Gene: IRS2

8660
IRS-2
insulin receptor substrate 2
protein-coding
13q34
Ensembl:ENSG00000185950 MIM:600797 Vega:OTTHUMG00000017338 UniprotKB:Q9Y4H2
NG_008154.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.896e-1 (AD)  8.858e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg05514401chr13:110436111IRS2Promoter5.121e-4Alcohol use disorders26763658
cg24670552chr13:110436780IRS21.740e-13Smoking28686328
cg05404236chr13:110437093IRS25.960e-9Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCND30.92
CCDC60.9
RANBP90.888
MECP20.886
NMT10.886
MAPK10.886
OCRL0.885
XPO70.885
FOXO30.885
PUM10.885

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.624
OR4F29-0.556
CTNNA3-0.385
FZD10-0.374
KLRB1-0.366
RAI14-0.36
CSAG1-0.357
FCRL1-0.354
CETP-0.35
C5orf64-0.346

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0447551-methyl-4-phenyl-2,3-dihydropyridinium"1-methyl-4-phenyl-2,3-dihydropyridinium results in decreased expression of IRS2 mRNA"21856379
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of IRS2 mRNA"20453058
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of IRS2 mRNA"21920950
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of IRS2 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of IRS2 mRNA"19167446
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of IRS2 mRNA"28433925
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of IRS2 mRNA"21346803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [IAPP protein promotes the reaction [rosiglitazone results in increased expression of IRS2 protein]]16204373
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of IRS2 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of IRS2 mRNA21420995|2906747
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of IRS2 mRNA22129741
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of IRS2 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of IRS2 mRNA16483693
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of IRS2 mRNA"18687144
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of IRS2 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IRS2 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IRS2 mRNA22316170
D004958EstradiolEstradiol promotes the reaction [Progesterone results in increased expression of IRS2 mRNA]15949379
D004958EstradiolEstradiol promotes the reaction [Progesterone results in increased expression of IRS2 protein]15949379
D004958EstradiolEstradiol promotes the reaction [Progesterone results in increased phosphorylation of IRS2 protein]15949379
D004958EstradiolEstradiol results in decreased expression of IRS2 mRNA19167446
D004958EstradiolEstradiol results in increased expression of IRS2 mRNA15949379
D004958EstradiolEstradiol results in increased expression of IRS2 protein15949379
D004958EstradiolEstradiol results in increased phosphorylation of IRS2 protein15949379
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of IRS2 mRNA17404688
C044887beta-methylcholinebeta-methylcholine affects the expression of IRS2 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of IRS2 mRNA26779933
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of IRS2 mRNA"28433925
C006780bisphenol Abisphenol A results in decreased expression of IRS2 protein22101236
C006780bisphenol Abisphenol A results in increased expression of IRS2 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of IRS2 mRNA26079696
D002104Cadmiummyricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased expression of IRS2 protein]24923654
D002104Cadmium[Streptozocin co-treated with Cadmium] results in decreased expression of IRS2 protein24923654
C081643candesartancandesartan inhibits the reaction [Palmitic Acid results in decreased phosphorylation of IRS2 protein]21255808
C081643candesartan[GCG protein co-treated with candesartan] inhibits the reaction [Palmitic Acid results in decreased phosphorylation of IRS2 protein]21255808
C459604candoxincandoxin results in decreased expression of IRS2 mRNA16309724
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of IRS2 protein12629582
D002392CatechinCatechin inhibits the reaction [Glucose results in decreased expression of IRS2 protein]24262486
D002392CatechinCatechin inhibits the reaction [Glucose results in decreased expression of IRS2 protein modified form]24262486
D002746ChlorpromazineChlorpromazine results in decreased expression of and results in decreased phosphorylation of IRS2 protein17512020
D002746ChlorpromazineChlorpromazine results in decreased expression of and results in increased degradation of IRS2 protein18308779
D002791Cholesterol, Dietary"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of and results in decreased phosphorylation of IRS2 protein"19509184
D003042CocaineCocaine results in increased expression of IRS2 mRNA27899881
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of IRS2 mRNA20971185
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of IRS2 mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of IRS2 mRNA19167446
C029892cupric chloridecupric chloride results in increased expression of IRS2 mRNA17211630
D003474CurcuminCurcumin affects the phosphorylation of IRS2 protein27208389
D016572CyclosporineCyclosporine results in decreased expression of IRS2 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of IRS2 mRNA20106945
C017160cypermethrincypermethrin results in decreased expression of IRS2 mRNA22528246
C014347decitabinedecitabine results in increased expression of IRS2 mRNA16367923
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IRS2 mRNA16054899
D003907DexamethasoneDexamethasone results in increased expression of IRS2 mRNA22733784
D003907DexamethasoneEGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IRS2 mRNA]16054899
D003907DexamethasoneTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IRS2 mRNA]16054899
D003976DiazinonDiazinon results in increased methylation of IRS2 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of IRS2 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of IRS2 mRNA17379624
D002945CisplatinCisplatin results in decreased expression of IRS2 mRNA27392435
D004041Dietary Fats"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of and results in decreased phosphorylation of IRS2 protein"19509184
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of IRS2 mRNA28433925
D004041Dietary Fats[Dietary Fats co-treated with Ethanol] results in increased expression of IRS2 mRNA24275070
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of IRS2 mRNA28433925
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of IRS2 mRNA"28433925
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of IRS2 protein25280772
D004052DiethylnitrosamineDiethylnitrosamine affects the expression of IRS2 mRNA20387270
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of IRS2 mRNA18164116
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of IRS2 mRNA22129741
C051904dinophysistoxin 1dinophysistoxin 1 results in increased expression of IRS2 mRNA28939011
D004317DoxorubicinDoxorubicin affects the expression of IRS2 mRNA25529476
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of IRS2 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of IRS2 mRNA22079256
D000431Ethanol[Dietary Fats co-treated with Ethanol] results in increased expression of IRS2 mRNA24275070
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of IRS2 mRNA23649840
D005047EtoposideIRS2 protein affects the susceptibility to Etoposide16217747
D005227Fatty AcidsFatty Acids affects the expression of IRS2 mRNA17940560
D005419FlavonoidsFlavonoids results in decreased expression of IRS2 mRNA18035473
D005485FlutamideFlutamide results in decreased expression of IRS2 mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of IRS2 mRNA23649840
D005632Fructose"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of and results in decreased phosphorylation of IRS2 protein"19509184
D005632FructoseFructose results in decreased expression of IRS2 mRNA19165636|2648887
D005632FructoseFructose results in decreased expression of IRS2 protein19008412
D005632FructoseNOS3 protein inhibits the reaction [Fructose results in decreased expression of IRS2 protein]19008412
D005632Fructoseresveratrol inhibits the reaction [Fructose results in decreased expression of IRS2 mRNA]26488877
C000599091fumosorinonefumosorinone results in increased phosphorylation of IRS2 protein25796170
C000599091fumosorinonefumosorinone results in increased phosphorylation of IRS2 protein25796170
C039281furanfuran results in decreased expression of IRS2 mRNA26194646
D019833GenisteinGenistein results in decreased expression of IRS2 mRNA19371625
D019833GenisteinGenistein results in increased expression of IRS2 mRNA22228119
C007845gingerolgingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS2 mRNA]22285432
C007845gingerolgingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS2 protein]22285432
D005947GlucoseCatechin inhibits the reaction [Glucose results in decreased expression of IRS2 protein]24262486
D005947GlucoseCatechin inhibits the reaction [Glucose results in decreased expression of IRS2 protein modified form]24262486
D005947GlucoseGlucose results in decreased expression of IRS2 protein24262486
D005947GlucoseGlucose results in decreased expression of IRS2 protein modified form24262486
D005947GlucoseGlucose results in increased phosphorylation of IRS2 protein10430617
D005947GlucosePlant Extracts inhibits the reaction [Glucose results in decreased expression of IRS2 protein]24262486
D005947GlucosePlant Extracts inhibits the reaction [Glucose results in decreased expression of IRS2 protein modified form]24262486
D005947GlucoseIRS2 gene mutant form results in increased abundance of Glucose20028942
D017313FenretinideFenretinide results in increased expression of IRS2 mRNA28973697
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of IRS2 mRNA22129741
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IRS2 mRNA16054899
D0150561-Methyl-3-isobutylxanthineEGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IRS2 mRNA]16054899
D0150561-Methyl-3-isobutylxanthineTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IRS2 mRNA]16054899
C515747isosteviolisosteviol promotes the reaction [Palmitic Acid results in increased expression of IRS2 mRNA]22479612
C515747isosteviolisosteviol results in increased expression of IRS2 mRNA22479612
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IRS2 mRNA23086925
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of IRS2 mRNA24796395
