Gene: EIF3A

8661
EIF3|EIF3S10|P167|TIF32|eIF3-p170|eIF3-theta|p180|p185
eukaryotic translation initiation factor 3 subunit A
protein-coding
10q26.11
Ensembl:ENSG00000107581 MIM:602039 Vega:OTTHUMG00000019144 UniprotKB:Q14152
NC_000010.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.399e-1 (AD)  6.516e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DCAF70.945
GIGYF20.908
HDLBP0.907
NOP90.906
TGOLN20.905
CSDE10.903
FBXW110.898
MON1B0.896
DNAJC140.89
DHX380.887

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.709
OR4F5-0.681
OR4F16-0.212
RSPO1-0.203
MTRNR2L6-0.189
GRHL2-0.183
MTRNR2L10-0.175
C20orf85-0.17
NUTM2E-0.162
C17orf112-0.16

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of EIF3A mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of EIF3A mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of EIF3A mRNA"18648102
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of EIF3A mRNA20829426
D000082AcetaminophenAcetaminophen results in decreased expression of EIF3A mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of EIF3A mRNA17562736
D001205Ascorbic AcidAscorbic Acid results in decreased expression of EIF3A mRNA19197388
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with Dextran Sulfate] results in increased expression of EIF3A mRNA26271895
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EIF3A mRNA17275222|1768167
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EIF3A mRNA21839799
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EIF3A mRNA"19150397
D004958EstradiolEstradiol affects the expression of EIF3A mRNA15598610
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of EIF3A mRNA28628672
C006780bisphenol Abisphenol A affects the expression of EIF3A mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of EIF3A protein24552547
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EIF3A mRNA28628672
D002104CadmiumCadmium results in decreased expression of EIF3A mRNA24084258
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of EIF3A mRNA21297351
D002220CarbamazepineCarbamazepine affects the expression of EIF3A mRNA24752500
D002737ChloropreneChloroprene results in increased expression of EIF3A mRNA23125180
D004390ChlorpyrifosChlorpyrifos results in decreased expression of EIF3A mRNA18668222|2069171
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of EIF3A mRNA28472532
C012843cinnamic aldehydecinnamic aldehyde results in increased metabolism of EIF3A protein29267982
D003042CocaineCocaine results in increased expression of EIF3A mRNA17898221
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of EIF3A mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of EIF3A mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of EIF3A mRNA25562108
D003703DemecolcineDemecolcine results in decreased expression of EIF3A mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of EIF3A mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EIF3A mRNA28628672
D016264Dextran Sulfate[Benzo(a)pyrene co-treated with Dextran Sulfate] results in increased expression of EIF3A mRNA26271895
D003976DiazinonDiazinon results in increased expression of EIF3A mRNA29108742
D002945CisplatinCisplatin results in decreased expression of EIF3A mRNA25450742
D002945CisplatinEIF3A results in increased susceptibility to Cisplatin21610145|2162520
D002945CisplatinEIF3A results in increased susceptibility to Cisplatin21610145
D004008DiclofenacDiclofenac affects the expression of EIF3A mRNA24752500
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of EIF3A mRNA26924002
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of EIF3A mRNA"22485181
C024629dimethyl phthalatedimethyl phthalate affects the expression of EIF3A mRNA26924002
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased metabolism of EIF3A protein29267982
D004317DoxorubicinEIF3A results in increased susceptibility to Doxorubicin21610145
D004317DoxorubicinEIF3A results in increased susceptibility to Doxorubicin21610145
D004391DustDust results in decreased expression of EIF3A mRNA17805423
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of EIF3A mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EIF3A mRNA17942748
D005047EtoposideEIF3A results in increased susceptibility to Etoposide21610145
D005047EtoposideEIF3A results in increased susceptibility to Etoposide21610145
D005485FlutamideFlutamide results in increased expression of EIF3A mRNA24136188
D005839GentamicinsGentamicins results in increased expression of EIF3A mRNA22061828
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of EIF3A mRNA20044591|2117940
C013038hydroxyhydroquinonehydroxyhydroquinone results in decreased expression of EIF3A mRNA17572062
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of EIF3A mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EIF3A mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EIF3A mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of EIF3A mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EIF3A mRNA28628672
D007657Ketone BodiesKetone Bodies results in increased expression of EIF3A mRNA16807920
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of EIF3A mRNA"18930950
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of EIF3A mRNA21641980
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of EIF3A protein25809596
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of EIF3A mRNA"26251327
C517284monomethyl phthalatemonomethyl phthalate affects the expression of EIF3A mRNA26924002
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of EIF3A mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of EIF3A mRNA"25554681
C031721naphthalenenaphthalene analog results in increased expression of EIF3A mRNA24976557
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of EIF3A mRNA20971185
C025589ochratoxin Aochratoxin A results in decreased expression of EIF3A protein19445961
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of EIF3A mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of EIF3A mRNA24205000
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of EIF3A protein28126411
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of EIF3A mRNA17616710
D010634PhenobarbitalPhenobarbital results in decreased expression of EIF3A mRNA23091169
D011794QuercetinQuercetin affects the expression of EIF3A protein15221776
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of EIF3A mRNA21427059
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of EIF3A mRNA19244175
D018038Sodium SeleniteSodium Selenite results in increased expression of EIF3A mRNA18175754
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of EIF3A mRNA21641980
C061133tamibarotenetamibarotene results in decreased expression of EIF3A mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EIF3A mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EIF3A mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EIF3A mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of EIF3A protein24648495
D013806TheophyllineTheophylline results in increased expression of EIF3A mRNA16083514
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of EIF3A mRNA25729387
D014212TretinoinTretinoin results in decreased expression of EIF3A mRNA15498508
C012589trichostatin Atrichostatin A affects the expression of EIF3A mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of EIF3A mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of EIF3A mRNA28973697
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of EIF3A mRNA"18930950
C406224valdecoxibvaldecoxib results in decreased expression of EIF3A mRNA24136188
D014635Valproic AcidValproic Acid results in decreased expression of EIF3A mRNA21427059
D001335Vehicle EmissionsVehicle Emissions affects the methylation of EIF3A gene25560391
C025643vinclozolinvinclozolin results in decreased expression of EIF3A mRNA18042343
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of EIF3A mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of EIF3A mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003723RNA binding-IDA25849773  27462815  
GO:0003729mRNA binding-IBA21873635  
GO:0003743translation initiation factor activityCONTRIBUTES_TOIBA21873635  
GO:0003743translation initiation factor activitycontributes_toIC17322308  18599441  
GO:0003743translation initiation factor activitycontributes_toIDA17581632  25849773  
GO:0005198structural molecule activity-NAS9150439  
GO:0005515protein binding-IPI8816444  11169732  14688252  16763566  17353931  17468741  
18423202  18599441  18628297  19245811  19615732  21124883  
22190034  23623729  24396066  
GO:0030971receptor tyrosine kinase binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001732formation of cytoplasmic translation initiation complex-IBA21873635  
GO:0001732formation of cytoplasmic translation initiation complex-IDA17581632  
GO:0002188translation reinitiation-IBA21873635  
GO:0006413translational initiation-IC17322308  18599441  
GO:0006413translational initiation-TAS-  
GO:0070373negative regulation of ERK1 and ERK2 cascade-IEA-  
GO:0075522IRES-dependent viral translational initiation-IDA9573242  23766293  24357634  
GO:0075525viral translational termination-reinitiation-IDA21347434  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005730nucleolus-IDA-  
GO:0005737cytoplasm-NAS9150439  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005852eukaryotic translation initiation factor 3 complex-IDA17322308  17581632  18599441  25849773  
GO:0005874microtubule-IEA-  
GO:0016020membrane-HDA19946888  
GO:0043614multi-eIF complex-IBA21873635  
GO:0071540eukaryotic translation initiation factor 3 complex, eIF3e-IBA21873635  
GO:0071541eukaryotic translation initiation factor 3 complex, eIF3m-IBA21873635  
KEGG ID KEGG Term
hsa03013RNA transport
Reactome ID Reactome Term Evidence
R-HSA-156827L13a-mediated translational silencing of Ceruloplasmin expressionTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-72613Eukaryotic Translation InitiationTAS
R-HSA-72649Translation initiation complex formationTAS
R-HSA-72662Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43STAS
R-HSA-72689Formation of a pool of free 40S subunitsTAS
R-HSA-72695Formation of the ternary complex, and subsequently, the 43S complexTAS
R-HSA-72702Ribosomal scanning and start codon recognitionTAS
R-HSA-72706GTP hydrolysis and joining of the 60S ribosomal subunitTAS
R-HSA-72737Cap-dependent Translation InitiationTAS
R-HSA-72766TranslationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27333287Impact of a Eukaryotic Translation Initiation Factor 3a Polymorphism on Susceptibility to Gastric Cancer. (2016)Liu KMed Princ Pract