Gene: SLC4A4

8671
HNBC1|KNBC|NBC1|NBC2|NBCe1-A|SLC4A5|hhNMC|kNBC1|pNBC
solute carrier family 4 member 4
protein-coding
4q13.3
Ensembl:ENSG00000080493 MIM:603345 Vega:OTTHUMG00000129907 UniprotKB:Q9Y6R1
NG_012653.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.231e-1 (AD)  7.253e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2198341chr4:71197327 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg15621697chr4:72166462SLC4A44.300e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ELOVL20.948
SLC1A20.929
PREX20.924
GPC50.924
SLCO1C10.918
GPAM0.917
SPON10.917
ARHGEF260.914
EDNRB0.914
SLC1A30.914

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CACNA1F-0.434
NRG1-0.392
TRABD2A-0.381
ADTRP-0.366
ARHGEF28-0.366
LIPH-0.365
DUSP27-0.363
DPP4-0.357
OSBPL10-0.356
SH3BP5-0.356

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01390Sodium bicarbonateSmall Molecule144-55-8ApprovedTransporter
ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SLC4A4 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of SLC4A4 mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SLC4A4 mRNA"25380136
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of SLC4A4 mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of SLC4A4 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of SLC4A4 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of SLC4A4 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC4A4 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SLC4A4 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC4A4 mRNA19770486
D000638AmiodaroneAmiodarone results in increased expression of SLC4A4 mRNA24535564
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC4A4 mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in increased activity of SLC4A4 protein17325238
C010680antibiotic G 418antibiotic G 418 results in increased expression of SLC4A4 protein mutant form18614622
D001151ArsenicArsenic affects the methylation of SLC4A4 gene25304211
D001151ArsenicArsenic results in increased methylation of SLC4A4 gene25325195
D001280AtrazineAtrazine results in decreased expression of SLC4A4 mRNA25929836
D001280AtrazineAtrazine results in increased expression of SLC4A4 mRNA27614199
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC4A4 mRNA19770486
D004958EstradiolEstradiol results in increased expression of SLC4A4 mRNA19484750
D004958EstradiolEstradiol results in decreased expression of SLC4A4 mRNA20068009
C053541bicalutamidebicalutamide results in decreased expression of SLC4A4 mRNA15638997
C006780bisphenol Abisphenol A results in increased expression of SLC4A4 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of SLC4A4 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SLC4A4 mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of SLC4A4 mRNA17484886
D002509CephaloridineCephaloridine results in decreased expression of SLC4A4 mRNA18500788
D002737ChloropreneChloroprene results in increased expression of SLC4A4 mRNA23125180
C019304ciprofibrateciprofibrate results in increased expression of SLC4A4 mRNA12771043
D003042CocaineCocaine affects the expression of SLC4A4 mRNA20187946
D003042CocaineCocaine results in increased expression of SLC4A4 mRNA17898221
D003471CuprizoneCuprizone results in increased expression of SLC4A4 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of SLC4A4 mRNA20106945|2490755
D016572CyclosporineCyclosporine results in decreased expression of SLC4A4 mRNA19770486
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC4A4 mRNA16054899
D003907DexamethasoneEGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC4A4 mRNA]16054899
D003907DexamethasoneTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC4A4 mRNA]16054899
D004008DiclofenacDiclofenac results in increased expression of SLC4A4 mRNA26934552
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SLC4A4 mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of SLC4A4 mRNA25016146
D004041Dietary FatsDietary Fats results in increased expression of SLC4A4 mRNA21852083
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of SLC4A4 mRNA]21852083
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of SLC4A4 mRNA12771043
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of SLC4A4 mRNA25242112
D0178784,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid"4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of SLC4A4 protein"17325238
D0178784,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid"4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of SLC4A4 protein"17666794
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of SLC4A4 mRNA25380136
D000431EthanolEthanol results in decreased expression of SLC4A4 mRNA29018328
D005419FlavonoidsFlavonoids results in increased expression of SLC4A4 mRNA18035473
D005485FlutamideFlutamide results in decreased expression of SLC4A4 mRNA24136188|2479361
D005839GentamicinsGentamicins results in decreased expression of SLC4A4 protein19967075
D005944GlucosamineGlucosamine results in decreased expression of SLC4A4 mRNA17109745
D017313FenretinideFenretinide results in increased expression of SLC4A4 mRNA28973697
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC4A4 mRNA16054899
D0150561-Methyl-3-isobutylxanthineEGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC4A4 mRNA]16054899
D0150561-Methyl-3-isobutylxanthineTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC4A4 mRNA]16054899
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SLC4A4 mRNA26752646
C045463leflunomideleflunomide results in increased expression of SLC4A4 mRNA24136188
