Gene: CBLB

868
Cbl-b|Nbla00127|RNF56
Cbl proto-oncogene B
protein-coding
3q13.11
Ensembl:ENSG00000114423 MIM:604491 Vega:OTTHUMG00000150654 UniprotKB:Q13191
NG_055547.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.695e-1 (AD)  4.892e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NUP1600.834
SMC50.818
CHD10.817
NUP2050.808
NFKB10.804
NUP980.801
RNF2170.801
TMEM39A0.796
SFMBT10.795
SENP10.794

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.399
OR4F29-0.368
CRH-0.268
LCN1-0.262
HES5-0.255
LYPD8-0.246
NANOS3-0.238
BTBD17-0.212
PVALB-0.211
SPRR2A-0.209

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CBLB mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CBLB mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CBLB mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CBLB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CBLB mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of CBLB mRNA"19561079
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of CBLB mRNA"21346803
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of CBLB mRNA12419474
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CBLB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CBLB mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of CBLB mRNA25458485
D000082AcetaminophenAcetaminophen results in increased expression of CBLB mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CBLB protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CBLB gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CBLB mRNA16483693
C015001arsenitearsenite results in decreased expression of CBLB mRNA18191166
D001280AtrazineAtrazine results in decreased expression of CBLB mRNA25929836
D001554BenzeneBenzene results in increased expression of CBLB mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CBLB mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CBLB mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CBLB mRNA"19150397
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of CBLB mRNA]24758408
D004958EstradiolEstradiol results in decreased expression of CBLB mRNA24758408
C006780bisphenol Abisphenol A results in increased expression of CBLB mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CBLB gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of CBLB mRNA26079696
C018021cobaltous chloridecobaltous chloride results in increased expression of CBLB mRNA19376846
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of CBLB mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of CBLB mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CBLB mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of CBLB mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of CBLB mRNA20106945|2556210
D003907DexamethasoneDexamethasone results in increased expression of CBLB22733784
D003907DexamethasoneDexamethasone results in increased expression of CBLB mRNA22733784
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of CBLB mRNA21318169
D002117CalcitriolCalcitriol results in decreased expression of CBLB mRNA16002434
D004147DioxinsDioxins affects the expression of CBLB mRNA20463971
D004237DiuronDiuron results in increased expression of CBLB mRNA21551480
D004317DoxorubicinDoxorubicin results in increased expression of CBLB mRNA25896364
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of CBLB mRNA22079256
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CBLB mRNA22079256
C004912ethylbenzeneethylbenzene results in increased expression of CBLB mRNA20955722
D011345FenofibrateFenofibrate results in increased expression of CBLB mRNA21318169
D011345FenofibratePPARA protein affects the reaction [Fenofibrate results in increased expression of CBLB mRNA]21318169
D005557FormaldehydeFormaldehyde results in decreased expression of CBLB mRNA17938736|2065599
D005839GentamicinsGentamicins results in increased expression of CBLB mRNA22061828
C030691gluconic acidgluconic acid results in decreased expression of CBLB mRNA16556975
D017313FenretinideFenretinide results in decreased expression of CBLB mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CBLB mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of CBLB mRNA18951874
D007213IndomethacinIndomethacin results in decreased expression of CBLB mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CBLB mRNA25613284
D007545IsoproterenolIsoproterenol results in increased expression of CBLB mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CBLB mRNA22802445
D007854LeadLead affects the expression of CBLB mRNA28903495
D007854LeadLead affects the splicing of CBLB mRNA28903495
C008261lead acetatelead acetate results in decreased expression of CBLB mRNA21829687
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] affects the expression of CBLB mRNA26378955
D008727MethotrexateMethotrexate results in decreased expression of CBLB mRNA24449571
D008752Methylene ChlorideMethylene Chloride results in increased expression of CBLB mRNA20955722
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CBLB mRNA26011545
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of CBLB mRNA17475336
D009532NickelNickel results in increased expression of CBLB mRNA25583101
C029938nickel sulfatenickel sulfate results in increased expression of CBLB mRNA22714537
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of CBLB mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CBLB mRNA25729387
C016030pantogabpantogab results in increased expression of CBLB mRNA17379144
C046012pentanalpentanal results in decreased expression of CBLB mRNA26079696
D010634PhenobarbitalPhenobarbital affects the expression of CBLB mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CBLB mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CBLB mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of CBLB mRNA18301758|2131816
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of CBLB mRNA]21318169
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CBLB mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CBLB mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CBLB mRNA23608068
D012643SeleniumSelenium results in decreased expression of CBLB mRNA19244175
D012834SilverSilver results in decreased expression of CBLB mRNA27131904
D053260SootSoot results in increased expression of CBLB mRNA26551751
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] affects the expression of CBLB mRNA26378955
D013629TamoxifenTamoxifen results in increased expression of CBLB mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CBLB mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CBLB mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CBLB mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CBLB mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of CBLB mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CBLB mRNA22363418
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CBLB mRNA25729387
D019772TopotecanTopotecan results in decreased expression of CBLB mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased expression of CBLB mRNA20955722
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CBLB mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of CBLB mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CBLB mRNA"26179874
D014520UrethaneUrethane results in increased expression of CBLB mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CBLB mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CBLB mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CBLB mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased expression of CBLB mRNA24935251
D014810Vitamin EVitamin E results in decreased expression of CBLB mRNA19244175
C111237vorinostatvorinostat results in decreased expression of CBLB mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001784phosphotyrosine residue binding-IEA-  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI10022120  12177062  12577067  12829691  12935897  16189514  
17020880  17255943  18680311  19268472  19380743  20936779  
21706016  21900206  23663663  25218436  25416956  25814554  
26871637  27107012  
GO:0008270zinc ion binding-TAS7784085  
GO:0017124SH3 domain binding-IBA21873635  
GO:0030971receptor tyrosine kinase binding-IBA21873635  
GO:0061630ubiquitin protein ligase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006607NLS-bearing protein import into nucleus-TAS7784085  
GO:0007165signal transduction-IBA21873635  
GO:0007165signal transduction-TAS7784085  
GO:0007175negative regulation of epidermal growth factor-activated receptor activity-IBA21873635  
GO:0016567protein ubiquitination-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0045121membrane raft-IBA21873635  
KEGG ID KEGG Term
hsa04012ErbB signaling pathway
hsa04120Ubiquitin mediated proteolysis
hsa04144Endocytosis
hsa04630Jak-STAT signaling pathway
hsa04660T cell receptor signaling pathway
hsa04910Insulin signaling pathway
hsa05100Bacterial invasion of epithelial cells
hsa05200Pathways in cancer
hsa05220Chronic myeloid leukemia
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS
R-HSA-983695Antigen activates B Cell Receptor (BCR) leading to generation of second messengersTAS
R-HSA-983705Signaling by the B Cell Receptor (BCR)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29069827The effect of MVK-MMAB variants, their haplotypes and GxE interactions on serum lipid levels and the risk of coronary heart disease and ischemic stroke. (2017 Sep 22)Miao LOncotarget