Gene: HYAL2

8692
LUCA2
hyaluronoglucosaminidase 2
protein-coding
3p21.31
Ensembl:ENSG00000068001 MIM:603551 Vega:OTTHUMG00000156876 UniprotKB:Q12891
NC_000003.12
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.680e-1 (AD)  6.155e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NOS30.795
EPHB40.786
TAGLN20.782
ECE10.779
ICAM20.777
CLIC10.777
CLDN50.773
VASP0.771
FGR0.77
TINAGL10.766

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TYRP1-0.397
XKR4-0.396
VWC2-0.39
ABCC12-0.388
LHX6-0.385
SMIM18-0.381
CNTN6-0.378
ZNF385D-0.378
CALHM1-0.377
NEUROD6-0.374

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in decreased expression of HYAL2 mRNA"26377693
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of HYAL2 mRNA"19114083
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of HYAL2 mRNA"19561079
C1118556-formylindolo(3,2-b)carbazole"6-formylindolo(3,2-b)carbazole results in increased expression of HYAL2 mRNA"19799885
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HYAL2 mRNA16483693
D001554BenzeneBenzene results in increased expression of HYAL2 mRNA19162166
C006780bisphenol Abisphenol A affects the expression of HYAL2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased methylation of HYAL2 promoter27312807
C006780bisphenol Abisphenol A affects the expression of HYAL2 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of HYAL2 promoter22457795
C018021cobaltous chloridecobaltous chloride results in decreased expression of HYAL2 mRNA19320972|1937684
D019327Copper SulfateCopper Sulfate results in increased expression of HYAL2 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of HYAL2 mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HYAL2 mRNA17361019
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of HYAL2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of HYAL2 mRNA27392435
D004237DiuronDiuron results in increased expression of HYAL2 mRNA21551480
D004317DoxorubicinDoxorubicin results in decreased expression of HYAL2 mRNA19073829
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of HYAL2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of HYAL2 mRNA17942748
C069837fullerene C60fullerene C60 results in decreased expression of HYAL2 mRNA19167457
D005897GlafenineGlafenine results in increased expression of HYAL2 mRNA24136188
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HYAL2 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of HYAL2 mRNA27392435
C544151jinfukangjinfukang results in increased expression of HYAL2 mRNA27392435
C410337K 7174K 7174 results in decreased expression of HYAL2 mRNA24086573
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of HYAL2 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of HYAL2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of HYAL2 mRNA"25620056
D009569Nitric OxideNitric Oxide deficiency results in decreased expression of HYAL2 mRNA15878706
C484027oligofectamineoligofectamine results in increased expression of HYAL2 mRNA14668052
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of HYAL2 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of HYAL2 mRNA18301758|2381119
D011374ProgesteroneProgesterone results in decreased expression of HYAL2 mRNA18037150
C017947sodium arsenitesodium arsenite results in decreased expression of HYAL2 mRNA20371982
C016104sodium bichromatesodium bichromate results in decreased expression of HYAL2 mRNA12760830
D013629TamoxifenTamoxifen affects the expression of HYAL2 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HYAL2 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HYAL2 mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HYAL2 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HYAL2 mRNA19684285|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HYAL2 mRNA19799885
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HYAL2 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of HYAL2 mRNA28065790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HYAL2 mRNA"26743178
C057693troglitazonetroglitazone results in increased expression of HYAL2 mRNA28973697
D014635Valproic AcidValproic Acid results in decreased expression of HYAL2 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of HYAL2 gene29154799
C066075vanadium pentoxidevanadium pentoxide affects the expression of HYAL2 mRNA26210822

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IDA11296287  16191204  
GO:0003713transcription coactivator activity-IEA-  
GO:0004415hyalurononglucosaminidase activity-IDA9712871  11944887  16600643  17170110  18390475  19443707  
20554532  
GO:0004415hyalurononglucosaminidase activityNOTIDA11296287  
GO:0004415hyalurononglucosaminidase activity-TAS-  
GO:0005515protein binding-IPI12676986  16191204  25416956  
GO:0005540hyaluronic acid binding-IDA12676986  19443707  
GO:0019899enzyme binding-IPI19366691  
GO:0030294receptor signaling protein tyrosine kinase inhibitor activity-IDA12676986  
GO:0030971receptor tyrosine kinase binding-IPI12676986  
GO:0033906hyaluronoglucuronidase activity-IDA21699545  
GO:0050431transforming growth factor beta binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000302response to reactive oxygen species-IDA20554532  
GO:0001822kidney development-ISS-  
GO:0002244hematopoietic progenitor cell differentiation-IEA-  
GO:0005975carbohydrate metabolic process-IEA-  
GO:0006027glycosaminoglycan catabolic process-IDA9712871  
GO:0009615response to virus-IDA11296287  12676986  
GO:0010259multicellular organism aging-IEA-  
GO:0010764negative regulation of fibroblast migration-IDA19577615  
GO:0019064fusion of virus membrane with host plasma membrane-IDA11296287  
GO:0019087transformation of host cell by virus-IDA11296287  
GO:0019087transformation of host cell by virus-ISS-  
GO:0030214hyaluronan catabolic process-IDA17170110  19443707  20554532  21699545  
GO:0030214hyaluronan catabolic process-TAS-  
GO:0030308negative regulation of cell growth-IDA18725949  
GO:0035810positive regulation of urine volume-ISS-  
GO:0042117monocyte activation-IDA19443707  
GO:0042307positive regulation of protein import into nucleus-ISS-  
GO:0043407negative regulation of MAP kinase activity-IDA12676986  
GO:0044344cellular response to fibroblast growth factor stimulus-IDA19577615  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0046677response to antibiotic-IEP11944887  
GO:0046718viral entry into host cell-ISS-  
GO:0048705skeletal system morphogenesis-IEA-  
GO:0050729positive regulation of inflammatory response-IDA19443707  
GO:0051216cartilage development-IEP11944887  
GO:0051607defense response to virus-IEA-  
GO:0051898negative regulation of protein kinase B signaling-IDA12676986  
GO:0060586multicellular organismal iron ion homeostasis-IEA-  
GO:0061099negative regulation of protein tyrosine kinase activity-IDA12676986  
GO:0070295renal water absorption-ISS-  
GO:0071347cellular response to interleukin-1-IDA18390475  
GO:0071356cellular response to tumor necrosis factor-IEP18390475  
GO:0071493cellular response to UV-B-IDA21699545  
GO:0071560cellular response to transforming growth factor beta stimulus-IDA19366691  
GO:2000484positive regulation of interleukin-8 secretion-IDA19443707  
GO:2000778positive regulation of interleukin-6 secretion-IDA19443707  
GO:2001238positive regulation of extrinsic apoptotic signaling pathway-ISS19366691  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-ISS21740893  
GO:0005737cytoplasm-IDA17170110  
GO:0005764lysosome-IDA9712871  16600643  
GO:0005783endoplasmic reticulum-NAS16191204  
GO:0005829cytosol-IDA19366691  
GO:0005886plasma membrane-TAS-  
GO:0005902microvillus-IDA19366691  
GO:0009986cell surface-IDA17170110  
GO:0009986cell surface-ISS-  
GO:0016324apical plasma membrane-IDA20554532  
GO:0030139endocytic vesicle-IDA19366691  
GO:0031362anchored component of external side of plasma membrane-IDA11296287  16191204  20554532  
GO:0031362anchored component of external side of plasma membranecolocalizes_withIDA19443707  
GO:0031410cytoplasmic vesicle-IDA16600643  18390475  
GO:0045121membrane raft-IDA21740893  
GO:0046658anchored component of plasma membrane-IDA18390475  21740893  
GO:0048471perinuclear region of cytoplasm-IDA16600643  
GO:0090575RNA polymerase II transcription factor complex-ISS19366691  
KEGG ID KEGG Term
hsa00531Glycosaminoglycan degradation
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-2142845Hyaluronan metabolismTAS
R-HSA-2160916Hyaluronan uptake and degradationTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17255269Genetic deletions in sputum as diagnostic markers for early detection of stage I non-small cell lung cancer. (2007 Jan 15)Li RClin Cancer Res
22430805Peripheral blood DNA methylation profiles are indicative of head and neck squamous cell carcinoma: an epigenome-wide association study. (2012 Mar)Langevin SMEpigenetics