Gene: BECN1

8678
ATG6|VPS30|beclin1
beclin 1
protein-coding
17q21.31
Ensembl:ENSG00000126581 MIM:604378 Vega:OTTHUMG00000180653 UniprotKB:Q14457
NC_000017.11
PubMed
CD|OD|ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.257e-1 (AD)  4.350e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
G3BP20.927
PRPS10.924
GNL10.924
ARMCX30.923
PAFAH1B10.923
CHMP30.921
IDH3A0.921
TBRG10.92
SLC30A90.92
POLR2B0.92

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.532
OR4F29-0.521
MTRNR2L6-0.381
AKR1C3-0.37
MTRNR2L10-0.358
MTRNR2L9-0.353
FOXJ1-0.346
EYA2-0.34
HVCN1-0.335
CSAG1-0.335

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00783EstradiolSmall Molecule50-28-2Approved|InvestigationalTarget
DB13952Estradiol acetateSmall Molecule4245-41-4Approved|InvestigationalTarget
DB13953Estradiol benzoateSmall Molecule50-50-0Approved|InvestigationalTarget
DB13954Estradiol cypionateSmall Molecule313-06-4Approved|InvestigationalTarget
DB13955Estradiol dienanthateSmall Molecule7732-97-0Approved|InvestigationalTarget
DB13956Estradiol valerateSmall Molecule979-32-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
D0140131,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Rotenone results in increased expression of BECN1 protein]"18032788
D0140131,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Thenoyltrifluoroacetone results in increased expression of BECN1 protein]"18032788
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of BECN1 mRNA"19162173
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol results in increased activity of BECN1 mRNA]19748465
C0005162-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide results in increased expression of BECN1 protein26815770
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of BECN1 mRNA"19114083
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased expression of BECN1 protein]25955216
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of BECN1 mRNA"21346803
C00059917928-O-acetylbetulin-3-ylglucopyranosideBECN1 mutant form inhibits the reaction [28-O-acetylbetulin-3-ylglucopyranoside results in increased activity of CASP3 protein]22343715
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]28184909
C0259463-methyladenine3-methyladenine inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased expression of BECN1 protein]28130038
C0259463-methyladenine3-methyladenine inhibits the reaction [arsenic trioxide results in increased expression of BECN1]25110043
C0259463-methyladenine3-methyladenine inhibits the reaction [BECN1 protein results in decreased susceptibility to Staurosporine]16497721
C0259463-methyladenine3-methyladenine inhibits the reaction [E platinum results in increased expression of BECN1 protein]22322152
C0259463-methyladenine"3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]]"25622137
C0259463-methyladenine3-methyladenine inhibits the reaction [Hydrogen Peroxide promotes the reaction [BECN1 protein binds to PIK3C3 protein]]20525898
C0259463-methyladenine3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]28184909
C0259463-methyladenine"3-methyladenine inhibits the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]"25622137
C0259463-methyladenine3-methyladenine inhibits the reaction [rottlerin results in increased expression of BECN1 protein]22902833
C0259463-methyladenineBECN1 protein affects the susceptibility to 3-methyladenine22322152
C0259463-methyladenine3-methyladenine inhibits the reaction [4-nonylphenol results in increased expression of BECN1 protein]26804764
C0259463-methyladenine3-methyladenine results in decreased expression of BECN1 mRNA18619688
C0259463-methyladenine3-methyladenine results in decreased expression of BECN1 protein18619688
C0259463-methyladenine3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BECN1 protein]28803810
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of BECN1 mRNA"18648102
C525246(4,4-dimethyl-2,2-bipyridine)(acetylacetonate)copper(II)"(4,4-dimethyl-2,2-bipyridine)(acetylacetonate)copper(II) results in increased expression of BECN1 protein"22540380
C5857454-amino-2-trifluoromethyl-phenyl retinate3-methyladenine inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased expression of BECN1 protein]28130038
C5857454-amino-2-trifluoromethyl-phenyl retinate4-amino-2-trifluoromethyl-phenyl retinate results in increased expression of BECN1 mRNA28130038
C5857454-amino-2-trifluoromethyl-phenyl retinate4-amino-2-trifluoromethyl-phenyl retinate results in increased expression of BECN1 protein28130038
C0325384-cresol4-cresol results in increased expression of BECN1 protein25668154
C0325384-cresol4-cresol results in increased expression of BECN125668154
C0415944-nonylphenol3-methyladenine inhibits the reaction [4-nonylphenol results in increased expression of BECN1 protein]26804764
C0415944-nonylphenol4-nonylphenol results in increased expression of BECN1 mRNA28041982
C0415944-nonylphenol4-nonylphenol results in increased expression of BECN1 protein26804764|2804198
C0415944-nonylphenol"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [4-nonylphenol results in increased expression of BECN1 protein]"28041982
C0415944-nonylphenolAcetylcysteine inhibits the reaction [4-nonylphenol results in increased expression of BECN1 protein]26804764
C0415944-nonylphenolAICA ribonucleotide promotes the reaction [4-nonylphenol results in increased expression of BECN1 protein]28041982
C0415944-nonylphenolPRKAA1 protein promotes the reaction [4-nonylphenol results in increased expression of BECN1 protein]28041982
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Ethylmercury Compounds results in increased expression of BECN1 protein]27511942
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [4-nonylphenol results in increased expression of BECN1 protein]"28041982
C501332ABT-737ABT-737 inhibits the reaction [Cholecalciferol promotes the reaction [BECN1 protein binds to BCL2L1 protein]]18628207
D000111AcetylcysteineAcetylcysteine inhibits the reaction [brazilin results in increased expression of BECN1 protein]28063998
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Butyric Acid results in increased expression of BECN1 protein]28600122
D000111AcetylcysteineAcetylcysteine inhibits the reaction [cucurbitacin E results in increased expression of and results in increased phosphorylation of BECN1 protein]27106530
D000111AcetylcysteineAcetylcysteine inhibits the reaction [pyrovalerone analog results in increased expression of BECN1 protein]28578026
D000111AcetylcysteineAcetylcysteine inhibits the reaction [vorinostat results in increased expression of BECN1 protein]20543569
D000111AcetylcysteineAcetylcysteine inhibits the reaction [[CASP2 protein affects the susceptibility to Rotenone] which results in increased expression of BECN1 protein]21216964
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of BECN1 protein]24614525
D000111AcetylcysteineAcetylcysteine inhibits the reaction [4-nonylphenol results in increased expression of BECN1 protein]26804764
D000111AcetylcysteineAcetylcysteine inhibits the reaction [decamethrin results in increased expression of BECN1 protein]26588882
D012794Sialic AcidsSialic Acids inhibits the reaction [Lipopolysaccharides results in increased expression of BECN1 protein]24973090
C031143AICA ribonucleotideAICA ribonucleotide promotes the reaction [4-nonylphenol results in increased expression of BECN1 protein]28041982
C031143AICA ribonucleotideAICA ribonucleotide results in increased expression of BECN1 protein28041982
C067527aluminum maltolatealuminum maltolate results in increased expression of BECN122138567
D000643Ammonium ChlorideAmmonium Chloride affects the expression of BECN1 mRNA16483693
D000841AnisomycinAnisomycin promotes the reaction [Colistin results in increased expression of BECN1 protein]28842171
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of BECN1 mRNA24449571
D047310ApigeninApigenin promotes the reaction [Fluorouracil results in increased expression of BECN1 protein]28025107
D047310ApigeninApigenin results in increased expression of BECN1 protein28025107
D047310ApigeninFluorouracil promotes the reaction [Apigenin results in increased expression of BECN1 protein]28025107
C000228aristolochic acid I[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of BECN1 mRNA23912714
C042310aristolochic acid II[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of BECN1 mRNA23912714
D001151ArsenicArsenic affects the methylation of BECN1 gene25304211
D001151ArsenicBECN1 mutant form promotes the reaction [Arsenic results in decreased expression of CAT protein]26385919
D001151ArsenicBECN1 mutant form promotes the reaction [Arsenic results in decreased expression of SOD2 protein]26385919
C006632arsenic trioxide3-methyladenine inhibits the reaction [arsenic trioxide results in increased expression of BECN1]25110043
C006632arsenic trioxidearsenic trioxide results in increased expression of BECN125110043
C006632arsenic trioxidearsenic trioxide results in increased expression of BECN1 mRNA22519831
C006632arsenic trioxidearsenic trioxide results in increased expression of BECN1 protein16882451|2020047
C006632arsenic trioxideBECN1 protein promotes the reaction [arsenic trioxide results in increased degradation of BCR protein mutant form]22898604
C006632arsenic trioxideCycloheximide inhibits the reaction [arsenic trioxide results in increased expression of BECN1 protein]16882451
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased expression of BECN1 protein20876807
D001280AtrazineAtrazine results in increased expression of BECN1 mRNA22378314
D001280AtrazineAtrazine results in increased expression of BECN1 mRNA26075868
D001280AtrazineAtrazine results in increased expression of BECN1 protein26075868
C019264avermectinavermectin results in increased expression of BECN1 mRNA26541719
C019264avermectinavermectin results in increased expression of BECN1 protein26541719
D001387AzinphosmethylAzinphosmethyl results in increased expression of BECN1 mRNA26688254
C057620bafilomycin A[bafilomycin A co-treated with Deoxyglucose co-treated with demycarosyl-3D-digitoxosylmithramycin SK] results in decreased expression of BECN1 protein26079942
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BECN1 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BECN1 mRNA21839799
C517629benzyloxycarbonyl-valyl-alanyl-aspartic acidbenzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of BECN1 protein]25939952
C103712benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethanebenzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane results in increased expression of BECN1 protein28483490
D004958EstradiolEstradiol binds to BECN1 protein21034808
C014638beta-lapachoneBECN1 protein affects the susceptibility to beta-lapachone21035436
C009479beta-thujaplicinbeta-thujaplicin results in increased expression of BECN1 protein25044443
D001688Biological ProductsBiological Products results in increased expression of BECN1 protein28219700
C006780bisphenol Abisphenol A affects the expression of BECN1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of BECN1 mRNA26746108
C006780bisphenol ABECN1 protein affects the susceptibility to bisphenol A26139607
C006780bisphenol ABECN1 protein promotes the reaction [bisphenol A affects the localization of HMGB1 protein]26139607
C006780bisphenol Abisphenol A results in decreased expression of BECN1 mRNA27539358
C006780bisphenol Abisphenol A results in decreased expression of BECN1 protein27296223
C006780bisphenol Abisphenol A results in increased expression of BECN1 mRNA26139607
C006780bisphenol Abisphenol A results in increased expression of BECN1 protein26139607
C006780bisphenol Abisphenol A results in increased expression of BECN1 mRNA28819136
C557045BO-1051BECN1 protein inhibits the reaction [BO-1051 results in increased cleavage of CASP7 protein]21184746
D000069286BortezomibBECN1 mutant form promotes the reaction [Bortezomib results in increased cleavage of and results in increased activity of CASP3 protein]22842577
D000069286BortezomibBECN1 protein results in decreased susceptibility to Bortezomib22842577
C044362brazilinAcetylcysteine inhibits the reaction [brazilin results in increased expression of BECN1 protein]28063998
C044362brazilinBECN1 inhibits the reaction [brazilin results in increased activity of CASP3 protein]28063998
C044362brazilinBECN1 inhibits the reaction [brazilin results in increased expression of PARP1 protein modified form]28063998
C044362brazilinbrazilin results in increased expression of BECN1 mRNA28063998
C044362brazilinbrazilin results in increased expression of BECN1 protein28063998
C044362brazilinRELA protein promotes the reaction [brazilin results in increased expression of BECN1 mRNA]28063998
C044362brazilinRELA protein promotes the reaction [brazilin results in increased expression of BECN1 protein]28063998
D020148Butyric AcidAcetylcysteine inhibits the reaction [Butyric Acid results in increased expression of BECN1 protein]28600122
D020148Butyric AcidButyric Acid results in increased expression of BECN1 protein28600122
D002104CadmiumCadmium results in increased expression of BECN1 mRNA27492225
D002104CadmiumFOXO3 affects the reaction [Cadmium results in increased expression of BECN1 mRNA]27492225
D002104Cadmium2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased expression of BECN1 protein]25955216
D002104CadmiumCadmium results in increased expression of BECN1 protein23880342|2595521
D019256Cadmium ChlorideATG4A protein affects the reaction [Cadmium Chloride results in increased expression of BECN1 protein]29179951
D019256Cadmium ChlorideCadmium Chloride results in increased expression of BECN1 protein29179951
D019256Cadmium ChlorideCadmium Chloride results in increased expression of BECN1 protein29179951
C055085calcipotrienecalcipotriene results in increased expression of BECN1 protein21228817
D002211CapsaicinCapsaicin results in increased expression of BECN1 mRNA20349343
D002258Carbonyl Cyanide m-Chlorophenyl HydrazoneBECN1 protein inhibits the reaction [BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]]24879156
D002258Carbonyl Cyanide m-Chlorophenyl HydrazoneCarbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [BECN1 protein binds to PRKN protein]24879156
D002258Carbonyl Cyanide m-Chlorophenyl HydrazoneCarbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [BECN1 protein binds to PARK2 protein]24879156
D002258Carbonyl Cyanide m-Chlorophenyl HydrazoneBECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PINK1 protein]24879156
D002258Carbonyl Cyanide m-Chlorophenyl HydrazoneBECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]24879156
D002258Carbonyl Cyanide m-Chlorophenyl HydrazoneBECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of and results in increased ubiquitination of MFN2 protein]24879156
D002258Carbonyl Cyanide m-Chlorophenyl HydrazoneBECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased phosphorylation of PRKN protein]24879156
D002258Carbonyl Cyanide m-Chlorophenyl HydrazoneCarbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [BECN1 protein binds to PRKN protein]24879156
D002330CarmustineCarmustine results in decreased expression of BECN1 mRNA15980968
C043211carvedilolcarvedilol results in increased expression of BECN1 protein20079142
D002738ChloroquineCarboplatin promotes the reaction [Chloroquine results in decreased expression of BECN1 protein]27692344
D002738ChloroquineChloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]28184909
D002738ChloroquineChloroquine promotes the reaction [Carboplatin results in decreased expression of BECN1 protein]27692344
D002738ChloroquineChloroquine results in decreased expression of BECN1 protein27692344
C023676chloroquine diphosphatechloroquine diphosphate inhibits the reaction [Tobacco Smoke Pollution results in increased expression of BECN1 protein]27037187
D002791Cholesterol, Dietary"Cholesterol, Dietary results in decreased expression of BECN1 protein"24267781
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of BECN1 gene20938992
D002953CitrininCitrinin results in increased expression of BECN1 mRNA22771370
C018021cobaltous chloride[cobaltous chloride co-treated with TP53 gene mutant form] results in increased expression of BECN1 protein23380477
C018021cobaltous chloridecobaltous chloride results in increased expression of BECN1 mRNA23684559
C018021cobaltous chloridecobaltous chloride results in increased expression of BECN1 protein23684559
D003091ColistinAnisomycin promotes the reaction [Colistin results in increased expression of BECN1 protein]28842171
D003091ColistinColistin results in increased expression of BECN1 protein28842171
D003091Colistinpyrazolanthrone inhibits the reaction [Colistin results in increased expression of BECN1 protein]28842171
C102326cucurbitacin EAcetylcysteine inhibits the reaction [cucurbitacin E results in increased expression of and results in increased phosphorylation of BECN1 protein]27106530
C102326cucurbitacin Ecucurbitacin E results in increased expression of and results in increased phosphorylation of BECN1 protein27106530
D003513CycloheximideCycloheximide inhibits the reaction [arsenic trioxide results in increased expression of BECN1 protein]16882451
D003520CyclophosphamideBECN1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
D003609DactinomycinDactinomycin inhibits the reaction [Ethanol results in increased expression of BECN1 protein]24095927
C017180decamethrinAcetylcysteine inhibits the reaction [decamethrin results in increased expression of BECN1 protein]26588882
C017180decamethrindecamethrin results in increased expression of BECN1 protein26588882
C017180decamethrinpyrazolanthrone inhibits the reaction [decamethrin results in increased expression of BECN1 protein]26588882
C017180decamethrinSB 203580 inhibits the reaction [decamethrin results in increased expression of BECN1 protein]26588882
C017180decamethrinU 0126 inhibits the reaction [decamethrin results in increased expression of BECN1 protein]26588882
C014347decitabinedecitabine inhibits the reaction [sodium arsenite results in increased expression of BECN1 protein]19577553
D003676DeferoxamineDeferoxamine inhibits the reaction [Hydrogen Peroxide affects the localization of BECN1 protein]21742779
C576677demycarosyl-3D-digitoxosylmithramycin SK[bafilomycin A co-treated with Deoxyglucose co-treated with demycarosyl-3D-digitoxosylmithramycin SK] results in decreased expression of BECN1 protein26079942
C576677demycarosyl-3D-digitoxosylmithramycin SK[demycarosyl-3D-digitoxosylmithramycin SK co-treated with Deoxyglucose] results in increased expression of BECN1 mRNA26079942
C576677demycarosyl-3D-digitoxosylmithramycin SKdemycarosyl-3D-digitoxosylmithramycin SK results in increased expression of BECN1 mRNA26079942
D003847Deoxyglucose[bafilomycin A co-treated with Deoxyglucose co-treated with demycarosyl-3D-digitoxosylmithramycin SK] results in decreased expression of BECN1 protein26079942
D003847Deoxyglucose[demycarosyl-3D-digitoxosylmithramycin SK co-treated with Deoxyglucose] results in increased expression of BECN1 mRNA26079942
C539263di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone"BECN1 mutant form inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone results in increased expression of MAP1LC3B protein]"25301941
D016190CarboplatinCarboplatin promotes the reaction [Chloroquine results in decreased expression of BECN1 protein]27692344
D016190CarboplatinCarboplatin results in decreased expression of BECN1 protein27692344
D016190CarboplatinChloroquine promotes the reaction [Carboplatin results in decreased expression of BECN1 protein]27692344
D002945CisplatinBECN1 affects the reaction [NACC1 affects the susceptibility to Cisplatin]21743489
D002945CisplatinBECN1 mutant form results in increased susceptibility to Cisplatin24817946
D002945CisplatinCisplatin inhibits the reaction [Melatonin results in increased expression of BECN1 protein]24799992
D002945CisplatinCisplatin results in decreased expression of BECN1 protein24799992
D002945CisplatinCisplatin results in increased expression of BECN1 mRNA21151649
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in decreased expression of BECN1 mRNA26924002
C472036dihydromyricetindihydromyricetin results in increased expression of BECN124444546
C472036dihydromyricetindihydromyricetin promotes the reaction [Ethanol results in increased expression of BECN1 protein]28419832
D002117Calcitriol2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol results in increased activity of BECN1 mRNA]19748465
D002117CalcitriolBECN1 results in increased susceptibility to Calcitriol19748465
D002117CalcitriolCalcitriol results in increased expression of BECN1 mRNA19748465
D002117CalcitriolCAMP mutant form inhibits the reaction [Calcitriol results in increased expression of BECN1 mRNA]19748465
D002117Calcitriol[CAMP results in increased activity of CEBPB] affects the reaction [Calcitriol results in increased expression of BECN1 mRNA]19748465
D002117Calcitriol[CAMP results in increased activity of MAPK14] affects the reaction [Calcitriol results in increased expression of BECN1 mRNA]19748465
D002117Calcitriol[CAMP results in increased activity of MAPK1] affects the reaction [Calcitriol results in increased expression of BECN1 mRNA]19748465
D002117Calcitriol[CAMP results in increased activity of MAPK3] affects the reaction [Calcitriol results in increased expression of BECN1 mRNA]19748465
D002117CalcitriolCEBPB mutant form inhibits the reaction [Calcitriol results in increased expression of BECN1 mRNA]19748465
D002117CalcitriolSB 203580 inhibits the reaction [Calcitriol results in increased activity of BECN1 mRNA]19748465
C002302dimethoxondimethoxon results in decreased expression of BECN1 mRNA26688254
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of BECN1 mRNA"24576726
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of BECN1 protein"24576726
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of BECN1 mRNA26924002
D004178Diquat[Diquat co-treated with procyanidin B2] results in increased expression of BECN1 mRNA27057282
C009873divinyl sulfonedivinyl sulfone analog results in increased expression of BECN1 protein24875536
D004317DoxorubicinBECN1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
D004317DoxorubicinBECN1 protein affects the susceptibility to Doxorubicin16718815
D004317Doxorubicin[Doxorubicin co-treated with resveratrol] results in decreased expression of BECN1 protein26969377
D004317DoxorubicinDoxorubicin results in decreased expression of BECN1 protein26969377
D004317DoxorubicinDoxorubicin results in increased expression of BECN1 mRNA19001878
D004317DoxorubicinDoxorubicin results in increased expression of BECN1 protein19001878
D004317DoxorubicinPARP1 protein promotes the reaction [Doxorubicin results in increased expression of BECN1 mRNA]19001878
D004317DoxorubicinPARP1 protein promotes the reaction [Doxorubicin results in increased expression of BECN1 protein]19001878
D004317DoxorubicinDoxorubicin results in decreased expression of BECN1 protein25997894|2766600
D004317DoxorubicinDoxorubicin results in increased expression of BECN1 protein26678157
D004317Doxorubicin[Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] inhibits the reaction [Doxorubicin results in decreased expression of BECN1 protein]25997894
C572014E platinum3-methyladenine inhibits the reaction [E platinum results in increased expression of BECN1 protein]22322152
C572014E platinumE platinum results in increased expression of BECN1 protein22322152
D000069347Erlotinib HydrochlorideBECN1 protein results in decreased susceptibility to Erlotinib Hydrochloride23917044
D000431EthanolEthanol results in decreased expression of BECN1 protein21410490
D000431EthanolEthanol results in increased degradation of BECN1 protein21410490
D000431EthanolEthanol results in increased expression of BECN1 mRNA24095927
D000431EthanolSirolimus inhibits the reaction [Ethanol results in increased degradation of BECN1 protein]21410490
D000431Ethanolwortmannin promotes the reaction [Ethanol results in increased degradation of BECN1 protein]21410490
D000431EthanolDactinomycin inhibits the reaction [Ethanol results in increased expression of BECN1 protein]24095927
D000431Ethanoldihydromyricetin promotes the reaction [Ethanol results in increased expression of BECN1 protein]28419832
D000431EthanolEthanol results in increased expression of BECN1 mRNA24095927|2449248
D000431EthanolEthanol results in increased expression of BECN1 protein24095927|2449248
D000431EthanolFOXO3 protein affects the reaction [Ethanol results in increased expression of BECN1 mRNA]24095927
D000431EthanolFOXO3 protein affects the reaction [Ethanol results in increased expression of BECN1 protein]24095927
D000431EthanolNR1H4 gene mutant form inhibits the reaction [Ethanol results in increased expression of BECN1 mRNA]25460735
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BECN1 mRNA17942748
D005035Ethylmercury Compounds4-phenylbutyric acid inhibits the reaction [Ethylmercury Compounds results in increased expression of BECN1 protein]27511942
D005035Ethylmercury CompoundsEthylmercury Compounds results in increased expression of BECN1 protein27511942
D015025ZearalenoneZearalenone results in increased expression of BECN124530352
C000499ferric oxideferric oxide analog results in increased expression of BECN1 protein24068039
C000499ferric oxideferric oxide results in decreased expression of BECN1 protein25086211
D000068876Fingolimod HydrochlorideBECN1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]25939952
D000068876Fingolimod Hydrochloridebenzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of BECN1 protein]25939952
D000068876Fingolimod HydrochlorideFingolimod Hydrochloride results in increased expression of and results in increased cleavage of BECN1 protein25939952
D005472FluorouracilBECN1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
D005472FluorouracilApigenin promotes the reaction [Fluorouracil results in increased expression of BECN1 protein]28025107
D005472FluorouracilFluorouracil promotes the reaction [Apigenin results in increased expression of BECN1 protein]28025107
D005472FluorouracilFluorouracil results in increased expression of BECN1 protein28025107
D005473FluoxetineFluoxetine results in increased expression of BECN1 protein20503272
D005485FlutamideFlutamide results in increased expression of BECN1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of BECN1 gene20938992
C067584formosanin Cformosanin C results in increased expression of BECN1 protein27180204
D005620Freund's AdjuvantFreund's Adjuvant results in increased expression of BECN1 mRNA20349343
D005690Galactose[Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] inhibits the reaction [Doxorubicin results in decreased expression of BECN1 protein]25997894
C037032galangin[BECN1 mutant form co-treated with galangin] results in decreased activity of CASP3 protein25268046
C037032galangingalangin results in increased expression of BECN1 mRNA25268046
C037032galangingalangin results in increased expression of BECN1 protein25268046
C037032galanginLY2109761 inhibits the reaction [galangin results in increased expression of BECN1 protein]25268046
C037032galanginSMAD4 mutant form inhibits the reaction [galangin results in increased expression of BECN1 protein]25268046
C007845gingerol[gingerol co-treated with Hydrogen Peroxide] results in increased expression of BECN1 protein27451028
D005947Glucose[Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] inhibits the reaction [Doxorubicin results in decreased expression of BECN1 protein]25997894
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of BECN1 mRNA22634610
C010974glyphosateBECN1 results in increased susceptibility to glyphosate22504123
C010974glyphosateglyphosate results in increased expression of BECN1 mRNA26302742
C059922gossypetin"3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]]"25622137
C059922gossypetinBECN1 protein results in increased susceptibility to gossypetin25622137
C059922gossypetin"gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]"25622137
C059922gossypetin"gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of BECN1 protein]"25622137
D006108Graphite[Graphite analog co-treated with Tetradecanoylphorbol Acetate] results in increased expression of BECN1 protein25446327
D006861Hydrogen Peroxide3-methyladenine inhibits the reaction [Hydrogen Peroxide promotes the reaction [BECN1 protein binds to PIK3C3 protein]]20525898
D006861Hydrogen PeroxideBECN1 protein affects the reaction [Hydrogen Peroxide affects the localization of BAX protein]21742779
D006861Hydrogen PeroxideBECN1 protein affects the susceptibility to Hydrogen Peroxide21742779
D006861Hydrogen PeroxideDeferoxamine inhibits the reaction [Hydrogen Peroxide affects the localization of BECN1 protein]21742779
D006861Hydrogen Peroxide[gingerol co-treated with Hydrogen Peroxide] results in increased expression of BECN1 protein27451028
D006861Hydrogen PeroxideHydrogen Peroxide affects the localization of BECN1 protein21742779
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [BECN1 protein binds to PIK3C3 protein]20525898
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of BECN1 protein19451193
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with procyanidin B2] results in increased expression of BECN1 mRNA27057282
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of BECN1 protein24889822
C031927hydroquinonehydroquinone results in increased expression of BECN1 mRNA28263894
C031927hydroquinonehydroquinone results in increased expression of BECN1 protein28263894
C031927hydroquinonePARP1 protein promotes the reaction [hydroquinone results in increased expression of BECN1 mRNA]28263894
C031927hydroquinoneSIRT1 protein inhibits the reaction [hydroquinone results in increased expression of BECN1 mRNA]28263894
D0201553-Hydroxybutyric AcidBECN1 protein results in increased abundance of 3-Hydroxybutyric Acid25943029
C005044hydroxyethyl methacrylate3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]28184909
C005044hydroxyethyl methacrylate3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]28184909
C005044hydroxyethyl methacrylateChloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]28184909
C005044hydroxyethyl methacrylatehydroxyethyl methacrylate results in increased expression of BECN1 mRNA28184909
C005044hydroxyethyl methacrylatehydroxyethyl methacrylate results in increased expression of BECN1 protein28184909
D058085Iron CompoundsIron Compounds results in increased expression of BECN1 protein28483490
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of BECN1 mRNA23430699
D048628KetolidesKetolides analog results in increased expression of BECN1 mRNA24967691
D007657Ketone BodiesKetone Bodies results in decreased expression of BECN1 mRNA16807920
C096429L 709049L 709049 results in increased expression of BECN1 protein28483490
C008261lead acetatelead acetate results in increased cleavage of BECN1 protein22811615
C008261lead acetatelead acetate results in increased expression of BECN1 protein22811615
D001556LindaneLindane affects the expression of BECN1 protein19041923
D001556LindaneLindane promotes the reaction [BECN1 protein binds to BCL2 protein]19041923
D008044LinuronLinuron results in increased expression of BECN1 mRNA28705778
C440499lipopolysaccharide, Escherichia coli O111 B4"BECN1 protein affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of HMGB1 protein]"19265175
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of BECN1 protein24973090
D008070LipopolysaccharidesSialic Acids inhibits the reaction [Lipopolysaccharides results in increased expression of BECN1 protein]24973090
C530108LY2109761LY2109761 inhibits the reaction [galangin results in increased expression of BECN1 protein]25268046
C569869malondialdehyde-low density lipoprotein, human"3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]]"25622137
C569869malondialdehyde-low density lipoprotein, human"3-methyladenine inhibits the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]"25622137
C569869malondialdehyde-low density lipoprotein, human"gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]"25622137
C569869malondialdehyde-low density lipoprotein, human"gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of BECN1 protein]"25622137
C569869malondialdehyde-low density lipoprotein, human"malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]"25622137
C569869malondialdehyde-low density lipoprotein, human"malondialdehyde-low density lipoprotein, human results in increased expression of BECN1 protein"25622137
D008344ManebManeb results in increased expression of BECN1 protein22292029
C025340manganese chloridemanganese chloride promotes the reaction [BCL2 protein binds to BECN1 protein]28856835
C025340manganese chlorideN-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [manganese chloride promotes the reaction [BCL2 protein binds to BECN1 protein]]28856835
C025340manganese chloridemanganese chloride results in decreased expression of BECN1 protein23604964
C025340manganese chloridemanganese chloride results in increased expression of BECN1 protein23604964
C025340manganese chloridewortmannin inhibits the reaction [manganese chloride results in increased expression of BECN1 protein]23604964
D008376MaprotilineMaprotiline results in increased expression of BECN1 protein20503272
D008550MelatoninCisplatin inhibits the reaction [Melatonin results in increased expression of BECN1 protein]24799992
D008550MelatoninMelatonin results in increased expression of BECN1 protein24799992
C014655methamidophosmethamidophos results in increased expression of BECN1 mRNA26688254
D008694MethamphetamineDDIT4 protein promotes the reaction [Methamphetamine results in increased expression of BECN1 protein]26825372
D008694MethamphetamineMethamphetamine results in increased expression of BECN1 protein26825372
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of BECN1 gene20938992
D008727MethotrexateMethotrexate results in increased expression of BECN1 mRNA21678067
C587228methyl 3-hydroxyimino-11-oxoolean-12-en-28-oatemethyl 3-hydroxyimino-11-oxoolean-12-en-28-oate results in increased expression of BECN1 protein24291674
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium promotes the reaction [LRRK2 gene mutant form results in increased expression of BECN1 protein]25017139
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of BECN1 protein25017139
C517284monomethyl phthalatemonomethyl phthalate results in decreased expression of BECN1 mRNA26924002
D009020MorphineMorphine inhibits the reaction [BECN1 protein binds to BCL2 protein]20190558
D009020MorphineMorphine results in increased expression of BECN1 protein20190558
C496401N-((3-(aminomethyl)phenyl)methyl)ethanimidamideN-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [manganese chloride promotes the reaction [BCL2 protein binds to BECN1 protein]]28856835
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of BECN1 protein"23026733|2438911
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of BECN1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of BECN1 protein"24929217
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of BECN1"26327526
C002443neem oilBECN1 results in decreased susceptibility to neem oil22915764
