Gene: DNAH11

8701
CILD7|DNAHBL|DNAHC11|DNHBL|DPL11
dynein axonemal heavy chain 11
protein-coding
7p15.3
Ensembl:ENSG00000105877 MIM:603339 Vega:OTTHUMG00000152524 UniprotKB:Q96DT5
NG_012886.2
SNP Mapped
1   ANCO-SNPs
AD
0   
3.883e-1 (AD)  1.989e-1 (ND)   (Frontal_Cortex)
1.915e-1 (AD)  3.608e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9639395chr7:21740047 (GRCh38.p7)G>A / G>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC360.664
NEDD40.643
MYOF0.635
GJC10.631
CFH0.625
TFPI0.622
SIX10.619
CASP80.613
DPPA40.606
PLEKHG20.606

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C16orf95-0.499
TM7SF2-0.464
NT5M-0.46
NEUROD6-0.457
ANAPC15-0.455
CRH-0.453
CORT-0.442
SLC25A10-0.442
CDT1-0.435
ZNF575-0.432

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DNAH11 mRNA"15215175
D020106AcrylamideAcrylamide results in decreased expression of DNAH11 mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DNAH11 mRNA16483693
C015001arsenitearsenite results in decreased methylation of DNAH11 promoter23974009
C015001arsenitearsenite results in increased expression of DNAH11 mRNA23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DNAH11 mRNA27195522
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of DNAH11 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of DNAH11 mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DNAH11 mRNA20938992
D003471CuprizoneCuprizone results in increased expression of DNAH11 mRNA26577399|2752363
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of DNAH11 mRNA28628672
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DNAH11 mRNA20938992
D017313FenretinideFenretinide results in increased expression of DNAH11 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of DNAH11 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of DNAH11 mRNA28628672
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DNAH11 mRNA20938992
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DNAH11 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DNAH11 mRNA"25554681
C029938nickel sulfatenickel sulfate results in increased expression of DNAH11 mRNA22714537
D010100OxygenOxygen deficiency results in increased expression of DNAH11 mRNA24236059|2651600
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of DNAH11 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of DNAH11 mRNA20813756|2381119
D011374ProgesteroneProgesterone results in decreased expression of DNAH11 mRNA23018184
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of DNAH11 mRNA25895662
D013629TamoxifenTamoxifen results in decreased expression of DNAH11 mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DNAH11 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DNAH11 mRNA26377647
D014638VanadatesVanadates results in decreased expression of DNAH11 mRNA22714537
C025643vinclozolinvinclozolin results in decreased expression of DNAH11 mRNA23869203

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005524ATP binding-IEA-  
GO:0008569ATP-dependent microtubule motor activity, minus-end-directed-IBA21873635  
GO:0045503dynein light chain binding-IBA21873635  
GO:0045505dynein intermediate chain binding-IBA21873635  
GO:0051959dynein light intermediate chain binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0003356regulation of cilium beat frequency-IMP18022865  22184204  22499950  
GO:0007018microtubule-based movement-IBA21873635  
GO:0007368determination of left/right symmetry-IMP12142464  18022865  22184204  22499950  
GO:0007507heart development-IEA-  
GO:0007611learning or memory-IEA-  
GO:0030317flagellated sperm motility-IMP18492703  
GO:0035545determination of left/right asymmetry in nervous system-IEA-  
GO:0060287epithelial cilium movement involved in determination of left/right asymmetry-IEA-  
GO:1905419sperm flagellum movement involved in flagellated sperm motility-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005874microtubule-IEA-  
GO:0030286dynein complex-IBA21873635  
GO:00977289+0 motile cilium-IEA-  
GO:00977299+2 motile cilium-IDA26909801  
GO:0120134proximal portion of axoneme-IDA26909801  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal