Gene: B3GALT1

8708
beta3Gal-T1
beta-1,3-galactosyltransferase 1
protein-coding
2q24.3
Ensembl:ENSG00000172318 MIM:603093 Vega:OTTHUMG00000132163 UniprotKB:Q9Y5Z6
NG_050644.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.030e-1 (AD)  5.810e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1897339chr2:167551928 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LGI10.856
FLRT20.833
FUT90.827
CLDN120.819
LANCL20.814
SSX2IP0.813
TMEM560.812
SIPA1L10.802
CHST100.802
ASTN10.802

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFPI2-0.583
FCRLA-0.487
OR4F5-0.484
SGMS2-0.483
MBOAT1-0.482
CD2-0.482
SH2D2A-0.471
BEST3-0.47
VRK2-0.468
LINC00189-0.462

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of B3GALT1 mRNA19933214
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of B3GALT1 mRNA"18648102
D020106AcrylamideAcrylamide results in decreased expression of B3GALT1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of B3GALT1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of B3GALT1 mRNA19770486
C006780bisphenol Abisphenol A results in increased expression of B3GALT1 mRNA24586524
C006780bisphenol Abisphenol A results in decreased expression of B3GALT1 mRNA25181051
D002922CiguatoxinsCiguatoxins affects the expression of B3GALT1 mRNA18353800
D003471CuprizoneCuprizone results in decreased expression of B3GALT1 mRNA26577399|2752363
D016572CyclosporineCyclosporine results in decreased expression of B3GALT1 mRNA19770486
D004008DiclofenacDiclofenac results in increased expression of B3GALT1 mRNA26934552
D004041Dietary FatsDietary Fats affects the expression of B3GALT1 mRNA19680557
D000431EthanolEthanol affects the expression of B3GALT1 mRNA19167417
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of B3GALT1 mRNA29097150
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of B3GALT1 mRNA24796395
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of B3GALT1 mRNA27339419
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of B3GALT1 mRNA"20188158
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of B3GALT1 mRNA17412507
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of B3GALT1 mRNA16809437
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of B3GALT1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of B3GALT1 mRNA"25620056
D010634PhenobarbitalPhenobarbital results in decreased expression of B3GALT1 mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of B3GALT1 mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of B3GALT1 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of B3GALT1 mRNA20813756|2381119
D011192Potassium DichromatePotassium Dichromate results in decreased expression of B3GALT1 mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of B3GALT1 mRNA28903501
D012822Silicon DioxideSilicon Dioxide results in increased expression of B3GALT1 mRNA23221170
C013698tallowtallow affects the expression of B3GALT1 mRNA19680557
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to B3GALT1 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of B3GALT1 mRNA28213091
C057693troglitazonetroglitazone results in decreased expression of B3GALT1 mRNA28973697
D014415TunicamycinTunicamycin results in increased expression of B3GALT1 mRNA17127020
D014635Valproic AcidValproic Acid results in increased expression of B3GALT1 mRNA28001369
D014635Valproic AcidValproic Acid affects the expression of B3GALT1 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions affects the methylation of B3GALT1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008375acetylglucosaminyltransferase activity-IBA21873635  
GO:0008376acetylgalactosaminyltransferase activity-IBA21873635  
GO:0008499UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity-IBA21873635  
GO:0008499UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity-IDA9582303  
GO:0016758transferase activity, transferring hexosyl groups-IBA21873635  
GO:0047275glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006486protein glycosylation-IBA21873635  
GO:0006486protein glycosylation-IEA-  
GO:0006487protein N-linked glycosylation-IBA21873635  
GO:0006493protein O-linked glycosylation-IBA21873635  
GO:0006682galactosylceramide biosynthetic process-IDA9582303  
GO:0009312oligosaccharide biosynthetic process-IBA21873635  
GO:0009312oligosaccharide biosynthetic process-IDA9582303  
GO:0030259lipid glycosylation-IDA9582303  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005794Golgi apparatus-IBA21873635  
GO:0016020membrane-IBA21873635  
GO:0016021integral component of membrane-NAS9582303  
KEGG ID KEGG Term
hsa00601Glycosphingolipid biosynthesis - lacto and neolacto series
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal