Gene: ACTN1

87
BDPLT15
actinin alpha 1
protein-coding
14q24.1|14q22-q24
Ensembl:ENSG00000072110 MIM:102575 Vega:OTTHUMG00000171386 UniprotKB:P12814
NG_029480.1
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.734e-1 (AD)  7.715e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2268974chr14:68956447 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs2300877chr14:68939123 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00000289chr14:69341139ACTN13'UTR2.548e-4Alcohol use disorders26763658
cg08170227chr14:69422517ACTN16.600e-13Smoking27651444
cg08170227chr14:69422517ACTN19.450e-9Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MBTPS10.92
DIAPH10.918
CHST150.918
SIMC10.913
EFTUD20.913
KLHL180.912
ANXA110.911
UBP10.906
SMG70.905
MBD10.905

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.551
OR4F29-0.512
ASB4-0.397
MBNL3-0.379
CTNNA3-0.375
COPZ2-0.36
PON1-0.36
PDE11A-0.355
ENDOU-0.339
MYL3-0.331

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB06773Human calcitoninBiotechDrug21215-62-3Approved|InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C5411312,2',3,3',4,4',5-heptachlorobiphenyl"2,2',3,3',4,4',5-heptachlorobiphenyl results in decreased expression of ACTN1 mRNA"26238599
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ACTN1 mRNA"21346803
C0299552-nitrotoluene2-nitrotoluene results in decreased expression of ACTN1 mRNA16460773
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ACTN1 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACTN1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACTN1 mRNA"27188386
C0275764-hydroxy-2-nonenalACTN1 protein binds to 4-hydroxy-2-nonenal20043646
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACTN1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACTN1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ACTN1 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of ACTN1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of ACTN1 mRNA17562736
D000082Acetaminophen[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of ACTN1 mRNA25607892
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of ACTN1 mRNA28522335
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of ACTN1 protein26072098
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ACTN1 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of ACTN1 mRNA"22863853
D000726Androgen Antagonists[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of ACTN1 mRNA25607892
D001151ArsenicArsenic affects the methylation of ACTN1 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene metabolite results in increased expression of ACTN1 mRNA26314263
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ACTN1 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ACTN1 mRNA15034205|1977048
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ACTN1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ACTN1 mRNA"19150397
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ACTN1 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of ACTN1 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of ACTN1 mRNA25607892
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of ACTN1 mRNA26314263
D001761BleomycinBleomycin results in decreased expression of ACTN1 protein25933445
C099813bromochloroacetic acidbromochloroacetic acid results in decreased expression of ACTN1 mRNA16460773
C515564bromovaninbromovanin results in increased expression of ACTN1 protein21419150
D002065BuspironeBuspirone results in decreased expression of ACTN1 mRNA24136188
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ACTN1 mRNA15336504
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of ACTN1 mRNA25607892
D002101Cacodylic AcidCacodylic Acid results in increased expression of ACTN1 mRNA17720352
D000074262Canola OilCanola Oil metabolite results in decreased expression of ACTN1 mRNA27363782
D000074262Canola OilStarch analog inhibits the reaction [Canola Oil metabolite results in decreased expression of ACTN1 mRNA]27363782
D002220CarbamazepineCarbamazepine affects the expression of ACTN1 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ACTN1 mRNA17484886
D002330CarmustineCarmustine results in decreased expression of ACTN1 mRNA15980968
C100187chloropicrinchloropicrin affects the expression of ACTN1 mRNA26352163
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of ACTN1 protein28596144
D002994ClofibrateClofibrate results in increased expression of ACTN1 mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of ACTN1 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of ACTN1 mRNA26314263
D019327Copper SulfateCopper Sulfate results in increased expression of ACTN1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of ACTN1 mRNA22147139
D016572CyclosporineCyclosporine results in increased expression of ACTN1 mRNA25562108
C093628cyproconazolecyproconazole results in decreased expression of ACTN1 mRNA26238599
C014347decitabinedecitabine affects the methylation of ACTN1 gene17630775
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ACTN1 mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of ACTN1 mRNA22733784
D003976DiazinonDiazinon results in increased methylation of ACTN1 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ACTN1 mRNA21266533
