Gene: ALDH4A1

8659
ALDH4|P5CD|P5CDh
aldehyde dehydrogenase 4 family member A1
protein-coding
1p36.13
Ensembl:ENSG00000159423 MIM:606811 Vega:OTTHUMG00000002443 UniprotKB:P30038
NG_012283.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.729e-1 (AD)  7.361e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MLC10.938
ACSBG10.912
TNFSF130.907
SLC25A180.903
PBXIP10.9
NTSR20.891
ALDH6A10.89
FGFR30.881
SLC1A20.881
BMP70.876

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.455
OR4F29-0.441
SCARA5-0.439
CCDC68-0.431
TDRD1-0.429
SYNPO2-0.42
SAMD5-0.417
TYRP1-0.408
OSBPL10-0.401
IGSF10-0.399

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of ALDH4A1 mRNA"22496397
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein affects the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of ALDH4A1 mRNA]"22496397
C0668412,3,7,8-tetrabromodibenzo-4-dioxin"2,3,7,8-tetrabromodibenzo-4-dioxin results in decreased expression of ALDH4A1 protein"27604104
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of ALDH4A1 mRNA16788091
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to ALDH4A1 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to ALDH4A1 protein]26598702
D000082AcetaminophenAcetaminophen results in decreased expression of ALDH4A1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of ALDH4A1 mRNA17562736
D000082Acetaminophen[CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of ALDH4A1 protein25499718
D020106AcrylamideAcrylamide results in decreased expression of ALDH4A1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ALDH4A1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ALDH4A1 mRNA27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of ALDH4A1 mRNA28522335
C004984apocarotenalapocarotenal results in decreased expression of ALDH4A1 mRNA17034753
D001151ArsenicArsenic affects the methylation of ALDH4A1 gene25304211
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to ALDH4A1 protein]26598702
D001280AtrazineAtrazine results in decreased expression of ALDH4A1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ALDH4A1 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ALDH4A1 mRNA21839799
D019207beta Carotenebeta Carotene results in decreased expression of ALDH4A1 mRNA17034753
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ALDH4A1 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of ALDH4A1 mRNA19619570
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ALDH4A1 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ALDH4A1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of ALDH4A1 protein16603574
C006780bisphenol Abisphenol A affects the expression of ALDH4A1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ALDH4A1 mRNA28628672
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in increased expression of ALDH4A1 mRNA17998271
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ALDH4A1 mRNA15336504
D002104CadmiumCadmium results in increased expression of ALDH4A1 mRNA24376830
D002104CadmiumCadmium results in increased expression of ALDH4A1 mRNA24084258
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ALDH4A1 mRNA20938992
D002994ClofibrateClofibrate results in decreased expression of ALDH4A1 mRNA22300585
D002995Clofibric AcidClofibric Acid results in increased expression of ALDH4A1 mRNA17998271
D019327Copper SulfateCopper Sulfate results in decreased expression of ALDH4A1 mRNA19549813
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of ALDH4A1 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of ALDH4A1 mRNA20106945|2383089
D016572CyclosporineCyclosporine results in decreased expression of ALDH4A1 mRNA23830897
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ALDH4A1 mRNA]27941970
D003907DexamethasoneDexamethasone results in increased expression of ALDH4A1 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ALDH4A1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ALDH4A1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ALDH4A1 mRNA28628672
D064730Dexrazoxane[Doxorubicin co-treated with Dexrazoxane] results in increased expression of ALDH4A1 mRNA26873546
C049098diallyl phthalatediallyl phthalate results in decreased expression of ALDH4A1 protein16603574
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ALDH4A1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ALDH4A1 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of ALDH4A1 mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of ALDH4A1 mRNA17998271
D002117CalcitriolCalcitriol results in increased expression of ALDH4A1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of ALDH4A1 mRNA21592394
D004317Doxorubicin[Doxorubicin co-treated with Dexrazoxane] results in increased expression of ALDH4A1 mRNA26873546
D004317DoxorubicinDoxorubicin results in decreased expression of ALDH4A1 mRNA26873546
D004317DoxorubicinDoxorubicin results in decreased expression of ALDH4A1 protein21251210
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ALDH4A1 protein20227414
C540355fenamidonefenamidone results in increased expression of ALDH4A1 mRNA27029645
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ALDH4A1 mRNA20938992
C069837fullerene C60fullerene C60 results in increased expression of ALDH4A1 mRNA19167457
C039281furanfuran results in increased expression of ALDH4A1 mRNA26194646
D005897GlafenineGlafenine results in decreased expression of ALDH4A1 mRNA24136188
C071834glycidamideglycidamide results in decreased expression of ALDH4A1 mRNA17822822
D017313FenretinideFenretinide results in increased expression of ALDH4A1 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ALDH4A1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ALDH4A1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ALDH4A1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ALDH4A1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ALDH4A1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ALDH4A1 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ALDH4A1 mRNA27392435
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ALDH4A1 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride affects the expression of ALDH4A1 protein27012723
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ALDH4A1 mRNA23103053
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ALDH4A1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ALDH4A1 mRNA"25554681|2562005
D009532NickelNickel results in increased expression of ALDH4A1 mRNA24084258
C028007nickel monoxidenickel monoxide results in increased expression of ALDH4A1 mRNA19167457
D000073878Palm OilPalm Oil results in decreased expression of ALDH4A1 mRNA18042831
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of ALDH4A1 mRNA17097637
D010695PhlorhizinPhlorhizin results in decreased expression of ALDH4A1 mRNA22538082
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ALDH4A1 mRNA19710929
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ALDH4A1 mRNA28903501
C005556propionaldehydepropionaldehyde results in increased expression of ALDH4A1 mRNA26079696
D011794QuercetinQuercetin results in decreased expression of ALDH4A1 mRNA21632981
D011794QuercetinQuercetin results in decreased expression of ALDH4A1 mRNA16455785
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of ALDH4A1 mRNA19167446
C059514resveratrolresveratrol results in increased expression of ALDH4A1 mRNA22610192
C059514resveratrolresveratrol results in increased expression of ALDH4A1 protein25505154
D012643SeleniumSelenium results in increased expression of ALDH4A1 mRNA19244175
D013148SpironolactoneSpironolactone results in increased expression of ALDH4A1 mRNA17998271
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of ALDH4A1 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of ALDH4A1 mRNA21592394
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ALDH4A1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ALDH4A1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ALDH4A1 mRNA21570461
D014212TretinoinTretinoin results in decreased expression of ALDH4A1 mRNA23724009
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ALDH4A1 mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased expression of ALDH4A1 mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of ALDH4A1 mRNA17292431
D014640VancomycinVancomycin results in increased expression of ALDH4A1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ALDH4A1 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of ALDH4A1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00038421-pyrroline-5-carboxylate dehydrogenase activity-EXP8621661  
GO:0004029aldehyde dehydrogenase (NAD) activity-IDA4015840  
GO:0009055electron transfer activity-TAS8621661  
GO:0042802identical protein binding-IPI22516612  
GO ID GO Term Qualifier Evidence PubMed
GO:0006560proline metabolic process-TAS8621661  
GO:0006562proline catabolic process-TAS-  
GO:0010133proline catabolic process to glutamate-IEA-  
GO:00194704-hydroxyproline catabolic process-TAS21998747  
GO:0022900electron transport chain-IEA-  
GO:0046487glyoxylate metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
hsa00250Alanine, aspartate and glutamate metabolism
hsa00330Arginine and proline metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-389661Glyoxylate metabolism and glycine degradationTAS
R-HSA-6788656Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismTAS
R-HSA-70688Proline catabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
10971205Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease. (2000 Sep)Vasiliou VPharmacology