D001556LindaneLindane results in increased expression of SLC4A4 mRNA17785943
C018091maduramicinmaduramicin results in increased expression of SLC4A4 mRNA29128925
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SLC4A4 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of SLC4A4 promoter"26251327
C517284monomethyl phthalatemonomethyl phthalate affects the expression of SLC4A4 mRNA26924002
C500085muraglitazarmuraglitazar results in increased expression of SLC4A4 mRNA21515302
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of SLC4A4 mRNA25380136
C029938nickel sulfatenickel sulfate results in decreased expression of SLC4A4 mRNA22714537
D005996NitroglycerinNitroglycerin results in increased expression of SLC4A4 mRNA12102619
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of SLC4A4 mRNA19716841
D010100OxygenOxygen deficiency results in increased expression of SLC4A4 mRNA20880076
C016030pantogabpantogab results in increased expression of SLC4A4 mRNA17379144
D010416PentachlorophenolPentachlorophenol affects the expression of SLC4A4 mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of SLC4A4 mRNA19162173
D010634PhenobarbitalPhenobarbital affects the expression of SLC4A4 mRNA19136022|2309116
D010634PhenobarbitalPhenobarbital results in decreased expression of SLC4A4 mRNA19162173
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SLC4A4 mRNA19710929
C006253pirinixic acidpirinixic acid affects the expression of SLC4A4 mRNA19136022
C006253pirinixic acidpirinixic acid results in decreased expression of SLC4A4 mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of SLC4A4 mRNA18301758|2081375
C006253pirinixic acidpirinixic acid results in increased expression of SLC4A4 mRNA19162173|2248451
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of SLC4A4 mRNA27413110
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of SLC4A4 mRNA19162173
D011441PropylthiouracilPropylthiouracil results in decreased expression of SLC4A4 mRNA24780913
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of SLC4A4 mRNA]21852083
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC4A4 mRNA16054899
C089730rosiglitazoneEGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC4A4 mRNA]16054899
C089730rosiglitazoneTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC4A4 mRNA]16054899
C089730rosiglitazonerosiglitazone results in increased expression of SLC4A4 mRNA21515302
D012643SeleniumSelenium results in decreased expression of SLC4A4 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SLC4A4 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of SLC4A4 mRNA23221170
D012964SodiumSLC4A4 protein results in increased transport of Sodium18614622
C009277sodium arsenatesodium arsenate results in increased expression of SLC4A4 mRNA21795629
C017947sodium arsenitesodium arsenite affects the methylation of SLC4A4 gene28589171
D017693Sodium BicarbonateSLC4A4 protein results in increased transport of Sodium Bicarbonate18614622
C501413tesaglitazartesaglitazar results in increased expression of SLC4A4 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC4A4 mRNA]16054899
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC4A4 mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC4A4 mRNA16054898|1879615
D014212TretinoinTretinoin results in increased expression of SLC4A4 mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of SLC4A4 mRNA24935251|2670570
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of SLC4A4 mRNA17982090
D014415TunicamycinTunicamycin results in decreased expression of SLC4A4 mRNA17127020
D014635Valproic AcidValproic Acid results in increased expression of SLC4A4 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of SLC4A4 mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of SLC4A4 mRNA24535564
D014638VanadatesVanadates results in increased expression of SLC4A4 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SLC4A4 gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of SLC4A4 mRNA25423262
D014810Vitamin EVitamin E results in decreased expression of SLC4A4 mRNA19244175
C088658zoledronic acidzoledronic acid results in decreased expression of SLC4A4 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005452inorganic anion exchanger activity-IEA-  
GO:0005515protein binding-IPI15563508  16769890  
GO:0008509anion transmembrane transporter activity-IBA21873635  
GO:0008510sodium:bicarbonate symporter activity-IBA21873635  
GO:0008510sodium:bicarbonate symporter activity-IMP17661077  
GO:0008510sodium:bicarbonate symporter activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006814sodium ion transport-IDA16769890  
GO:0015698inorganic anion transport-IEA-  
GO:0015701bicarbonate transport-IBA21873635  
GO:0015701bicarbonate transport-TAS-  
GO:0051453regulation of intracellular pH-IBA21873635  
GO:0098656anion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS9235899  
GO:0016323basolateral plasma membrane-IDA17661077  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa04964Proximal tubule bicarbonate reclamation
hsa04972Pancreatic secretion
hsa04976Bile secretion
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425381Bicarbonate transportersTAS
R-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptidesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-5619054Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)TAS
R-HSA-5619102SLC transporter disordersTAS
R-HSA-5619115Disorders of transmembrane transportersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal