Gene: EED

8726
COGIS|HEED|WAIT1
embryonic ectoderm development
protein-coding
11q14.2
Ensembl:ENSG00000074266 MIM:605984 Vega:OTTHUMG00000167209 UniprotKB:O75530
NG_029595.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.747e-1 (AD)  8.278e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DERL10.887
PDS5A0.884
TOR1B0.873
CNIH40.873
NOL110.869
PCID20.869
GTF2E20.867
GID80.864
TIAL10.861
CCT30.858

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.637
OR4F29-0.592
KLRB1-0.258
HPDL-0.244
ENDOU-0.243
ASB4-0.239
FZD10-0.235
IL25-0.234
ALDH1L1-AS2-0.213
SOX3-0.213

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of EED mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of EED mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of EED mRNA"20406850
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EED mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EED mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of EED mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of EED gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of EED mRNA19770486
C430898AGN 194204AGN 194204 results in decreased expression of EED mRNA16339527
D000638AmiodaroneAmiodarone results in increased expression of EED mRNA19774075
D001151ArsenicArsenic results in increased expression of EED protein22843710
D001554BenzeneBenzene results in increased expression of EED mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased methylation of EED promoter28329817
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EED mRNA19770486|2222880
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EED mRNA21839799
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EED mRNA"19150397
C006780bisphenol Abisphenol A results in decreased expression of EED mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of EED mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of EED mRNA27339419
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of EED mRNA24690739
D019327Copper SulfateCopper Sulfate results in decreased expression of EED mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of EED mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of EED mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of EED mRNA19167446
D016572CyclosporineCyclosporine affects the expression of EED mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of EED mRNA20106945
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of EED mRNA26924002
D004026DieldrinDieldrin results in decreased expression of EED mRNA20584760
C024629dimethyl phthalatedimethyl phthalate affects the expression of EED mRNA26924002
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of EED mRNA24690739
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of EED mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EED mRNA17942748
D005557FormaldehydeFormaldehyde results in increased expression of EED mRNA23649840
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EED mRNA25613284
C410337K 7174K 7174 results in decreased expression of EED mRNA24086573
C045463leflunomideleflunomide results in decreased expression of EED mRNA28988120
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of EED mRNA25613284
D008727MethotrexateEED protein affects the susceptibility to Methotrexate16217747
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of EED mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of EED mRNA23649840
D008770MethylnitrosoureaEED protein affects the susceptibility to Methylnitrosourea11803473
C517284monomethyl phthalatemonomethyl phthalate affects the expression of EED mRNA26924002
D010936Plant ExtractsPlant Extracts results in increased expression of EED mRNA23557933
D015125OxyquinolineOxyquinoline results in decreased expression of EED mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of EED mRNA19167446
C059514resveratrolresveratrol results in decreased expression of EED protein25505154
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EED mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EED mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EED mRNA25613284
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EED mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of EED mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of EED mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0003682chromatin binding-IEA-  
GO:0005515protein binding-IPI16357870  17041588  17560333  20075857  20080539  20543829  
21078963  22009739  22094255  22439931  22897849  23238014  
26496610  27705803  28229514  
GO:0031491nucleosome bindingCONTRIBUTES_TOIBA21873635  
GO:0042054histone methyltransferase activityCONTRIBUTES_TOIBA21873635  
GO:0042054histone methyltransferase activity-IDA15385962  
GO:0042054histone methyltransferase activitycontributes_toIMP28229514  
GO:0042802identical protein binding-IPI11124122  
GO:0046976histone methyltransferase activity (H3-K27 specific)CONTRIBUTES_TOIBA21873635  
GO:0046976histone methyltransferase activity (H3-K27 specific)contributes_toIMP28229514  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0006342chromatin silencing-IBA21873635  
GO:0006349regulation of gene expression by genetic imprinting-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0021510spinal cord development-IEA-  
GO:0045814negative regulation of gene expression, epigenetic-TAS-  
GO:0045892negative regulation of transcription, DNA-templated-NAS9584199  
GO:0061087positive regulation of histone H3-K27 methylation-IEA-  
GO:0070317negative regulation of G0 to G1 transition-TAS-  
GO:0070734histone H3-K27 methylation-IEA-  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO:2000011regulation of adaxial/abaxial pattern formation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001739sex chromatin-IEA-  
GO:0005634nucleus-NAS9584199  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-IDA-  
GO:0035098ESC/E(Z) complex-IBA21873635  
GO:0035098ESC/E(Z) complex-IDA15385962  20075857  23104054  23273982  
GO:0045120pronucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1257604PIP3 activates AKT signalingIEA
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-212165Epigenetic regulation of gene expressionTAS
R-HSA-212300PRC2 methylates histones and DNATAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559580Oxidative Stress Induced SenescenceTAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-3214841PKMTs methylate histone lysinesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-4839726Chromatin organizationTAS
R-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesisIEA
R-HSA-5619507Activation of HOX genes during differentiationIEA
R-HSA-6807070PTEN RegulationTAS
R-HSA-6807070PTEN RegulationIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8943724Regulation of PTEN gene transcriptionTAS
R-HSA-8943724Regulation of PTEN gene transcriptionIEA
R-HSA-8953750Transcriptional Regulation by E2F6TAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006925Intracellular signaling by second messengersIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
12823154Prevalence of extra-oesophageal manifestations in gastro-oesophageal reflux disease: an analysis based on the ProGERD Study. (2003 Jun 15)Jaspersen DAliment Pharmacol Ther
28060453Model-based economic evaluations in smoking cessation and their transferability to new contexts: a systematic review. (2017 Jun)Berg MLAddiction