D009532NickelBECN1 protein promotes the reaction [Nickel results in increased cleavage of PARP1 protein]28330870
D009532NickelBECN1 protein promotes the reaction [Nickel results in increased expression of CASP3 protein modified form]28330870
D009532NickelBECN1 protein promotes the reaction [Nickel results in increased expression of CASP7 protein modified form]28330870
C010615Nonidet P-40Nonidet P-40 results in increased expression of BECN1 mRNA26552463
D009828Oleanolic AcidOleanolic Acid analog affects the expression of BECN1 protein26612655
D009842OligopeptidesBECN1 mutant form inhibits the reaction [Oligopeptides analog results in increased cleavage of PARP1 protein]24875536
D009842OligopeptidesOligopeptides analog results in increased expression of BECN1 protein24875536
D010126OzoneOzone results in increased expression of BECN1 protein22727909
D017239PaclitaxelBECN1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
D019308Palmitic AcidBECN1 protein promotes the reaction [resveratrol inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]]25943029
D010269Paraquat[Paraquat co-treated with MAP3K5 protein] results in increased expression of BECN1 protein20929985
D010269ParaquatParaquat results in increased expression of BECN1 mRNA27220436
D010269ParaquatParaquat results in increased expression of BECN1 protein20929985
D010269Paraquatsalubrinal promotes the reaction [[Paraquat co-treated with MAP3K5 protein] results in increased expression of BECN1 protein]20929985
D010269ParaquatParaquat results in increased expression of BECN1 protein22292029|2509264
D052638Particulate MatterParticulate Matter results in increased expression of BECN1 mRNA23685237|2712597
D010664Phenylmethylsulfonyl FluoridePhenylmethylsulfonyl Fluoride inhibits the reaction [tri-o-cresyl phosphate results in decreased expression of BECN1 protein]22366639
C030090phosphoramide mustardphosphoramide mustard results in increased expression of BECN1 mRNA27888070
C030090phosphoramide mustardphosphoramide mustard results in increased expression of BECN1 protein27888070
D010862PilocarpinePilocarpine results in increased expression of BECN1 mRNA17971868|1913867
D010862PilocarpinePilocarpine results in increased expression of BECN1 protein19138675
D010862PilocarpineVitamin E inhibits the reaction [Pilocarpine results in increased expression of BECN1 mRNA]19138675
D010862PilocarpineVitamin E inhibits the reaction [Pilocarpine results in increased expression of BECN1 protein]19138675
C479580procyanidin B2[Diquat co-treated with procyanidin B2] results in increased expression of BECN1 mRNA27057282
C479580procyanidin B2[Hydrogen Peroxide co-treated with procyanidin B2] results in increased expression of BECN1 mRNA27057282
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Colistin results in increased expression of BECN1 protein]28842171
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [decamethrin results in increased expression of BECN1 protein]26588882
C005719pyrovaleroneAcetylcysteine inhibits the reaction [pyrovalerone analog results in increased expression of BECN1 protein]28578026
C005719pyrovaleronepyrovalerone analog results in increased expression of BECN1 protein28578026
D019289Pyruvic Acid[Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] inhibits the reaction [Doxorubicin results in decreased expression of BECN1 protein]25997894
D011794QuercetinQuercetin results in increased expression of BECN1 protein25293876
D011794QuercetinQuercetin inhibits the reaction [Rotenone results in decreased expression of BECN1 protein]27252111
D017382Reactive Oxygen SpeciesBECN1 gene mutant form promotes the reaction [sodium arsenite results in increased abundance of Reactive Oxygen Species]22869613
C059514resveratrolBECN1 protein affects the reaction [resveratrol affects the metabolism of MAP1LC3B protein]23680031
C059514resveratrolBECN1 protein affects the reaction [resveratrol inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein]]21778691
C059514resveratrolBECN1 protein affects the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]24145604
C059514resveratrolBECN1 protein affects the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]24145604
C059514resveratrolBECN1 protein affects the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]24145604
C059514resveratrolBECN1 protein affects the reaction [resveratrol results in increased degradation of SNCA protein]21778691
C059514resveratrolBECN1 protein affects the reaction [[TNF protein co-treated with resveratrol] results in increased expression of MAP1LC3B protein alternative form]24145604
C059514resveratrolBECN1 protein affects the susceptibility to resveratrol23680031
C059514resveratrolBECN1 protein promotes the reaction [resveratrol inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]]25943029
C059514resveratrol[Doxorubicin co-treated with resveratrol] results in decreased expression of BECN1 protein26969377
C059514resveratrolresveratrol analog results in increased expression of BECN123273518
C059514resveratrolresveratrol promotes the reaction [TP53 protein binds to BECN1 protein]23088850
C059514resveratrolresveratrol results in decreased expression of BECN1 protein26969377
C059514resveratrolresveratrol results in increased expression of BECN1 mRNA23680031
C059514resveratrolresveratrol results in decreased expression of BECN1 protein26167810|2693612
C059514resveratrolresveratrol results in increased expression of BECN1 protein24534837
C089730rosiglitazonerosiglitazone results in increased expression of BECN1 protein21376716
D012402Rotenone"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Rotenone results in increased expression of BECN1 protein]"18032788
D012402RotenoneBECN1 protein affects the reaction [resveratrol inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein]]21778691
D012402RotenoneBECN1 protein affects the susceptibility to Rotenone18032788
D012402RotenoneRotenone results in increased expression of BECN1 protein18032788
D012402RotenoneSOD2 protein inhibits the reaction [Rotenone results in increased expression of BECN1 protein]18032788
D012402RotenoneAcetylcysteine inhibits the reaction [[CASP2 protein affects the susceptibility to Rotenone] which results in increased expression of BECN1 protein]21216964
D012402RotenoneBECN1 protein affects the susceptibility to Rotenone26847702
D012402Rotenone[CASP2 protein affects the susceptibility to Rotenone] which results in increased expression of BECN1 protein21216964
D012402RotenoneRotenone results in decreased expression of BECN1 mRNA23186747
D012402RotenoneRotenone results in decreased expression of BECN1 protein21216964
D012402RotenoneGAPDH mutant form promotes the reaction [Rotenone results in increased expression of BECN1 protein]25725130
D012402RotenoneQuercetin inhibits the reaction [Rotenone results in decreased expression of BECN1 protein]27252111
D012402RotenoneRotenone results in decreased expression of BECN1 protein27252111
D012402RotenoneRotenone results in increased expression of BECN1 protein25725130
C085746rottlerin3-methyladenine inhibits the reaction [rottlerin results in increased expression of BECN1 protein]22902833
C085746rottlerinrottlerin results in increased expression of BECN1 protein22902833
C496827salubrinalsalubrinal promotes the reaction [MAP3K5 protein results in increased expression of BECN1 protein]20929985
C496827salubrinalsalubrinal promotes the reaction [[Paraquat co-treated with MAP3K5 protein] results in increased expression of BECN1 protein]20929985
C093642SB 203580SB 203580 inhibits the reaction [Calcitriol results in increased activity of BECN1 mRNA]19748465
C093642SB 203580SB 203580 inhibits the reaction [decamethrin results in increased expression of BECN1 protein]26588882
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of BECN1 protein27613482
D019821SimvastatinSimvastatin results in increased expression of BECN1 protein23817226
D020123SirolimusSirolimus inhibits the reaction [Ethanol results in increased degradation of BECN1 protein]21410490
D020123SirolimusSirolimus results in increased expression of BECN1 protein27107786|2888848
D020123SirolimusSirolimus results in increased expression of BECN1 protein20358864
D020123SirolimusSirolimus results in increased expression of BECN1 protein26648565|2682537
C017947sodium arseniteATG5 protein affects the reaction [sodium arsenite results in increased expression of BECN1 protein]28888487
C017947sodium arseniteBECN1 gene mutant form promotes the reaction [sodium arsenite results in increased abundance of Reactive Oxygen Species]22869613
C017947sodium arsenitedecitabine inhibits the reaction [sodium arsenite results in increased expression of BECN1 protein]19577553
C017947sodium arseniteMIR21 mRNA affects the reaction [sodium arsenite results in increased expression of BECN1 protein]27107786
C017947sodium arsenitePTEN protein affects the reaction [MIR21 mRNA affects the reaction [sodium arsenite results in increased expression of BECN1 protein]]27107786
C017947sodium arsenitePTEN protein affects the reaction [sodium arsenite results in increased expression of BECN1 protein]27107786
C017947sodium arsenitesodium arsenite results in increased expression of BECN1 protein17683884|1957755
C017947sodium arseniteU 0126 inhibits the reaction [sodium arsenite results in increased expression of BECN1 protein]19577553|2710778
C017947sodium arsenitesodium arsenite results in decreased expression of BECN1 mRNA25270620
C017947sodium arsenitesodium arsenite results in increased expression of BECN1 protein26432159
D018038Sodium SeleniteSodium Selenite results in increased expression of BECN1 protein25204997
D019311Staurosporine3-methyladenine inhibits the reaction [BECN1 protein results in decreased susceptibility to Staurosporine]16497721
D019311StaurosporineBECN1 protein results in decreased susceptibility to Staurosporine16497721
D013311StreptozocinStreptozocin results in increased expression of BECN1 mRNA24889822
D013311StreptozocinStreptozocin results in increased expression of BECN1 protein24889822
C473478sunitinibsunitinib results in increased expression of BECN1 protein24751611
C473478sunitinibBECN1 protein results in increased susceptibility to sunitinib20637791
C047246temozolomidetemozolomide results in increased expression of BECN1 protein19567134
C047246temozolomideThalidomide promotes the reaction [temozolomide results in increased expression of BECN1 protein]19567134
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BECN1 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Graphite analog co-treated with Tetradecanoylphorbol Acetate] results in increased expression of BECN1 protein25446327
D009025MorpholinesMorpholines analog results in increased expression of BECN1 protein24875536
C009438tetrandrinetetrandrine results in decreased expression of BECN1 protein25266202
C009438tetrandrinetetrandrine results in increased expression of BECN1 protein26822499
D013792ThalidomideThalidomide promotes the reaction [temozolomide results in increased expression of BECN1 protein]19567134
D013804Thenoyltrifluoroacetone"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Thenoyltrifluoroacetone results in increased expression of BECN1 protein]"18032788
D013804ThenoyltrifluoroacetoneBECN1 protein affects the susceptibility to Thenoyltrifluoroacetone18032788
D013804ThenoyltrifluoroacetoneSOD2 protein inhibits the reaction [Thenoyltrifluoroacetone results in increased expression of BECN1 protein]18032788
D013804ThenoyltrifluoroacetoneThenoyltrifluoroacetone results in increased expression of BECN1 protein18032788
D013893ThiramThiram results in increased expression of BECN1 mRNA20530235
D014028Tobacco Smoke Pollutionchloroquine diphosphate inhibits the reaction [Tobacco Smoke Pollution results in increased expression of BECN1 protein]27037187
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of BECN1 mRNA22003194
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of BECN1 protein27037187
D014212TretinoinTretinoin results in increased expression of BECN1 protein28130038
C011559tributyltintributyltin results in decreased expression of BECN1 protein26079211
C467051trifloxystrobintrifloxystrobin results in increased expression of BECN1 protein27853101
C025541tri-o-cresyl phosphatePhenylmethylsulfonyl Fluoride inhibits the reaction [tri-o-cresyl phosphate results in decreased expression of BECN1 protein]22366639
C025541tri-o-cresyl phosphatetri-o-cresyl phosphate results in decreased expression of BECN1 protein22366639
C025541tri-o-cresyl phosphatetri-o-cresyl phosphate results in increased expression of BECN1 protein25385720
C001899triptolidetriptolide results in increased expression of BECN1 protein26990902
C113580U 0126U 0126 inhibits the reaction [sodium arsenite results in increased expression of BECN1 protein]19577553|2710778
C113580U 0126U 0126 inhibits the reaction [decamethrin results in increased expression of BECN1 protein]26588882
C005466ursolic acidursolic acid inhibits the reaction [BCL2 protein binds to BECN1 protein]24802810
C005466ursolic acid[ursolic acid results in increased phosphorylation of BCL2 protein] inhibits the reaction [BCL2 protein binds to BECN1 protein]24802810
D014635Valproic AcidValproic Acid affects the expression of BECN1 mRNA25979313
D014638VanadatesVanadates results in decreased expression of BECN1 mRNA22714537
C025643vinclozolinvinclozolin results in decreased expression of BECN1 mRNA23034163
D002762CholecalciferolABT-737 inhibits the reaction [Cholecalciferol promotes the reaction [BECN1 protein binds to BCL2L1 protein]]18628207
D002762CholecalciferolBECN1 mutant form inhibits the reaction [Cholecalciferol promotes the reaction [PIK3C3 protein binds to BECN1 protein]]18628207|1862820
D002762CholecalciferolBECN1 mutant form inhibits the reaction [Cholecalciferol results in increased expression of BCL2L1 protein]18628207
D002762CholecalciferolCholecalciferol promotes the reaction [BECN1 protein binds to BCL2L1 protein]18628207
D002762CholecalciferolCholecalciferol promotes the reaction [PIK3C3 protein binds to BECN1 protein]18628207
D002762CholecalciferolCholecalciferol results in increased expression of BECN1 protein18628207