C008261lead acetatelead acetate results in decreased expression of IRS2 mRNA21829687
C045463leflunomideleflunomide results in increased expression of IRS2 mRNA24136188
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of IRS2 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IRS2 mRNA16415329
D008070LipopolysaccharidesRanitidine promotes the reaction [Lipopolysaccharides results in increased expression of IRS2 mRNA]16415329
D008344Maneb[Maneb co-treated with Paraquat] results in decreased expression of IRS2 mRNA23963992
D008344ManebMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IRS2 mRNA]23963992
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of IRS2 mRNA20843944
D008550MelatoninMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IRS2 mRNA]23963992
D008627Mercuric ChlorideMercuric Chloride results in increased expression of IRS2 mRNA16507785
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of IRS2 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride affects the expression of IRS2 mRNA20864626
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of IRS2 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of IRS2 protein26364587
D0156551-Methyl-4-phenylpyridiniumINS protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of IRS2 protein]26364587
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of IRS2 mRNA25543134
C002373monobutyryl cyclic AMPCREM protein inhibits the reaction [monobutyryl cyclic AMP results in increased expression of IRS2 mRNA]25381014
C002373monobutyryl cyclic AMPmonobutyryl cyclic AMP results in increased expression of IRS2 mRNA25381014
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of IRS2 protein24625837
C040015myricetinmyricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased expression of IRS2 protein]24923654
C061545myrtenalmyrtenal inhibits the reaction [Streptozocin results in decreased expression of IRS2 protein]27417257
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of IRS2 mRNA"25554681|2562005
D009532NickelNickel results in decreased expression of IRS2 mRNA24768652|2558310
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of IRS2 protein21411721
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of IRS2 mRNA20971185
D019301Oleic AcidIRS2 inhibits the reaction [Oleic Acid results in increased cleavage of CASP9 protein]14604813
D019301Oleic AcidOleic Acid inhibits the reaction [IRS2 results in increased phosphorylation of and results in increased activity of AKT1 protein]14604813
D010126OzoneOzone results in increased expression of IRS2 mRNA25838073
D019308Palmitic Acidcandesartan inhibits the reaction [Palmitic Acid results in decreased phosphorylation of IRS2 protein]21255808
D019308Palmitic Acid[GCG protein co-treated with candesartan] inhibits the reaction [Palmitic Acid results in decreased phosphorylation of IRS2 protein]21255808
D019308Palmitic AcidGCG protein inhibits the reaction [Palmitic Acid results in decreased phosphorylation of IRS2 protein]21255808
D019308Palmitic AcidPalmitic Acid results in decreased phosphorylation of IRS2 protein21255808
D019308Palmitic Acidisosteviol promotes the reaction [Palmitic Acid results in increased expression of IRS2 mRNA]22479612
D019308Palmitic AcidPalmitic Acid results in increased expression of IRS2 mRNA22479612
D010269Paraquat[Maneb co-treated with Paraquat] results in decreased expression of IRS2 mRNA23963992
D010269ParaquatMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IRS2 mRNA]23963992
D052638Particulate MatterParticulate Matter results in increased methylation of IRS2 gene28495853
D010634PhenobarbitalPhenobarbital results in decreased expression of IRS2 mRNA19270015|2309116
C006253pirinixic acidpirinixic acid results in increased expression of IRS2 mRNA18445702
D010894PiroxicamPiroxicam results in decreased expression of IRS2 mRNA21858171
D010936Plant ExtractsPlant Extracts inhibits the reaction [Glucose results in decreased expression of IRS2 protein]24262486
D010936Plant ExtractsPlant Extracts inhibits the reaction [Glucose results in decreased expression of IRS2 protein modified form]24262486
D010938Plant OilsPlant Oils results in increased expression of IRS2 mRNA23370395
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of IRS2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of IRS2 mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of IRS2 mRNA27413110
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of IRS2 mRNA28903501
D011374ProgesteroneEstradiol promotes the reaction [Progesterone results in increased expression of IRS2 mRNA]15949379
D011374ProgesteroneEstradiol promotes the reaction [Progesterone results in increased expression of IRS2 protein]15949379
D011374ProgesteroneEstradiol promotes the reaction [Progesterone results in increased phosphorylation of IRS2 protein]15949379
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of IRS2 mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of IRS2 mRNA15949379|1740468
D011374ProgesteroneProgesterone results in increased expression of IRS2 protein15949379|2179573
D011374ProgesteroneProgesterone results in increased phosphorylation of IRS2 protein15949379
D011374ProgesteroneProgesterone results in decreased expression of IRS217510236
D011899RanitidineRanitidine promotes the reaction [Lipopolysaccharides results in increased expression of IRS2 mRNA]16415329
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA]25554529
C059514resveratrolresveratrol inhibits the reaction [IRS2 gene mutant form inhibits the reaction [INS protein results in increased expression of IRS2 protein]]25808216|2580821
C059514resveratrolresveratrol inhibits the reaction [IRS2 gene mutant form inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]]25808216
C059514resveratrolresveratrol inhibits the reaction [IRS2 gene mutant form inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]25808216
C059514resveratrolresveratrol results in decreased expression of IRS2 mRNA25667456
C059514resveratrolresveratrol inhibits the reaction [IRS2 gene mutant form results in decreased expression of HMOX1 mRNA]25808216
C059514resveratrolresveratrol inhibits the reaction [IRS2 gene mutant form results in increased activity of PTPN1 protein]20028942
C059514resveratrolresveratrol inhibits the reaction [IRS2 gene mutant form results in increased expression of PTPN1 mRNA]20028942|2580821
C059514resveratrolresveratrol inhibits the reaction [IRS2 gene mutant form results in increased expression of PTPN1 protein]25808216
C059514resveratrolresveratrol inhibits the reaction [Fructose results in decreased expression of IRS2 mRNA]26488877
C059514resveratrolresveratrol inhibits the reaction [Streptozocin results in decreased expression of IRS2 mRNA]26071184
C059514resveratrolresveratrol results in increased expression of IRS2 mRNA25238689|2607118
C089730rosiglitazone2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [IAPP protein promotes the reaction [rosiglitazone results in increased expression of IRS2 protein]]16204373
C089730rosiglitazoneIAPP protein promotes the reaction [rosiglitazone results in increased expression of IRS2 protein]16204373
C089730rosiglitazonerosiglitazone results in increased expression of IRS2 protein16204373
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IRS2 mRNA16054899
C089730rosiglitazoneEGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IRS2 mRNA]16054899
C089730rosiglitazoneTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IRS2 mRNA]16054899
C085746rottlerinrottlerin results in decreased expression of IRS2 protein18308779
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of IRS2 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of IRS2 mRNA25351596
D012834SilverSilver results in increased expression of IRS2 mRNA26551752
C017947sodium arsenitegingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS2 mRNA]22285432
C017947sodium arsenitegingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS2 protein]22285432
C017947sodium arsenitesodium arsenite results in decreased expression of IRS2 mRNA22285432
C017947sodium arsenitesodium arsenite results in decreased expression of IRS2 protein22285432
D017673Sodium Chloride, Dietary"Sodium Chloride, Dietary results in increased phosphorylation of IRS2 protein"14670806
D012999SomanSoman results in increased expression of IRS2 mRNA19281266
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA]25554529
D013311Streptozocinmyricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased expression of IRS2 protein]24923654
D013311Streptozocinmyrtenal inhibits the reaction [Streptozocin results in decreased expression of IRS2 protein]27417257
D013311Streptozocinresveratrol inhibits the reaction [Streptozocin results in decreased expression of IRS2 mRNA]26071184
D013311Streptozocin[Streptozocin co-treated with Cadmium] results in decreased expression of IRS2 protein24923654
D013311StreptozocinStreptozocin results in decreased expression of IRS2 mRNA26071184
D013311StreptozocinStreptozocin results in decreased expression of IRS2 protein27417257
D014284TriiodothyronineTriiodothyronine results in increased expression of IRS2 mRNA17403546
D013739TestosteroneTestosterone results in increased expression of IRS2 mRNA21632903
D013739TestosteroneTestosterone affects the expression of IRS2 mRNA20843997
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IRS2 mRNA21570461
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of IRS2 mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IRS2 mRNA]16054899
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IRS2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IRS2 mRNA21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased phosphorylation of IRS2 protein23639626
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of IRS2 mRNA28973375
C009495titanium dioxidetitanium dioxide analog results in increased expression of IRS2 mRNA25111187
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of IRS2 mRNA20133372
D014212TretinoinTretinoin results in increased expression of IRS2 mRNA16249480|2372400
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRS2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of IRS2 mRNA24935251|2627250
C057693troglitazonetroglitazone results in increased expression of IRS2 mRNA19140230
D014520UrethaneUrethane results in decreased expression of IRS2 mRNA28818685
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased expression of IRS2 mRNA15885361
