Gene: ADAM19

8728
FKSG34|MADDAM|MLTNB
ADAM metallopeptidase domain 19
protein-coding
5q33.3
Ensembl:ENSG00000135074 MIM:603640 Vega:OTTHUMG00000130242 UniprotKB:Q9H013
NG_046960.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.350e-3 (AD)  4.535e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HERC10.879
AACS0.878
UNC790.877
DLGAP20.875
MAPK130.875
SLC25A440.874
TLN20.873
POLR3A0.87
TANC20.869
MAP3K90.868

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASB4-0.529
RAB13-0.504
COPZ2-0.495
RHOD-0.495
TMEM176A-0.485
HEY2-0.485
LRAT-0.484
PHEX-0.482
YES1-0.482
IMPA2-0.481

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0131862,3-pentanedione"2,3-pentanedione results in increased expression of ADAM19 mRNA"25710175
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of ADAM19 mRNA"27567155
D000082AcetaminophenAcetaminophen results in decreased expression of ADAM19 mRNA21420995
C430898AGN 194204AGN 194204 results in increased expression of ADAM19 mRNA16339527
D000447AldehydesAldehydes results in increased expression of ADAM19 mRNA25014914
D001104ArbutinArbutin results in decreased expression of ADAM19 mRNA17103032
C006780bisphenol Abisphenol A results in decreased expression of ADAM19 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of ADAM19 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of ADAM19 mRNA18958704
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ADAM19 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of ADAM19 mRNA26079696
D002166CamptothecinADAM19 mRNA results in decreased susceptibility to Camptothecin25269479
D002220CarbamazepineCarbamazepine affects the expression of ADAM19 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ADAM19 mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADAM19 mRNA20938992
D003042CocaineCocaine results in decreased expression of ADAM19 mRNA17898221
D019327Copper SulfateCopper Sulfate results in increased expression of ADAM19 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of ADAM19 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of ADAM19 mRNA25562108
D003561CytarabineCytarabine results in decreased expression of ADAM19 mRNA21198554
C014347decitabinedecitabine affects the expression of ADAM19 mRNA23300844
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of ADAM19 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ADAM19 mRNA21266533
D002945CisplatinCisplatin affects the expression of ADAM19 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ADAM19 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ADAM19 mRNA27392435
D002117CalcitriolCalcitriol results in increased expression of ADAM19 mRNA16002434
D004317DoxorubicinDoxorubicin results in decreased expression of ADAM19 mRNA18510171
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ADAM19 mRNA22079256
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADAM19 mRNA20938992
C069837fullerene C60fullerene C60 results in decreased expression of ADAM19 mRNA19167457
C039281furanfuran results in increased expression of ADAM19 mRNA27387713
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of ADAM19 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADAM19 mRNA25613284
C051890irinotecanirinotecan analog results in increased expression of ADAM19 mRNA18927307
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of ADAM19 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ADAM19 mRNA27392435
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of ADAM19 mRNA25119042
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ADAM19 mRNA25119042
C008261lead acetatelead acetate results in decreased expression of ADAM19 mRNA22613225
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADAM19 mRNA20938992
C005219methyl cellosolvemethyl cellosolve results in increased expression of ADAM19 mRNA21061450
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ADAM19 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ADAM19 mRNA"26251327
D009532NickelNickel results in increased expression of ADAM19 mRNA25583101
C028007nickel monoxidenickel monoxide results in decreased expression of ADAM19 mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of ADAM19 mRNA16166746
D009538NicotineNicotine results in increased expression of ADAM19 mRNA23825647
C030110oxaliplatinoxaliplatin results in increased expression of ADAM19 mRNA16510598
C506614PD 0325901[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of ADAM19 mRNA25119042
C506614PD 0325901PD 0325901 results in decreased expression of ADAM19 mRNA25119042
C046012pentanalpentanal results in increased expression of ADAM19 mRNA26079696
D010795Phthalic AcidsPhthalic Acids results in decreased expression of ADAM19 mRNA21061450
D010795Phthalic AcidsPhthalic Acids results in increased expression of ADAM19 mRNA21061450
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ADAM19 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ADAM19 mRNA22079256
C005556propionaldehydepropionaldehyde results in increased expression of ADAM19 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of ADAM19 mRNA24780913
C502851quinocetonequinocetone results in increased expression of ADAM19 mRNA27046791
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ADAM19 mRNA19059307
D012906SmokeSmoke results in increased expression of ADAM19 mRNA21095227
C009277sodium arsenatesodium arsenate results in decreased expression of ADAM19 mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of ADAM19 mRNA21795629
C017947sodium arsenitesodium arsenite affects the methylation of ADAM19 gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of ADAM19 mRNA16014739
D014284Triiodothyronine[Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ADAM19 mRNA14761676
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in increased expression of ADAM19 mRNA19059307
D013749Tetrachlorodibenzodioxin[Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ADAM19 mRNA14761676
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADAM19 mRNA25613284
D014212TretinoinTretinoin results in increased expression of ADAM19 mRNA23724009|2383079
D014212TretinoinTretinoin results in decreased expression of ADAM19 mRNA16604517
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of ADAM19 mRNA19042947
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of ADAM19 mRNA29024780
D014635Valproic AcidValproic Acid results in decreased expression of ADAM19 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of ADAM19 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased methylation of ADAM19 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ADAM19 gene25560391
D024483Vitamin K 3Vitamin K 3 results in decreased expression of ADAM19 mRNA25270620
D015032ZincZinc deficiency results in increased expression of ADAM19 mRNA22171008
C088658zoledronic acidzoledronic acid results in decreased expression of ADAM19 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004222metalloendopeptidase activity-IMP11162584  
GO:0005515protein binding-IPI11162584  12463424  
GO:0017124SH3 domain binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001890placenta development-IEP19727588  
GO:0006509membrane protein ectodomain proteolysis-IEA-  
GO:0007507heart development-IEA-  
GO:0010628positive regulation of gene expression-IDA19727588  
GO:0030198extracellular matrix organization-TAS-  
GO:2000049positive regulation of cell-cell adhesion mediated by cadherin-IDA19727588  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA19727588  
GO:0005794Golgi apparatus-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-8941237Invadopodia formationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22837378Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. (2012 Oct 1)Wilk JBAm J Respir Crit Care Med