inhibits tankyrase, stabilizing AXINTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6807070PTEN RegulationTAS
R-HSA-8948751Regulation of PTEN stability and activityTAS
R-HSA-9006925Intracellular signaling by second messengersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23050049Genetic and lifestyle influence on telomere length and subsequent risk of colon cancer in a case control study. (2012)Pellatt AJInt J Mol Epidemiol Genet
29455858A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. (2018 Mar 1)Sung YJAm J Hum Genet