D014635Valproic AcidValproic Acid results in increased expression of IRS2 mRNA26272509|2800136
D014635Valproic AcidValproic Acid results in increased methylation of IRS2 gene29154799
D014638VanadatesVanadates results in increased expression of IRS2 protein17874149
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of IRS2 gene28495853
D015032ZincZinc results in decreased expression of IRS2 protein19913001

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005158insulin receptor binding-IBA21873635  
GO:0005515protein binding-IPI8662806  15161933  15324660  17353931  17901049  21241768  
23617393  24255178  26496610  
GO:00163031-phosphatidylinositol-3-kinase activity-TAS-  
GO:0019901protein kinase binding-IEA-  
GO:0019903protein phosphatase binding-IEA-  
GO:0019904protein domain specific binding-IEA-  
GO:0043548phosphatidylinositol 3-kinase binding-IBA21873635  
GO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity-TAS-  
GO:007188914-3-3 protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0002053positive regulation of mesenchymal cell proliferation-IEA-  
GO:0002903negative regulation of B cell apoptotic process-ISS-  
GO:0006006glucose metabolic process-TAS9495343  
GO:0007165signal transduction-TAS7675087  
GO:0007411axon guidance-TAS-  
GO:0007420brain development-IEA-  
GO:0008283cell proliferation-IEA-  
GO:0008284positive regulation of cell proliferation-NAS17925406  
GO:0008286insulin receptor signaling pathway-IBA21873635  
GO:0008286insulin receptor signaling pathway-ISS-  
GO:0009749response to glucose-ISS-  
GO:0010748negative regulation of plasma membrane long-chain fatty acid transport-IMP16814735  
GO:0010907positive regulation of glucose metabolic process-IMP16814735  
GO:0019216regulation of lipid metabolic process-IBA21873635  
GO:0019216regulation of lipid metabolic process-TAS16814735  
GO:0030335positive regulation of cell migration-IEA-  
GO:0030879mammary gland development-IEA-  
GO:0030890positive regulation of B cell proliferation-ISS-  
GO:0032000positive regulation of fatty acid beta-oxidation-IMP16814735  
GO:0032024positive regulation of insulin secretion-ISS-  
GO:0032869cellular response to insulin stimulus-IMP16814735  
GO:0033673negative regulation of kinase activity-ISS-  
GO:0036092phosphatidylinositol-3-phosphate biosynthetic process-IEA-  
GO:0038111interleukin-7-mediated signaling pathway-TAS-  
GO:0045725positive regulation of glycogen biosynthetic process-IMP16814735  
GO:0045725positive regulation of glycogen biosynthetic process-NAS17925406  
GO:0046326positive regulation of glucose import-IMP16814735  
GO:0046854phosphatidylinositol phosphorylation-IEA-  
GO:0048015phosphatidylinositol-mediated signaling-TAS-  
GO:0051897positive regulation of protein kinase B signaling-TAS-  
GO:0055088lipid homeostasis-TAS16814735  
GO:0071333cellular response to glucose stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0032991protein-containing complex-IEA-  
KEGG ID KEGG Term
hsa04722Neurotrophin signaling pathway
hsa04910Insulin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04930Type II diabetes mellitus
hsa04960Aldosterone-regulated sodium reabsorption
Reactome ID Reactome Term Evidence
R-HSA-109704PI3K CascadeTAS
R-HSA-112399IRS-mediated signallingTAS
R-HSA-112399IRS-mediated signallingIEA
R-HSA-112412SOS-mediated signallingTAS
R-HSA-112412SOS-mediated signallingIEA
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1266695Interleukin-7 signalingTAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-166520Signaling by NTRKsTAS
R-HSA-166520Signaling by NTRKsIEA
R-HSA-168256Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-187037Signaling by NTRK1 (TRKA)TAS
R-HSA-187037Signaling by NTRK1 (TRKA)IEA
R-HSA-198203PI3K/AKT activationTAS
R-HSA-198203PI3K/AKT activationIEA
R-HSA-199418Negative regulation of the PI3K/AKT networkTAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-2219530Constitutive Signaling by Aberrant PI3K in CancerTAS
R-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)TAS
R-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)IEA
R-HSA-2428924IGF1R signaling cascadeTAS
R-HSA-2428924IGF1R signaling cascadeIEA
R-HSA-2428928IRS-related events triggered by IGF1RTAS
R-HSA-2428928IRS-related events triggered by IGF1RIEA
R-HSA-2586552Signaling by LeptinIEA
R-HSA-422475Axon guidanceTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingTAS
R-HSA-74713IRS activationTAS
R-HSA-74749Signal attenuationTAS
R-HSA-74751Insulin receptor signalling cascadeTAS
R-HSA-74751Insulin receptor signalling cascadeIEA
R-HSA-74752Signaling by Insulin receptorTAS
R-HSA-74752Signaling by Insulin receptorIEA
R-HSA-8853659RET signalingTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA
R-HSA-982772Growth hormone receptor signalingIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25557790An exon variant in insulin receptor gene is associated with susceptibility to colorectal cancer in women. (2015 May)Mahmoudi TTumour Biol
24175768Is there an association between variants in candidate insulin pathway genes IGF-I, IGFBP-3, INSR, and IRS2 and risk of colorectal cancer in the Iranian population? (2013)Karimi KAsian Pac J Cancer Prev