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ACTN1 mRNA25607892
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ACTN1 mRNA21266533
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ACTN1 mRNA25607892
D004008DiclofenacDiclofenac affects the expression of ACTN1 mRNA19022234
C000944dicrotophosdicrotophos results in increased expression of ACTN1 mRNA28302478
D004026DieldrinDieldrin affects the expression of ACTN1 mRNA22546817
D004041Dietary FatsDietary Fats results in increased expression of ACTN1 mRNA25016146
D004041Dietary FatsDietary Fats results in increased expression of ACTN1 protein25016146
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ACTN1 mRNA25607892
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of ACTN1 mRNA20920545
D0151279,10-Dimethyl-1,2-benzanthracene"[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of ACTN1 protein"22248470
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of ACTN1 protein"22248470
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of ACTN1 mRNA25380136
D004237DiuronDiuron results in increased expression of ACTN1 mRNA21551480
D004317DoxorubicinACTN1 protein affects the susceptibility to Doxorubicin16217747
C118739entinostatentinostat results in increased expression of ACTN1 mRNA27188386
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of ACTN1 mRNA24534155
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of ACTN1 mRNA25607892
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ACTN1 protein23301498
D004837EpinephrineEpinephrine results in increased expression of ACTN1 protein19464573
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ACTN1 mRNA25607892
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ACTN1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACTN1 mRNA17942748
C540355fenamidonefenamidone results in increased expression of ACTN1 mRNA27029645
D005839GentamicinsGentamicins results in increased expression of ACTN1 mRNA22061828
D017313FenretinideFenretinide results in increased expression of ACTN1 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ACTN1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of ACTN1 mRNA25613284
D015759IonomycinIonomycin promotes the reaction [CAMK2A protein binds to ACTN1 protein]19217379
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ACTN1 mRNA28628672
D007529Isoflavones"[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of ACTN1 protein"22248470
C045463leflunomideleflunomide results in increased expression of ACTN1 mRNA28988120
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ACTN1 mRNA25607892
D008687MetforminMetformin results in increased expression of ACTN1 mRNA19022234
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ACTN1 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACTN1 mRNA"27188386
C030957methylmercury IImethylmercury II results in increased expression of ACTN1 mRNA26314263
C406082monomethylarsonous acidmonomethylarsonous acid affects the expression of ACTN1 mRNA20886546
C523799MRK 003ACTN1 results in increased susceptibility to MRK 00319903844
C500085muraglitazarmuraglitazar results in decreased expression of ACTN1 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ACTN1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ACTN1 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of ACTN1 mRNA25380136
C025589ochratoxin Aochratoxin A metabolite results in increased expression of ACTN1 mRNA26314263
C025589ochratoxin Aochratoxin A results in increased expression of ACTN1 mRNA26314263
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of ACTN1 mRNA25607892
D010098OxycodoneOxycodone results in decreased expression of ACTN1 mRNA23439660
C410127PCB 180PCB 180 results in decreased expression of ACTN1 mRNA26238599
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACTN1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ACTN1 mRNA26272509
D011192Potassium DichromatePotassium Dichromate results in decreased expression of ACTN1 protein23718831
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ACTN1 mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ACTN1 mRNA25607892
D011374ProgesteroneProgesterone results in decreased expression of ACTN1 mRNA18037150
C100573prostaglandin A1prostaglandin A1 analog results in increased metabolism of ACTN1 protein19800325
C513428pyrachlostrobinpyrachlostrobin results in increased expression of ACTN1 mRNA27029645
C012526quercitrinquercitrin affects the expression of ACTN1 mRNA25193878
C059514resveratrolresveratrol results in decreased expression of ACTN1 protein25505154
D012643SeleniumSelenium results in increased expression of ACTN1 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog affects the secretion of ACTN1 protein25895662
C009277sodium arsenatesodium arsenate results in increased expression of ACTN1 mRNA21795629
C017947sodium arsenitesodium arsenite results in decreased expression of ACTN1 mRNA20308225
D012969Sodium FluorideSodium Fluoride results in increased expression of ACTN1 protein27548804
D012999SomanSoman results in increased expression of ACTN1 mRNA19281266
D013213StarchStarch analog inhibits the reaction [Canola Oil metabolite results in decreased expression of ACTN1 mRNA]27363782
