Gene: EIF3H

8667
EIF3S3|eIF3-gamma|eIF3-p40
eukaryotic translation initiation factor 3 subunit H
protein-coding
8q23.3-q24.11
Ensembl:ENSG00000147677 MIM:603912 Vega:OTTHUMG00000164919 UniprotKB:O15372
NC_000008.11
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.228e-1 (AD)  1.435e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7833054chr8:116668792 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NPM10.947
BTF30.942
RPL50.938
RPL7A0.933
RPL150.93
NACA0.928
C1orf430.927
RPL60.927
EIF10.923
EIF3F0.923

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.804
OR4F5-0.796
SEC14L3-0.165
FANCD2OS-0.163
PRDM14-0.162
SSX5-0.153
OR52H1-0.153
TAS2R41-0.15
SDIM1-0.149
IFNK-0.149

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of EIF3H mRNA"18648102
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of EIF3H mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EIF3H mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EIF3H mRNA21839799
C006780bisphenol Abisphenol A results in increased expression of EIF3H mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of EIF3H mRNA18804290
C100187chloropicrinchloropicrin affects the expression of EIF3H mRNA26352163
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of EIF3H mRNA17602206
D016572CyclosporineCyclosporine results in increased expression of EIF3H mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of EIF3H mRNA21266533
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of EIF3H mRNA17602206
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of EIF3H mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EIF3H mRNA17942748
D005472FluorouracilFluorouracil results in increased expression of EIF3H protein15585135|1680352
D005839GentamicinsGentamicins results in increased expression of EIF3H protein22061828
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of EIF3H mRNA22634610
D007657Ketone BodiesKetone Bodies results in increased expression of EIF3H mRNA16807920
D008748MethylcholanthreneMethylcholanthrene results in increased expression of EIF3H mRNA18804290
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of EIF3H mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of EIF3H protein26558463
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of EIF3H protein26558463
D008777MethyltestosteroneMethyltestosterone results in decreased expression of EIF3H mRNA29191790
C017557nickel subsulfidenickel subsulfide results in decreased expression of EIF3H mRNA21086188
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of EIF3H protein19716841
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of EIF3H mRNA18804290
D059808PolyphenolsPolyphenols results in decreased expression of EIF3H mRNA16293270
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of EIF3H mRNA28903501
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of EIF3H mRNA"21148743
D018038Sodium SeleniteSodium Selenite results in increased expression of EIF3H mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EIF3H mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EIF3H mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EIF3H mRNA21215274
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of EIF3H gene25560391
C025643vinclozolinvinclozolin results in decreased expression of EIF3H mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0003743translation initiation factor activityCONTRIBUTES_TOIBA21873635  
GO:0003743translation initiation factor activitycontributes_toIC17322308  18599441  
GO:0003743translation initiation factor activitycontributes_toIDA17581632  25849773  
GO:0005515protein binding-IPI12812986  16189514  17043677  17353931  18599441  18628297  
19060904  19615732  19748344  22190034  23623729  26100019  
GO:0008237metallopeptidase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006413translational initiation-IC17322308  18599441  
GO:0006413translational initiation-IDA17581632  
GO:0006413translational initiation-TAS-  
GO:0006446regulation of translational initiation-TAS9341143  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0005852eukaryotic translation initiation factor 3 complex-IBA21873635  
GO:0005852eukaryotic translation initiation factor 3 complex-IDA17322308  17581632  18599441  25849773  
GO:0016020membrane-HDA19946888  
GO:0016282eukaryotic 43S preinitiation complex-IBA21873635  
GO:0042788polysomal ribosome-IBA21873635  
GO:0070062extracellular exosome-HDA19056867  
GO:0071541eukaryotic translation initiation factor 3 complex, eIF3m-IEA-  
KEGG ID KEGG Term
hsa03013RNA transport
Reactome ID Reactome Term Evidence
R-HSA-156827L13a-mediated translational silencing of Ceruloplasmin expressionTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-72613Eukaryotic Translation InitiationTAS
R-HSA-72649Translation initiation complex formationTAS
R-HSA-72662Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43STAS
R-HSA-72689Formation of a pool of free 40S subunitsTAS
R-HSA-72695Formation of the ternary complex, and subsequently, the 43S complexTAS
R-HSA-72702Ribosomal scanning and start codon recognitionTAS
R-HSA-72706GTP hydrolysis and joining of the 60S ribosomal subunitTAS
R-HSA-72737Cap-dependent Translation InitiationTAS
R-HSA-72766TranslationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22367214Characterization of gene-environment interactions for colorectal cancer susceptibility loci. (2012 Apr 15)Hutter CMCancer Res