D002762CholecalciferolMTOR mutant form promotes the reaction [Cholecalciferol results in increased expression of BECN1 protein]18628207
D002762CholecalciferolPIK3C3 mutant form inhibits the reaction [Cholecalciferol promotes the reaction [PIK3C3 protein binds to BECN1 protein]]18628207
D014810Vitamin EVitamin E inhibits the reaction [Pilocarpine results in increased expression of BECN1 mRNA]19138675
D014810Vitamin EVitamin E inhibits the reaction [Pilocarpine results in increased expression of BECN1 protein]19138675
D014810Vitamin EVitamin E results in decreased expression of BECN1 protein19138675
D024483Vitamin K 3Vitamin K 3 affects the expression of BECN1 mRNA20044591
C111237vorinostatAcetylcysteine inhibits the reaction [vorinostat results in increased expression of BECN1 protein]20543569
C111237vorinostatBECN1 protein promotes the reaction [vorinostat results in increased cleavage of MAP1LC3B protein]17881280
C111237vorinostatvorinostat results in increased expression of BECN1 protein17881280|2054356
C009687wortmanninwortmannin promotes the reaction [Ethanol results in increased degradation of BECN1 protein]21410490
C009687wortmanninwortmannin inhibits the reaction [manganese chloride results in increased expression of BECN1 protein]23604964
C009687wortmanninwortmannin results in decreased expression of BECN1 protein23604964
C078549xestospongin Bxestospongin B inhibits the reaction [BCL2 protein binds to BECN1 protein]19325567
C078549xestospongin BBCL2 mutant form promotes the reaction [xestospongin B inhibits the reaction [ITPR1 protein binds to BECN1 protein]]19325567
C078549xestospongin BBCL2 protein inhibits the reaction [xestospongin B inhibits the reaction [ITPR1 protein binds to BECN1 protein]]19325567
C078549xestospongin Bxestospongin B inhibits the reaction [ITPR1 protein binds to BECN1 protein]19325567
D015034Zinc OxideAcetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of BECN1 protein]24614525
D015034Zinc OxideZinc Oxide analog results in increased expression of BECN1 protein24614525
D019287Zinc Sulfate3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BECN1 protein]28803810
D019287Zinc SulfateZinc Sulfate results in increased expression of BECN1 protein28803810
C088658zoledronic acidzoledronic acid results in decreased expression of BECN1 protein28871336

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16417406  17446862  17724469  19050071  19180116  19270696  
19959994  20562859  20638385  20819940  21062745  21139567  
21241894  21358617  21597469  21962518  22028648  22081109  
22095288  22493499  23112296  23182941  23197835  23316280  
23332761  23364696  23478334  23541952  23878393  23954414  
23974797  24034250  24056301  24056303  24113155  24349490  
24443581  24472739  24785657  25127057  25438055  25490155  
25594178  26347139  26496610  28445460  28479384  
GO:0019901protein kinase binding-IPI27853422  
GO:0031625ubiquitin protein ligase binding-IPI25127057  
GO:0042803protein homodimerization activity-IEA-  
GO:0043548phosphatidylinositol 3-kinase binding-IPI23878393  
GO:0051020GTPase binding-IPI25891078  
GO ID GO Term Qualifier Evidence PubMed
GO:0000045autophagosome assembly-IBA21873635  
GO:0000045autophagosome assembly-ISS-  
GO:0000422autophagy of mitochondrion-IMP25215947  
GO:0000423mitophagy-IMP23878393  
GO:0001666response to hypoxia-IEA-  
GO:0006914autophagy-IDA23629966  
GO:0006914autophagy-IMP23184933  24056303  
GO:0006915apoptotic process-IEA-  
GO:0006968cellular defense response-TAS9765397  
GO:0006995cellular response to nitrogen starvation-IBA21873635  
GO:0007040lysosome organization-IEA-  
GO:0007080mitotic metaphase plate congression-IMP23478334  
GO:0007568aging-IEA-  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0010040response to iron(II) ion-IEA-  
GO:0010288response to lead ion-IEA-  
GO:0010613positive regulation of cardiac muscle hypertrophy-IEA-  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-NAS25215947  
GO:0016032viral process-IEA-  
GO:0016236macroautophagy-ISS-  
GO:0016236macroautophagy-TAS-  
GO:0016579protein deubiquitination-TAS-  
GO:0032258protein localization by the Cvt pathway-IBA21873635  
GO:0032465regulation of cytokinesis-IMP20208530  20643123  
GO:0032801receptor catabolic process-IMP20643123  
GO:0033197response to vitamin E-IEA-  
GO:0034198cellular response to amino acid starvation-IEA-  
GO:0042149cellular response to glucose starvation-ISS-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0043652engulfment of apoptotic cell-IEA-  
GO:0045022early endosome to late endosome transport-IMP26783301  
GO:0045324late endosome to vacuole transport-IBA21873635  
GO:0048666neuron development-IEA-  
GO:0050435amyloid-beta metabolic process-IEA-  
GO:0050790regulation of catalytic activity-IEA-  
GO:0051301cell division-IEA-  
GO:0051607defense response to virus-IEA-  
GO:0060548negative regulation of cell death-IMP19273585  
GO:0070301cellular response to hydrogen peroxide-IEA-  
GO:0071275cellular response to aluminum ion-IEA-  
GO:0071280cellular response to copper ion-IEA-  
GO:0071364cellular response to epidermal growth factor stimulus-IEA-  
GO:0098780response to mitochondrial depolarisation-IMP23878393  
GO:1902425positive regulation of attachment of mitotic spindle microtubules to kinetochore-IMP23478334  
GO:1902902negative regulation of autophagosome assembly-IEA-  
GO:1905672negative regulation of lysosome organization-IEA-  
GO:2000378negative regulation of reactive oxygen species metabolic process-IEA-  
GO:2000786positive regulation of autophagosome assembly-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000407phagophore assembly site-IBA21873635  
GO:0005634nucleus-IEA-  
GO:0005739mitochondrioncolocalizes_withIMP23878393  
GO:0005768endosome-IDA23878393  
GO:0005776autophagosome-IEA-  
GO:0005783endoplasmic reticulum-IDA23878393  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005802trans-Golgi network-IEA-  
GO:0005829cytosol-TAS-  
GO:0010008endosome membrane-IEA-  
GO:0019898extrinsic component of membrane-IBA21873635  
GO:0019898extrinsic component of membrane-IDA23878393  
GO:0030425dendrite-IEA-  
GO:0031966mitochondrial membrane-IEA-  
GO:0034271phosphatidylinositol 3-kinase complex, class III, type I-IBA21873635  
GO:0034272phosphatidylinositol 3-kinase complex, class III, type II-IBA21873635  
GO:0035032phosphatidylinositol 3-kinase complex, class III-ISS-  
GO:0045335phagocytic vesicle-IEA-  
KEGG ID KEGG Term
hsa04140Regulation of autophagy
Reactome ID Reactome Term Evidence
R-HSA-1632852MacroautophagyTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23325812Cigarette smoke exposure elicits increased autophagy and dysregulation of mitochondrial dynamics in murine granulosa cells. (2013 Mar)Gannon AMBiol Reprod
26043790Cocaine-mediated microglial activation involves the ER stress-autophagy axis. (2015)Guo MLAutophagy
25355898HIV-1 and morphine regulation of autophagy in microglia: limited interactions in the context of HIV-1 infection and opioid abuse. (2015 Jan 15)El-Hage NJ Virol