C025462sulindac sulfidesulindac sulfide results in decreased expression of ACTN1 mRNA16184548
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of ACTN1 mRNA15885361
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ACTN1 mRNA17884332
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ACTN1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of ACTN1 mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACTN1 mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of ACTN1 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ACTN1 mRNA21354282
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ACTN1 protein21354282
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ACTN1 mRNA15034205|1532836
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of ACTN1 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of ACTN1 mRNA22378314
C096900thrombin receptor-activating peptide SFLLRNPNDKYthrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of ACTN1 protein17303692
C009495titanium dioxidetitanium dioxide results in increased expression of ACTN1 mRNA27760801
C032910triadimefontriadimefon analog results in decreased expression of ACTN1 mRNA26238599
C032910triadimefontriadimefon results in decreased expression of ACTN1 mRNA26238599
C011559tributyltintributyltin results in increased expression of ACTN1 mRNA26314263
C057693troglitazonetroglitazone results in decreased expression of ACTN1 mRNA21515302
C057693troglitazonetroglitazone results in increased expression of ACTN1 mRNA19022234
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of ACTN1 mRNA15885361
D014635Valproic AcidValproic Acid results in increased expression of ACTN1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of ACTN1 gene29154799
D014640VancomycinVancomycin results in decreased expression of ACTN1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ACTN1 gene25560391
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ACTN1 mRNA25607892
C088658zoledronic acidzoledronic acid results in decreased expression of ACTN1 protein28871336

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003725double-stranded RNA binding-IDA21266579  
GO:0005178integrin binding-IDA7983147  
GO:0005178integrin binding-IPI11223950  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI10793131  11101506  12223541  12446711  14623081  16189514  
16291744  16464232  20120020  25241761  25416956  25910212  
26871637  
GO:0017166vinculin binding-IDA11223950  
GO:0017166vinculin binding-IPI15988023  
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity-IDA22351778  
GO:0042803protein homodimerization activity-IDA11223950  
GO:0044325ion channel binding-IPI17944866  19943616  
GO:0051015actin filament binding-IDA11223950  
GO ID GO Term Qualifier Evidence PubMed
GO:0002576platelet degranulation-TAS-  
GO:0007015actin filament organization-IMP23434115  
GO:0030168platelet activationNOTIMP24069336  
GO:0030220platelet formation-IMP23434115  
GO:0036344platelet morphogenesis-IMP23434115  24069336  
GO:0042981regulation of apoptotic process-NAS16807302  
GO:0048041focal adhesion assembly-IMP16807302  
GO:0051017actin filament bundle assembly-IEA-  
GO:0051271negative regulation of cellular component movement-IMP7983147  
GO:0051639actin filament network formation-IMP24069336  
GO:0051764actin crosslink formation-IEA-  
GO:0070527platelet aggregationNOTIMP23434115  
GO:1903508positive regulation of nucleic acid-templated transcription-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001725stress fiber-IDA11223950  
GO:0001726ruffle-IDA11223950  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA16502470  
GO:0005622intracellular-IDA21784188  
GO:0005737cytoplasm-IDA16464232  23434115  
GO:0005829cytosol-TAS-  
GO:0005884actin filamentcolocalizes_withIDA23434115  24069336  
GO:0005886plasma membrane-IEA-  
GO:0005903brush border-IEA-  
GO:0005911cell-cell junction-IDA11223950  
GO:0005916fascia adherens-IEA-  
GO:0005925focal adhesion-HDA21423176  
GO:0005925focal adhesion-IDA11223950  
GO:0005925focal adhesion-IMP16807302  
GO:0030018Z disc-IEA-  
GO:0031093platelet alpha granule lumen-TAS-  
GO:0031143pseudopodium-TAS1629252  
GO:0042995cell projection-IDA16464232  
GO:0070062extracellular exosome-HDA19056867  19199708  21362503  23533145  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04520Adherens junction
hsa04530Tight junction
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
hsa05146Amoebiasis
hsa05322Systemic lupus erythematosus
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1500931Cell-Cell communicationTAS
R-HSA-1500931Cell-Cell communicationIEA
R-HSA-3000170Syndecan interactionsIEA
R-HSA-3000171Non-integrin membrane-ECM interactionsIEA
R-HSA-373753Nephrin family interactionsIEA
R-HSA-446353Cell-extracellular matrix interactionsTAS
R-HSA-446388Regulation of cytoskeletal remodeling and cell spreading by IPP complex componentsTAS
R-HSA-446728Cell junction organizationTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22719919Glutamate and synaptic plasticity systems and smoking behavior: results from a genetic association study. (2012)dos Santos VAPLoS One